{"id":"https://openalex.org/W3047054312","doi":"https://doi.org/10.1039/d0mt00108b","title":"Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination","display_name":"Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination","publication_year":2020,"publication_date":"2020-08-01","ids":{"openalex":"https://openalex.org/W3047054312","doi":"https://doi.org/10.1039/d0mt00108b","mag":"3047054312","pmid":"https://pubmed.ncbi.nlm.nih.gov/32744273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9346619"},"language":"en","primary_location":{"id":"doi:10.1039/d0mt00108b","doi":"https://doi.org/10.1039/d0mt00108b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0mt00108b","pdf_url":"https://academic.oup.com/metallomics/article-pdf/12/8/1208/41702543/d0mt00108b.pdf","source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/metallomics/article-pdf/12/8/1208/41702543/d0mt00108b.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100378656","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-1580-1356","observed_orcids":["https://orcid.org/0000-0003-1580-1356","https://orcid.org/0009-0009-7012-5216","https://orcid.org/0000-0002-1980-539X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038009988","display_name":"Agust\u00edn Anastas\u00eda","orcid":"https://orcid.org/0000-0001-7238-9041","observed_orcids":["https://orcid.org/0000-0001-7238-9041"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I166401450","display_name":"Universidad Nacional de C\u00f3rdoba","ror":"https://ror.org/056tb7j80","country_code":"AR","type":"education","lineage":["https://openalex.org/I166401450"]},{"id":"https://openalex.org/I4210145890","display_name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra","ror":"https://ror.org/04nh79216","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I166401450","https://openalex.org/I4210123736","https://openalex.org/I4210130626","https://openalex.org/I4210145890","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Agustin Anastasia","raw_affiliation_strings":["Instituto Ferreyra (INIMEC-CONICET-Universidad Nacional de C\u00f3rdoba), C\u00f3rdoba, Argentina","Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ferreyra (INIMEC-CONICET-Universidad Nacional de C\u00f3rdoba), C\u00f3rdoba, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I166401450","https://openalex.org/I4210145890"]},{"raw_affiliation_string":"Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087553039","display_name":"Henrietta Bains","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henrietta Bains","raw_affiliation_strings":["Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473","Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010112404","display_name":"Joanna I. Giza","orcid":"https://orcid.org/0000-0003-0585-4673","observed_orcids":["https://orcid.org/0000-0003-0585-4673"]},"institutions":[{"id":"https://openalex.org/I15653065","display_name":"Borough of Manhattan Community College","ror":"https://ror.org/040hwr020","country_code":"US","type":"education","lineage":["https://openalex.org/I15653065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna I Giza","raw_affiliation_strings":["Department of Science, Borough of Manhattan Community College, York, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-0585-4673","affiliations":[{"raw_affiliation_string":"Department of Science, Borough of Manhattan Community College, York, New York, NY, USA","institution_ids":["https://openalex.org/I15653065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072632804","display_name":"David G Clossey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G Clossey","raw_affiliation_strings":["Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048861317","display_name":"Jingjing Deng","orcid":"https://orcid.org/0000-0002-8457-4380","observed_orcids":["https://orcid.org/0000-0002-8457-4380"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingjing Deng","raw_affiliation_strings":["Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067978392","display_name":"Thomas A. Neubert","orcid":"https://orcid.org/0000-0001-7049-2088","observed_orcids":["https://orcid.org/0000-0001-7049-2088"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A Neubert","raw_affiliation_strings":["New York University Langone Health, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-7049-2088","affiliations":[{"raw_affiliation_string":"New York University Langone Health, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002216914","display_name":"William J. Rice","orcid":"https://orcid.org/0000-0002-5187-255X","observed_orcids":["https://orcid.org/0000-0002-5187-255X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J Rice","raw_affiliation_strings":["New York University Langone Health, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-5187-255X","affiliations":[{"raw_affiliation_string":"New York University Langone Health, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052066350","display_name":"Francis S. Lee","orcid":"https://orcid.org/0000-0002-7108-9650","observed_orcids":["https://orcid.org/0000-0002-7108-9650"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis S Lee","raw_affiliation_strings":["Weill Cornell Medicine, Department of Psychiatry, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Psychiatry, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086974646","display_name":"Barbara L. Hempstead","orcid":"https://orcid.org/0009-0002-9957-564X","observed_orcids":["https://orcid.org/0009-0002-9957-564X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara L