{"id":"https://openalex.org/W3045996701","doi":"https://doi.org/10.3892/ijo.2020.5105","title":"E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions","display_name":"E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions","publication_year":2020,"publication_date":"2020-07-29","ids":{"openalex":"https://openalex.org/W3045996701","doi":"https://doi.org/10.3892/ijo.2020.5105","mag":"3045996701","pmid":"https://pubmed.ncbi.nlm.nih.gov/32945372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7473757"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2020.5105","doi":"https://doi.org/10.3892/ijo.2020.5105","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2020.5105","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2020.5105/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/ijo.2020.5105/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084177175","display_name":"Perla Uc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Perla Uc","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006348634","display_name":"Jael Miranda","orcid":"https://orcid.org/0000-0003-0122-5132","observed_orcids":["https://orcid.org/0000-0003-0122-5132"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jael Miranda","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027115437","display_name":"Arturo Raya\u2010Sandino","orcid":"https://orcid.org/0000-0001-7858-8017","observed_orcids":["https://orcid.org/0000-0001-7858-8017"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Arturo Raya\u2011Sandino","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096904789","display_name":"Lourdes Alarc\ufffdn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lourdes Alarc\ufffdn","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096904790","display_name":"Mar\ufffda Rold\ufffdn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mar\ufffda Rold\ufffdn","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083103164","display_name":"Rodolfo Ocadiz\u2010Delgado","orcid":"https://orcid.org/0000-0002-4576-881X","observed_orcids":["https://orcid.org/0000-0002-4576-881X"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rodolfo Ocadiz\u2011Delgado","raw_affiliation_strings":["Department of Genetics and Molecular Biology, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Molecular Biology, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087022666","display_name":"Enoc Mariano Cort\u00e9s-Malag\u00f3n","orcid":"https://orcid.org/0000-0002-6240-3468","observed_orcids":["https://orcid.org/0000-0002-6240-3468"]},"institutions":[{"id":"https://openalex.org/I4210153604","display_name":"Hospital Ju\u00e1rez de M\u00e9xico","ror":"https://ror.org/04cepy814","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210153604"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Enoc Cort\ufffds\u2011Malag\ufffdn","raw_affiliation_strings":["Research Unit on Genetics and Cancer, Research Division, Hospital Ju\ufffdrez de M\ufffdxico, Mexico City 07760, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit on Genetics and Cancer, Research Division, Hospital Ju\ufffdrez de M\ufffdxico, Mexico City 07760, Mexico","institution_ids":["https://openalex.org/I4210153604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096904791","display_name":"Bibiana Ch\ufffdvez\u2010Mungu\ufffda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Bibiana Ch\ufffdvez\u2011Mungu\ufffda","raw_affiliation_strings":["Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096904792","display_name":"Georgina Ram\ufffdrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Georgina Ram\ufffdrez","raw_affiliation_strings":["Department of Electrical Engineering, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096904787","display_name":"Ren\ufffd Asomoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ren\ufffd Asomoza","raw_affiliation_strings":["Department of Electrical Engineering, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047042806","display_name":"Liora Shoshani","orcid":"https://orcid.org/0000-0002-3442-4333","observed_orcids":["https://orcid.org/0000-0002-3442-4333","https://orcid.org/0000-0003-2030-9817"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Liora Shoshani","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077663215","display_name":"Patricio Gariglio","orcid":"https://orcid.org/0000-0003-4603-3249","observed_orcids":["https://orcid.org/0000-0003-4603-3249"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Patricio Gariglio","raw_affiliation_strings":["Department of Genetics and Molecular Biology, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Molecular Biology, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":null,"display_name":"Lorenza Gonz\ufffdlez\u2011Mariscal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lorenza Gonz\ufffdlez\u2011Mariscal","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.295,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.49928406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"57","issue":"4","first_page":"905","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.2808000147342682,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv16-e7","display_name":"HPV16 