{"id":"https://openalex.org/W3046604192","doi":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","title":"Experience with the use of recombinant humanized monoclonal antibodies to the human receptor for interleukin-6 in patients with CoVID-19","display_name":"Experience with the use of recombinant humanized monoclonal antibodies to the human receptor for interleukin-6 in patients with CoVID-19","publication_year":2020,"publication_date":"2020-08-02","ids":{"openalex":"https://openalex.org/W3046604192","doi":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","mag":"3046604192"},"language":"en","primary_location":{"id":"doi:10.22625/2072-6732-2020-12-3-28-33","doi":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","pdf_url":"https://journal.niidi.ru/jofin/article/download/1074/811","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journal.niidi.ru/jofin/article/download/1074/811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033022834","display_name":"Denis A. Gusev","orcid":"https://orcid.org/0000-0001-9202-3231","observed_orcids":["https://orcid.org/0000-0001-9202-3231"]},"institutions":[{"id":"https://openalex.org/I4210160772","display_name":"Clinical Infectious Disease Hospital named after S.P. Botkin","ror":"https://ror.org/0585bbm72","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210160772"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. \u0410. Gusev","raw_affiliation_strings":["National Medical Research Centre named after V.A. Almazov; Clinical Infectious Hospital named after S.P. Botkin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Medical Research Centre named after V.A. Almazov; Clinical Infectious Hospital named after S.P. Botkin","institution_ids":["https://openalex.org/I4210160772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029509327","display_name":"Maria A. Vashukova","orcid":"https://orcid.org/0000-0002-0296-0481","observed_orcids":["https://orcid.org/0000-0002-0296-0481"]},"institutions":[{"id":"https://openalex.org/I4210121251","display_name":"Botkin Hospital","ror":"https://ror.org/01xbp4f63","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210121251"]},{"id":"https://openalex.org/I4210160772","display_name":"Clinical Infectious Disease Hospital named after S.P. Botkin","ror":"https://ror.org/0585bbm72","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210160772"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u041c. \u0410. Vashukova","raw_affiliation_strings":["Clinical Infectious Hospital named after S.P. Botkin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Infectious Hospital named after S.P. Botkin","institution_ids":["https://openalex.org/I4210121251","https://openalex.org/I4210160772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031594231","display_name":"\u0424\u0435\u0434\u0443\u043d\u044f\u043a \u0418\u0432\u0430\u043d \u041f\u0430\u0432\u043b\u043e\u0432\u0438\u0447","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]},{"id":"https://openalex.org/I4210160772","display_name":"Clinical Infectious Disease Hospital named after S.P. Botkin","ror":"https://ror.org/0585bbm72","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210160772"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. P. Feduniak","raw_affiliation_strings":["Clinical Infectious Hospital named after S.P. Botkin; North-Western State Medical University named after I.I. Mechnikov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Infectious Hospital named after S.P. Botkin; North-Western State Medical University named after I.I. Mechnikov","institution_ids":["https://openalex.org/I4210151936","https://openalex.org/I4210160772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084429064","display_name":"\u041c\u0443\u0441\u0430\u0442\u043e\u0432 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440 \u0411\u043e\u0440\u0438\u0441\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-2428-3802","observed_orcids":["https://orcid.org/0000-0003-2428-3802"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]},{"id":"https://openalex.org/I4210160772","display_name":"Clinical Infectious Disease Hospital named after S.P. Botkin","ror":"https://ror.org/0585bbm72","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210160772"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. B. Musatov","raw_affiliation_strings":["Clinical Infectious Hospital named after S.P. Botkin; Saint-Petersburg State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Infectious Hospital named after S.P. Botkin; Saint-Petersburg State University","institution_ids":["https://openalex.org/I172901346","https://openalex.org/I4210160772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028887035","display_name":"\u041a\u0430\u043f\u0430\u0446\u044b\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-8959-0873","observed_orcids":["https://orcid.org/0000-0002-8959-0873"]},"institutions":[{"id":"https://openalex.org/I4210121251","display_name":"Botkin Hospital","ror":"https://ror.org/01xbp4f63","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210121251"]},{"id":"https://openalex.org/I4210160772","display_name":"Clinical Infectious Disease Hospital named after S.P. Botkin","ror":"https://ror.org/0585bbm72","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210160772"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. A. Kapatsyna","raw_affiliation_strings":["Clinical Infectious Hospital named after S.P. Botkin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Infectious Hospital named after