Hempstead","raw_affiliation_strings":["Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Medicine, New York, NY, USA. Tel: +212 746-6215","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086932565","display_name":"Clay Bracken","orcid":"https://orcid.org/0000-0002-8067-7796","observed_orcids":["https://orcid.org/0000-0002-8067-7796"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clay Bracken","raw_affiliation_strings":["Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473"],"raw_orcid":"https://orcid.org/0000-0002-8067-7796","affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, Department of Biochemistry, New York, NY, USA. Tel: +212 746-6473","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5086932565","https://openalex.org/A5086974646"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":{"value":2653,"currency":"USD","value_usd":2653},"apc_paid":null,"fwci":0.4806,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55138207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"1208","last_page":"1219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/zinc-binding","display_name":"zinc binding","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8510000109672546},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7149999737739563},{"id":"https://openalex.org/keywords/synaptic-pruning","display_name":"synaptic pruning","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dendritic-spine-remodeling","display_name":"dendritic spine remodeling","score":0.843999981880188},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6803041696548462},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5713873505592346},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.47268372774124146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47048118710517883},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.430339515209198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32403045892715454},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26027339696884155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17348873615264893}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/d0mt00108b","doi":"https://doi.org/10.1039/d0mt00108b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0mt00108b","pdf_url":"https://academic.oup.com/metallomics/article-pdf/12/8/1208/41702543/d0mt00108b.pdf","source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},{"id":"pmid:32744273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32744273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics : integrated biometal science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9346619","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9346619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Metallomics","raw_type":"Text"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/140127","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/140127","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1039/d0mt00108b","doi":"https://doi.org/10.1039/d0mt00108b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0mt00108b","pdf_url":"https://academic.oup.com/metallomics/article-pdf/12/8/1208/41702543/d0mt00108b.pdf","source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1018958963","display_name":"Acquisition of a 500 MHz NMR Spectrometer","funder_award_id":"S10RR023694","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1364411911","display_name":"Acquisition of Detector for JEOL 3200 FSC Electron Microscope","funder_award_id":"1S10OD019994-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3424582138","display_name":null,"funder_award_id":"S10 OD019994-01","funder_id":"https://openalex.org/F4320311180","funder_display_name":"Agouron Institute"},{"id":"https://openalex.org/G3855040992","display_name":"300 kV Electron Microscope for Structural Biology","funder_award_id":"S10RR017291","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4020928953","display_name":"LTQ-Orbitrap Mass Spectrometer.","funder_award_id":"S10RR027990","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4493401679","display_name":"Dual-Beam Scanning Electron Microscope for New York Structural Biology Center","funder_award_id":"1s10rr029300-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5004220402","display_name":null,"funder_award_id":"F00316","funder_id":"https://openalex.org/F4320311180","funder_display_name":"Agouron Institute"},{"id":"https://openalex.org/G5143453582","display_name":"Acquisition of a Cold Probe and Console for a 600MHz NMR spectrometer","funder_award_id":"1s10od016320-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G533446661","display_name":null,"funder_award_id":"S10 RR029300","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5338163581","display_name":"Structure and Interactions of BDNF","funder_award_id":"R21NS090322","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6173960741","display_name":"Functional analysis of variant BDNF (Val66Met)","funder_award_id":"R01NS052819","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G638793136","display_name":"Protein Mass Spectrometry Core Facility for Neuroscience","funder_award_id":"P30NS050276","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7891647507","display_name":"EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION","funder_award_id":"C06RR017528","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000173464","display_name":null,"funder_award_id":"NS050276","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000297285","display_name":null,"funder_award_id":"RO1 NS050276","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311180","display_name":"Agouron Institute","ror":"https://ror.org/05vmwhp17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047054312.pdf","grobid_xml":"https://content.openalex.org/works/W3047054312.