{"id":"https://openalex.org/W3046970531","doi":"https://doi.org/10.1158/1538-7445.pedca19-b57","title":"Abstract B57: A combination of IL7R\u03b1 and NRAS mutations sheds light on the oncogenesis of T-cell acute lymphoblastic leukemia in a murine model","display_name":"Abstract B57: A combination of IL7R\u03b1 and NRAS mutations sheds light on the oncogenesis of T-cell acute lymphoblastic leukemia in a murine model","publication_year":2020,"publication_date":"2020-07-15","ids":{"openalex":"https://openalex.org/W3046970531","doi":"https://doi.org/10.1158/1538-7445.pedca19-b57","mag":"3046970531"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.pedca19-b57","doi":"https://doi.org/10.1158/1538-7445.pedca19-b57","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pedca19-b57","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069495446","display_name":"Hila Y. Winer","orcid":"https://orcid.org/0000-0002-1064-0154","observed_orcids":["https://orcid.org/0000-0002-1064-0154"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hila Winer","raw_affiliation_strings":["NIH/NCI, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH/NCI, Frederick, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009096424","display_name":"Gisele Olinto Libanio Rodrigues","orcid":"https://orcid.org/0000-0002-8526-2258","observed_orcids":["https://orcid.org/0000-0002-8526-2258"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gisele Rodrigues","raw_affiliation_strings":["NIH/NCI, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH/NCI, Frederick, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621748","display_name":"Wenqing Li","orcid":"https://orcid.org/0000-0002-8336-5552","observed_orcids":["https://orcid.org/0000-0002-8336-5552","https://orcid.org/0009-0002-3470-4148"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenqing Li","raw_affiliation_strings":["NIH/NCI, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH/NCI, Frederick, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008492058","display_name":"Julie A. Hixon","orcid":"https://orcid.org/0000-0002-6505-2392","observed_orcids":["https://orcid.org/0000-0002-6505-2392"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Hixon","raw_affiliation_strings":["NIH/NCI, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH/NCI, Frederick, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394893","display_name":"Scott Kenneth Durum","orcid":"https://orcid.org/0000-0003-1307-9582","observed_orcids":["https://orcid.org/0000-0003-1307-9582"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Durum","raw_affiliation_strings":["NIH/NCI, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH/NCI, Frederick, MD","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"14_Supplement","first_page":"B57","last_page":"B57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6069999933242798},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6579999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.656000018119812},{"id":"https://openalex.org/keywords/rag-deficient-mice","display_name":"RAG-deficient mice","score":0.6859999895095825},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/leukemia-relapse","display_name":"leukemia relapse","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.9427958726882935},{"id":"https://openalex.org/C123982805","wikidata":"https://www.wikidata.org/wiki/Q6046964","display_name":"Interleukin-7 receptor","level":5,"score":0.8113127946853638},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.6462596654891968},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5547903776168823},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5126132369041443},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4977424442768097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47461357712745667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38117480278015137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3720461130142212},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35149210691452026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30399608612060547},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.15087589621543884},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10836213827133179},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0980583131313324}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.pedca19-b57","doi":"https://doi.org/10.1158/1538-7445.pedca19-b57","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.pedca19-b57","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3180140457","https://openalex.org/W2791821033","https://openalex.org/W1985799952","https://openalex.org/W3123263630","https://openalex.org/W2039616075","https://openalex.org/W3097968714","https://openalex.org/W2807245918","https