{"id":"https://openalex.org/W3047747802","doi":"https://doi.org/10.3390/cells9081867","title":"Circulating MicroRNAs from Serum Exosomes May Serve as a Putative Biomarker in the Diagnosis and Treatment of Patients with Focal Cortical Dysplasia","display_name":"Circulating MicroRNAs from Serum Exosomes May Serve as a Putative Biomarker in the Diagnosis and Treatment of Patients with Focal Cortical Dysplasia","publication_year":2020,"publication_date":"2020-08-10","ids":{"openalex":"https://openalex.org/W3047747802","doi":"https://doi.org/10.3390/cells9081867","mag":"3047747802","pmid":"https://pubmed.ncbi.nlm.nih.gov/32785072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7465068"},"language":"en","primary_location":{"id":"doi:10.3390/cells9081867","doi":"https://doi.org/10.3390/cells9081867","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells9081867","pdf_url":"https://www.mdpi.com/2073-4409/9/8/1867/pdf?version=1597059044","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/9/8/1867/pdf?version=1597059044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057584898","display_name":"Shang\u2010Der Chen","orcid":"https://orcid.org/0000-0001-7879-2579","observed_orcids":["https://orcid.org/0000-0001-7879-2579"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shang-Der Chen","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-7879-2579","affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031806033","display_name":"Hsiu-Yung Pan","orcid":"https://orcid.org/0009-0001-7341-4082","observed_orcids":["https://orcid.org/0009-0001-7341-4082"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiu-Yung Pan","raw_affiliation_strings":["Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061666618","display_name":"Jyun-Bin Huang","orcid":"https://orcid.org/0000-0002-2537-9710","observed_orcids":["https://orcid.org/0000-0002-2537-9710"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jyun-Bin Huang","raw_affiliation_strings":["Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046504510","display_name":"Xuan-Ping Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Xuan-Ping Liu","raw_affiliation_strings":["Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050547990","display_name":"Jie-Hau Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jie-Hau Li","raw_affiliation_strings":["Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009059047","display_name":"Chen-Jui Ho","orcid":"https://orcid.org/0000-0001-8800-3932","observed_orcids":["https://orcid.org/0000-0001-8800-3932"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Jui Ho","raw_affiliation_strings":["Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052822606","display_name":"Meng\u2010Han Tsai","orcid":"https://orcid.org/0000-0002-4570-5712","observed_orcids":["https://orcid.org/0000-0002-4570-5712"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Meng-Han Tsai","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-4570-5712","affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010349545","display_name":"Jenq\u2010Lin Yang","orcid":"https://orcid.org/0000-0002-9897-8087","observed_orcids":["https://orcid.org/0000-0002-9897-8087"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jenq-Lin Yang","raw_affiliation_strings":["Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9897-8087","affiliations":[{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110423001","display_name":"Shufang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Fang Chen","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005305648","display_name":"Nai-Ching Chen","orcid":"https://orcid.org/0000-0003-2684-0377","observed_orcids":["https://orcid.org/0000-0003-2684-0377"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nai-Ching Chen","raw_affiliation_strings":["Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087191020","display_name":"Yao\u2010Chung Chuang","orcid":"https://orcid.org/0000-0001-9131-7385","observed_orcids":["https://orcid.org/0000-0001-9131-7385","https://orcid.org/0000-0003-2847-2176"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yao-Chung Chuang","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","Department of Biological Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","Department of Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Biological Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087191020"],"corresponding_institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029","https://openalex.org/I173093425","https://openalex.org/I4210093821"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":0.7135,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62000785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"8","first_page":"1867","last_page":"1867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-cortical-dysplasia","display_name":"focal cortical dysplasia","score":1.0},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.8450000286102295},{"id":"https://openalex.org/keywords/serum-exosomes","display_name":"serum