{"id":"https://openalex.org/W3047880500","doi":"https://doi.org/10.17352/2455-2968.000108","title":"Long term follow-up of a large patient population with stage 2 and 3 esophageal cancer","display_name":"Long term follow-up of a large patient population with stage 2 and 3 esophageal cancer","publication_year":2020,"publication_date":"2020-07-17","ids":{"openalex":"https://openalex.org/W3047880500","doi":"https://doi.org/10.17352/2455-2968.000108","mag":"3047880500"},"language":"en","primary_location":{"id":"doi:10.17352/2455-2968.000108","doi":"https://doi.org/10.17352/2455-2968.000108","is_oa":true,"landing_page_url":"https://doi.org/10.17352/2455-2968.000108","pdf_url":"https://www.peertechz.com/articles/JSSR-6-208.pdf","source":{"id":"https://openalex.org/S4210201272","display_name":"Journal of Surgery and Surgical Research","issn_l":"2455-2968","issn":["2455-2968"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.peertechz.com/articles/JSSR-6-208.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105787175","display_name":"Christensen Diana M","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christensen Diana M","raw_affiliation_strings":["Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103920057","display_name":"Paulsson Anna K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paulsson Anna K","raw_affiliation_strings":["Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066787915","display_name":"Balkarn S. Thind","orcid":"https://orcid.org/0000-0001-8719-8870","observed_orcids":["https://orcid.org/0000-0001-8719-8870"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thind Balkarn S","raw_affiliation_strings":["De- partment of Radiology , University of Washington , 11244 Greenwood Ave N #1-303 , Seattle , WA 98133 , USA,","Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De- partment of Radiology , University of Washington , 11244 Greenwood Ave N #1-303 , Seattle , WA 98133 , USA,","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111480061","display_name":"M T","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miller Trevor T","raw_affiliation_strings":["Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062492688","display_name":"Jing Zeng","orcid":"https://orcid.org/0000-0001-7388-8926","observed_orcids":["https://orcid.org/0000-0001-7388-8926"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeng Jing","raw_affiliation_strings":["Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104111803","display_name":"Shilpen A. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patel Shilpen A","raw_affiliation_strings":["Department of Radiology, University of Washington, USA","partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"partment of Radiology, University of Washington, 11244 Greenwood Ave N #1-303, Seattle, WA 98133, USA,","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5105787175"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14823759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"110","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trimodality-therapy","display_name":"trimodality therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/esophagectomy","display_name":"esophagectomy","score":0.765999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9419999718666077},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gender-differences-in-survival","display_name":"gender differences in survival","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.7298327684402466},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.7141421437263489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5512637495994568},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5301462411880493},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4668017029762268},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4570200443267822},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37684887647628784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.331556499004364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08291769027709961},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07686370611190796},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07518526911735535},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.05451124906539917},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17352/2455-2968.000108","doi":"https://doi.org/10.17352/2455-2968.000108","is_oa":true,"landing_page_url":"https://doi.org/10.17352/2455-2968.000108","pdf_url":"https://www.peertechz.com/articles/JSSR-6-208.pdf","source":{"id":"https://openalex.org/S4210201272","display_name":"Journal