{"id":"https://openalex.org/W3047490286","doi":"https://doi.org/10.1371/journal.pntd.0008424","title":"Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins","display_name":"Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins","publication_year":2020,"publication_date":"2020-08-03","ids":{"openalex":"https://openalex.org/W3047490286","doi":"https://doi.org/10.1371/journal.pntd.0008424","mag":"3047490286","pmid":"https://pubmed.ncbi.nlm.nih.gov/32745093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7425990"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0008424","doi":"https://doi.org/10.1371/journal.pntd.0008424","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0008424","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008424&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008424&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047780265","display_name":"Murilo Sena Amaral","orcid":"https://orcid.org/0000-0003-4999-5099","observed_orcids":["https://orcid.org/0000-0003-4999-5099"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Murilo Sena Amaral","raw_affiliation_strings":["Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4999-5099","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059092884","display_name":"Ernesto Goulart","orcid":"https://orcid.org/0000-0001-9526-8701","observed_orcids":["https://orcid.org/0000-0001-9526-8701"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ernesto Goulart","raw_affiliation_strings":["Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9526-8701","affiliations":[{"raw_affiliation_string":"Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010985814","display_name":"Luiz Carlos de Caires-Junior","orcid":"https://orcid.org/0000-0002-1735-2008","observed_orcids":["https://orcid.org/0000-0002-1735-2008"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz Carlos Caires-J\u00fanior","raw_affiliation_strings":["Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1735-2008","affiliations":[{"raw_affiliation_string":"Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000357455","display_name":"David A. Morales-Vicente","orcid":"https://orcid.org/0000-0003-0329-8386","observed_orcids":["https://orcid.org/0000-0003-0329-8386"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"David Abraham Morales-Vicente","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0329-8386","affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013661541","display_name":"Alessandra Soares Schanoski","orcid":"https://orcid.org/0000-0002-6514-8458","observed_orcids":["https://orcid.org/0000-0002-6514-8458"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alessandra Soares-Schanoski","raw_affiliation_strings":["Laboratorio de Bacteriologia, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6514-8458","affiliations":[{"raw_affiliation_string":"Laboratorio de Bacteriologia, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016960129","display_name":"Roselane P. Gomes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roselane Paiva Gomes","raw_affiliation_strings":["Laboratorio de Imunologia Viral, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Imunologia Viral, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048799275","display_name":"Giovanna Gon\u00e7alves de Oliveira Olberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanna Gon\u00e7alves de Oliveira Olberg","raw_affiliation_strings":["Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064419688","display_name":"Renato Mancini Astray","orcid":"https://orcid.org/0000-0002-6983-5298","observed_orcids":["https://orcid.org/0000-0002-6983-5298"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renato Mancini Astray","raw_affiliation_strings":["Laboratorio de Imunologia Viral, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6983-5298","affiliations":[{"raw_affiliation_string":"Laboratorio de Imunologia Viral, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033255349","display_name":"Jorge Elias Kalil","orcid":"https://orcid.org/0000-0001-8415-4274","observed_orcids":["https://orcid.org/0000-0001-8415-4274"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jorge E. Kalil","raw_affiliation_strings":["Laborat\u00f3rio de Imunologia, Faculdade de Medicina e Instituto do Cora\u00e7\u00e3o, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8415-4274","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunologia, Faculdade de Medicina e Instituto do Cora\u00e7\u00e3o, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070788089","display_name":"Mayana Zatz","orcid":"https://orcid.org/0000-0003-3970-8025","observed_orcids":["https://orcid.org/0000-0003-3970-8025"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mayana Zatz","raw_affiliation_strings":["Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Gen\u00e9tica e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e