{"id":"https://openalex.org/W3047121069","doi":"https://doi.org/10.31274/rtd-20200803-131","title":"Exercise induced enhancement of T cell function and ERK p42[superscript MAPK] and p44[superscript MAPK] phosphorylation with advancing age in humans and mice","display_name":"Exercise induced enhancement of T cell function and ERK p42[superscript MAPK] and p44[superscript MAPK] phosphorylation with advancing age in humans and mice","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W3047121069","doi":"https://doi.org/10.31274/rtd-20200803-131","mag":"3047121069"},"language":"en","primary_location":{"id":"doi:10.31274/rtd-20200803-131","doi":"https://doi.org/10.31274/rtd-20200803-131","is_oa":true,"landing_page_url":"https://doi.org/10.31274/rtd-20200803-131","pdf_url":"https://dr.lib.iastate.edu/bitstreams/127414a5-b3fc-470f-bc41-1278824cb56d/download","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iowa State University","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dr.lib.iastate.edu/bitstreams/127414a5-b3fc-470f-bc41-1278824cb56d/download","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072786470","display_name":"Sarah Jean Borengasser","orcid":"https://orcid.org/0000-0002-9984-0178","observed_orcids":["https://orcid.org/0000-0002-9984-0178"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah Jean Borengasser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072786470"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.8820000290870667},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.609000027179718},{"id":"https://openalex.org/keywords/mapk1","display_name":"MAPK1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.7990000247955322},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.796999990940094},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitogenic-stimulation","display_name":"mitogen stimulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7971624732017517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46950674057006836},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.45963722467422485},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.42801207304000854},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3868675231933594},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3364045023918152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2086344063282013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14507725834846497}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.31274/rtd-20200803-131","doi":"https://doi.org/10.31274/rtd-20200803-131","is_oa":true,"landing_page_url":"https://doi.org/10.31274/rtd-20200803-131","pdf_url":"https://dr.lib.iastate.edu/bitstreams/127414a5-b3fc-470f-bc41-1278824cb56d/download","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iowa State University","raw_type":"dissertation"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/97276","doi":null,"is_oa":false,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/97276","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"archive/lib.dr.iastate.edu/rtd/19909/Borengasser_ISU_2003_B668.pdf|||Fri Jan 14 22:01:05 UTC 2022","raw_type":"thesis"},{"id":"pmh:oai:lib.dr.iastate.edu:rtd-20908","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=20908&context=rtd","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrospective Theses and Dissertations","raw_type":"text"}],"best_oa_location":{"id":"doi:10.31274/rtd-20200803-131","doi":"https://doi.org/10.31274/rtd-20200803-131","is_oa":true,"landing_page_url":"https://doi.org/10.31274/rtd-20200803-131","pdf_url":"https://dr.lib.iastate.edu/bitstreams/127414a5-b3fc-470f-bc41-1278824cb56d/download","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iowa State University","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047121069.pdf","grobid_xml":"https://content.openalex.org/works/W3047121069.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W18630108","https://openalex.org/W127766257","https://openalex.org/W216228190","https://openalex.org/W1883645593","https://openalex.org/W1944432999","https://openalex.org/W1971977518","https://openalex.org/W1974654016","https://openalex.org/W2002712477","https://openalex.org/W2007241464","https://openalex.org/W2017353764","https://openalex.org/W2025548430","https://openalex.org/W2025976726","https://openalex.org/W2026405734","https://openalex.org/W2033149788","https://openalex.org/W2033844726","https://openalex.org/W2034240213","https://openalex.org/W2035820068","https://openalex.org/W2043014100","https://openalex.org/W2043464691","https://openalex.org/W2043770396","https://openalex.org/W2084605077","https://openalex.org/W2086940038","https://openalex.org/W2092109378","https://openalex.org/W2093832497","https://openalex.org/W2094278677","https://openalex.org/W2154647037","https://openalex.org/W4292820908","https://openalex.org/W6608577746"],"related_works":["https://openalex.org/W4402299999","https://openalex.org/W4246450666","https://openalex.org/W4388998267","https://openalex.org/W2898370298","https://openalex.org/W2137437058","https://openalex.org/W2884249467","https://openalex.org/W4396520874","https://openalex.org/W2009037891","https://openalex.org/W1521411817","https://openalex.org/W1982459028"],"abstract_inverted_index":{"An":[0],"age-related":[1],"decline":[2,11],"in":[3,23,27,56,101,177,186],"immune":[4,99],"function":[5],"occurs":[6],"with":[7,69,112,195],"advancing":[8],"age.":[9,70],"This":[10],"increases":[12],"the":[13,28,80,96,124,151,196],"incidence":[14],"and":[15,25,31,46,60,67,78,110,127,144,165,171,182,190],"severity":[16],"of":[17,85,123],"infection,":[18],"leading":[19],"to":[20,35,64,75,89],"an":[21,132],"increase":[22,76,201],"morbidity":[24],"mortality":[26],"elderly":[29],"population":[30],"is":[32,61,88,115,175],"largely":[33],"due":[34],"diminished":[36],"T":[37,57,117,180],"cell":[38,58,118],"function,":[39],"that":[40,105,198],"adversely":[41],"affects":[42],"proliferation,":[43],"cytokine":[44],"production,":[45],"signal":[47],"transduction.":[48],"The":[49,83],"MAPK":[50],"pathway":[51],"plays":[52],"a":[53],"crucial":[54],"role":[55],"proliferation":[59,109,143],"specifically":[62],"linked":[63],"IL-2":[65,145],"production":[66,146],"declines":[68],"Exercise":[71],"has":[72],"been":[73],"shown":[74],"activation":[77,122],"phosphorylation":[79,130,174],"ERK":[81],"pathway.":[82],"purpose":[84],"this":[86],"study":[87],"determine":[90],"if":[91],"moderate":[92],"exercise":[93,114,199],"can":[94],"improve":[95],"mitogen":[97,178],"induced":[98],"response":[100],"humans.":[102],"One":[103],"mechanism":[104],"may":[106,183,200],"explain":[107],"increased":[108],"IL-production":[111],"chronic":[113],"enhanced":[116],"signaling,":[119],"specifically,":[120],"greater":[121],"p44[superscript":[125,169],"MAPK]":[126,129,170,173],"p42[superscript":[128,172],"using":[131],"aged":[133],"mouse":[134],"model.":[135],"In":[136,154],"humans,":[137],"there":[138,156],"were":[139,157],"trends":[140],"towards":[141],"exercised-induced":[142],"but":[147],"no":[148,158,193],"differences":[149,159],"for":[150],"other":[152],"cytokines.":[153],"mice,":[155],"between":[160],"old":[161,163],"exercise,":[162],"control,":[164],"young":[166],"mice.":[167],"However,":[168],"detectable":[176,185],"stimulated":[179,188],"cells":[181,189,191],"be":[184],"antigen":[187],"receiving":[192],"stimulation":[194],"possibility":[197],"phosphorylation.":[202]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}