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W205881385","https://openalex.org/W1642181682","https://openalex.org/W1691536622","https://openalex.org/W1970310239","https://openalex.org/W1970577444","https://openalex.org/W1976708355","https://openalex.org/W1980133582","https://openalex.org/W1983544779","https://openalex.org/W1988226054","https://openalex.org/W1992225671","https://openalex.org/W1994330158","https://openalex.org/W1998261300","https://openalex.org/W2000209446","https://openalex.org/W2005670463","https://openalex.org/W2008113854","https://openalex.org/W2011724363","https://openalex.org/W2015262462","https://openalex.org/W2017193677","https://openalex.org/W2027220567","https://openalex.org/W2032562864","https://openalex.org/W2038412379","https://openalex.org/W2043986265","https://openalex.org/W2061209918","https://openalex.org/W2066577103","https://openalex.org/W2067302534","https://openalex.org/W2069294500","https://openalex.org/W2077273627","https://openalex.org/W2081150698","https://openalex.org/W2083500052","https://openalex.org/W2084899195","https://openalex.org/W2086569749","https://openalex.org/W2089618587","https://openalex.org/W2109939279","https://openalex.org/W2112610528","https://openalex.org/W2121963535","https://openalex.org/W2127287358","https://openalex.org/W2130417276","https://openalex.org/W2130834237","https://openalex.org/W2131545168","https://openalex.org/W2136332525","https://openalex.org/W2137572159","https://openalex.org/W2138182618","https://openalex.org/W2139984345","https://openalex.org/W2142925967","https://openalex.org/W2155855194","https://openalex.org/W2158590037","https://openalex.org/W2164765293","https://openalex.org/W2169821755","https://openalex.org/W2396676392","https://openalex.org/W2510233326","https://openalex.org/W2527024095","https://openalex.org/W2557592343","https://openalex.org/W2608970480","https://openalex.org/W2610695657","https://openalex.org/W2736247826","https://openalex.org/W2750119959","https://openalex.org/W2753988086","https://openalex.org/W2805430790","https://openalex.org/W2807907895","https://openalex.org/W2980365785","https://openalex.org/W3011231588","https://openalex.org/W6752266565"],"related_works":["https://openalex.org/W2084899195","https://openalex.org/W2614099101","https://openalex.org/W2753988086","https://openalex.org/W2005670463","https://openalex.org/W2557592343","https://openalex.org/W2906268822","https://openalex.org/W2807907895","https://openalex.org/W345892937","https://openalex.org/W2193984745","https://openalex.org/W2737890381"],"abstract_inverted_index":{"Human":[0],"brain":[1],"derived":[2],"neurotrophic":[3],"factor":[4],"(BDNF)":[5],"encodes":[6],"a":[7,12,37,186,192,236],"protein":[8],"product":[9],"consisting":[10],"of":[11,45,71,194,208,225,235,242],"C-terminal":[13],"mature":[14],"domain":[15],"(mature":[16],"BDNF)":[17],"and":[18,48,55,76,94,113,125,143,150,157,165,190],"an":[19,24],"N-terminal":[20],"prodomain,":[21,47,61,66],"which":[22],"is":[23,49,178,202],"intrinsically":[25],"disordered":[26],"protein.":[27],"A":[28],"common":[29],"single":[30],"nucleotide":[31],"polymorphism":[32],"in":[33,36,101,104,154,174,212],"humans":[34],"results":[35,153,230],"methionine":[38],"substitution":[39],"for":[40,180],"valine":[41],"at":[42],"position":[43],"66":[44],"the":[46,64,83,92,105,131,136,148,175,199,205,209,226,233,243],"associated":[50],"with":[51,82,122],"memory":[52],"deficits,":[53],"depression":[54],"anxiety":[56],"disorders.":[57],"The":[58],"BDNF":[59],"Met66":[60,93,114,132,149,176,195,218,244],"but":[62],"not":[63],"Val66":[65,95,112,137,151],"promotes":[67],"rapid":[68],"structural":[69,102],"remodeling":[70],"hippocampal":[72],"neurons'":[73],"growth":[74],"cones":[75],"dendritic":[77],"spines":[78],"by":[79,141,161],"interacting":[80],"directly":[81],"SorCS2":[84],"receptor.":[85],"While":[86],"it":[87],"has":[88],"been":[89],"reported":[90],"that":[91,111,217],"prodomains":[96,115,152],"exhibit":[97],"only":[98],"modest":[99],"differences":[100,159],"propensities":[103],"apo":[106],"state,":[107],"here":[108],"we":[109,183,215],"show":[110],"differentially":[116],"bind":[117],"zinc":[118],"(Zn).":[119],"Zn2+":[120,145,170,187],"binds":[121],"higher":[123,238],"affinity":[124],"more":[126],"broadly":[127],"impacts":[128],"residues":[129],"on":[130],"prodomain":[133,138,177,196,210,219,245],"compared":[134],"to":[135,147,232,246],"as":[139],"shown":[140],"NMR":[142],"ITC.":[144],"binding":[146,188],"distinct":[155],"conformational":[156,172],"macroscopic":[158],"observed":[160,191],"NMR,":[162],"light":[163],"scattering":[164],"cryoEM.":[166],"To":[167],"determine":[168],"if":[169],"mediated":[171,223],"change":[173],"required":[179],"biological":[181],"effect,":[182],"mutated":[184],"His40,":[185],"site,":[189],"loss":[193],"bioactivity.":[197],"As":[198],"His40":[200,222],"site":[201],"distant":[203],"from":[204],"known":[206],"region":[207],"involved":[211],"receptor":[213],"binding,":[214],"suggest":[216],"bioactivity":[220],"involves":[221],"stabilization":[224],"multimeric":[227],"structure.":[228],"Our":[229],"point":[231],"necessity":[234],"Zn2+-mediated":[237],"order":[239],"molecular":[240],"assembly":[241],"mediate":[247],"neuronal":[248],"remodeling.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-10T00:00:00"}