{"id":"https://openalex.org/W3047017342","doi":null,"title":"FIVE YEARS OF DENOSUMAB TREATMENT IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS : PRELIMINARY RESULTS FROM THE FREEDOM EXTENSION STUDY","display_name":"FIVE YEARS OF DENOSUMAB TREATMENT IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS : PRELIMINARY RESULTS FROM THE FREEDOM EXTENSION STUDY","publication_year":2011,"publication_date":"2011-05-31","ids":{"openalex":"https://openalex.org/W3047017342","mag":"3047017342"},"language":"en","primary_location":{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3013775","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/118180","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VOLUME=41;STARTPAGE=26;ENDPAGE=26;TITLE=None","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057643841","display_name":"Socrates E. Papapoulos","orcid":"https://orcid.org/0000-0003-2243-6940","observed_orcids":["https://orcid.org/0000-0003-2243-6940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Socrates E. Papapoulos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2243-6940","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036528950","display_name":"Roland D Chapurlat","orcid":"https://orcid.org/0000-0001-8214-6385","observed_orcids":["https://orcid.org/0000-0001-8214-6385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Chapurlat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8214-6385","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055069129","display_name":"Maria Luisa Brandi","orcid":"https://orcid.org/0000-0002-8741-0592","observed_orcids":["https://orcid.org/0000-0002-8741-0592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Luisa Brandi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8741-0592","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032907896","display_name":"Jacques P. Brown","orcid":"https://orcid.org/0000-0003-1910-788X","observed_orcids":["https://orcid.org/0000-0003-1910-788X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacques P. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112248900","display_name":"Edward J. Czerwinski","orcid":"https://orcid.org/0000-0002-2564-7658","observed_orcids":["https://orcid.org/0000-0002-2564-7658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. J. Czerwi\u0144ski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055135931","display_name":"Nadia S Daizadeh","orcid":"https://orcid.org/0000-0002-4136-4068","observed_orcids":["https://orcid.org/0000-0002-4136-4068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia Daizadeh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4136-4068","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008203290","display_name":"Andreas Grauer","orcid":"https://orcid.org/0000-0001-5098-8262","observed_orcids":["https://orcid.org/0000-0001-5098-8262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Grauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5098-8262","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112357547","display_name":"MA Krieg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Krieg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090943213","display_name":"Zulema Man","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. Man","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047826903","display_name":"Dan Mellstr\u00f6m","orcid":"https://orcid.org/0000-0003-2761-3723","observed_orcids":["https://orcid.org/0000-0003-2761-3723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Mellstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2761-3723","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030599616","display_name":"S. Radominski","orcid":"https://orcid.org/0000-0001-6366-8401","observed_orcids":["https://orcid.org/0000-0001-6366-8401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebasti\u00e3o C\u00e9zar Radominski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6366-8401","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108636106","display_name":"J.-Y. Reginster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.-Y. Reginster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049544471","display_name":"Heinrich Resch","orcid":"https://orcid.org/0000-0003-0236-9998","observed_orcids":["https://orcid.org/0000-0003-0236-9998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinrich Resch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112553762","display_name":"J. Rom\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Rom\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Camille Roux","orcid":"https://orcid.org/0000-0001-9497-1446","observed_orcids":["https://orcid.org/0000-0001-9497-1446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camille Roux","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9497-1446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618463","display_name":"Steven R. Cummings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. R. Cummings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009972236","display_name":"Cesar R. Libanati","orcid":"https://orcid.org/0000-0003-1427-7839","observed_orcids":["https://orcid.org/0000-0003-1427-7839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesar Libanati","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1427-7839","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010429279","display_name":"Henry G. Bone","orcid":"https://orcid.org/0000-0002-4227-2595","observed_orcids":["https://orcid.org/0000-0002-4227-2595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry G. Bone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4227-2595","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54073961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9879999756813049},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.5619999766349792},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/c-terminal-telopeptide","display_name":"C-terminal telopeptide","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fracture-incidence","display_name":"fracture incidence","score":0.6019999980926514},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.671999990940094},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.7020000219345093},{"id":"https://openalex.org/keywords/calcium-and-vitamin-d-supplementation","display_name":"calcium