{"id":"https://openalex.org/W3047131981","doi":"https://doi.org/10.36740/wlek202004128","title":"OPTIMIZATION OF PATHOGENETIC THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE","display_name":"OPTIMIZATION OF PATHOGENETIC THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3047131981","doi":"https://doi.org/10.36740/wlek202004128","mag":"3047131981","pmid":"https://pubmed.ncbi.nlm.nih.gov/32731714"},"language":"en","primary_location":{"id":"doi:10.36740/wlek202004128","doi":"https://doi.org/10.36740/wlek202004128","is_oa":true,"landing_page_url":"https://doi.org/10.36740/wlek202004128","pdf_url":"https://doi.org/10.36740/wlek202004128","source":{"id":"https://openalex.org/S2753386633","display_name":"Wiadomo\u015bci Lekarskie","issn_l":"0043-5147","issn":["0043-5147","0860-8865","2719-342X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322614463","host_organization_name":"Foundation of Polish Physicians-Pro-Medica","host_organization_lineage":["https://openalex.org/P4322614463"],"host_organization_lineage_names":["Foundation of Polish Physicians-Pro-Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomo\u015bci Lekarskie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.36740/wlek202004128","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061640087","display_name":"Maksim Potyazhenko","orcid":"https://orcid.org/0000-0001-9398-1378","observed_orcids":["https://orcid.org/0000-0001-9398-1378"]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"M\u0430ksym M. Potyazhenko","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059988388","display_name":"K.Ye. Ishcheikin","orcid":"https://orcid.org/0000-0001-7887-0995","observed_orcids":["https://orcid.org/0000-0001-7887-0995"]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Kostiantyn Ye. Ishcheikin","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]},{"raw_affiliation_string":"Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine","institution_ids":["https://openalex.org/I194701111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045087406","display_name":"\u0422\u0435\u0442\u044f\u043d\u0430 \u0412\u0456\u043a\u0442\u043e\u0440\u0456\u0432\u043d\u0430 \u041d\u0430\u0441\u0442\u0440\u043e\u0433\u0430","orcid":"https://orcid.org/0000-0001-5347-6094","observed_orcids":["https://orcid.org/0000-0001-5347-6094"]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tetiana V. Nastroga","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]},{"raw_affiliation_string":"Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine","institution_ids":["https://openalex.org/I194701111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025829109","display_name":"Nina L. Sokolyuk","orcid":"https://orcid.org/0000-0002-7436-9965","observed_orcids":["https://orcid.org/0000-0002-7436-9965"]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nina L. Sokolyuk","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]},{"raw_affiliation_string":"Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine","institution_ids":["https://openalex.org/I194701111"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Oksana Ye. Kitura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Oksana Ye. Kitura","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]},{"raw_affiliation_string":"Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine","institution_ids":["https://openalex.org/I194701111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029455131","display_name":"I. M. Gorodnytska","orcid":"https://orcid.org/0000-0002-5550-4666","observed_orcids":["https://orcid.org/0000-0002-5550-4666"]},"institutions":[{"id":"https://openalex.org/I194701111","display_name":"Ukrainian Medical Stomatological Academy","ror":"https://ror.org/05cczs510","country_code":"UA","type":"education","lineage":["https://openalex.org/I194701111","https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Inesa M. Gorodnytska","raw_affiliation_strings":["UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY, POLTAVA, UKRAINE","institution_ids":["https://openalex.org/I194701111"]},{"raw_affiliation_string":"Department of Internal Medicine and Emergency Medicine Ukrainian Medical Stomatological Academy Shevchenko street, 23, Poltava, Ukraine","institution_ids":["https://openalex.org/I194701111"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194701111"],"apc_list":null,"apc_paid":null,"fwci":0.4637,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6537934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"73","issue":"4","first_page":"773","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ambroxol","display_name":"ambroxol","score":0.9330000281333923},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mucolytic-therapy","display_name":"mucolytic therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/halotherapy","display_name":"halotherapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/reactive-anxiety","display_name":"reactive