C\u00e9lulas Tronco, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006714133","display_name":"Sergio Verjovski\u2010Almeida","orcid":"https://orcid.org/0000-0002-6356-2401","observed_orcids":["https://orcid.org/0000-0002-6356-2401"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Sergio Verjovski-Almeida","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6356-2401","affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laborat\u00f3rio de Parasitologia, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006714133"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I2800423888"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":3.4752,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.9367793,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"8","first_page":"e0008424","last_page":"e0008424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/congenital-zika-syndrome","display_name":"congenital Zika syndrome","score":1.0},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.9670000076293945},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.640999972820282},{"id":"https://openalex.org/keywords/placental-barrier","display_name":"placental barrier","score":0.6610000133514404},{"id":"https://openalex.org/keywords/host-genetic-susceptibility","display_name":"host genetic susceptibility","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chemokine-secretion","display_name":"chemokine secretion","score":0.6650000214576721},{"id":"https://openalex.org/keywords/ccl5-rantes","display_name":"CCL5/RANTES","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9120000004768372},{"id":"https://openalex.org/keywords/extracellular-matrix-genes","display_name":"extracellular matrix genes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/leukocyte-activation","display_name":"leukocyte activation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/placental-immunity","display_name":"placental immunity","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8961976766586304},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.58379065990448},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5398222208023071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5275777578353882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42973455786705017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4018627107143402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3329389691352844},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11686688661575317}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":true},{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014429","descriptor_name":"Twins, Dizygotic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pntd.0008424","doi":"https://doi.org/10.1371/journal.pntd.0008424","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0008424","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008424&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"doi:10.1101/867465","doi":"https://doi.org/10.1101/867465","is_oa":true,"landing_page_url":"https://doi.org/10.1101/867465","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/07/867465.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:32745093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32745093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:003045376","doi":null,"is_oa":true,"landing_page_url":"https://observatorio.fm.usp.br/handle/OPI/37630","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:7425990","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7425990/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:35d072fede284611890fbf6f0a98bb17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/35d072fede284611890fbf6f0a98bb17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008424 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0008424","doi":"https://doi.org/10.1371/journal.pntd.0008424","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0008424","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008424&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1207375514","display_name":null,"funder_award_id":"Code 001","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1211188917","display_name":"CEGH-CEL - Human Genome and Stem Cell Research Center","funder_award_id":"13/08028-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G121811674","display_name":null,"funder_award_id":"Finance Code 001).","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G2686999566","display_name":null,"funder_award_id":"2013/08028-1","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G29316538","display_name":null,"funder_award_id":"(Code 001)","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G295657101","display_name":null,"funder_award_id":"2019/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3446003243","display_name":"Mechanisms of action of long non-coding