{"id":"https://openalex.org/W3047400476","doi":"https://doi.org/10.3390/ijms21165604","title":"Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells","display_name":"Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells","publication_year":2020,"publication_date":"2020-08-05","ids":{"openalex":"https://openalex.org/W3047400476","doi":"https://doi.org/10.3390/ijms21165604","mag":"3047400476","pmid":"https://pubmed.ncbi.nlm.nih.gov/32764353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7460636"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21165604","doi":"https://doi.org/10.3390/ijms21165604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165604","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5604/pdf?version=1596702041","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/16/5604/pdf?version=1596702041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072506882","display_name":"Achille Schild","orcid":"https://orcid.org/0000-0002-7987-8013","observed_orcids":["https://orcid.org/0000-0002-7987-8013"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Achille Schild","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7987-8013","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043082375","display_name":"Rajesh Bhardwaj","orcid":"https://orcid.org/0000-0002-5599-487X","observed_orcids":["https://orcid.org/0000-0002-5599-487X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rajesh Bhardwaj","raw_affiliation_strings":["Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5599-487X","affiliations":[{"raw_affiliation_string":"Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018197608","display_name":"Nicolas Wenger","orcid":"https://orcid.org/0000-0002-8042-3796","observed_orcids":["https://orcid.org/0000-0002-8042-3796"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Wenger","raw_affiliation_strings":["Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005696023","display_name":"Dominic Tscherrig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominic Tscherrig","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029168779","display_name":"Palanivel Kandasamy","orcid":"https://orcid.org/0000-0003-3795-2876","observed_orcids":["https://orcid.org/0000-0003-3795-2876"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Palanivel Kandasamy","raw_affiliation_strings":["Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3795-2876","affiliations":[{"raw_affiliation_string":"Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072034929","display_name":"Jan Derni\u010d","orcid":"https://orcid.org/0009-0001-2883-2605","observed_orcids":["https://orcid.org/0009-0001-2883-2605"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jan Derni\u010d","raw_affiliation_strings":["Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034050688","display_name":"Roland Baur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roland Baur","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035115736","display_name":"Christine Peinelt","orcid":"https://orcid.org/0000-0002-3474-6893","observed_orcids":["https://orcid.org/0000-0002-3474-6893"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christine Peinelt","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3474-6893","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045219887","display_name":"Martin Lochner","orcid":"https://orcid.org/0000-0003-4930-1886","observed_orcids":["https://orcid.org/0000-0003-4930-1886"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Martin Lochner","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4930-1886","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine, University of Bern, B\u00fchlstrasse 28, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045219887","https://openalex.org/A5078842111"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":402,"currency":"EUR","value_usd":433},"fwci":1.8334,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88817343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"16","first_page":"5604","last_page":"5604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9950000047683716},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6470000147819519},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7620000243186951},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.6129999756813049},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium-stores","display_name":"endoplasmic reticulum calcium stores","score":0.7979999780654907},{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8205569982528687},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.7674695253372192},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7233928442001343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5905797481536865},{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.5395767688751221},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.5270816683769226},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5177344679832458},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5034438967704773},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.45726215839385986},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.4529286324977875},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4498603940010071},{"id":"https://openalex.org/C935647","wikidata":"https://www.wikidata.org/wiki/Q17113155","display_name":"Calcium