{"id":"https://openalex.org/W3046205167","doi":"https://doi.org/10.1161/atvb.39.suppl_1.455","title":"Abstract 455: Enhanced Autophagy by Celastrol Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice","display_name":"Abstract 455: Enhanced Autophagy by Celastrol Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W3046205167","doi":"https://doi.org/10.1161/atvb.39.suppl_1.455","mag":"3046205167"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.39.suppl_1.455","doi":"https://doi.org/10.1161/atvb.39.suppl_1.455","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.39.suppl_1.455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047640192","display_name":"Aida Javidan","orcid":"https://orcid.org/0009-0006-2455-8270","observed_orcids":["https://orcid.org/0009-0006-2455-8270"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aida Javidan","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033714582","display_name":"Weihua Jiang","orcid":"https://orcid.org/0000-0001-6529-7843","observed_orcids":["https://orcid.org/0000-0001-6529-7843"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Jiang","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086015666","display_name":"Lihua Yang","orcid":"https://orcid.org/0000-0002-6293-4816","observed_orcids":["https://orcid.org/0000-0002-6293-4816"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Yang","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103283466","display_name":"Venkateswaran Subramanian","orcid":"https://orcid.org/0000-0002-1183-7717","observed_orcids":["https://orcid.org/0000-0002-1183-7717"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkateswaran Subramanian","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.984000027179718},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/celastrol","display_name":"celastrol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ldl-receptor-knockout-mice","display_name":"LDL receptor knockout mice","score":0.7929999828338623},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8080000281333923},{"id":"https://openalex.org/keywords/aortic-dilation","display_name":"aortic dilatation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.8019999861717224},{"id":"https://openalex.org/keywords/autophagy-inducers","display_name":"autophagy inducers","score":0.5440000295639038},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5619999766349792},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.5699999928474426},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6190000176429749},{"id":"https://openalex.org/keywords/aortic-remodeling","display_name":"aortic remodeling","score":0.3630000054836273},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.4050000011920929},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6349999904632568},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.7781984806060791},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7435860633850098},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6999104022979736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.579615592956543},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.5551156401634216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4809529185295105},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.44395777583122253},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4401634931564331},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35717856884002686},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.28448301553726196},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2728722095489502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2657511234283447},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.14185327291488647},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11851030588150024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10128650069236755}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1161/atvb.39.suppl_1.455","doi":"https://doi.org/10.1161/atvb.39.suppl_1.455","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.39.suppl_1.455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"mag:3046205167","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atvb.39.suppl_1.455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis Thrombosis and Vascular Biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6903723658","https://openalex.org/W4285370134","https://openalex.org/W4361003257","https://openalex.org/W2307110925","https://openalex.org/W4238383685","https://openalex.org/W2328496584","https://openalex.org/W1997432154","https://openalex.org/W2618933801","https://openalex.org/W3027272686","https://openalex.org/W2787002821"],"abstract_inverted_index":{"Background":[0],"and":[1,33,58,108,111,192,229,278,337],"Objective:":[2],"Abdominal":[3],"Aortic":[4],"Aneurysms":[5],"(AAAs)":[6],"are":[7,67],"permanent":[8],"dilations":[9],"of":[10,23,85,93,147,252,342],"the":[11,45,91],"abdominal":[12,253],"aorta":[13],"with":[14,136,153,176],"greater":[15,28],"than":[16,31],"80%":[17],"mortality":[18],"after":[19],"rupture.":[20],"The":[21,83],"prevalence":[22],"AAAs":[24,104,262,343],"is":[25,80,88],"4\u20135":[26],"times":[27],"in":[29,70,77,105,172,189,213,263,320,344],"males":[30],"females":[32,34],"seem":[35],"to":[36,44,89,339],"be":[37],"protected":[38],"from":[39],"developing":[40],"AAAs.":[41,72],"Autophagy":[42],"refers":[43],"cellular":[46,52],"self-eating":[47],"degradation":[48],"process,":[49],"which":[50],"regulates":[51],"homeostasis":[53],"by":[54,162,247,330],"recycling":[55],"damaged":[56],"organelles":[57],"long-lived":[59],"protein.":[60],"Recent":[61],"findings":[62,325],"demonstrated":[63],"that":[64,256,327],"autophagy\u2013related":[65],"genes":[66],"markedly":[68],"upregulated":[69],"human":[71],"However,":[73],"its":[74],"functional":[75],"role":[76],"AAA":[78,335],"development":[79],"still":[81],"unclear.":[82],"purpose":[84],"this":[86],"study":[87],"test":[90],"effect":[92,199],"Celastrol":[94,139,177,179,205,257,293,331],"supplementation":[95,180,206,258,294,332],"as":[96,245],"an":[97],"autophagy":[98,173,329],"inducer":[99],"on":[100,200],"Angiotensin":[101],"II":[102],"(AngII)-induced":[103],"mice.":[106,292,322,345],"Methods":[107],"Results:":[109],"Male":[110],"female":[112,193,230,279],"LDL":[113],"receptor":[114],"-/-":[115],"mice":[116,150,194],"(8":[117],"weeks":[118],"old;":[119],"n=":[120],"12":[121],"per":[122],"group)":[123],"were":[124,151],"fed":[125],"a":[126,169],"fat-enriched":[127],"diet":[128,148],"(21%":[129],"wt/wt":[130,133],"fat;":[131],"0.15%":[132],"cholesterol)":[134],"supplemented":[135],"or":[137,156],"without":[138],"(10mg/kg/day)":[140],"for":[141,159],"5":[142],"weeks.":[143],"After":[144],"1":[145],"week":[146],"feeding,":[149],"infused":[152],"AngII":[154],"(500":[155],"1000":[157],"ng/kg/min)":[158],"28":[160],"days":[161],"osmotic":[163],"minipumps.":[164],"Western":[165],"blot":[166],"analyses":[167],"showed":[168],"significant":[170],"increase":[171],"protein":[174],"(LC3-II)":[175],"supplementation.":[178],"significantly":[181,259,296],"suppressed":[182],"high":[183],"fat":[184],"diet-induced":[185],"body":[186],"weight":[187],"gain":[188],"both":[190,214,264],"male":[191,215,265,321],"(P<0.001),":[195],"but":[196],"had":[197],"no":[198],"AngII-induced":[201,209,261,298,334],"systolic":[202],"blood":[203],"pressure.":[204],"profoundly":[207],"increased":[208,260,297],"aortic":[210,300],"luminal":[211],"dilation":[212],"(Con":[216,231,302],"=":[217,223,232,238,272,286,303,311],"1.25":[218],"\u00b1":[219,225,234,240,268,274,282,288,305,313],"0.05":[220],"versus":[221,236,270,284,309],"Celas":[222,237,271,285,310],"1.55":[224],"0.09":[226,269],"mm,":[227,242,276,290],"P<0.05)":[228,277,291],"1.17":[233],"0.30":[235],"1.57":[239],"0.21":[241],"P<0.001)":[243],"mice,":[244],"measured":[246],"ultra-sonography.":[248],"Ex":[249],"vivo":[250],"measurement":[251],"aortas":[254],"revealed":[255],"(Con=":[266,280],"1.01":[267],"1.62":[273],"0.14":[275],"0.94":[281],"0.03":[283],"1.36":[287],"0.25":[289],"also":[295],"ascending":[299],"expansion":[301],"18.1":[304],"1.12":[306],"mm":[307,315],"2":[308,316],"24.9":[312],"0.91":[314],",":[317],"P<0.05),":[318],"only":[319],"Conclusion:":[323],"These":[324],"demonstrate":[326],"enhanced":[328],"accelerates":[333],"formation,":[336],"contributes":[338],"sexual":[340],"dimorphism":[341]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2020-08-03T00:00:00"}