RNAs involved with gene activation programs in eukaryotes","funder_award_id":"18/23693-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3572101131","display_name":null,"funder_award_id":"2014/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3869979969","display_name":null,"funder_award_id":"2018/23693-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3988461379","display_name":null,"funder_award_id":"2013/08028-1","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4013256246","display_name":null,"funder_award_id":"2015/14821-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G429285467","display_name":null,"funder_award_id":"2014-5","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4402799499","display_name":null,"funder_award_id":"2015/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4618397387","display_name":"Characterization of the mechanisms of action of long non-coding RNAs involved with gene activation programs in human cells","funder_award_id":"14/03620-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4899290434","display_name":null,"funder_award_id":"08028-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5189966350","display_name":null,"funder_award_id":"2019/18469-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5408099524","display_name":null,"funder_award_id":"2013/ 08028-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5699622428","display_name":"Aging and genetic disorders: genomics and metagenomics","funder_award_id":"14/50931-3","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5733206293","display_name":null,"funder_award_id":"465355/2014-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6142990206","display_name":null,"funder_award_id":"2013/08028","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6312815382","display_name":null,"funder_award_id":"465355/2014-5","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G711682412","display_name":null,"funder_award_id":"2017/16283-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7418193128","display_name":null,"funder_award_id":"2014-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7760717560","display_name":null,"funder_award_id":"2018/23693-5","funder_id":"https://openalex.org/F4320323529","funder_display_name":"Funda\u00e7\u00e3o Butantan"},{"id":"https://openalex.org/G8316234802","display_name":null,"funder_award_id":"465355/2014-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323339","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748"},{"id":"https://openalex.org/F4320323529","display_name":"Funda\u00e7\u00e3o Butantan","ror":"https://ror.org/01whwkf30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047490286.pdf","grobid_xml":"https://content.openalex.org/works/W3047490286.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W79625932","https://openalex.org/W1544385648","https://openalex.org/W1857453373","https://openalex.org/W1971602395","https://openalex.org/W1975120587","https://openalex.org/W1996353737","https://openalex.org/W1997060829","https://openalex.org/W1998310721","https://openalex.org/W1999574084","https://openalex.org/W2035618305","https://openalex.org/W2053856421","https://openalex.org/W2053992388","https://openalex.org/W2065276673","https://openalex.org/W2065744527","https://openalex.org/W2084358775","https://openalex.org/W2084426473","https://openalex.org/W2091789910","https://openalex.org/W2096804991","https://openalex.org/W2105469909","https://openalex.org/W2108680698","https://openalex.org/W2126908512","https://openalex.org/W2130116522","https://openalex.org/W2131836848","https://openalex.org/W2138052298","https://openalex.org/W2142987044","https://openalex.org/W2145308907","https://openalex.org/W2145782275","https://openalex.org/W2145809469","https://openalex.org/W2169456326","https://openalex.org/W2169523292","https://openalex.org/W2265249939","https://openalex.org/W2281227512","https://openalex.org/W2285713692","https://openalex.org/W2289704315","https://openalex.org/W2292422784","https://openalex.org/W2295245778","https://openalex.org/W2307185071","https://openalex.org/W2316180691","https://openalex.org/W2326233293","https://openalex.org/W2329948077","https://openalex.org/W2337135418","https://openalex.org/W2339979511","https://openalex.org/W2341790184","https://openalex.org/W2372368841","https://openalex.org/W2384699986","https://openalex.org/W2399179221","https://openalex.org/W2400827254","https://openalex.org/W2401411142","https://openalex.org/W2461605911","https://openalex.org/W2472922462","https://openalex.org/W2482354067","https://openalex.org/W2532259047","https://openalex.org/W2560106869","https://openalex.org/W2568604158","https://openalex.org/W2581094579","https://openalex.org/W2586343602","https://openalex.org/W2586860795","https://openalex.org/W2588268036","https://openalex.org/W2588452414","https://openalex.org/W2592541537","https://openalex.