{"id":"https://openalex.org/W3046047217","doi":"https://doi.org/10.1002/jat.4044","title":"Toxicological safety evaluation of pasteurized Akkermansia muciniphila","display_name":"Toxicological safety evaluation of pasteurized Akkermansia muciniphila","publication_year":2020,"publication_date":"2020-07-28","ids":{"openalex":"https://openalex.org/W3046047217","doi":"https://doi.org/10.1002/jat.4044","mag":"3046047217","pmid":"https://pubmed.ncbi.nlm.nih.gov/32725676","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7818173"},"language":"en","primary_location":{"id":"doi:10.1002/jat.4044","doi":"https://doi.org/10.1002/jat.4044","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.4044","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4044","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078238483","display_name":"C\u00e9line Druart","orcid":"https://orcid.org/0000-0002-7786-9172","observed_orcids":["https://orcid.org/0000-0002-7786-9172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9line Druart","raw_affiliation_strings":["A-Mansia Biotech SA, Mont-Saint-Guibert, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A-Mansia Biotech SA, Mont-Saint-Guibert, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048673504","display_name":"Hubert Plovier","orcid":"https://orcid.org/0000-0001-9494-8094","observed_orcids":["https://orcid.org/0000-0001-9494-8094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Plovier","raw_affiliation_strings":["A-Mansia Biotech SA, Mont-Saint-Guibert, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A-Mansia Biotech SA, Mont-Saint-Guibert, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042192451","display_name":"Matthias Van Hul","orcid":"https://orcid.org/0000-0002-5503-107X","observed_orcids":["https://orcid.org/0000-0002-5503-107X"]},"institutions":[{"id":"https://openalex.org/I4210142098","display_name":"Walloon Excellence in Lifesciences and Biotechnology","ror":"https://ror.org/04qbvw321","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210142098"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Matthias Van Hul","raw_affiliation_strings":["Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Metabolism and Nutrition Research Group, Louvain Drug Research Institute UCLouvain, Universit\u00e9 catholique de Louvain  Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Metabolism and Nutrition Research Group, Louvain Drug Research Institute UCLouvain, Universit\u00e9 catholique de Louvain  Brussels Belgium","institution_ids":["https://openalex.org/I4210142098","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082548865","display_name":"Aliz\u00e9e Brient","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aliz\u00e9e Brient","raw_affiliation_strings":["Citoxlab France, Evreux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Citoxlab France, Evreux, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061738496","display_name":"Kirt R. Phipps","orcid":"https://orcid.org/0000-0002-7152-654X","observed_orcids":["https://orcid.org/0000-0002-7152-654X"]},"institutions":[{"id":"https://openalex.org/I4210140224","display_name":"Intertek (United Kingdom)","ror":"https://ror.org/0459j6s55","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210140224"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirt R. Phipps","raw_affiliation_strings":["Intertek Health Sciences Inc., Farnborough, Hampshire, UK"],"raw_orcid":"https://orcid.org/0000-0002-7152-654X","affiliations":[{"raw_affiliation_string":"Intertek Health Sciences Inc., Farnborough, Hampshire, UK","institution_ids":["https://openalex.org/I4210140224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054572740","display_name":"Willem M. de Vos","orcid":"https://orcid.org/0000-0002-0273-3166","observed_orcids":["https://orcid.org/0000-0002-0273-3166"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["FI","NL"],"is_corresponding":false,"raw_author_name":"Willem M. de Vos","raw_affiliation_strings":["Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland","Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070336660","display_name":"Patrice D. Cani","orcid":"https://orcid.org/0000-0003-2040-2448","observed_orcids":["https://orcid.org/0000-0003-2040-2448"]},"institutions":[{"id":"https://openalex.org/I4210142098","display_name":"Walloon Excellence in Lifesciences and Biotechnology","ror":"https://ror.org/04qbvw321","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210142098"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Patrice D. Cani","raw_affiliation_strings":["Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Metabolism and Nutrition Research Group, Louvain Drug Research Institute UCLouvain, Universit\u00e9 