{"id":"https://openalex.org/W3047263296","doi":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","title":"Cytokine Removal and Immunomodulation in COVID-19 Severe Pulmonary Respiratory Infection","display_name":"Cytokine Removal and Immunomodulation in COVID-19 Severe Pulmonary Respiratory Infection","publication_year":2020,"publication_date":"2020-04-17","ids":{"openalex":"https://openalex.org/W3047263296","doi":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","mag":"3047263296"},"language":"en","primary_location":{"id":"doi:10.14293/s2199-1006.1.sor-.ppwlc61.v1","doi":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","is_oa":true,"landing_page_url":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","pdf_url":"https://www.scienceopen.com/document_file/191ca692-50f3-4e4c-8ab4-07f10ad17013/ScienceOpenPreprint/Cytokine%20and%20Immunomodulation%20therapy.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ScienceOpen","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.scienceopen.com/document_file/191ca692-50f3-4e4c-8ab4-07f10ad17013/ScienceOpenPreprint/Cytokine%20and%20Immunomodulation%20therapy.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005843863","display_name":"Karen Courville","orcid":"https://orcid.org/0000-0002-4182-6736","observed_orcids":["https://orcid.org/0000-0002-4182-6736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Courville","raw_affiliation_strings":["Instituto de Ciencias M\u00e9dicas, Nefrolog\u00eda"],"raw_orcid":"https://orcid.org/0000-0002-4182-6736","affiliations":[{"raw_affiliation_string":"Instituto de Ciencias M\u00e9dicas, Nefrolog\u00eda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055933534","display_name":"Norman Bustamante","orcid":"https://orcid.org/0000-0002-8896-5194","observed_orcids":["https://orcid.org/0000-0002-8896-5194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norman Bustamante","raw_affiliation_strings":["Instituto de Ciencias M\u00e9dicas, Nefrolog\u00eda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ciencias M\u00e9dicas, Nefrolog\u00eda","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015207630","display_name":"Maydelin Pecchio","orcid":"https://orcid.org/0000-0002-6322-5034","observed_orcids":["https://orcid.org/0000-0002-6322-5034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maydelin Pecchio","raw_affiliation_strings":["Instituto de Ciencias M\u00e9dicas, Infectolog\u00eda"],"raw_orcid":"https://orcid.org/0000-0002-6322-5034","affiliations":[{"raw_affiliation_string":"Instituto de Ciencias M\u00e9dicas, Infectolog\u00eda","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9769999980926514},{"id":"https://openalex.org/keywords/severe-pulmonary-infection","display_name":"severe pulmonary infection","score":0.6610000133514404},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9110000133514404},{"id":"https://openalex.org/keywords/high-volume-hemofiltration","display_name":"high-volume hemofiltration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytosorb","display_name":"CytoSorb","score":0.8709999918937683},{"id":"https://openalex.org/keywords/adsorption-therapy","display_name":"adsorption therapy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/low-dose-corticosteroids","display_name":"low-dose corticosteroids","score":0.8629999756813049},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6190000176429749},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.8925371170043945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6872857213020325},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.639211893081665},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5227301716804504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5009095668792725},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.46094781160354614},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4530200958251953},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.44422003626823425},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.4293373227119446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27599388360977173},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15697461366653442},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.06883591413497925}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.14293/s2199-1006.1.sor-.ppwlc61.v1","doi":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","is_oa":true,"landing_page_url":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","pdf_url":"https://www.scienceopen.com/document_file/191ca692-50f3-4e4c-8ab4-07f10ad17013/ScienceOpenPreprint/Cytokine%20and%20Immunomodulation%20therapy.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ScienceOpen","raw_type":"posted-content"},{"id":"pmh:oai:zenodo.org:4484015","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4484015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.14293/s2199-1006.1.sor-.ppwlc61.v1","doi":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","is_oa":true,"landing_page_url":"https://doi.org/10.14293/s2199-1006.1.sor-.ppwlc61.v1","pdf_url":"https://www.scienceopen.com/document_file/191ca692-50f3-4e4c-8ab4-07f10ad17013/ScienceOpenPreprint/Cytokine%20and%20Immunomodulation%20therapy.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ScienceOpen","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047263296.pdf","grobid_xml":"https://content.openalex.org/works/W3047263296.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1526891398","https://openalex.org/W2030097812","https://openalex.org/W2096458783","https://openalex.org/W2125444608","https://openalex.org/W2127589947","https://openalex.org/W2127645629","https://openalex.org/W2942853781","https://openalex.org/W3001118548","https://openalex.org/W3002457465","https://openalex.org/W3006873276","https://openalex.org/W3009314935","https://openalex.org/W3010084248","https://openalex.org/W3011152298","https://openalex.org/W3012205890","https://openalex.org/W3012421327","https://openalex.org/W3014663601","https://openalex.org/W4254196242"],"related_works":["https://openalex.org/W3161224826","https://openalex.org/W3193841951","https://openalex.org/W4388797735","https://openalex.org/W3108474272","https://openalex.org/W3032517960","https://openalex.org/W4368358217","https://openalex.org/W3196204127","https://openalex.org/W3106660304","https://openalex.org/W3157400711","https://openalex.org/W3033572984"],"abstract_inverted_index":{"Coronavirus":[0],"infection":[1],"produces":[2],"a":[3,10,72],"cytokine":[4],"storm":[5],"in":[6,35,56],"some":[7],"patients,":[8,40],"developing":[9],"moderate":[11],"to":[12,19,63,95],"severe":[13,25],"clinical":[14],"condition":[15],"that":[16],"is":[17],"associated":[18],"increased":[20],"mortality":[21],"mainly":[22],"because":[23],"of":[24,30,42,59,74],"pulmonary":[26],"involvement.":[27],"Elevated":[28],"levels":[29],"IL-6":[31],"have":[32],"been":[33],"found":[34],"non-survivor":[36],"patients.":[37],"In":[38],"these":[39],"clearance":[41],"cytokines":[43,70],"with":[44,52,84],"extracorporeal":[45],"therapies,":[46],"Pulse":[47],"High-":[48],"Volume":[49],"Hemofiltration":[50],"together":[51],"adsorption":[53],"columns":[54],"Cytosorb,":[55],"short":[57],"periods":[58],"time":[60],"for":[61,92],"1":[62],"3":[64],"days,":[65],"could":[66,88],"help":[67],"remove":[68],"inflammatory":[69,76],"allowing":[71],"downregulation":[73],"the":[75,80,93],"response;":[77],"and,":[78],"at":[79],"same":[81],"time,":[82],"treatment":[83],"low":[85],"dose":[86],"steroids,":[87],"give":[89],"an":[90],"opportunity":[91],"host":[94],"reach":[96],"homeostasis,":[97],"decreasing":[98],"lung":[99],"damage":[100],"and":[101],"improving":[102],"survival.":[103]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-08-10T00:00:00"}