{"id":"https://openalex.org/W304771556","doi":"https://doi.org/10.1007/978-1-4614-0598-6_10","title":"Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy","display_name":"Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy","publication_year":2011,"publication_date":"2011-08-10","ids":{"openalex":"https://openalex.org/W304771556","doi":"https://doi.org/10.1007/978-1-4614-0598-6_10","mag":"304771556"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-0598-6_10","doi":"https://doi.org/10.1007/978-1-4614-0598-6_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-0598-6_10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insulin-like Growth Factors and Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W162494757","display_name":"Insulin-like Growth Factors and Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000288481","display_name":"David R. Clemmons","orcid":"https://orcid.org/0000-0001-9946-788X","observed_orcids":["https://orcid.org/0000-0001-9946-788X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David R. Clemmons","raw_affiliation_strings":["Division of Endocrinology, University of North Carolina, School of Medicine, Burnett-Womack, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, University of North Carolina, School of Medicine, Burnett-Womack, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000288481"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":2.2634,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87323944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"193","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/downstream-signaling","display_name":"downstream signaling","score":0.5619999766349792},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.5730000138282776},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5938501358032227},{"id":"https://openalex.org/C2908605954","wikidata":"https://www.wikidata.org/wiki/Q25098752","display_name":"Insulin-Like Growth Factor Receptor","level":5,"score":0.5791544914245605},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5780276656150818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5771130323410034},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5765750408172607},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.5624191761016846},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5463060736656189},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5334546566009521},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5272554159164429},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5253486037254333},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4877949059009552},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.45220327377319336},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4179390072822571},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41477152705192566},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41404715180397034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3962395191192627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34390658140182495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3013082444667816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28961533308029175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0634724497795105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4614-0598-6_10","doi":"https://doi.org/10.1007/978-1-4614-0598-6_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-0598-6_10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insulin-like Growth Factors and Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W177274944","https://openalex.org/W1522008678","https://openalex.org/W1539015594","https://openalex.org/W1807852583","https://openalex.org/W1834944463","https://openalex.org/W1871669466","https://openalex.org/W1907196312","https://openalex.org/W1925087632","https://openalex.org/W1968654699","https://openalex.org/W1972061654","https://openalex.org/W1980446197","https://openalex.org/W1982602011","https://openalex.org/W1990063646","https://openalex.org/W1997006452","https://openalex.org/W1999395736","https://openalex.org/W2001447115","https://openalex.org/W2004066054","https://openalex.org/W2005790049","https://openalex.org/W2005890897","https://openalex.org/W2007278291","https://openalex.org/W2008585163","https://openalex.org/W2009641813","https://openalex.org/W2014202037","https://openalex.org/W2015673732","https://openalex.org/W2025033420","https://openalex.org/W2031964028","https://openalex.org/W2040104879","https://openalex.org/W2040461176","https://openalex.org/W2051839343","https://openalex.org/W2052432810","https://openalex.org/W2056103926","https://openalex.org/W2058614391","https://openalex.org/W2060999361","https://openalex.org/W2061016985","https://openalex.org/W2065302180","https://openalex.org/W2065997104","https://openalex.org/W2072201354","https://openalex.org/W2081869005","https://openalex.org/W2086849370","https://openalex.org/W2087681835","https://openalex.org/W2091874984","https://openalex.org/W2093153734","https://openalex.org/W2098544382","https://openalex.org/W2101091645","https://openalex.org/W2102388598","https://openalex.org/W2105095453","https://openalex.org/W2105963137","https://openalex.org/W2107294830","https://openalex.org/W2108183713","https://openalex.org/W2111843196","https://openalex.org/W2112474467","https://openalex.org/W2113510356","https://openalex.org/W2115147895","https://openalex.org/W2117701806","https://openalex.org/W2120878737","https://openalex.org/W2121168477","https://openalex.org/W2121520362","https://openalex.org/W2126522908","https://openalex.org/W2126783165","https://openalex.org/W2127628047","https://openalex.org/W2136137911","https://openalex.org/W2137125727","https://openalex.org/W2137340845","https://openalex.org/W2138405392","https://openalex.org/W2140512094","https://openalex.org/W2142927748","https://openalex.org/W2142964541","https://openalex.org/W2147909933","https://openalex.org/W2152274262","https://openalex.org/W2155941706","https://openalex.org/W2156136395","https://openalex.org/W2157707796","https://openalex.org/W2161437969","https://openalex.org/W2161513275","https://openalex.org/W2164484108","https://openalex.org/W2164576311","https://openalex.org/W2166934199","https://openalex.org/W2167156722","https://openalex.org/W2168409332","https://openalex.org/W2171212733","https://openalex.org/W2171313739","https://openalex.org/W2209952108","https://openalex.org/W2226227623","https://openalex.org/W2241286838","https://openalex.org/W2244786128","https://openalex.org/W2246814730","https://openalex.org/W2248003239","https://openalex.org/W2287758884","https://openalex.org/W2340451576","https://openalex.org/W2407468163","https://openalex.org/W2410691869","https://openalex.org/W2437020673","https://openalex.org/W2484691022","https://openalex.org/W2495871154","https://openalex.org/W2529461044","https://openalex.org/W2529602925","https://openalex.org/W2532022854","https://openalex.org/W2536191595","https://openalex.org/W2538590401","https://openalex.org/W2581303447","https://openalex.org/W2589345015","https://openalex.org/W2617635878","https://openalex.org/W2894225495"],"related_works":["https://openalex.org/W3173642100","https://openalex.org/W1977424304","https://openalex.org/W2061926387","https://openalex.org/W7096188332","https://openalex.org/W2037566862","https://openalex.org/W2094025115","https://openalex.org/W2021688157","https://openalex.org/W2094503340","https://openalex.org/W2049388837","https://openalex.org/W2000776621"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}