{"id":"https://openalex.org/W3046538587","doi":"https://doi.org/10.1038/s41598-020-69746-w","title":"Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for \u2018leaky-gut\u2019 in inflammatory bowel disease","display_name":"Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for \u2018leaky-gut\u2019 in inflammatory bowel disease","publication_year":2020,"publication_date":"2020-07-31","ids":{"openalex":"https://openalex.org/W3046538587","doi":"https://doi.org/10.1038/s41598-020-69746-w","mag":"3046538587","pmid":"https://pubmed.ncbi.nlm.nih.gov/32737354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7395150"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-69746-w","doi":"https://doi.org/10.1038/s41598-020-69746-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69746-w","pdf_url":"https://www.nature.com/articles/s41598-020-69746-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-69746-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061248345","display_name":"Valerie C. Wasinger","orcid":"https://orcid.org/0000-0001-5338-0869","observed_orcids":["https://orcid.org/0000-0001-5338-0869"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4405259150","display_name":"Mark Wainwright Analytical Centre","ror":"https://ror.org/01trzbr20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Valerie C. Wasinger","raw_affiliation_strings":["Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia. v.wasinger@unsw.edu.au","School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia. v.wasinger@unsw.edu.au","Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia. v.wasinger@unsw.edu.au","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]},{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia. v.wasinger@unsw.edu.au","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenneth Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kenneth Lu","raw_affiliation_strings":["School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041706697","display_name":"Yunki Y. Yau","orcid":"https://orcid.org/0000-0001-8832-8200","observed_orcids":["https://orcid.org/0000-0001-8832-8200"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yunki Y. Yau","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia","School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Justin Nash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4405259150","display_name":"Mark Wainwright Analytical Centre","ror":"https://ror.org/01trzbr20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Justin Nash","raw_affiliation_strings":["Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jess Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jess Lee","raw_affiliation_strings":["School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044129454","display_name":"Jeff Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800249840","display_name":"Concord Repatriation General Hospital","ror":"https://ror.org/04b0n4406","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800249840"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jeff Chang","raw_affiliation_strings":["Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia","institution_ids":["https://openalex.org/I2800249840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000808663","display_name":"Sudarshan Paramsothy","orcid":"https://orcid.org/0000-0002-9097-6028","observed_orcids":["https://orcid.org/0000-0002-9097-6028"]},"institutions":[{"id":"https://openalex.org/I2800249840","display_name":"Concord Repatriation General Hospital","ror":"https://ror.org/04b0n4406","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800249840"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sudarshan Paramsothy","raw_affiliation_strings":["Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia","institution_ids":["https://openalex.org/I2800249840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052376582","display_name":"Nadeem Omar Kaakoush","orcid":"https://orcid.org/0000-0003-4017-1077","observed_orcids":["https://orcid.org/0000-0003-4017-1077"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nadeem O. Kaakoush","raw_affiliation_strings":["School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077272573","display_name":"Hazel M. Mitchell","orcid":"https://orcid.org/0000-0002-0046-4812","observed_orcids":["https://orcid.org/0000-0002-0046-4812"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hazel M. Mitchell","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020598469","display_name":"Rupert Wing Loong Leong","orcid":"https://orcid.org/0000-0001-5944-3488","observed_orcids":["https://orcid.org/0000-0001-5944-3488"]},"institutions":[{"id":"https://openalex.org/I2800249840","display_name":"Concord Repatriation General Hospital","ror":"https://ror.org/04b0n4406","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800249840"]},{"id":"https://openalex.org/I2800681009","display_name":"Bankstown Lidcombe Hospital","ror":"https://ror.org/00qrpt643","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2800681009","https://openalex.org/I2801351115","https://openalex.org/I4210163551"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rupert W. L. Leong","raw_affiliation_strings":["Department of Gastroenterology, Bankstown-Lidcombe Hospital, Eldridge Rd, Bankstown, NSW, Australia","Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia","School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Bankstown-Lidcombe Hospital, Eldridge Rd, Bankstown, NSW, Australia","institution_ids":["https://openalex.org/I2800681009"]},{"raw_affiliation_string":"Gastroenterology Department, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, Australia","institution_ids":["https://openalex.org/I2800249840"]},{"raw_affiliation_string":"School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061248345"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":1.7327,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83987719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"12932","last_page":"12932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9010000228881836},{"id":"https://openalex.org/keywords/leaky-gut","display_name":"leaky gut","score":0.949999988079071},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.6340000033378601},{"id":"https://openalex.org/keywords/confocal-laser-endomicroscopy","display_name":"confocal laser