exosomes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.625},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mir-15a-5p","display_name":"miR-15a-5p","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mir-132-3p","display_name":"miR-132-3p","score":1.0},{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":1.0},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/exosome-isolation","display_name":"exosome isolation","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9162817001342773},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8222872614860535},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8201760053634644},{"id":"https://openalex.org/C2777060296","wikidata":"https://www.wikidata.org/wiki/Q1316942","display_name":"Cortical dysplasia","level":3,"score":0.6736558079719543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5205639004707336},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.5144956111907959},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.4394698739051819},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38262230157852173},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3594871163368225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2924836277961731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18164533376693726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11854827404022217},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09381711483001709},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0906047523021698}],"mesh":[{"descriptor_ui":"D000074166","descriptor_name":"Circulating MicroRNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074166","descriptor_name":"Circulating MicroRNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065703","descriptor_name":"Malformations of Cortical Development, Group I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D065703","descriptor_name":"Malformations of Cortical Development, Group I","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D065703","descriptor_name":"Malformations of Cortical Development, Group I","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D065703","descriptor_name":"Malformations of Cortical Development, Group I","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells9081867","doi":"https://doi.org/10.3390/cells9081867","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells9081867","pdf_url":"https://www.mdpi.com/2073-4409/9/8/1867/pdf?version=1597059044","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7465068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7465068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:32785072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32785072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7945b35af10140bcb3ae534cf3093cad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7945b35af10140bcb3ae534cf3093cad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 9, Iss 8, p 1867 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells9081867","doi":"https://doi.org/10.3390/cells9081867","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells9081867","pdf_url":"https://www.mdpi.com/2073-4409/9/8/1867/pdf?version=1597059044","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1830415264","display_name":null,"funder_award_id":"CMRPG8G0231","funder_id":"https://openalex.org/F4320322767","funder_display_name":"Chang Gung Medical Foundation"},{"id":"https://openalex.org/G6893749683","display_name":"The Regulating Role of Nuclear Factor-\u039ab Dependent Micrornas in Exosomes to Neuroinflammations and Epileptogenesis","funder_award_id":"MOST106-2314-B182A-071","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047747802.pdf","grobid_xml":"https://content.openalex.org/works/W3047747802.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W149256433","https://openalex.org/W1487838396","https://openalex.org/W1609044025","https://openalex.org/W1756596146","https://openalex.org/W1762620449","https://openalex.org/W1864118872","https://openalex.org/W1987048365","https://openalex.org/W1987520879","https://openalex.org/W1995903088","https://openalex.org/W2010852678","https://openalex.org/W2020889306","https://openalex.org/W2047160796","https://openalex.org/W2061460624","https://openalex.org/W2067013656","https://openalex.org/W2078812502","https://openalex.org/W2080893765","https://openalex.org/W2082087902","https://openalex.org/W2102226828","https://openalex.org/W2111043432","https://openalex.org/W2112220310","https://openalex.org/W2121827607","https://openalex.org/W2124077349","https://openalex.org/W2130382882","https://openalex.org/W2135767041","https://openalex.org/W2141889578","https://openalex.org/W2156518600","https://openalex.org/W2158135353","https://openalex.org/W2168348516","https://openalex.org/W2185957033","https://openalex.org/W2195191066","https://openalex.org/W2214989086","https://openalex.org/W2269843685","https://openalex.org/W2292908037","https://openalex.org/W2347029403","https://openalex.org/W2400650084","https://openalex.org/W2401746660","https://openalex.org/W2516618401","https://openalex.org/W2545481670","https://openalex.org/W2553245189","https://openalex.org/W2554056675","https://openalex.org/W2554