anxiety","score":0.6800000071525574},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2776330663","wikidata":"https://www.wikidata.org/wiki/Q221637","display_name":"Ambroxol","level":2,"score":0.9351896643638611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8697622418403625},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.7915596961975098},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6479704976081848},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6344676613807678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.539839506149292},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5317823886871338},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.4772765040397644},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4755501449108124},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32799339294433594},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2138904631137848},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000551","descriptor_name":"Ambroxol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005100","descriptor_name":"Expectorants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.36740/wlek202004128","doi":"https://doi.org/10.36740/wlek202004128","is_oa":true,"landing_page_url":"https://doi.org/10.36740/wlek202004128","pdf_url":"https://doi.org/10.36740/wlek202004128","source":{"id":"https://openalex.org/S2753386633","display_name":"Wiadomo\u015bci Lekarskie","issn_l":"0043-5147","issn":["0043-5147","0860-8865","2719-342X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322614463","host_organization_name":"Foundation of Polish Physicians-Pro-Medica","host_organization_lineage":["https://openalex.org/P4322614463"],"host_organization_lineage_names":["Foundation of Polish Physicians-Pro-Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomo\u015bci Lekarskie","raw_type":"journal-article"},{"id":"pmid:32731714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32731714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomosci lekarskie (Warsaw, Poland : 1960)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.36740/wlek202004128","doi":"https://doi.org/10.36740/wlek202004128","is_oa":true,"landing_page_url":"https://doi.org/10.36740/wlek202004128","pdf_url":"https://doi.org/10.36740/wlek202004128","source":{"id":"https://openalex.org/S2753386633","display_name":"Wiadomo\u015bci Lekarskie","issn_l":"0043-5147","issn":["0043-5147","0860-8865","2719-342X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322614463","host_organization_name":"Foundation of Polish Physicians-Pro-Medica","host_organization_lineage":["https://openalex.org/P4322614463"],"host_organization_lineage_names":["Foundation of Polish Physicians-Pro-Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiadomo\u015bci Lekarskie","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047131981.pdf","grobid_xml":"https://content.openalex.org/works/W3047131981.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1841444077","https://openalex.org/W2625277523","https://openalex.org/W2625541553","https://openalex.org/W2896147349","https://openalex.org/W2911440693"],"related_works":["https://openalex.org/W3084032234","https://openalex.org/W3096872421","https://openalex.org/W2360761254","https://openalex.org/W7006024450","https://openalex.org/W2886220511","https://openalex.org/W2351042912","https://openalex.org/W3206428628","https://openalex.org/W3176991941","https://openalex.org/W2351680875","https://openalex.org/W4393197972"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,113,187],"aim":[2],"of":[3,11,14,16,25,28,43,82,105,139,168,191,197,211,214,216],"the":[4,9,12,23,29,41,66,69,100,116,137,156,176,195,198,209,212],"study":[5],"is":[6],"to":[7,88,208],"increase":[8,149],"effectiveness":[10],"treatment":[13],"exacerbation":[15],"COPD":[17,56,192],"group":[18,118,178],"B":[19],"GOLD":[20,58],"II":[21],"with":[22,55,136,194],"use":[24],"combined":[26,30,199],"therapy":[27,78,135,190],"drug":[31,200],"PulmoBRIZ":[32],"containing":[33],"two":[34,64],"components":[35],"-":[36,68,72,79,86,103],"ambroxol":[37,140,201],"and":[38,40,49,84,128,141,143,166,202,204],"acetylcysteine":[39,85,142,203],"course":[42],"halotherapy.":[44],"PATIENTS":[45],"AND":[46],"METHODS:":[47],"Materials":[48],"methods:":[50],"We":[51],"observed":[52],"60":[53],"patients":[54,73,174,193],"B,":[57],"II.":[59],"They":[60],"were":[61],"divided":[62],"into":[63],"groups:":[65],"first":[67],"main":[70],"(n=30)":[71],"receiving":[74,134],"basic":[75,122],"therapy,":[76,123],"mucolytic":[77],"a":[80,93,147],"combination":[81,138],"Ambroxol":[83],"200/30":[87],"1":[89,107],"tabl.":[90],"2":[91],"times":[92],"day,":[94],"number":[95],"7":[96],"days":[97],"and,":[98],"from":[99],"3rd":[101],"day":[102,110],"sessions":[104,145,206],"halotherapy":[106,129,144,205],"time":[108],"per":[109],"\u2116":[111],"10.":[112],"second":[114],"group,":[115],"control":[117,177],"(n=30),":[119],"followed":[120],"only":[121],"did":[124,181],"not":[125,182],"take":[126],"mucolytics":[127],"sessions.":[130],"RESULTS:":[131],"Results:":[132],"Patients":[133],"experienced":[146],"significant":[148],"in":[150,173,175],"FEV1":[151],"by":[152],"8.3%":[153],"(p":[154],"<0.05);":[155],"Tiffon":[157],"index":[158],"was":[159],"7.2%":[160],"(p<0.05),":[161],"reactive":[162],"anxiety":[163],"levels":[164],"(RA)":[165],"manifestations":[167],"autonomic":[169],"dysfunction":[170],"decreased,":[171],"whereas":[172],"these":[179],"indicators":[180],"improve":[183],"significantly.":[184],"CONCLUSION:":[185],"Conclusions:":[186],"proposed":[188],"complex":[189],"inclusion":[196],"contributes":[207],"improvement":[210],"quality":[213],"life":[215],"patients.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-08-10T00:00:00"}
