{"id":"https://openalex.org/W3047636746","doi":"https://doi.org/10.1093/nar/gkaa634","title":"Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains","display_name":"Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains","publication_year":2020,"publication_date":"2020-08-06","ids":{"openalex":"https://openalex.org/W3047636746","doi":"https://doi.org/10.1093/nar/gkaa634","mag":"3047636746","pmid":"https://pubmed.ncbi.nlm.nih.gov/32766806","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7498309"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkaa634","doi":"https://doi.org/10.1093/nar/gkaa634","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa634","pdf_url":"https://academic.oup.com/nar/article-pdf/48/16/9204/33746362/gkaa634.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/48/16/9204/33746362/gkaa634.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024581004","display_name":"Dalia Smalakyt\u0117","orcid":"https://orcid.org/0000-0002-6913-6884","observed_orcids":["https://orcid.org/0000-0002-6913-6884"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Dalia Smalakyte","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086452069","display_name":"Migle Kazlauskiene","orcid":"https://orcid.org/0000-0003-2329-0410","observed_orcids":["https://orcid.org/0000-0003-2329-0410"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Migle Kazlauskiene","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089156037","display_name":"Jesper Foged Havelund","orcid":"https://orcid.org/0000-0002-9797-5431","observed_orcids":["https://orcid.org/0000-0002-9797-5431"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper F.\u00a0Havelund","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009282284","display_name":"Audron\u0117 Ruk\u0161\u0117nait\u0117","orcid":"https://orcid.org/0000-0003-2744-486X","observed_orcids":["https://orcid.org/0000-0003-2744-486X","https://orcid.org/0000-0001-6517-6558"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Audron\u0117 Ruk\u0161\u0117nait\u0117","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116499369","display_name":"Auguste Rimaite","orcid":"https://orcid.org/0009-0004-6840-1668","observed_orcids":["https://orcid.org/0009-0004-6840-1668"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Auguste Rimaite","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023540959","display_name":"Giedr\u0117 Tamulaitien\u0117","orcid":"https://orcid.org/0000-0002-9794-3544","observed_orcids":["https://orcid.org/0000-0002-9794-3544"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Giedre Tamulaitiene","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041757990","display_name":"Nils Joakim F\u00e6rgeman","orcid":"https://orcid.org/0000-0002-9281-5287","observed_orcids":["https://orcid.org/0000-0002-9281-5287"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nils J F\u00e6rgeman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101871886","display_name":"Gintautas Tamulaitis","orcid":"https://orcid.org/0000-0002-2259-3033","observed_orcids":["https://orcid.org/0000-0002-2259-3033"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":true,"raw_author_name":"Gintautas Tamulaitis","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001141726","display_name":"Virginijus \u0160ik\u0161nys","orcid":"https://orcid.org/0000-0003-1983-2096","observed_orcids":["https://orcid.org/0000-0003-1983-2096"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":true,"raw_author_name":"Virginijus Siksnys","raw_affiliation_strings":["Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania"],"raw_orcid":"https://orcid.org/0000-0003-1983-2096","affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, Vilnius University, Saul\u0117tekio av. 7, LT-10257 Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001141726","https://openalex.org/A5101871886"],"corresponding_institution_ids":["https://openalex.org/I173212132"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.5722,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.83308756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"48","issue":"16","first_page":"9204","last_page":"9217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6129999756813049},{"id":"https://openalex.org/keywords/rna-degradation","display_name":"RNA degradation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/streptococcus-thermophilus","display_name":"Streptococcus thermophilus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/crispr-cas-immunity","display_name":"CRISPR-Cas immunity","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C97343561","wikidata":"https://www.wikidata.org/wiki/Q18026873","display_name":"HEXA","level":2,"score":0.8897663950920105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8733782172203064},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.7602773308753967},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7438541650772095},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6865667104721069},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38037633895874023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3457118272781372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31873488426208496},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22196736931800842},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13027602434158325}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048249","descriptor_name":"Streptococcus thermophilus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048249","descriptor_name":"Streptococcus thermophilus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkaa634","doi":"https://doi.org/10.1093/nar/gkaa634","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa634","pdf_url":"https://academic.oup.com/nar/article-pdf/48/16/9204/33746362/gkaa634.