://openalex.org/W6996786370","https://openalex.org/W4389180104","https://openalex.org/W3163535355"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"lymphoblastic":[2,387],"leukemia":[3,388],"(ALL)":[4],"is":[5,35,152],"the":[6,27,144,173,197,205,242,263,279,316,382,397,402],"most":[7,13,46],"common":[8],"cancer":[9],"in":[10,26,40,64,74,95,122,136,157,172,176,196,204,212,227,245,262,278,298,315,345,389,404],"children.":[11,43],"While":[12],"cases":[14],"of":[15,42,57,69,86,117,194,217,224,291,352,374,384,396],"ALL":[16,70,87],"arise":[17],"from":[18,23,111],"B-cell":[19,266],"precursors,":[20],"15%":[21],"originate":[22],"T":[24],"cells":[25],"thymus":[28],"(T-ALL).":[29],"With":[30],"current":[31],"treatments,":[32],"survival":[33,135],"rate":[34],"high,":[36],"but":[37],"relapse":[38],"occurs":[39],"15-20%":[41],"In":[44,287,308],"addition,":[45,309],"treatments":[47],"are":[48,82,105],"highly":[49],"toxic,":[50],"with":[51,125,163,167,230],"severe":[52,120,218],"side":[53],"effects.":[54],"Approximately":[55],"10%":[56],"T-ALL":[58,110,121,156,246,332,344],"patients":[59,71],"have":[60,72],"somatic":[61],"gain-of-function":[62],"mutations":[63,73,81,94,296,378],"IL7R\u03b1":[65,97,128,148,169,236,293,375],"gene,":[66],"and":[67,129,149,170,200,208,237,254,271,274,294,330,354,376],"15-22%":[68],"NRAS":[75,102,130,150,171,295,377],"or":[76,100,234],"KRAS.":[77],"Furthermore,":[78],"Ras":[79],"pathway":[80],"responsible":[83],"for":[84,356],"30%-50%":[85],"relapse.":[88],"Recently,":[89],"our":[90,336],"lab":[91,337],"showed":[92,190,259],"that":[93,143],"human":[96,101],"alone":[98,103],"(c.731_732insTTGTCCCAC)":[99],"(G13D)":[104],"not":[106],"sufficient":[107],"to":[108,133,154,181,326,342],"induce":[109],"primary":[112,164],"cells.":[113],"However,":[114],"a":[115,177,191,209,275,312,339,390],"combination":[116,290,373],"both":[118,292],"causes":[119],"mice.":[123,138,158],"Treatment":[124],"inhibitors":[126],"against":[127],"signaling":[131],"led":[132,180],"prolonged":[134],"these":[137,248],"Our":[139,257],"new":[140],"data":[141],"indicate":[142],"correct":[145],"ratio":[146],"between":[147],"expression":[151],"necessary":[153],"generate":[155],"Using":[159],"RAG-/-":[160],"mice":[161,189,228],"injected":[162,229],"thymocytes":[165,328],"transduced":[166],"mutated":[168,238],"optimal":[174],"sequence":[175],"polycistronic":[178],"vector":[179,233],"fatal":[182],"disease":[183,225],"3":[184],"weeks":[185],"after":[186],"injection.":[187],"These":[188],"30-fold":[192],"increase":[193,203,211,314],"leukocytes":[195],"blood,":[198],"spleen,":[199],"thymus,":[201],"80-fold":[202],"lymph":[206],"nodes,":[207],"5-fold":[210],"spleen":[213],"weight,":[214],"all":[215],"indications":[216],"T-ALL.":[219],"There":[220],"was":[221],"no":[222],"indication":[223],"progression":[226],"either":[231],"empty":[232],"wild-type":[235],"NRAS.":[239],"To":[240],"identify":[241],"pathways":[243,351],"involved":[244],"by":[247,304],"mutations,":[249],"we":[250,310],"used":[251],"mass":[252],"spectrometry":[253],"RNA":[255],"sequencing.":[256],"analysis":[258],"significant":[260,313],"increases":[261],"well-known":[264],"antiapoptotic,":[265],"lymphoma":[267],"2":[268],"(BCL-2),":[269],"mRNA,":[270],"protein":[272,285,317],"levels":[273],"major":[276],"decrease":[277],"proapoptotic":[280],"BCL-2":[281],"antagonist/killer":[282],"1":[283],"(BAK-1)":[284],"levels.":[286],"this":[288],"manner,":[289],"resulted":[297],"high":[299],"Bcl-2:Bak-1":[300],"ratio,":[301],"supported":[302],"also":[303],"Western":[305],"blot":[306],"analysis.":[307],"observed":[311],"cytokinesis":[318],"midbody":[319],"regulator":[320],"citron":[321],"kinase":[322],"(Cit),":[323],"potentially":[324],"leading":[325],"increased":[327],"proliferation":[329],"driving":[331],"formation.":[333],"Taken":[334],"together,":[335],"developed":[338],"strong":[340],"model":[341,392],"study":[343],"mice,":[346],"shedding":[347],"light":[348,380],"on":[349,381,401],"novel":[350],"oncogenesis":[353,383],"targets":[355],"better":[357],"therapeutic":[358],"development.":[359],"Citation":[360],"Format:":[361],"Hila":[362],"Winer,":[363],"Gisele":[364],"Rodrigues,":[365],"Wenqing":[366],"Li,":[367],"Julie":[368],"Hixon,":[369],"Scott":[370],"Durum.":[371],"A":[372],"sheds":[379],"T-cell":[385],"acute":[386],"murine":[391],"[abstract].":[393],"In:":[394],"Proceedings":[395],"AACR":[398],"Special":[399],"Conference":[400],"Advances":[403],"Pediatric":[405],"Cancer":[406,417],"Research;":[407],"2019":[408],"Sep":[409],"17-20;":[410],"Montreal,":[411],"QC,":[412],"Canada.":[413],"Philadelphia":[414],"(PA):":[415],"AACR;":[416],"Res":[418],"2020;80(14":[419],"Suppl):Abstract":[420],"nr":[421],"B57.":[422]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2020-08-10T00:00:00"}