catholique de Louvain  Brussels Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2040-2448","affiliations":[{"raw_affiliation_string":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Metabolism and Nutrition Research Group, Louvain Drug Research Institute UCLouvain, Universit\u00e9 catholique de Louvain  Brussels Belgium","institution_ids":["https://openalex.org/I4210142098","https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070336660"],"corresponding_institution_ids":["https://openalex.org/I4210142098","https://openalex.org/I95674353"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":4.8623,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95083426,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"41","issue":"2","first_page":"276","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.3061999976634979,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":1.0},{"id":"https://openalex.org/keywords/pasteurization","display_name":"pasteurization","score":0.7099999785423279},{"id":"https://openalex.org/keywords/probiotic-safety","display_name":"probiotic safety","score":0.6600000262260437},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/90-day-toxicity-study","display_name":"90-day toxicity study","score":0.8080000281333923},{"id":"https://openalex.org/keywords/no-observed-adverse-effect-level","display_name":"no-observed-adverse-effect level","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8059999942779541},{"id":"https://openalex.org/keywords/food-ingredients","display_name":"food ingredients","score":0.5609999895095825},{"id":"https://openalex.org/keywords/wistar-han-rats","display_name":"Wistar Han rats","score":0.6299999952316284},{"id":"https://openalex.org/keywords/bacterial-reverse-mutation","display_name":"bacterial reverse mutation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.8479999899864197},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.46700000762939453},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.9837942719459534},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7390444278717041},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5220596790313721},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4671005308628082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45151519775390625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4459036886692047},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37068647146224976},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.36916714906692505},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35545843839645386},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3293885588645935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24055883288383484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1918538212776184}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059022","descriptor_name":"Food Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061352","descriptor_name":"Pasteurization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1002/jat.4044","doi":"https://doi.org/10.1002/jat.4044","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.4044","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4044","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7818173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7818173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Appl Toxicol","raw_type":"Text"},{"id":"pmid:32725676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32725676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/568981","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/toxicological-safety-evaluation-of-pasteurized-akkermansia-mucini","pdf_url":"https://edepot.wur.nl/529972","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0260-437X","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:dial.uclouvain.be:boreal:238798","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/238798","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of applied toxicology : JAT, p. [1-15] (2020)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/325992","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/325992","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/568981","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/toxicological-safety-evaluation-of-pasteurized-akkermansia-mucini","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Applied Toxicology, 41(2), 276 - 290","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/jat.4044","doi":"https://doi.org/10.1002/jat.4044","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.4044","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4044","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3046047217.pdf","grobid_xml":"https://content.openalex.org/works/W3046047217.