911478","https://openalex.org/W2555055207","https://openalex.org/W2559664784","https://openalex.org/W2582025421","https://openalex.org/W2590724511","https://openalex.org/W2596379844","https://openalex.org/W2606754742","https://openalex.org/W2606887047","https://openalex.org/W2729582032","https://openalex.org/W2751861194","https://openalex.org/W2752942423","https://openalex.org/W2768534964","https://openalex.org/W2770049589","https://openalex.org/W2770151606","https://openalex.org/W2774085034","https://openalex.org/W2777756804","https://openalex.org/W2789976756","https://openalex.org/W2791322140","https://openalex.org/W2793783592","https://openalex.org/W2794298491","https://openalex.org/W2799586894","https://openalex.org/W2805418802","https://openalex.org/W2901736755","https://openalex.org/W2902030875","https://openalex.org/W2902255849","https://openalex.org/W2913434929","https://openalex.org/W2914453053","https://openalex.org/W2918073486","https://openalex.org/W2936916919","https://openalex.org/W2938517878","https://openalex.org/W2940964825","https://openalex.org/W2952564037","https://openalex.org/W2962176767","https://openalex.org/W2964789193","https://openalex.org/W2967911475","https://openalex.org/W2980784433","https://openalex.org/W2983860615","https://openalex.org/W2990316624","https://openalex.org/W3005886510","https://openalex.org/W4246271082","https://openalex.org/W6694256383"],"related_works":["https://openalex.org/W4415772491","https://openalex.org/W2225007466","https://openalex.org/W4290779445","https://openalex.org/W7172389407","https://openalex.org/W2300124987","https://openalex.org/W2810137415","https://openalex.org/W7116882570","https://openalex.org/W3089331967","https://openalex.org/W2790570242","https://openalex.org/W2786653123"],"abstract_inverted_index":{"Focal":[0],"cortical":[1,9,13],"dysplasia":[2],"(FCD)":[3],"is":[4,32],"a":[5,140,270,292],"congenital":[6],"malformation":[7],"of":[8,41,51,63,86,127,142,157,166,216,226,276],"development":[10],"where":[11],"the":[12,17,24,33,48,83,87,97,122,152,163,247,274,285],"neurons":[14],"located":[15],"in":[16,23,54,74,188,206,273,301],"brain":[18],"area":[19],"fail":[20],"to":[21,46,95,111,240],"migrate":[22],"proper":[25],"formation.":[26],"Epilepsy,":[27],"particularly":[28],"medically":[29],"refractory":[30,279,306],"epilepsy,":[31],"most":[34],"common":[35],"clinical":[36],"presentation":[37],"for":[38,295],"all":[39],"types":[40],"FCD.":[42,241],"This":[43],"study":[44],"aimed":[45],"explore":[47],"expression":[49,125,205],"change":[50,148],"circulating":[52,128,286],"miRNAs":[53,130,144,184,202,287],"patients":[55,65,189,207,302],"with":[56,66,145,190,208,211,303],"FCD":[57,67,191,209,277,304],"from":[58,82,121,150,185,288],"serum":[59,78,186],"exosomes.":[60,98],"A":[61],"total":[62,141],"nine":[64],"and":[68,102,155,171,176,198,218,223,257,261,278,298,305],"four":[69,181,201,227],"healthy":[70],"volunteers":[71],"were":[72,80,105,131,192],"enrolled":[73],"this":[75],"study.":[76],"The":[77,124],"exosomes":[79,120,187,289],"isolated":[81],"peripheral":[84],"blood":[85],"subjects.":[88],"Transmission":[89],"electron":[90],"microscopy":[91],"(TEM)":[92],"was":[93],"used":[94],"identify":[96],"Both":[99],"exosomal":[100,129],"markers":[101,104],"neuronal":[103],"detected":[106],"by":[107,178],"Western":[108],"blotting":[109],"analysis":[110,136,222],"prove":[112],"that":[113,236,246,268,284],"we":[114,230,244],"could":[115],"obtain":[116],"central":[117],"nervous":[118],"system-derived":[119],"circulation.":[123],"profiles":[126],"assessed":[132],"using":[133],"next-generation":[134],"sequencing":[135],"(NGS).":[137],"We":[138],"obtained":[139],"107":[143],"dominant":[146],"fold":[147],"(>2-fold)":[149],"both":[151],"annotated":[153],"5p-arm":[154],"3p-arm":[156],"2780":[158],"mature":[159],"miRNAs.":[160],"Based":[161],"on":[162],"integrated":[164],"platform":[165],"HMDD":[167],"v3.2,":[168],"miRway":[169],"DB":[170],"DIANA-miRPath":[172],"v3.0":[173],"online":[174],"tools,":[175],"confirmed":[177],"MiRBase":[179],"analysis,":[180],"potentially":[182],"predicted":[183],"identified,":[193],"including":[194],"miR194-2-5p,":[195],"miR15a-5p,":[196],"miR-132-3p,":[197],"miR-145-5p.":[199],"All":[200],"presented":[203],"upregulated":[204],"compared":[210],"controls.":[212],"Through":[213],"Kyoto":[214],"Encyclopedia":[215],"Genes":[217],"Genomes":[219],"(KEGG)":[220],"pathway":[221,224,264],"category":[225],"target":[228],"miRNAs,":[229],"found":[231],"eight":[232],"possible":[233],"signaling":[234,249,252,255,263],"pathways":[235,267],"may":[237,290],"be":[238],"related":[239],"Among":[242],"them,":[243],"suggest":[245,283],"mTOR":[248],"pathway,":[250,253,256],"PI3K-Akt":[251],"p53":[254],"cell":[258],"cycle":[259],"regulation":[260],"TGF-beta":[262],"are":[265],"high-risk":[266],"play":[269],"crucial":[271],"role":[272],"pathogenesis":[275],"epilepsy.":[280,307],"Our":[281],"results":[282],"provide":[291],"potential":[293],"biomarker":[294],"diagnostic,":[296],"prognostic,":[297],"therapeutic":[299],"adjuncts":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-08-13T00:00:00"}