{"id":"https://openalex.org/W3047284435","doi":null,"title":"Role of CTNNB1 in the Development of Avian Reproductive System and Ovarian Carcinomas","display_name":"Role of CTNNB1 in the Development of Avian Reproductive System and Ovarian Carcinomas","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W3047284435","mag":"3047284435"},"language":"en","primary_location":{"id":"pmh:oai:s-space.snu.ac.kr:10371/126050","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/126050","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\ubc30\uc2b9\ubbfc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\ubc30\uc2b9\ubbfc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.996999979019165},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.921999990940094},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.7039999961853027},{"id":"https://openalex.org/keywords/embryonic-gonads","display_name":"embryonic gonads","score":0.7279999852180481},{"id":"https://openalex.org/keywords/oviduct-development","display_name":"oviduct development","score":0.9070000052452087},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.39800000190734863},{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.9729999899864197},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.6050000190734863},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8429999947547913},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.6959999799728394},{"id":"https://openalex.org/keywords/ccnd1","display_name":"CCND1","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3966783285140991},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3432922959327698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28695011138916016}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:s-space.snu.ac.kr:10371/126050","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/126050","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3047284435","doi":null,"is_oa":false,"landing_page_url":"https://s-space.snu.ac.kr/bitstream/10371/126050/1/000000017090.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":168,"referenced_works":["https://openalex.org/W169609848","https://openalex.org/W1483519527","https://openalex.org/W1522261940","https://openalex.org/W1595489573","https://openalex.org/W1606300031","https://openalex.org/W1627466708","https://openalex.org/W1648352264","https://openalex.org/W1661647511","https://openalex.org/W1886443720","https://openalex.org/W1920739536","https://openalex.org/W1941707492","https://openalex.org/W1963785171","https://openalex.org/W1965154594","https://openalex.org/W1965542501","https://openalex.org/W1965657782","https://openalex.org/W1967103103","https://openalex.org/W1967199332","https://openalex.org/W1968297570","https://openalex.org/W1968584814","https://openalex.org/W1972383287","https://openalex.org/W1972708772","https://openalex.org/W1972728574","https://openalex.org/W1972880831","https://openalex.org/W1981808812","https://openalex.org/W1982604012","https://openalex.org/W1983606581","https://openalex.org/W1984071195","https://openalex.org/W1987082843","https://openalex.org/W1987535549","https://openalex.org/W1988653486","https://openalex.org/W1990588284","https://openalex.org/W1996014231","https://openalex.org/W1996281468","https://openalex.org/W1997126674","https://openalex.org/W1999819100","https://openalex.org/W2000184125","https://openalex.org/W2003339629","https://openalex.org/W2006193439","https://openalex.org/W2011440748","https://openalex.org/W2011989060","https://openalex.org/W2012736441","https://openalex.org/W2015641421","https://openalex.org/W2020352839","https://openalex.org/W2020515914","https://openalex.org/W2020617101","https://openalex.org/W2021274076","https://openalex.org/W2021948935","https://openalex.org/W2022045037","https://openalex.org/W2023307129","https://openalex.org/W2029091895","https://openalex.org/W2031843272","https://openalex.org/W2032543804","https://openalex.org/W2033106726","https://openalex.org/W2033582458","https://openalex.org/W2036809958","https://openalex.org/W2037561079","https://openalex.org/W2038885470","https://openalex.org/W2039834791","https://openalex.org/W2040844620","https://openalex.org/W2041195664","https://openalex.org/W2041291640","https://openalex.org/W2041527227","https://openalex.org/W2043290155","https://openalex.org/W2044724645","https://openalex.org/W2044822742","https://openalex.org/W2045398119","https://openalex.org/W2050343841","https://openalex.org/W2050386042","https://openalex.org/W2055480930","https://openalex.org/W2056517897","https://openalex.org/W2057810528","https://openalex.org/W2058970280","https://openalex.org/W2060851069","https://openalex.org/W2061893642","https://openalex.org/W2064292256","https://openalex.org/W2064964414","https://openalex.org/W2068206049","https://openalex.org/W2070404132","https://openalex.org/W2071205198","https://openalex.org/W2071862896","https://openalex.org/W2072335762","https://openalex.org/W2075458954","https://openalex.org/W2078740942","https://openalex.org/W2080043180","https://openalex.org/W2086623967","https://openalex.org/W2088968639","https://openalex.org/W2090035083","https://openalex.org/W2090985686","https://openalex.org/W2091965691","https://openalex.org/W2092125592","https://openalex.org/W2092999180","https://openalex.org/W2093676604","https://openalex.org/W2093740859","https://openalex.org/W2095083522","https://openalex.org/W2095609742","https://openalex.org/W2095613768","https://openalex.org/W2095677872","https://openalex.org/W2100272691","https://openalex.org/W2100735085","https://openalex.org/W2100898329","https://openalex.org/W2101422819","https://openalex.org/W2105391020","https://openalex.org/W2106640891","https://openalex.org/W2106787323","https://openalex.org/W2107277218","https://openalex.org/W2109069210","https://openalex.org/W2112670264","https://openalex.org/W2113067579","https://openalex.org/W2113263838","https://openalex.org/W2113800845","https://openalex.org/W2116097991","https://openalex.org/W2116112998","https://openalex.org/W2119284420","https://openalex.org/W2120653485","https://openalex.org/W2122055852","https://openalex.org/W2125901725","https://openalex.org/W2125967276","https://openalex.org/W2127089802","https://openalex.org/W2128382171","https://openalex.org/W2129998916","https://openalex.org/W2134936717","https://openalex.org/W2135387903","https://openalex.org/W2136691417","https://openalex.org/W2138202356","https://openalex.org/W2138797069","https://openalex.org/W2139222330","https://openalex.org/W2140034535","https://openalex.org/W2141269411","https://openalex.org/W2141452193","https://openalex.org/W2144320247","https://openalex.org/W2144788911","https://openalex.org/W2145439554","https://openalex.org/W2145497173","https://openalex.org/W2145738078","https://openalex.org/W2146697101","https://openalex.org/W2146812359","https://openalex.org/W2147156983","https://openalex.org/W2147278996","https://openalex.org/W2148690886","https://openalex.org/W2150171625","https://openalex.org/W2150948354","https://openalex.org/W2152971499","https://openalex.org/W2153988048","https://openalex.org/W2155984740","https://openalex.org/W2156742144","https://openalex.org/W2157758516","https://openalex.org/W2158021558","https://openalex.org/W2158346600","https://openalex.org/W2158351490","https://openalex.org/W2160276016","https://openalex.org/W2160915478","https://openalex.org/W2165961307","https://openalex.org/W2166310305","https://openalex.org/W2167969817","https://openalex.org/W2168060990","https://openalex.org/W2168215385","https://openalex.org/W2169425202","https://openalex.org/W2170261890","https://openalex.org/W2313740314","https://openalex.org/W2334963332","https://openalex.org/W2335082894","https://openalex.org/W2410032162","https://openalex.org/W2410411656","https://openalex.org/W2481953999","https://openalex.org/W2593984668","https://openalex.org/W3016519892","https://openalex.org/W3201339379","https://openalex.org/W4253530840"],"related_works":["https://openalex.org/W2316985718","https://openalex.org/W1480847662","https://openalex.org/W3031360269","https://openalex.org/W2007255895","https://openalex.org/W3049451509","https://openalex.org/W3216275046","https://openalex.org/W7042975321","https://openalex.org/W3112039583","https://openalex.org/W2011844621","https://openalex.org/W2796598148"],"abstract_inverted_index":{"the":[0,7,14,26,35,44,51,75,124,178,284,288,309,319,322,342,400],"developmental":[1],"biology":[2],"of":[3,41,47,54,65,85,126,152,166,214,224,238,256,271,321,329,336,348,373,380,399,423,441],"vertebrate":[4],"embryonic":[5,48,167],"gonad,":[6],"oviduct":[8,57,293,310,402],"development