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1973195696","https://openalex.org/W1982522570","https://openalex.org/W2005156172","https://openalex.org/W2021251015","https://openalex.org/W2024098972","https://openalex.org/W2030735755","https://openalex.org/W2032112360","https://openalex.org/W2056204961","https://openalex.org/W2085265179","https://openalex.org/W2134241692","https://openalex.org/W2139334262","https://openalex.org/W2147790901","https://openalex.org/W2157176317","https://openalex.org/W2157650196","https://openalex.org/W2188930066","https://openalex.org/W2267861477","https://openalex.org/W2342540743","https://openalex.org/W2344498019","https://openalex.org/W2427089839","https://openalex.org/W2559267012","https://openalex.org/W2559958749","https://openalex.org/W2588157141","https://openalex.org/W2608502548","https://openalex.org/W2755222624","https://openalex.org/W2758183934","https://openalex.org/W2883041645","https://openalex.org/W2912646121","https://openalex.org/W2915518036","https://openalex.org/W2925318921","https://openalex.org/W2941578712","https://openalex.org/W2954124338","https://openalex.org/W2985780919","https://openalex.org/W3003710691","https://openalex.org/W3008005014","https://openalex.org/W3010829439","https://openalex.org/W3012095940","https://openalex.org/W3166618611","https://openalex.org/W4229648659"],"related_works":["https://openalex.org/W7123901794","https://openalex.org/W3196639218","https://openalex.org/W4367048112","https://openalex.org/W2427089839","https://openalex.org/W4415905070","https://openalex.org/W3203227091","https://openalex.org/W7165152256","https://openalex.org/W4391351101","https://openalex.org/W4399977591","https://openalex.org/W4410064959"],"abstract_inverted_index":{"Abstract":[0],"Gut":[1],"microorganisms":[2],"are":[3,33,63],"vital":[4],"for":[5,76,159,250],"many":[6],"aspects":[7],"of":[8,25,38,54,126,197],"human":[9],"health,":[10],"and":[11,44,60,82,97,104,175,183,190,192],"the":[12,110,118,213,239],"commensal":[13],"bacterium":[14],"Akkermansia":[15],"muciniphila":[16,31,56,73,123,152,232,247],"has":[17,57],"repeatedly":[18],"been":[19],"identified":[20],"as":[21,42,78,238,252],"a":[22,79,87,105,176,253],"key":[23],"component":[24],"intestinal":[26],"microbiota.":[27],"Reductions":[28],"in":[29,98,199,212],"A.":[30,55,72,122,151,231,246],"abundance":[32],"associated":[34],"with":[35,117],"increased":[36],"prevalence":[37],"metabolic":[39],"disorders":[40],"such":[41],"obesity":[43],"type":[45],"2":[46],"diabetes.":[47],"It":[48],"was":[49,83,236],"recently":[50],"discovered":[51],"that":[52,61,244],"administration":[53],"beneficial":[58],"effects":[59,167,209],"these":[62],"not":[64],"diminished,":[65],"but":[66],"rather":[67],"enhanced":[68],"after":[69],"pasteurization.":[70],"Pasteurized":[71],"is":[74,248],"proposed":[75],"use":[77,251],"food":[80,182,254],"ingredient,":[81],"therefore":[84],"subjected":[85],"to":[86,135,226],"nonclinical":[88],"safety":[89],"assessment,":[90],"comprising":[91],"genotoxicity":[92,201],"assays":[93],"(bacterial":[94],"reverse":[95],"mutation":[96],"vitro":[99,200],"mammalian":[100],"cell":[101],"micronucleus":[102],"tests)":[103],"90\u2010day":[106,214],"toxicity":[107],"study.":[108],"For":[109],"latter,":[111],"Han":[112],"Wistar":[113],"rats":[114],"were":[115,203,210],"administered":[116],"vehicle":[119],"or":[120,129,146],"pasteurized":[121,245],"at":[124],"doses":[125],"75,":[127],"375":[128],"1500":[130,217],"mg/kg":[131,218],"body":[132,154,180,219,234],"weight/day":[133,220],"(equivalent":[134],"4.8":[136],"\u00d7":[137,142,148,228],"10":[138,143,144,149,150,229,230],"9":[139],",":[140,145],"2.4":[141],"9.6":[147,227],"cells/kg":[153,233],"weight/day)":[155,235],"by":[156],"oral":[157],"gavage":[158],"90":[160],"consecutive":[161],"days.":[162],"The":[163,195],"study":[164],"assessed":[165],"potential":[166],"on":[168],"clinical":[169,186],"observations":[170,174],"(including":[171],"detailed":[172],"arena":[173],"modified":[177],"Irwin":[178],"test),":[179],"weight,":[181],"water":[184],"consumption,":[185],"pathology,":[187],"organ":[188],"weights,":[189],"macroscopic":[191],"microscopic":[193],"pathology.":[194],"results":[196,242],"both":[198],"studies":[202],"negative.":[204],"No":[205],"test":[206],"item\u2010related":[207],"adverse":[208],"observed":[211],"study;":[215],"therefore,":[216],"(the":[221],"highest":[222],"dose":[223],"tested,":[224],"equivalent":[225],"established":[237],"no\u2010observed\u2010adverse\u2010effect\u2010level.":[240],"These":[241],"support":[243],"safe":[249],"ingredient.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-08-03T00:00:00"}