endomicroscopy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.8759999871253967},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8053940534591675},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6741728186607361},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.6123164296150208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5748577117919922},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5326544642448425},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5059410929679871},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4704766869544983},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45468616485595703},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.4526297450065613},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.44986581802368164},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4387112259864807},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.43518197536468506},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4255518615245819},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37614187598228455},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30032217502593994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2421557605266571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23752361536026},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08514291048049927}],"mesh":[{"descriptor_ui":"D000069467","descriptor_name":"Fecal Microbiota Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-69746-w","doi":"https://doi.org/10.1038/s41598-020-69746-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69746-w","pdf_url":"https://www.nature.com/articles/s41598-020-69746-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7395150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7395150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32737354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32737354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-69746-w","doi":"https://doi.org/10.1038/s41598-020-69746-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69746-w","pdf_url":"https://www.nature.com/articles/s41598-020-69746-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3585768615","display_name":null,"funder_award_id":"IBD-0391R","funder_id":"https://openalex.org/F4320306301","funder_display_name":"Crohn's and Colitis Foundation of America"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320319755","display_name":"Analytical Center for the Government of the Russian Federation","ror":"https://ror.org/01zwzc219"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3046538587.pdf","grobid_xml":"https://content.openalex.org/works/W3046538587.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1253797328","https://openalex.org/W1510318546","https://openalex.org/W1643854141","https://openalex.org/W1968952516","https://openalex.org/W1969676825","https://openalex.org/W1972429412","https://openalex.org/W1976496457","https://openalex.org/W1993098310","https://openalex.org/W1997153399","https://openalex.org/W1999648062","https://openalex.org/W2014874996","https://openalex.org/W2015359885","https://openalex.org/W2018397538","https://openalex.org/W2052724916","https://openalex.org/W2058468225","https://openalex.org/W2059856367","https://openalex.org/W2061791452","https://openalex.org/W2065147071","https://openalex.org/W2076477971","https://openalex.org/W2080195364","https://openalex.org/W2080621711","https://openalex.org/W2081253554","https://openalex.org/W2085707483","https://openalex.org/W2095909925","https://openalex.org/W2112129392","https://openalex.org/W2131139620","https://openalex.org/W2134059673","https://openalex.org/W2134897177","https://openalex.org/W2147954623","https://openalex.org/W2156272127","https://openalex.org/W2167279371","https://openalex.org/W2256840116","https://openalex.org/W2337247566","https://openalex.org/W2339192304","https://openalex.org/W2485268076","https://openalex.org/W2566679774","https://openalex.org/W2588070196","https://openalex.org/W2612723059","https://openalex.org/W2624069514","https://openalex.org/W2626512744","https://openalex.org/W2741948394","https://openalex.org/W2753100975","https://openalex.org/W2777966573","https://openalex.org/W2895812679","https://openalex.org/W2913164636","https://openalex.org/W2955390203","https://openalex.org/W4389022008"],"related_works":["https://openalex.org/W7097960209","https://openalex.org/W2176502392","https://openalex.org/W2795212503","https://openalex.org/W2955966845","https://openalex.org/W4256436601","https://openalex.org/W2485268076","https://openalex.org/W2586405748","https://openalex.org/W6945851946","https://openalex.org/W2624069514","https://openalex.org/W4246051941"],"abstract_inverted_index":{"Epithelial":[0],"barrier":[1,34,168],"injury":[2],"allows":[3],"contaminants":[4],"to":[5,17,83,109,176,186,192],"cross-over":[6],"into":[7],"the":[8,49,67,85,161,177,184,209],"blood":[9,189],"stream":[10],"and":[11,54,74,78,99,138,150,194],"trigger":[12],"an":[13],"inflammatory":[14,18],"response,":[15],"contributing":[16],"bowel":[19],"disease":[20],"(IBD).":[21],"Currently":[22],"there":[23],"is":[24,156],"no":[25],"single":[26],"test":[27],"that":[28],"can":[29],"reliably":[30],"diagnose":[31],"intestinal":[32,56],"mucosal":[33,90],"function":[35],"or":[36],"measure":[37],"impaired":[38],"epithelial":[39],"cell":[40],"integrity":[41],"associated":[42,129],"with":[43,104,130],"increasing":[44,148],"permeability.":[45],"Here,":[46],"we":[47],"assess":[48,84],"association":[50],"between":[51,147],"serum":[52],"proteins":[53],"small":[55],"permeability":[57,128,182],"as":[58,112,114],"detected":[59],"by":[60],"confocal":[61],"laser":[62],"endomicroscopy":[63],"(CLE);":[64],"in":[65,89,142,166,171],"particular":[66],"known":[68],"IBD":[69,97],"marker-secreted":[70],"phosphoprotein":[71],"24":[72],"(SPP24)":[73],"its":[75],"binding":[76],"partners;":[77],"use":[79],"developed":[80],"monoclonal":[81],"antibodies":[82],"role":[86,163],"of":[87,160,164,203],"SPP24":[88,151,165],"healing.":[91],"Sera":[92],"were":[93],"obtained":[94],"from":[95,107,118],"28":[96],"patients":[98,120],"non-IBD":[100],"controls":[101],"undergoing":[102,121],"CLE":[103,179],"scores":[105],"ranging":[106],"low":[108],"high":[110],"permeability,":[111],"well":[113],"active":[115],"ulcerative":[116,172],"colitis":[117],"53":[119],"fecal":[122],"microbiota":[123],"transplant":[124],"therapy":[125,196],"(FMT).":[126],"Higher":[127],"altered":[131],"lipid":[132],"metabolism,":[133],"heightened":[134],"innate":[135],"immune":[136],"response":[137],"junctional":[139],"protein":[140],"signalling":[141],"UC":[143],"patients.":[144],"A":[145],"correlation":[146,175],"leak":[149],"peptide":[152],"was":[153],"observed.":[154],"There":[155],"a":[157,188,200],"strong":[158],"indication":[159],"novel":[162],"gut":[167],"dysfunction":[169],"particularly":[170],"colitis.":[173],"Its":[174],"established":[178],"for":[180,205],"monitoring":[181],"has":[183],"potential":[185],"provide":[187],"based":[190],"parallel":[191],"monitor":[193],"guide":[195],"more":[197],"readily":[198],"across":[199],"broad":[201],"spectrum":[202],"illnesses":[204],"which":[206],"'leak'":[207],"dominates":[208],"pathology.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-07T00:00:00"}