pump","level":4,"score":0.44515663385391235},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4444262981414795},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3980773389339447},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.395528107881546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3540589213371277},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.24328604340553284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16932538151741028},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071736","descriptor_name":"Stromal Interaction Molecules","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071736","descriptor_name":"Stromal Interaction Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071737","descriptor_name":"Stromal Interaction Molecule 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071737","descriptor_name":"Stromal Interaction Molecule 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071740","descriptor_name":"ORAI1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071740","descriptor_name":"ORAI1 Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/ijms21165604","doi":"https://doi.org/10.3390/ijms21165604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165604","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5604/pdf?version=1596702041","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7460636","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7460636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:32764353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32764353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:doi:10.7892/boris.145882","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/55220","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:145882","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/145882/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Derni\u010d, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A.; Lochner, Martin (2020). Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. International journal of molecular sciences, 21(16) MDPI 10.3390/ijms21165604 <http://dx.doi.org/10.3390/ijms21165604>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5e40f6c15bbf4406b19eff638db0b261","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e40f6c15bbf4406b19eff638db0b261","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 5604, p 5604 (2020)","raw_type":"article"},{"id":"doi:10.7892/boris.145882","doi":"https://doi.org/10.7892/boris.145882","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.145882","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.3390/ijms21165604","doi":"https://doi.org/10.3390/ijms21165604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165604","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5604/pdf?version=1596702041","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1644856387","display_name":"Store-operated calcium channels in health and disease","funder_award_id":"160782","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2036690167","display_name":"Purchase of a single crystal X-ray diffractometer for high resolution and accurate studies on molecular crystals","funder_award_id":"128724","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G298171496","display_name":null,"funder_award_id":"206021","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6770941065","display_name":"The role of mitochondrial carriers in metabolic tuning and reprogramming by calcium flow across membrane contact sites","funder_award_id":"180326","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047400476.pdf","grobid_xml":"https://content.openalex.org/works/W3047400476.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W99404869","https://openalex.org/W1503698015","https://openalex.org/W1534752717","https://openalex.org/W1546599127","https://openalex.org/W1575476642","https://openalex.org/W1579848174","https://openalex.org/W1840415699","https://openalex.org/W1934528477","https://openalex.org/W1935830997","https://openalex.org/W1966152110","https://openalex.org/W1966994683","https://openalex.org/W1970629236","https://openalex.org/W1972370037","https://openalex.org/W1974342767","https://openalex.org/W1978593035","https://openalex.org/W1982620047","https://openalex.org/W1983208296","https://openalex.org/W1984888793","https://openalex.org/W1985924867","https://openalex.org/W1986531910","https://openalex.org/W1993000366","https://openalex.org/W1997725063","https://openalex.org/W2006849038","https://openalex.org/W2009594530","https://openalex.org/W2015080011","https://openalex.org/W2015480034","https://openalex.org/W2016348702","https://openalex.org/W2019961716","https://openalex.org/W2028975474","https://openalex.org/W2032770343","https://openalex.org/W2037289981","https://openalex.org/W2041383551","https://openalex.org/W2045505533","https://openalex.org/W2047029475","https://openalex.org/W2047701578","https://