{"id":"https://openalex.org/W3046981728","doi":"https://doi.org/10.1371/journal.pgen.1008941","title":"A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein","display_name":"A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein","publication_year":2020,"publication_date":"2020-08-06","ids":{"openalex":"https://openalex.org/W3046981728","doi":"https://doi.org/10.1371/journal.pgen.1008941","mag":"3046981728","pmid":"https://pubmed.ncbi.nlm.nih.gov/32760060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7444587"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1008941","doi":"https://doi.org/10.1371/journal.pgen.1008941","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008941","pdf_url":null,"source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pgen.1008941","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072210131","display_name":"Meredith H. Wilson","orcid":"https://orcid.org/0000-0002-6152-7127","observed_orcids":["https://orcid.org/0000-0002-6152-7127"]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith H. Wilson","raw_affiliation_strings":["Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6152-7127","affiliations":[{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086157288","display_name":"Sujith Rajan","orcid":"https://orcid.org/0000-0002-8376-0587","observed_orcids":["https://orcid.org/0000-0002-8376-0587"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujith Rajan","raw_affiliation_strings":["New York University Long Island School of Medicine, Mineola, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8376-0587","affiliations":[{"raw_affiliation_string":"New York University Long Island School of Medicine, Mineola, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000141229","display_name":"Aidan Danoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aidan Danoff","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053576017","display_name":"Richard Joseph White","orcid":"https://orcid.org/0000-0003-1842-412X","observed_orcids":["https://orcid.org/0000-0003-1842-412X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard J. White","raw_affiliation_strings":["Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom","Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1842-412X","affiliations":[{"raw_affiliation_string":"Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041689931","display_name":"Monica R. Hensley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica R. Hensley","raw_affiliation_strings":["Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025667289","display_name":"Vanessa H. Quinlivan","orcid":"https://orcid.org/0000-0002-8546-6592","observed_orcids":["https://orcid.org/0000-0002-8546-6592"]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa H. Quinlivan","raw_affiliation_strings":["Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8546-6592","affiliations":[{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080008815","display_name":"Rosario Recacha","orcid":"https://orcid.org/0000-0002-8953-0483","observed_orcids":["https://orcid.org/0000-0002-8953-0483"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Rosario Recacha","raw_affiliation_strings":["Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":"https://orcid.org/0000-0002-8953-0483","affiliations":[{"raw_affiliation_string":"Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015692478","display_name":"James H. Thierer","orcid":"https://orcid.org/0000-0002-1679-2255","observed_orcids":["https://orcid.org/0000-0002-1679-2255"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Thierer","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1679-2255","affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050762631","display_name":"Frederick J. Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick J. Tan","raw_affiliation_strings":["Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026550780","display_name":"Elisabeth M. Busch\u2010Nentwich","orcid":"https://orcid.org/0000-0001-6450-744X","observed_orcids":["https://orcid.org/0000-0001-6450-744X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elisabeth M. Busch-Nentwich","raw_affiliation_strings":["Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom","Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6450-744X","affiliations":[{"raw_affiliation_string":"Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016746605","display_name":"Lloyd W. Ruddock","orcid":"https://orcid.org/0000-0002-6247-686X","observed_orcids":["https://orcid.org/0000-0002-6247-686X"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Lloyd Ruddock","raw_affiliation_strings":["Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":"https://orcid.org/0000-0002-6247-686X","affiliations":[{"raw_affiliation_string":"Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055404631","display_name":"M. Mahmood Hussain","orcid":"https://orcid.org/0000-0002-9663-300X","observed_orcids":["https://orcid.org/0000-0002-9663-300X"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Mahmood Hussain","raw_affiliation_strings":["New York University Long Island School of Medicine, Mineola, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Long Island School of Medicine, Mineola, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039868907","display_name":"Steven Arthur Farber","orcid":"https://orcid.org/0000-0002-8037-7312","observed_orcids":["https://orcid.org/0000-0002-8037-7312"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven A. Farber","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8037-7312","affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5039868907","https://openalex.org/A5055404631"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I196817621","https://openalex.org/I4210117844","https://openalex.org/I57206974"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.6231,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.91998839,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"8","first_page":"e1008941","last_page":"e1008941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsomal-triglyceride-transfer-protein","display_name":"microsomal triglyceride transfer protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mtp","display_name":"MTP","score":0.6859999895095825},{"id":"https://openalex.org/keywords/apolipoprotein-b-containing-lipoproteins","display_name":"apolipoprotein B-containing lipoproteins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.7570000290870667},{"id":"https://openalex.org/keywords/yolk-syncytial-layer","display_name":"yolk syncytial layer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/lipid-transfer","display_name":"lipid transfer","score":0.6959999799728394},{"id":"https://openalex.org/keywords/triglyceride-transfer","display_name":"triglyceride transfer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phospholipid-transfer","display_name":"phospholipid transfer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.7310000061988831},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intestinal-fat-malabsorption","display_name":"intestinal fat malabsorption","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.843999981880188},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.47699999809265137},{"id":"https://openalex.org/keywords/protein-structure-modeling","display_name":"protein structure modeling","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C13028836","wikidata":"https://www.wikidata.org/wiki/Q21122998","display_name":"Microsomal triglyceride transfer protein","level":5,"score":0.9281973838806152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6222423315048218},{"id":"https://openalex.org/C7251936","wikidata":"https://www.wikidata.org/wiki/Q7201525","display_name":"Plant lipid transfer proteins","level":3,"score":0.593312680721283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5714139342308044},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.544242262840271},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5035540461540222},{"id":"https://openalex.org/C2781321622","wikidata":"https://www.wikidata.org/wiki/Q181409","display_name":"Yolk","level":2,"score":0.4563082754611969},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4172552525997162},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2662128806114197},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.16907042264938354},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.14083033800125122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13704365491867065},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1008941","doi":"https://doi.org/10.1371/journal.pgen.1008941","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008941","pdf_url":null,"source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/701813","doi":"https://doi.org/10.1101/701813","is_oa":true,"landing_page_url":"https://doi.org/10.1101/701813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/22/701813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7444587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7444587","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:32760060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32760060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/309329","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/309329","pdf_url":"https://www.repository.cam.ac.uk/handle/1810/309329","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:c8a3fa12b57c47668859e647c2dbd300","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c8a3fa12b57c47668859e647c2dbd300","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 16, Iss 8, p e1008941 (2020)","raw_type":"article"},{"id":"doi:10.17863/cam.56421","doi":"https://doi.org/10.17863/cam.56421","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.56421","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1008941","doi":"https://doi.org/10.1371/journal.pgen.1008941","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008941","pdf_url":null,"source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1863692627","display_name":"Effects of miR-30c deficiency on plasma cholesterol and atherosclerosis","funder_award_id":"R01HL137202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G203482354","display_name":null,"funder_award_id":"HL-137202-01A1","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2471424637","display_name":null,"funder_award_id":"R56 DK046900-17A1","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2592540266","display_name":null,"funder_award_id":"F32DK109592","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G3078397762","display_name":"Mechanisms of cytoplasmic lipid droplet regulation in the intestine","funder_award_id":"F32DK109592","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3787607271","display_name":null,"funder_award_id":"R01 DK093399","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4056208550","display_name":"Acquisition of GE Typhoon FLA9500 Variable Mode Imager","funder_award_id":"1s10od021567-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4250926344","display_name":"Mapping MTP lipid transfer activities for better therapeutics","funder_award_id":"R01HL158054","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4976292069","display_name":null,"funder_award_id":"I01 BX004113","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4978035579","display_name":"In vivo HTS assay for novel modulators","funder_award_id":"R01DK116079","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5068228932","display_name":null,"funder_award_id":"098051 and 