":[9,58,311],"in":[10,21,56,67,74,97,106,139,158,163,184,195,226,236,266,277,287,308,318,334,376,388,396,410,428,443],"response":[11],"to":[12,192,362],"estrogen,":[13],"human":[15,68,257],"epithelial-derived":[16],"ovarian":[17,278,337,412,426,451],"cancer":[18,108,427],"(EOC).":[19],"Therefore,":[20,229,415],"this":[22,381,432],"study,":[23],"we":[24,131,249,281],"used":[25,419],"chicken":[27,289,401,411],"as":[28,62,88,199,218,252,354],"biological":[29,77],"research":[30],"model":[31],"for":[32,420,425],"investigate:":[33],"1)":[34],"functional":[36,439],"roles":[37,96,440],"and":[38,59,83,90,105,149,161,172,182,203,242,269,273,294,312,327,345,358,403,445,449],"expression":[39,147,307,314,365,375,391],"pattern":[40],"CTNNB1":[42,55,66,114,133,153,170,230,251,261,285,306,330,364,374,385,442],"during":[43,143,177,245],"morphological":[45],"changes":[46],"gonad":[49,168],"2)":[50],"estrogen-dependent":[52],"regulation":[53,372],"potential":[60],"functions":[61],"a":[63,94,136,233,253,263,301],"biomarker":[64,255],"EOC.\\n\\n":[69],"Beta-catenin":[70],"(CTNNB1)":[71],"is":[72,206,274,386,392,406],"involved":[73],"various":[76,107],"processes,":[78],"including":[79,292],"embryogenesis,":[80],"tumorigenesis,":[81,267],"angiogenesis":[82,268],"progression":[84,270],"metastasis.":[86],"CTNNB1,":[87],"multifunctional":[89],"oncogenic":[91],"protein,":[92],"play":[93,232,262],"important":[95,276],"adhesion":[98,142,215],"between":[99],"Sertoli":[100,140,179,185,211,227,243],"cells":[101,241,244,398],"by":[102,110,156,394],"N-cadherin-dependent":[103],"manner":[104],"type":[109],"its":[111,313,367,390],"over-activation.":[112],"Also":[113],"can":[115],"interact":[116],"with":[117],"estrogen/estrogen":[118],"receptor":[119],"\u03b1":[120],"complex,":[121],"which":[122,188,369],"regulated":[123],"transcription":[125],"Wnt/\u03b2-catenin":[127],"target":[128],"genes.\\n\\n":[129],"First,":[130],"identified":[132,250],"that":[134,193,298,384,389,404],"has":[135,189],"crucial":[137,234,264],"role":[138,235,265],"cell":[141,180,186,212],"testicular":[144],"development.":[145,169],"The":[146],"patterns":[148,191],"cell-specific":[150],"localization":[151],"was":[154,315],"determined":[155,297],"qRT-PCR,":[157],"situ":[159],"hybridization":[160],"immunohistochemistry":[162],"different":[164],"stage":[165],"mRNA":[171,326],"protein":[173,216,328],"were":[174,360],"most":[175],"abundant":[176],"maturation":[181],"localized":[183,316],",":[187],"similar":[190],"detected":[194],"CTNNB1-related":[196],"genes":[197],"such":[198,217,353],"ESR":[200],"\u03b1,":[201],"CCND1":[202,225],"CDH2.":[204],"Estrogen":[205],"not":[207,341],"only":[208],"stimulate":[209],"immature":[210],"biosynthesis":[213],"N-cadherin":[219],"but":[220,340],"also":[221,275,407],"induces":[222],"up-regulation":[223],"cell.":[228],"may":[231,417],"proliferation":[237],"seminiferous":[239],"epithelial":[240,397],"testis":[246],"morphogenesis.\\n\\n":[247],"Secondly,":[248],"novel":[254,387],"EOC.":[258],"Over":[259],"active":[260],"metastasis":[272],"cancer.":[279],"Thus,":[280],"focused":[282],"on":[283],"gene":[286],"reproductive":[290,447],"track":[291],"ovary.":[295],"We":[296],"DES":[299],"(diethylstilbestrol,":[300],"synthetic":[302],"non-steroidal":[303],"estrogen)":[304],"increased":[305],"predominantly":[317],"LE":[320],"magnum.":[323],"In":[324],"addition,":[325],"are":[331],"significantly":[332],"expressed":[333],"GE":[335],"endometrioid":[338,413],"carcinoma,":[339],"other":[343],"cancerous":[344],"normal":[346],"ovaries":[347],"hens.":[349],"Further,":[350],"four":[351],"miRNAs":[352],"miR-217,":[355],"miR-1467,":[356],"miR-1623":[357],"miR-1697":[359],"discovered":[361],"influence":[363],"via":[366],"3-UTR,":[368],"suggests":[370],"post-transcriptional":[371],"chickens.":[377],"Collectively,":[378,431],"results":[379],"study":[382,434],"indicate":[383],"up-regulated":[393],"estrogen":[395],"it":[405],"abundantly":[408],"exist":[409],"carcinoma.":[414],"CTTNB1":[416],"be":[418],"mornitoring":[421],"effects":[422],"therapies":[424],"laying":[429],"hens.\\n\\n":[430],"present":[433],"provides":[435],"new":[436],"insights":[437],"into":[438],"male":[444],"female":[446],"tract":[448],"Epithelial-derived":[450],"carcinogenesis.":[452]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-08-10T00:00:00"}