{"id":"https://openalex.org/W3046986058","doi":"https://doi.org/10.3390/molecules25163577","title":"Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones","display_name":"Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones","publication_year":2020,"publication_date":"2020-08-06","ids":{"openalex":"https://openalex.org/W3046986058","doi":"https://doi.org/10.3390/molecules25163577","mag":"3046986058","pmid":"https://pubmed.ncbi.nlm.nih.gov/32781642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7463537"},"language":"en","primary_location":{"id":"doi:10.3390/molecules25163577","doi":"https://doi.org/10.3390/molecules25163577","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules25163577","pdf_url":"https://www.mdpi.com/1420-3049/25/16/3577/pdf?version=1597024133","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/25/16/3577/pdf?version=1597024133","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011446383","display_name":"Yuri E. Sabutski","orcid":"https://orcid.org/0000-0003-3815-6142","observed_orcids":["https://orcid.org/0000-0003-3815-6142"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Yuri E. Sabutski","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052937752","display_name":"Ekaterina S. Menchinskaya","orcid":"https://orcid.org/0000-0002-4027-9064","observed_orcids":["https://orcid.org/0000-0002-4027-9064"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina S. Menchinskaya","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011220789","display_name":"\u041b. \u0421. \u0428\u0435\u0432\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-4991-4949","observed_orcids":["https://orcid.org/0000-0003-4991-4949"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ludmila S. Shevchenko","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089128668","display_name":"Ekaterina A. Chingizova","orcid":"https://orcid.org/0000-0003-0093-5757","observed_orcids":["https://orcid.org/0000-0003-0093-5757"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina A. Chingizova","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021382314","display_name":"Artur R. Chingizov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artur R. Chingizov","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047305755","display_name":"Roman Sergeevich Popov","orcid":"https://orcid.org/0000-0002-1727-6164","observed_orcids":["https://orcid.org/0000-0002-1727-6164"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Roman S. Popov","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062812556","display_name":"\u0412. \u0410. \u0414\u0435\u043d\u0438\u0441\u0435\u043d\u043a\u043e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir A. Denisenko","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112967351","display_name":"Valery V. Mikhailov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valery V. Mikhailov","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042713618","display_name":"Dmitry L. Aminin","orcid":"https://orcid.org/0000-0002-1073-4994","observed_orcids":["https://orcid.org/0000-0002-1073-4994"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU","TW"],"is_corresponding":false,"raw_author_name":"Dmitry L. Aminin","raw_affiliation_strings":["Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034347000","display_name":"\u0421\u0435\u0440\u0433\u0435\u0439 \u0413\u0435\u043e\u0440\u0433\u0438\u0435\u0432\u0438\u0447 \u041f\u043e\u043b\u043e\u043d\u0438\u043a","orcid":"https://orcid.org/0000-0002-5382-8296","observed_orcids":["https://orcid.org/0000-0002-5382-8296"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Sergey G. Polonik","raw_affiliation_strings":["G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences. Prospekt 100-let Vladivostoku 159, 690022 Vladivostok, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011446383","https://openalex.org/A5034347000"],"corresponding_institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":1.5658,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77937678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"16","first_page":"3577","last_page":"3577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-4-naphthoquinone","display_name":"1,4-naphthoquinone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/juglone","display_name":"juglone","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tetracyclic-heterocycles","display_name":"tetracyclic heterocycles","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.7120000123977661},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9789999723434448},{"id":"https://openalex.org/keywords/arabinoside","display_name":"arabinoside","score":0.6549999713897705},{"id":"https://openalex.org/keywords/xylosides","display_name":"xylosides","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7174801230430603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6959742307662964},{"id":"https://openalex.org/C2777118263","wikidata":"https://www.wikidata.org/wiki/Q131307","display_name":"Bacillus