206194","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5388152886","display_name":null,"funder_award_id":"R01 GM63904","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G5417895055","display_name":"Role Of Microsomal Triglyceride Transfer Protein In Adipose Tissue","funder_award_id":"19POST34410063","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5574936099","display_name":"Discovery and characterization of novel regulators of Apo-B in larval zebrafish","funder_award_id":"F31HL139338","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5678557786","display_name":null,"funder_award_id":"BX004113","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5837258156","display_name":"Molecular mechanisms of chylomicron assembly","funder_award_id":"R56DK046900","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6247377714","display_name":"Role of Lipoprotein Assembly in Maternal-Fetal Transport of Beta-Carotene","funder_award_id":"R01HD094778","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6504515028","display_name":null,"funder_award_id":"318182","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G675588505","display_name":null,"funder_award_id":"19POST34410063","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7086285712","display_name":null,"funder_award_id":"F31HL139338","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G7105783532","display_name":null,"funder_award_id":"BX004113-01A1","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7549917023","display_name":"Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers.","funder_award_id":"206194","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8462315843","display_name":"Circadian Regulation of Lipoprotein Assembly","funder_award_id":"R01DK121490","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8666890344","display_name":"Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers","funder_award_id":"098051","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G9000094951","display_name":null,"funder_award_id":"GM63904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000190761","display_name":null,"funder_award_id":"DK046900","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000237333","display_name":null,"funder_award_id":"DK093399","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000269549","display_name":null,"funder_award_id":"DK046900-17A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000863390","display_name":"Systematic Vertebrate Functional Genomics","funder_award_id":"R01GM063904","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000880984","display_name":"Cellular and Molecular Biology","funder_award_id":"T32GM141804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000901268","display_name":"Identifying genes required for digestive physiology and lipid metabolism","funder_award_id":"R01DK093399","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306420","display_name":"G. Harold and Leila Y. Mathers Charitable Foundation","ror":"https://ror.org/02a7hjv13"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W11746928","https://openalex.org/W103864615","https://openalex.org/W1495890492","https://openalex.org/W1516430698","https://openalex.org/W1528309942","https://openalex.org/W1563885314","https://openalex.org/W1572955611","https://openalex.org/W1579912134","https://openalex.org/W1591366077","https://openalex.org/W1803102843","https://openalex.org/W1867264484","https://openalex.org/W1869365701","https://openalex.org/W1892158199","https://openalex.org/W1903300978","https://openalex.org/W1919257374","https://openalex.org/W1964590451","https://openalex.org/W1967764462","https://openalex.org/W1970877840","https://openalex.org/W1973856139","https://openalex.org/W1974501719","https://openalex.org/W1975411923","https://openalex.org/W1978529094","https://openalex.org/W1985176073","https://openalex.org/W1993322544","https://openalex.org/W1994148776","https://openalex.org/W1994786692","https://openalex.org/W1996810831","https://openalex.org/W1996904509","https://openalex.org/W2002536671","https://openalex.org/W2002711805","https://openalex.org/W2002892589","https://openalex.org/W2003212900","https://openalex.org/W2004793722","https://openalex.org/W2007633966","https://openalex.org/W2008688211","https://openalex.org/W2010231822","https://openalex.org/W2012007076","https://openalex.org/W2013768888","https://openalex.org/W2014333297","https://openalex.org/W2014628902","https://openalex.org/W2015804255","https://openalex.org/W2016299657","https://openalex.org/W2023899667","https://openalex.org/W2025097384","https://openalex.org/W2026534590","https://openalex.org/W2028872016","https://openalex.org/W2035003435","https://openalex.org/W2035415061","https://openalex.org/W2036095011","https://openalex.org/W2039192165","https://openalex.org/W2039890032","https://openalex.org/W2040278443","https://openalex.org/W2040693319","https://openalex.org/W2042381594","https://openalex.org/W2043748634","https://openalex.org/W2044472606","https://openalex.org/W2048438175","https://openalex.org/W2052008556","https://openalex.org/W2052261620","https://openalex.org/W2057814450","https://openalex.org/W2059231058","https://openalex.org/W2059352465","https://openalex.org/W2060460124","https://openalex.org/W2061795728","https://openalex.org/W2062661754","https://openalex.org/W2064602625","https://openalex.org/W2065037382","https://openalex.org/W2068032890","https://openalex.org/W2070582635","https://openalex.org/W2071101563","https://openalex.org/W2073540391","https://openalex.org/W2074982082","https://openalex.org/W2081800482","https://openalex.org/W2083520071","https://openalex.org/W2084496881","https://openalex.org/W2086183522","https://openalex.org/W2088254495","https://openalex.org/W2089491135","https://openalex.org/W2091760375","https://openalex.org/W2095374317","https://openalex.org/W2102238081","https://openalex.org/W2106992467","https://openalex.org/W2110065044","https://openalex.org/W2114389547","https://openalex.org/W2114622716","https://openalex.org/W2119951970","https://openalex.org/W2121366725","https://openalex.org/W2122844026","https://openalex.org/W2125349610","https://openalex.org/W2127427274","https://openalex.org/W2131507044","https://openalex.org/W2132629607","https://openalex.org/W2136007979","https://openalex.org/W2137886330","https://openalex.org/W2138267862","https://openalex.org/W2138311594","https://openalex.org/W2139766250","https://openalex.org/W2139775530","https://openalex.org/W2140729960","https://openalex.org/W2142526970","https://openalex.org/W2144081223","https://openalex.org/W2151276108","https://openalex.org/W2151400756","https://openalex.org/W2151540088","https://openalex.org/W2151583983","https://openalex.org/W2155117797","https://openalex.org/W2158507234","https://openalex.org/W2159962872","https://openalex.org/W2160347316","https://openalex.org/W2161533644","https://openalex.org/W2165386758","https://openalex.org/W2165791625","https://openalex.org/W2167279371","https://openalex.org/W2177551494","https://openalex.org/W2180229411","https://openalex.org/W2188054210","https://openalex.org/W2262501496","https://openalex.org/W2320610184","https://openalex.org/W2336319651","https://openalex.org/W2346493405","https://openalex.org/W2417483443","https://openalex.org/W2495808191","https://openalex.org/W2523515391","https://openalex.org/W2526822722","https://openalex.org/W2540941256","https://openalex.org/W2580875020","https://openalex.org/W2582743722","https://openalex.org/W2592680546","https://openalex.org/W2594035655","https://openalex.org/W2613713616","https://openalex.org/W2734434515","https://openalex.org/W2743619083","https://openalex.org/W2804822363","https://openalex.org/W2810343167","https://openalex.org/W2883550257","https://openalex.org/W2903107073","https://openalex.org/W2908747603","https://openalex.org/W2911252126","https://openalex.org/W2918399347","https://openalex.org/W2947327091","https://openalex.org/W2965510852","https://openalex.org/W2966905689","https://openalex.org/W3205881446","https://openalex.org/W4200006152","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2048438175","https://openalex.org/W2023899667","https://openalex.org/W2131507044","https://openalex.org/W2301907817","https://openalex.org/W1985176073","https://openalex.org/W2495808191","https://openalex.org/W2886961585","https://openalex.org/W3176722177","https://openalex.org/W2008688211","https://openalex.org/W2055759350"],"abstract_inverted_index":{"Apolipoprotein":[0],"B-containing":[1],"lipoproteins":[2],"(B-lps)":[3],"are":[4],"essential":[5,78],"for":[6,50,79,142,255,272],"the":[7,16,28,62,112,122,140,160,177,186,201,208,213,219,227,262],"transport":[8,266],"of":[9,25,53,64,84,107,121,167,176,188,212,237,264],"hydrophobic":[10],"dietary":[11],"and":[12,98,134,196,251],"endogenous":[13],"lipids":[14,35],"through":[15],"circulation":[17],"in":[18,27,42,68,100,111,139,200],"vertebrates.":[19],"Zebrafish":[20],"embryos":[21],"produce":[22],"large":[23],"numbers":[24],"B-lps":[26],"yolk":[29,37,46,101,265],"syncytial":[30],"layer":[31],"(YSL)":[32],"to":[33,38,89,104,136,184,248,268],"move":[34],"from":[36],"growing":[39],"tissues.":[40],"Disruptions":[41],"B-lp":[43,57,80,96,143,273],"production":[44,97],"perturb":[45],"morphology,":[47],"readily":[48],"allowing":[49],"visual":[51],"identification":[52],"mutants":[54],"with":[55],"altered":[56],"metabolism.":[58],"Here":[59],"we":[60],"report":[61],"discovery":[63],"a":[65,74,85,244],"missense":[66],"mutation":[67,83,221],"microsomal":[69],"triglyceride":[70,157,224,239],"transfer":[71,148,158,169,174,240],"protein":[72,75,163,181],"(Mtp),":[73],"that":[76,120,151,234],"is":[77,117,182],"production.":[81],"This":[82,171],"conserved":[86],"glycine":[87],"residue":[88],"valine":[90],"(zebrafish":[91],"G863V,":[92],"human":[93,215],"G865V)":[94],"reduces":[95],"results":[99],"opacity":[102],"due":[103],"aberrant":[105],"accumulation":[106],"cytoplasmic":[108],"lipid":[109,147],"droplets":[110],"YSL.":[113],"However,":[114],"this":[115],"phenotype":[116],"milder":[118],"than":[119],"previously":[123],"reported":[124],"L475P":[125],"stalactite":[126],"(stl)":[127],"mutation.":[128],"MTP":[129,154,216,238],"transfers":[130],"lipids,":[131],"including":[132],"triglycerides":[133],"phospholipids,":[135],"apolipoprotein":[137],"B":[138],"ER":[141],"assembly.":[144],"In":[145],"vitro":[146],"assays":[149],"reveal":[150],"while":[152],"both":[153],"mutations":[155],"eliminate":[156],"activity,":[159],"G863V":[161,178],"mutant":[162,180,203],"unexpectedly":[164],"retains":[165],"~80%":[166],"phospholipid":[168,173],"activity.":[170],"residual":[172],"activity":[175,241],"mttp":[179],"sufficient":[183],"support":[185],"secretion":[187],"small":[189],"B-lps,":[190],"which":[191],"prevents":[192],"intestinal":[193],"fat":[194],"malabsorption":[195],"growth":[197],"defects":[198],"observed":[199],"mttpstl/stl":[202],"zebrafish.":[204],"Modeling":[205],"based":[206],"on":[207],"recent":[209],"crystal":[210],"structure":[211],"heterodimeric":[214],"complex":[217],"suggests":[218],"G865V":[220],"may":[222,242],"block":[223],"entry":[225],"into":[226],"lipid-binding":[228],"cavity.":[229],"Together,":[230],"these":[231],"data":[232,259],"argue":[233],"selective":[235],"inhibition":[236],"be":[243],"feasible":[245],"therapeutic":[246],"approach":[247],"treat":[249],"dyslipidemia":[250],"provide":[252],"structural":[253],"insight":[254],"drug":[256],"design.":[257],"These":[258],"also":[260],"highlight":[261],"power":[263],"studies":[267],"identify":[269],"proteins":[270],"critical":[271],"biology.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-08-10T00:00:00"}