of Surgery and Surgical Research","issn_l":"2455-2968","issn":["2455-2968"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Surgical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.17352/2455-2968.000108","doi":"https://doi.org/10.17352/2455-2968.000108","is_oa":true,"landing_page_url":"https://doi.org/10.17352/2455-2968.000108","pdf_url":"https://www.peertechz.com/articles/JSSR-6-208.pdf","source":{"id":"https://openalex.org/S4210201272","display_name":"Journal of Surgery and Surgical Research","issn_l":"2455-2968","issn":["2455-2968"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Surgical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047880500.pdf","grobid_xml":"https://content.openalex.org/works/W3047880500.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W117791687","https://openalex.org/W1962925388","https://openalex.org/W1967152842","https://openalex.org/W1970762542","https://openalex.org/W2038688720","https://openalex.org/W2099567806","https://openalex.org/W2111674123","https://openalex.org/W2127114913","https://openalex.org/W2127996441","https://openalex.org/W2139265855","https://openalex.org/W2154444715","https://openalex.org/W2163914042","https://openalex.org/W2383944832","https://openalex.org/W2605100575","https://openalex.org/W2613152766"],"related_works":["https://openalex.org/W4408470968","https://openalex.org/W2127996441","https://openalex.org/W4403586653","https://openalex.org/W2033238073","https://openalex.org/W2725626688","https://openalex.org/W1553520219","https://openalex.org/W2022141909","https://openalex.org/W2078007239","https://openalex.org/W2307731066","https://openalex.org/W2055188498"],"abstract_inverted_index":{"Objectives:":[0],"Patients":[1,48],"with":[2,12,49,137,194,238],"stage":[3,50],"II":[4,51],"and":[5,25,32,62,69,75,119,151,229],"III":[6,53],"esophageal":[7,36,54,180,240],"cancer":[8,37,181],"are":[9],"often":[10],"incurable":[11],"surgery":[13],"alone,":[14],"suggesting":[15],"the":[16,30,113,128,234],"importance":[17],"of":[18,35,131,236],"optimizing":[19],"other":[20,44],"treatments":[21],"such":[22],"as":[23],"chemotherapy":[24],"radiation.This":[26],"retrospective":[27],"analysis":[28,94],"compared":[29,76,109],"survival":[31,71,99,177,218,235],"treatment-related":[33,221],"toxicities":[34],"patients":[38,102,126,166,182,199,209,237],"receiving":[39,210],"trimodality":[40,211],"therapy":[41,82,212],"to":[42,110,185,232],"two":[43],"common":[45],"clinical":[46,227],"regimens.Methods:":[47],"or":[52,87],"carcinoma":[55],"who":[56,79],"presented":[57],"for":[58,66,100,164,179,203],"treatment":[59,152],"between":[60,77],"1995":[61],"2016":[63],"were":[64],"eligible":[65],"inclusion.Median":[67],"overall":[68,98,176,217],"disease-free":[70],"(DFS)":[72],"was":[73,103,143,167],"calculated":[74],"those":[78,111],"received":[80],"Trimodality":[81],"(T),":[83],"Surgery":[84],"alone":[85,89],"(S),":[86],"Chemoradiation":[88],"(CH":[90],"+":[91,115,124],"R).Results:":[92],"This":[93],"included":[95],"358":[96],"patients.Median":[97],"T":[101,136],"superior":[104],"(42.8":[105],"months,":[106,133,139],"p":[107],"<0.001)":[108],"in":[112],"CH":[114],"R":[116,125],"(21.5":[117],"months)":[118],"S":[120],"groups":[121],"(19.3":[122],"months).CH":[123],"had":[127,156],"greatest":[129],"DFS":[130],"21":[132],"followed":[134],"by":[135],"15.5":[138],"though":[140],"this":[141],"difference":[142],"not":[144],"signifi":[145,157],"cant":[146,158],"(p=0.56).Patient":[147],"gender":[148],"(p":[149,154],"<0.036)":[150],"toxicity":[153],"<0.002)":[155],"effects":[159],"on":[160],"outcome.Median":[161],"follow-up":[162,196],"time":[163],"all":[165],"22":[168],"months":[169],"(range":[170],"1-250":[171],"mos).Conclusions:":[172],"Though":[173],"fi":[174],"ve-year":[175],"rates":[178],"remain":[183],"close":[184],"20%,":[186],"neoadjuvant":[187],"chemoradiation":[188],"may":[189,224],"improve":[190,233],"outcomes.This":[191],"large":[192],"study":[193],"long":[195],"demonstrates":[197],"that":[198,208],"can":[200],"be":[201],"selected":[202],"appropriate":[204],"therapy.Our":[205],"results":[206],"suggest":[207],"have":[213],"a":[214],"higher":[215],"median":[216],"without":[219],"increased":[220],"toxicity.This":[222],"data":[223],"help":[225],"guide":[226],"decision-making":[228],"patient":[230],"selection":[231],"advanced":[239],"cancer.":[241]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-08-13T00:00:00"}