org/W2602095193","https://openalex.org/W2604098753","https://openalex.org/W2606839707","https://openalex.org/W2609139828","https://openalex.org/W2613031442","https://openalex.org/W2614980328","https://openalex.org/W2617873512","https://openalex.org/W2621647460","https://openalex.org/W2622967054","https://openalex.org/W2623128299","https://openalex.org/W2760364797","https://openalex.org/W2767916436","https://openalex.org/W2794704627","https://openalex.org/W2797695913","https://openalex.org/W2808160997","https://openalex.org/W2884607707","https://openalex.org/W2888683909","https://openalex.org/W2889774426","https://openalex.org/W2889979622","https://openalex.org/W2890344556","https://openalex.org/W2898598946","https://openalex.org/W2908761681","https://openalex.org/W2909107489","https://openalex.org/W2914654039","https://openalex.org/W2918355393","https://openalex.org/W2921483894","https://openalex.org/W2921947324","https://openalex.org/W2946986721","https://openalex.org/W2950033619","https://openalex.org/W2951912016","https://openalex.org/W2954073341","https://openalex.org/W2960914418","https://openalex.org/W2961388244","https://openalex.org/W2971720183","https://openalex.org/W2972764221","https://openalex.org/W2996262624","https://openalex.org/W3036487478","https://openalex.org/W4252553635","https://openalex.org/W4300787673","https://openalex.org/W4313375380","https://openalex.org/W6663829462"],"related_works":["https://openalex.org/W2794704627","https://openalex.org/W3181487095","https://openalex.org/W4232844874","https://openalex.org/W2512976482","https://openalex.org/W4386547521","https://openalex.org/W3112036806","https://openalex.org/W7077173717","https://openalex.org/W4382776696","https://openalex.org/W2782342663","https://openalex.org/W3007837237"],"abstract_inverted_index":{"Zika":[0,5],"virus":[1],"(ZIKV)":[2],"causes":[3],"congenital":[4],"syndrome":[6],"(CZS),":[7],"which":[8,214],"is":[9,60],"characterized":[10],"by":[11,50,56,123],"fetal":[12,30],"demise,":[13],"microcephaly":[14],"and":[15,33,121,129,177,210,220,237,271],"other":[16,69],"abnormalities.ZIKV":[17],"in":[18,35,42,66,84,103,132,166,179,195,268,272],"the":[19,25,39,67,76,98,111,125,160,180,196,201,254,274],"pregnant":[20,47],"woman":[21],"circulation":[22],"must":[23],"cross":[24],"placental":[26],"barrier":[27],"that":[28,53,83,248,261],"includes":[29],"endothelial":[31],"cells":[32,95],"trophoblasts,":[34,181],"order":[36],"to":[37,135,151,206,211,256,264,277],"reach":[38],"fetus.CZS":[40],"occurs":[41],"~1-40%":[43],"of":[44,46,87,170,203,234],"cases":[45],"women":[48],"infected":[49],"ZIKV,":[51],"suggesting":[52],"mothers'":[54],"infection":[55,154,192,240],"ZIKV":[57,105,138,152,171,186,190,242],"during":[58],"pregnancy":[59],"not":[61],"deterministic":[62],"for":[63,91,217],"CZS":[64],"phenotype":[65],"fetus.Therefore,":[68],"susceptibility":[70,106],"factors":[71],"might":[72],"be":[73],"involved,":[74],"including":[75],"host":[77],"genetic":[78],"background.We":[79],"have":[80,253],"previously":[81],"shown":[82],"three":[85],"pairs":[86],"dizygotic":[88],"twins":[89,100,120,146,229,252],"discordant":[90],"CZS,":[92],"neural":[93],"progenitor":[94],"(NPCs)":[96],"from":[97,110,118,127,144,159,198,227,250],"CZS-affected":[99,128,145,199],"presented":[101],"differential":[102],"vitro":[104,133],"compared":[107,122,156],"with":[108,157,241],"NPCs":[109],"non-affected.Here,":[112],"we":[113],"analyzed":[114],"human-induced-pluripotent-stem-cell-derived":[115],"(hiPSC-derived)":[116],"trophoblasts":[117,126,143,158,197,226,249],"these":[119],"RNA-Seq":[124],"non-affected":[130,228,251],"twins.Following":[131],"exposure":[134],"a":[136],"Brazilian":[137],"strain":[139],"(ZIKV":[140],"BR":[141,153,187,191,243],"),":[142],"were":[147],"significantly":[148,231],"more":[149,257],"susceptible":[150],"when":[155],"non-affected.Transcriptome":[161],"profiling":[162],"revealed":[163],"no":[164],"differences":[165],"gene":[167],"expression":[168],"levels":[169],"candidate":[172],"attachment":[173],"factors,":[174],"IFN":[175,178],"receptors":[176],"either":[182],"before":[183],"or":[184],"after":[185,239],"infection.Most":[188],"importantly,":[189],"caused,":[193],"only":[194,225],"twins,":[200],"downregulation":[202],"genes":[204,260],"related":[205],"extracellular":[207],"matrix":[208],"organization":[209],"leukocyte":[212],"activation,":[213],"are":[215,262],"important":[216,266],"trophoblast":[218],"adhesion":[219,270],"immune":[221,275],"response":[222,276],"activation.In":[223],"addition,":[224],"secreted":[230],"increased":[232],"amounts":[233],"chemokines":[235],"RANTES/CCL5":[236],"IP10":[238],".Overall,":[244],"our":[245],"results":[246],"showed":[247],"ability":[255],"efficiently":[258],"activate":[259],"known":[263],"play":[265],"roles":[267],"cell":[269],"triggering":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-08-10T00:00:00"}