S.P. Botkin","institution_ids":["https://openalex.org/I4210121251","https://openalex.org/I4210160772"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2192,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66698846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"12","issue":"3","first_page":"28","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9850000143051147},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.8080000281333923},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8709999918937683},{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.9729999899864197},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.5460000038146973},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6579999923706055},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9628335237503052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8260315656661987},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.6865584850311279},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5689147710800171},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5198181867599487},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.48783114552497864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4869876801967621},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.4306359887123108},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.42679959535598755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41559308767318726},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4070049226284027},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3610531687736511}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.22625/2072-6732-2020-12-3-28-33","doi":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","pdf_url":"https://journal.niidi.ru/jofin/article/download/1074/811","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:17ca653f57b048b98aee7dc981980702","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/17ca653f57b048b98aee7dc981980702","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0416\u0443\u0440\u043d\u0430\u043b \u0438\u043d\u0444\u0435\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438, Vol 12, Iss 3, Pp 28-33 (2020)","raw_type":"article"},{"id":"pmh:oai:oai.jofin.elpub.ru:article/1074","doi":null,"is_oa":true,"landing_page_url":"https://journal.niidi.ru/jofin/article/view/1074","pdf_url":null,"source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Infectology; \u0422\u043e\u043c 12, \u2116 3 (2020); 28-33","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22625/2072-6732-2020-12-3-28-33","doi":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2020-12-3-28-33","pdf_url":"https://journal.niidi.ru/jofin/article/download/1074/811","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3046604192.pdf","grobid_xml":"https://content.openalex.org/works/W3046604192.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2927678279","https://openalex.org/W2994934623","https://openalex.org/W3003154936","https://openalex.org/W3009314935","https://openalex.org/W3009834387","https://openalex.org/W3011610993","https://openalex.org/W3013469577","https://openalex.org/W3015030076","https://openalex.org/W3015050005","https://openalex.org/W3015539298","https://openalex.org/W3017125154","https://openalex.org/W3020869775","https://openalex.org/W3025471343","https://openalex.org/W3025830962","https://openalex.org/W3036447018","https://openalex.org/W3126061642","https://openalex.org/W4236312227"],"related_works":["https://openalex.org/W3046267351","https://openalex.org/W3036918368","https://openalex.org/W4220950385","https://openalex.org/W3080168502","https://openalex.org/W3032822372","https://openalex.org/W4399214920","https://openalex.org/W3013789297","https://openalex.org/W3209269094","https://openalex.org/W3183132432","https://openalex.org/W3022970339"],"abstract_inverted_index":{"The":[0,119,186,237],"new":[1],"coronavirus":[2],"infection":[3],"(COVID-19)":[4],"has":[5],"become":[6],"a":[7,125,142,192,208,210,227],"truly":[8],"global":[9],"challenge":[10],"for":[11,18,85,121,134,239],"all":[12],"of":[13,36,39,55,64,67,72,106,116,124,145,157,171,174,181,188,195,203,215,233,242,251],"humanity,":[14],"and,":[15,206],"above":[16],"all,":[17],"the":[19,31,37,40,56,104,114,117,122,131,146,155,168,172,175,213,222,231,234,249,252,255],"healthcare":[20],"system.":[21],"Among":[22],"its":[23,149],"most":[24],"important":[25,220],"aspects":[26],"requiring":[27],"careful":[28],"analysis":[29,63],"are":[30,151],"clinical":[32,169],"and":[33,59,98,148,200],"laboratory":[34,99,184],"features":[35],"course":[38,144,173],"disease,":[41,176,253],"which":[42,177],"make":[43],"it":[44,162],"possible":[45],"to":[46,49,130,165,191,259],"determine":[47],"approaches":[48],"pathogenetic":[50],"therapy":[51],"in":[52,79,139,183,212,226],"severe":[53,73,143,158],"forms":[54],"disease.":[57,118],"Materials":[58],"methods.":[60],"A":[61],"retrospective":[62],"medical":[65],"records":[66],"patients":[68,75,140,159],"(n":[69],"=":[70],"31)":[71],"COVID-19":[74],"who":[76],"were":[77,101],"hospitalized":[78],"St.":[80],"Petersburg":[81],"City":[82],"Clinical":[83,97],"Hospital":[84],"Infectious":[86],"Diseases":[87],"named":[88],"after":[89],"S.P.":[90],"Botkin":[91],"\u201din":[92],"March":[93],"\u2013":[94,137],"May":[95],"2020.":[96],"characteristics":[100],"evaluated,":[102],"including":[103],"level":[105],"ferritin,":[107],"C-reactive":[108],"protein,":[109],"D-dimer,":[110],"interleukin-6,":[111],"depending":[112],"on":[113],"severity":[115],"criteria":[120],"appointment":[123],"recombinant":[126],"humanized":[127],"monoclonal":[128],"antibody":[129],"human":[132],"receptor":[133],"interleukin-6":[135],"(INN":[136],"tocilizumab)":[138],"with":[141,160],"disease":[147],"effectiveness":[150],"determined.":[152],"Results.":[153],"In":[154],"treatment":[156],"COVID-19,":[161],"is":[163,218,224,257],"necessary":[164],"carefully":[166],"evaluate":[167],"picture":[170],"may":[178],"be":[179],"ahead":[180],"changes":[182],"parameters.":[185],"introduction":[187],"tocilizumab":[189,243],"leads":[190],"rapid":[193],"regression":[194],"general":[196],"infectious":[197],"symptoms,":[198],"subjective":[199],"objective":[201],"manifestations":[202],"respiratory":[204],"failure":[205],"as":[207],"consequence,":[209],"decrease":[211],"duration":[214],"hospitalization.":[216],"It":[217],"extremely":[219],"that":[221],"drug":[223],"administered":[225],"timely":[228],"manner":[229],"during":[230],"rise":[232],"\u201ccytokine":[235],"storm\u201d.":[236],"time":[238],"optimal":[240],"administration":[241],"begins":[244],"from":[245,248],"8-9":[246],"days":[247],"onset":[250],"until":[254],"patient":[256],"transferred":[258],"mechanical":[260],"ventilation.":[261]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-07T00:00:00"}