and vitamin D supplementation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.7490000128746033},{"id":"https://openalex.org/keywords/total-hip","display_name":"total hip","score":0.8619999885559082},{"id":"https://openalex.org/keywords/osteoporosis-prevention","display_name":"osteoporosis prevention","score":0.46000000834465027},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8535553812980652},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.652460515499115},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.6297332048416138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.590652346611023},{"id":"https://openalex.org/C3018571302","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Postmenopausal osteoporosis","level":4,"score":0.4597184658050537},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.4530498683452606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24890270829200745},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16888397932052612},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.09318903088569641},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3013775","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/118180","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VOLUME=41;STARTPAGE=26;ENDPAGE=26;TITLE=None","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940753583002711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/118180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:iris.unil.ch:iris/90312","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/90312","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/118180","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/118180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"41","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3013775","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/118180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:serval.unil.ch:BIB_2D6B365B7172","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_2D6B365B7172","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Australian Rheumatology Association in conjunction with Rheumatology Health Professionals Association, 52nd Annual Scientific Meeting, vol. 41, pp. 26","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:3047017342","doi":null,"is_oa":false,"landing_page_url":"https://www.narcis.nl/publication/RecordID/oai%3Ascholarlypublications.universiteitleiden.nl%3Aitem_3013775","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087574295","https://openalex.org/W2776889447","https://openalex.org/W2949353329","https://openalex.org/W2553478815","https://openalex.org/W2099385877","https://openalex.org/W1030819271","https://openalex.org/W6996575247","https://openalex.org/W2320638110","https://openalex.org/W2279827378","https://openalex.org/W2330588325"],"abstract_inverted_index":{"Aims:":[0],"The":[1,276],"pivotal":[2],"FREEDOM":[3,31,70,191],"study":[4,126],"evaluated":[5],"the":[6,37,50,74,137,152,159,182,198,216,248,256,259],"effi":[7,40],"cacy":[8,41,118],"and":[9,39,97,100,128,176,179,193,195,227,268,304],"safety":[10,38,278],"of":[11,42,55,139,188,204,251,258,265,302],"3":[12,85],"years'":[13,62,86,108,112,211],"denosumab":[14,44,90,115,212,242,277],"treatment":[15,287],"in":[16,122,151,171,173,215,223,244,293],"women":[17,214,294],"with":[18,247,295],"postmenopausal":[19],"osteoporosis":[20,23],"(PMO).1":[21],"Since":[22],"is":[24],"a":[25,186,202],"chronic":[26],"condition":[27],"requiring":[28],"long-term":[29,43,160],"therapy,":[30],"was":[32,238,271],"extended":[33],"to":[34,60,65,78,149,185,201,290,306],"further":[35,164],"elucidate":[36],"administration.":[45],"We":[46],"present":[47],"data":[48,104],"from":[49,124,190],"fi":[51,208],"rst":[52,209],"2":[53,111,210],"years":[54,174,292],"this":[56],"extension,":[57],"representing":[58],"up":[59,289],"5":[61,107,291],"continuous":[63,114],"exposure":[64],"denosumab.Methods:":[66],"Patients":[67],"who":[68,141],"completed":[69,142],"were":[71,163],"eligible":[72],"for":[73,273,288],"extension.":[75],"Women":[76],"continued":[77],"receive":[79],"(long-term":[80],"group),":[81,89],"or":[82,110],"started":[83],"after":[84],"placebo":[87],"(cross-over":[88],"60":[91],"mg":[92],"sc":[93],"every":[94],"6":[95],"months":[96],"daily":[98],"calcium":[99],"vitamin":[101],"D.":[102],"These":[103],"refl":[105],"ect":[106],"(long-term)":[109],"(cross-over)":[113],"treatment.":[116],"Effi":[117],"measures":[119],"include":[120],"changes":[121],"BMD":[123,172,230],"extension":[125,153],"baseline":[127,192],"bone":[129],"turnover":[130],"markers":[131],"(BTM).":[132],"P-values":[133],"are":[134],"descriptive.Results:":[135],"Of":[136],"83.0%":[138],"subjects":[140],"FREEDOM,":[143],"70.2%":[144],"(N":[145],"=":[146],"4550)":[147],"agreed":[148],"participate":[150],"(long-term:":[154],"2343;":[155],"cross-over:":[156],"2207).":[157],"In":[158],"group,":[161],"there":[162],"signifi":[165,220],"cant":[166,221],"gains":[167],"(P":[168,232],"<":[169,233],"0.0001)":[170],"4":[175],"5:":[177],"1.9%":[178],"1.7%":[180],"at":[181,197,255],"lumbar":[183,224],"spine":[184,225],"total":[187,199,203,228],"13.7%":[189],"0.7%":[194],"0.6%":[196],"hip":[200,229],"7.0%.":[205],"During":[206],"their":[207],"treatment,":[213],"cross-over":[217],"group":[218],"had":[219],"improvements":[222],"(7.9%)":[226],"(4.1%)":[231],"0.0001).":[234],"Serum":[235],"C-telopeptide":[236],"(CTX)":[237],"rapidly":[239],"reduced":[240],"following":[241],"dosing":[243,260],"both":[245,274],"groups,":[246],"characteristic":[249],"attenuation":[250],"CTX":[252],"reduction":[253,301],"observed":[254],"end":[257],"interval.":[261],"A":[262],"low":[263],"incidence":[264],"new":[266],"vertebral":[267],"nonvertebral":[269],"fractures":[270],"reported":[272],"groups.":[275],"profi":[279],"le":[280],"did":[281],"not":[282],"change":[283],"over":[284],"time.Conclusions:":[285],"Denosumab":[286],"PMO":[296],"remains":[297],"well":[298],"tolerated,":[299],"maintains":[300],"BTMs":[303],"continues":[305],"significantly":[307],"increase":[308],"BMD.Reference1.":[309],"Cummings.":[310],"NEJM":[311],"2009;361:756.":[312]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2020-08-10T00:00:00"}