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:32766806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32766806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7498309","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7498309/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:sdu.dk:openaire/746e9059-2264-4205-9126-281885e42213","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/746e9059-2264-4205-9126-281885e42213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Smalakyte, D, Kazlauskiene, M, F Havelund, J, Ruk\u0161\u0117nait\u0117, A, Rimaite, A, Tamulaitiene, G, F\u00e6rgeman, N J, Tamulaitis, G & Siksnys, V 2020, 'Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains', Nucleic Acids Research, vol. 48, no. 16, pp. 9204-9217. https://doi.org/10.1093/nar/gkaa634","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkaa634","doi":"https://doi.org/10.1093/nar/gkaa634","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa634","pdf_url":"https://academic.oup.com/nar/article-pdf/48/16/9204/33746362/gkaa634.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1980920135","display_name":"Csm efektorinio komplekso \u017eym\u0117jimas vienos molekul\u0117s FRET eksperimentams","funder_award_id":"APP-3/2016","funder_id":"https://openalex.org/F4320322689","funder_display_name":"Lietuvos Mokslo Taryba"},{"id":"https://openalex.org/G3123122688","display_name":null,"funder_award_id":"MIP-40/2013","funder_id":"https://openalex.org/F4320322689","funder_display_name":"Lietuvos Mokslo Taryba"}],"funders":[{"id":"https://openalex.org/F4320322689","display_name":"Lietuvos Mokslo Taryba","ror":"https://ror.org/02gs16m83"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047636746.pdf","grobid_xml":"https://content.openalex.org/works/W3047636746.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1517221380","https://openalex.org/W1554484593","https://openalex.org/W1977531433","https://openalex.org/W2006877162","https://openalex.org/W2011718165","https://openalex.org/W2032672026","https://openalex.org/W2034767282","https://openalex.org/W2060118135","https://openalex.org/W2113420364","https://openalex.org/W2118022632","https://openalex.org/W2144175569","https://openalex.org/W2146263030","https://openalex.org/W2158714788","https://openalex.org/W2159511040","https://openalex.org/W2163241233","https://openalex.org/W2168974130","https://openalex.org/W2169244146","https://openalex.org/W2252611736","https://openalex.org/W2269848625","https://openalex.org/W2274320127","https://openalex.org/W2341289363","https://openalex.org/W2536485573","https://openalex.org/W2548339677","https://openalex.org/W2565810278","https://openalex.org/W2582363697","https://openalex.org/W2732924043","https://openalex.org/W2734470795","https://openalex.org/W2763042654","https://openalex.org/W2803102575","https://openalex.org/W2810758248","https://openalex.org/W2837043602","https://openalex.org/W2890242658","https://openalex.org/W2913248674","https://openalex.org/W2917815849","https://openalex.org/W2920477391","https://openalex.org/W2943943258","https://openalex.org/W2946892453","https://openalex.org/W2950684512","https://openalex.org/W2951567133","https://openalex.org/W2960176412","https://openalex.org/W2968452410","https://openalex.org/W2974769796","https://openalex.org/W2995081665","https://openalex.org/W2999052663","https://openalex.org/W2999070159","https://openalex.org/W3000405636","https://openalex.org/W3012634279","https://openalex.org/W3013719558","https://openalex.org/W3018012244","https://openalex.org/W4235939910"],"related_works":["https://openalex.org/W3013719558","https://openalex.org/W2960176412","https://openalex.org/W7147025211","https://openalex.org/W4415550740","https://openalex.org/W4387002170","https://openalex.org/W3160019512","https://openalex.org/W2837043602","https://openalex.org/W4389947003","https://openalex.org/W2237054207","https://openalex.org/W2801946662"],"abstract_inverted_index":{"The":[0],"type":[1,36],"III":[2],"CRISPR-Cas":[3,38],"systems":[4],"provide":[5],"immunity":[6],"against":[7],"invading":[8],"nucleic":[9],"acids":[10],"through":[11],"the":[12,32,45,50,68,79,115,152,156,166,181],"coordinated":[13,175],"transcription-dependent":[14],"DNA":[15],"targeting":[16],"and":[17,57,91,113,130,159,180],"cyclic":[18],"adenylate":[19],"(cAn)-activated":[20],"RNA":[21,76],"degradation.":[22],"Here,":[23],"we":[24,86],"show":[25],"that":[26,43,65,88,98,142],"both":[27,89,146],"these":[28],"pathways":[29],"contribute":[30],"to":[31,67,73,101,110,114,138],"Streptococcus":[33],"thermophilus":[34],"(St)":[35],"III-A":[37],"immunity.":[39],"HPLC-MS":[40],"analysis":[41],"revealed":[42],"in":[44,155,165],"heterologous":[46],"Escherichia":[47],"coli":[48],"host":[49],"StCsm":[51],"effector":[52,179],"complex":[53],"predominantly":[54],"produces":[55],"cA5":[56],"cA6.":[58],"cA6":[59,109,133],"acts":[60],"as":[61,95],"a":[62,174],"signaling":[63,103],"molecule":[64],"binds":[66],"CARF":[69,90,105],"domain":[70,158],"of":[71,145,151,177],"StCsm6":[72,84],"activate":[74],"non-specific":[75],"degradation":[77],"by":[78,173],"HEPN":[80,92,119,157],"domain.":[81],"By":[82],"dissecting":[83],"domains":[85,93],"demonstrate":[87],"act":[94],"ring":[96,106,127,147],"nucleases":[97,148],"degrade":[99],"cAns":[100,136],"switch":[102],"off.":[104],"nuclease":[107,128],"converts":[108],"linear":[111],"A6>p":[112],"final":[116],"A3>p":[117],"product.":[118],"domain,":[120],"which":[121],"typically":[122],"degrades":[123,132],"RNA,":[124],"also":[125],"shows":[126],"activity":[129,154],"indiscriminately":[131],"or":[134],"other":[135],"down":[137],"A>p.":[139],"We":[140],"propose":[141],"concerted":[143],"action":[144,176],"enables":[149],"self-regulation":[150],"RNase":[153],"eliminates":[160],"all":[161],"cAn":[162],"secondary":[163],"messengers":[164],"cell":[167],"when":[168],"viral":[169],"infection":[170],"is":[171],"combated":[172],"Csm":[178],"cA6-activated":[182],"Csm6":[183],"ribonuclease.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-13T00:00:00"}