cereus","level":3,"score":0.5221141576766968},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.326577365398407},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2751392722129822},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1646689474582672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13833087682724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010075","descriptor_name":"Oxathiins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013863","descriptor_name":"Thioglucosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013863","descriptor_name":"Thioglucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013863","descriptor_name":"Thioglucosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules25163577","doi":"https://doi.org/10.3390/molecules25163577","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules25163577","pdf_url":"https://www.mdpi.com/1420-3049/25/16/3577/pdf?version=1597024133","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:32781642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32781642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7463537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7463537/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4d8fa0a23f3c4979b906b4a660d36265","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d8fa0a23f3c4979b906b4a660d36265","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 25, Iss 16, p 3577 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules25163577","doi":"https://doi.org/10.3390/molecules25163577","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules25163577","pdf_url":"https://www.mdpi.com/1420-3049/25/16/3577/pdf?version=1597024133","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3696277857","display_name":null,"funder_award_id":"18-33-","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G3936522559","display_name":null,"funder_award_id":"\u2116 18-33-00492_mol_a","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G970705136","display_name":null,"funder_award_id":"19-14-00047","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3046986058.pdf","grobid_xml":"https://content.openalex.org/works/W3046986058.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W26684565","https://openalex.org/W1496928723","https://openalex.org/W1750119960","https://openalex.org/W1969373355","https://openalex.org/W1972692384","https://openalex.org/W1983754950","https://openalex.org/W1992083862","https://openalex.org/W2010282985","https://openalex.org/W2015442165","https://openalex.org/W2017464987","https://openalex.org/W2017918262","https://openalex.org/W2046130688","https://openalex.org/W2049148809","https://openalex.org/W2068514394","https://openalex.org/W2071937834","https://openalex.org/W2125272176","https://openalex.org/W2132524012","https://openalex.org/W2336373035","https://openalex.org/W2469115809","https://openalex.org/W2498457182","https://openalex.org/W2534055420","https://openalex.org/W2560663889","https://openalex.org/W2765200219","https://openalex.org/W2774937776","https://openalex.org/W2792780613","https://openalex.org/W2914303170","https://openalex.org/W2941009528","https://openalex.org/W2950202934","https://openalex.org/W2954937780","https://openalex.org/W2982512225","https://openalex.org/W2985753020","https://openalex.org/W2998218278","https://openalex.org/W4233729049","https://openalex.org/W4248232688","https://openalex.org/W4256662163","https://openalex.org/W6765377064"],"related_works":["https://openalex.org/W2810554058","https://openalex.org/W2971523991","https://openalex.org/W2001697936","https://openalex.org/W2905830510","https://openalex.org/W2058161111","https://openalex.org/W2400795892","https://openalex.org/W2417894862","https://openalex.org/W3108391715","https://openalex.org/W2003163764","https://openalex.org/W2156701186"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,16,55,63,79,122,158,169],"new":[3],"tetracyclic":[4,36],"oxathiine-fused":[5],"quinone-thioglycoside":[6],"conjugates":[7,37,80,110],"based":[8],"on":[9,162],"biologically":[10],"active":[11],"1,4-naphthoquinones":[12,170],"and":[13,21,27,32,65,68,94,97,116,136,164],"1-mercapto":[14],"derivatives":[15],"per-O-acetyl":[17],"d-glucose,":[18],"d-galactose,":[19],"d-xylose,":[20],"l-arabinose":[22,114],"have":[23],"been":[24],"synthesized,":[25],"characterized,":[26],"evaluated":[28],"for":[29,60,167],"their":[30],"cytotoxic":[31,47,163],"antimicrobial":[33,77,130,165],"activities.":[34],"Six":[35],"bearing":[38],"a":[39,155],"hydroxyl":[40,117],"group":[41,118,168],"in":[42,52],"naphthoquinone":[43,123],"core":[44,124],"showed":[45,129,147],"high":[46],"activity":[48,71,78,131,149,166],"with":[49,111,133,150,160],"EC50":[50],"values":[51],"the":[53,102],"range":[54],"0.3":[56],"to":[57,73],"0.9":[58],"\u03bcM":[59],"various":[61],"types":[62],"cancer":[64],"normal":[66],"cells":[67],"no":[69],"hemolytic":[70],"up":[72],"25":[74],"\u03bcM.":[75],"The":[76,106],"was":[81,171],"screened":[82],"against":[83,138],"Gram-positive":[84,139],"bacteria":[85,91,140],"(Staphylococcus":[86],"aureus,":[87],"Bacillus":[88],"cereus),":[89],"Gram-negative":[90],"(Pseudomonas":[92],"aeruginosa":[93],"Escherichia":[95],"coli),":[96],"fungus":[98],"Candida":[99],"albicans":[100],"by":[101],"agar":[103],"diffusion":[104],"method.":[105],"most":[107],"effective":[108],"juglone":[109],"d-xylose":[112],"or":[113],"moiety":[115],"at":[119,125],"C-7":[120],"position":[121],"concentration":[126],"10":[127],"\u00b5g/well":[128],"comparable":[132],"antibiotics":[134],"vancomicin":[135],"gentamicin":[137],"strains.":[141],"In":[142],"liquid":[143],"media,":[144],"juglone-arabinosidic":[145],"tetracycles":[146],"highest":[148],"MIC":[151],"6.25":[152],"\u00b5M.":[153],"Thus,":[154],"positive":[156],"effect":[157],"heterocyclization":[159],"mercaptosugars":[161],"shown.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-10T00:00:00"}