openalex.org/W2049332705","https://openalex.org/W2049960163","https://openalex.org/W2051766064","https://openalex.org/W2058622754","https://openalex.org/W2060904119","https://openalex.org/W2063535351","https://openalex.org/W2065100759","https://openalex.org/W2068675667","https://openalex.org/W2083897778","https://openalex.org/W2084077773","https://openalex.org/W2088685419","https://openalex.org/W2091882194","https://openalex.org/W2101586949","https://openalex.org/W2114048169","https://openalex.org/W2118988881","https://openalex.org/W2124353324","https://openalex.org/W2133615985","https://openalex.org/W2135609872","https://openalex.org/W2136448440","https://openalex.org/W2143390270","https://openalex.org/W2143654194","https://openalex.org/W2146341872","https://openalex.org/W2170319165","https://openalex.org/W2258994777","https://openalex.org/W2329811405","https://openalex.org/W2345685532","https://openalex.org/W2409191099","https://openalex.org/W2475025913","https://openalex.org/W2530078134","https://openalex.org/W2556034766","https://openalex.org/W2585702370","https://openalex.org/W2793378737","https://openalex.org/W2794362013","https://openalex.org/W2802633175","https://openalex.org/W2809090821","https://openalex.org/W2895854258","https://openalex.org/W2899082153","https://openalex.org/W2900526197","https://openalex.org/W2904746330","https://openalex.org/W2910525664","https://openalex.org/W2913485995","https://openalex.org/W2916273903","https://openalex.org/W2920743482","https://openalex.org/W2921398125","https://openalex.org/W2955212108","https://openalex.org/W2992881311","https://openalex.org/W3000544553","https://openalex.org/W3011006662","https://openalex.org/W3011593562","https://openalex.org/W3014265931","https://openalex.org/W6603996576"],"related_works":["https://openalex.org/W2016348702","https://openalex.org/W2978563283","https://openalex.org/W2013961119","https://openalex.org/W2060904119","https://openalex.org/W2084077773","https://openalex.org/W2025638032","https://openalex.org/W1976415902","https://openalex.org/W2088685419","https://openalex.org/W2585702370","https://openalex.org/W7055830897"],"abstract_inverted_index":{"Calcium":[0],"ions":[1],"regulate":[2],"a":[3,44,94,151,189],"wide":[4],"array":[5],"of":[6,38,105,170,182,184,206],"physiological":[7],"functions":[8],"including":[9],"cell":[10],"differentiation,":[11],"proliferation,":[12],"muscle":[13],"contraction,":[14],"neurotransmission,":[15],"and":[16,28,71,116,132,136,144,154,174],"fertilization.":[17],"The":[18,82],"endoplasmic":[19],"reticulum":[20,111],"(ER)":[21],"is":[22,150],"the":[23,55,59,68,72,78,99,106,109,185,209],"major":[24],"intracellular":[25],"Ca2+":[26,60,90,96],"store":[27,34],"cellular":[29],"events":[30],"that":[31,92,227],"induce":[32],"ER":[33,69,107],"depletion":[35],"(e.g.,":[36],"activation":[37],"inositol":[39],"1,4,5-triphosphate":[40],"(IP3)":[41],"receptors)":[42],"trigger":[43],"refilling":[45,104],"process":[46],"known":[47,152],"as":[48,123],"store-operated":[49],"calcium":[50,112,196],"entry":[51],"(SOCE).":[52],"It":[53],"requires":[54],"intricate":[56],"interaction":[57,63],"between":[58],"sensing":[61],"stromal":[62],"molecules":[64],"(STIM)":[65],"located":[66],"in":[67,77,134,217],"membrane":[70,80],"channel":[73],"forming":[74],"Orai":[75,117,137],"proteins":[76],"plasma":[79],"(PM).":[81],"resulting":[83],"active":[84],"STIM/Orai":[85],"complexes":[86],"form":[87],"highly":[88],"selective":[89],"channels":[91],"facilitate":[93],"measurable":[95],"influx":[97],"into":[98],"cytosol":[100],"followed":[101],"by":[102,108],"successive":[103],"sarcoplasmic/endoplasmic":[110],"ATPase":[113],"(SERCA).":[114],"STIM":[115,135],"have":[118,138,165,200,223],"attracted":[119],"significant":[120],"therapeutic":[121],"interest,":[122],"enhanced":[124],"SOCE":[125,210,229],"has":[126],"been":[127,139],"associated":[128],"with":[129],"several":[130,167],"cancers,":[131],"mutations":[133],"linked":[140],"to":[141],"immunodeficiency,":[142],"autoimmune,":[143],"muscular":[145],"diseases.":[146],"2-Aminoethyl":[147],"diphenylborinate":[148],"(2-APB)":[149],"modulator":[153],"depending":[155],"on":[156,179],"its":[157],"concentration":[158],"can":[159],"inhibit":[160],"or":[161],"enhance":[162],"SOCE.":[163,238],"We":[164,222],"synthesized":[166],"novel":[168],"derivatives":[169,226],"2-APB,":[171],"introducing":[172],"halogen":[173],"other":[175],"small":[176],"substituents":[177],"systematically":[178],"each":[180],"position":[181],"one":[183],"phenyl":[186],"rings.":[187],"Using":[188],"fluorometric":[190],"imaging":[191,197],"plate":[192],"reader":[193],"(FLIPR)":[194],"Tetra-based":[195],"assay":[198],"we":[199],"studied":[201],"how":[202],"these":[203],"structural":[204],"changes":[205],"2-APB":[207,225,235],"affect":[208],"modulation":[211],"activity":[212],"at":[213,230,233],"different":[214],"compound":[215],"concentrations":[216],"MDA-MB-231":[218],"breast":[219],"cancer":[220],"cells.":[221],"discovered":[224],"block":[228],"low":[231],"concentrations,":[232],"which":[234],"usually":[236],"enhances":[237]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-08-10T00:00:00"}