E7","score":0.9819999933242798},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.7390000224113464},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/claudin-10","display_name":"claudin-10","score":0.9950000047683716},{"id":"https://openalex.org/keywords/claudin-4","display_name":"claudin-4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/claudin-2","display_name":"claudin-2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.42100000381469727},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.699999988079071},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.9028170704841614},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.8817490339279175},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.5815855264663696},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.5607993006706238},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.5534864068031311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5381560921669006},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4763500988483429},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4481654167175293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42940133810043335},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.4238261878490448},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40977564454078674},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4010313153266907},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.380169540643692},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.32238996028900146},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24918094277381897},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.1178446114063263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057167","descriptor_name":"Claudins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057167","descriptor_name":"Claudins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057167","descriptor_name":"Claudins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.2020.5105","doi":"https://doi.org/10.3892/ijo.2020.5105","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2020.5105","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2020.5105/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:32945372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32945372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7473757","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7473757/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ijo.2020.5105","doi":"https://doi.org/10.3892/ijo.2020.5105","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2020.5105","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2020.5105/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311777","display_name":"Secretar\u00eda de Educaci\u00f3n P\u00fablica","ror":"https://ror.org/02e1c4h55"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320323401","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045996701.pdf","grobid_xml":"https://content.openalex.org/works/W3045996701.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W131885260","https://openalex.org/W181516228","https://openalex.org/W201125491","https://openalex.org/W347656695","https://openalex.org/W881385220","https://openalex.org/W925903496","https://openalex.org/W1230171729","https://openalex.org/W1490241574","https://openalex.org/W1496350633","https://openalex.org/W1498232526","https://openalex.org/W1512065983","https://openalex.org/W1533255714","https://openalex.org/W1553719213","https://openalex.org/W1585800035","https://openalex.org/W1601943231","https://openalex.org/W1754027570","https://openalex.org/W1769562746","https://openalex.org/W1828695701","https://openalex.org/W1844745998","https://openalex.org/W1862989971","https://openalex.org/W1918711739","https://openalex.org/W1920809125","https://openalex.org/W1958481102","https://openalex.org/W1961719289","https://openalex.org/W1968174606","https://openalex.org/W1970790252","https://openalex.org/W1971498153","https://openalex.org/W1973959503","https://openalex.org/W1974657780","https://openalex.org/W1976116333","https://openalex.org/W1976369464","https://openalex.org/W1977602797","https://openalex.org/W1979207410","https://openalex.org/W1980119698","https://openalex.org/W1981234790","https://openalex.org/W1981734045","https://openalex.org/W1986039468","https://openalex.org/W1987611673","https://openalex.org/W1987689639","https://openalex.org/W1987788164","https://openalex.org/W1988780041","https://openalex.org/W1990578192","https://openalex.org/W1990770553","https://openalex.org/W1997873472","https://openalex.org/W1998372028","https://openalex.org/W2000422049","https://openalex.org/W2001096226","https://openalex.org/W2001141591","https://openalex.org/W2001497370","https://openalex.org/W2004326366","https://openalex.org/W2005473660","https://openalex.org/W2009368557","https://openalex.org/W2011674367","https://openalex.org/W2014073692","https://openalex.org/W2020142016","https://openalex.org/W2022174383","https://openalex.org/W2022606160","https://openalex.org/W2024005495","https://openalex.org/W2024575518","https://openalex.org/W2025357648","https://openalex.org/W2026240985","https://openalex.org/W2026628414","https://openalex.org/W2030871823","https://openalex.org/W2032428709","https://openalex.org/W2032925493","https://openalex.org/W2035630698","https://openalex.org/W2037627249","https://openalex.org/W2038500217","https://openalex.org/W2048070053","https://openalex.org/W2050899382","https://openalex.org/W2052038911","https://openalex.org/W2057575418","https://openalex.org/W2059375118","https://openalex.org/W2060786724","https://openalex.org/W2060986062","https://openalex.org/W2061558153","https://openalex.org/W2063714844","https://openalex.org/W2065675729","https://openalex.org/W2065703686","https://openalex.org/W2065836489","https://openalex.org/W2066301699","https://openalex.org/W2067052531","https://openalex.org/W2068364383","https://openalex.org/W2071110150","https://openalex.org/W2072171166","https://openalex.org/W2072172421","https://openalex.org/W2073862596","https://openalex.org/W2074036521","https://openalex.org/W2074112219","https://openalex.org/W2076344382","https://openalex.org/W2076601321","https://openalex.org/W2080675024","https://openalex.org/W2086731629","https://openalex.org/W2087710101","https://openalex.org/W2089185363","https://openalex.org/W2089851631","https://openalex.org/W2093592194","https://openalex.org/W2094301481","https://openalex.org/W2099777779","https://openalex.org/W2100483442","https://openalex.org/W2102015799","https://openalex.org/W2102194654","https://openalex.org/W2105196805","https://openalex.org/W2110965039","https://openalex.org/W2111704637","https://openalex.org/W2116511148","https://openalex.org/W2117070336","https://openalex.org/W2118594039","https://openalex.org/W2123512929","https://openalex.org/W2124957627","https://openalex.org/W2125696070","https://openalex.org/W2126741970","https://openalex.org/W2128157486","https://openalex.org/W2128616002","https://openalex.org/W2130976383","https://openalex.org/W2131007362","https://openalex.org/W2132024007","https://openalex.org/W2132087311","https://openalex.org/W2132226772","https://openalex.org/W2135643465","https://openalex.org/W2136236728","https://openalex.org/W2136984184","https://openalex.org/W2137485628","https://openalex.org/W2138569498","https://openalex.org/W2138865332","https://openalex.org/W2139898710","https://openalex.org/W2145716903","https://openalex.org/W2146320402","https://openalex.org/W2148888894","https://openalex.org/W2149899704","https://openalex.org/W2150688238","https://openalex.org/W2154625078","https://openalex.org/W2157655195","https://openalex.org/W2157924932","https://openalex.org/W2159791426","https://openalex.org/W2162074180","https://openalex.org/W2165912994","https://openalex.org/W2166610285","https://openalex.org/W2167235505","https://openalex.org/W2168110414","https://openalex.org/W2170441266","https://openalex.org/W2176074655","https://openalex.org/W2183308769","https://openalex.org/W2208294397","https://openalex.org/W2209322568","https://openalex.org/W2300992720","https://openalex.org/W2410032162","https://openalex.org/W2411193523","https://openalex.org/W2433794126","https://openalex.org/W2463781404","https://openalex.org/W2490967792","https://openalex.org/W2524414779","https://openalex.org/W2531345178","https://openalex.org/W2587690719","https://openalex.org/W2601868035","https://openalex.org/W2604643316","https://openalex.org/W2610636284","https://openalex.org/W2612876782","https://openalex.org/W2614146260","https://openalex.org/W2618165410","https://openalex.org/W2644353389","https://openalex.org/W2647011234","https://openalex.org/W2748895446","https://openalex.org/W2762760150","https://openalex.org/W2806548928","https://openalex.org/W2889646458","https://openalex.org/W2891629709","https://openalex.org/W2893577998","https://openalex.org/W2895566723","https://openalex.org/W2901270441","https://openalex.org/W2901472288","https://openalex.org/W2902227050","https://openalex.org/W2903581385","https://openalex.org/W2963850496","https://openalex.org/W2975579427","https://openalex.org/W2982146945","https://openalex.org/W2990604092","https://openalex.org/W2999417355","https://openalex.org/W3008615800","https://openalex.org/W3016226585","https://openalex.org/W6608270602","https://openalex.org/W6633239641","https://openalex.org/W6637936573","https://openalex.org/W6640002542","https://openalex.org/W6640979489","https://openalex.org/W6658250913","https://openalex.org/W6667068142","https://openalex.org/W6685108608","https://openalex.org/W6714802132","https://openalex.org/W6769374226"],"related_works":["https://openalex.org/W7057990475","https://openalex.org/W2093592194","https://openalex.org/W2417349345","https://openalex.org/W1914585949","https://openalex.org/W2103852160","https://openalex.org/W2143928248","https://openalex.org/W7165034952","https://openalex.org/W201890936","https://openalex.org/W2032891625","https://openalex.org/W2063929792"],"abstract_inverted_index":{"Tight":[0],"junctions":[1],"(TJs)":[2],"are":[3],"cell\u2011cell":[4],"adhesion":[5],"structures":[6],"frequently":[7],"altered":[8,174],"by":[9,130,192,236,242],"oncogenic":[10],"transformation.":[11],"In":[12,78,159],"the":[13,16,26,34,64,90,100,105,109,136,162,168,175,178,181,210,245,252],"present":[14],"study":[15],"role":[17],"of":[18,28,37,58,66,92,102,108,135,165,177,183,187,196,212,247,249,254,256],"human":[19],"papillomavirus":[20],"(HPV)":[21],"16":[22],"E7":[23,166,208,238],"oncoprotein":[24,239],"on":[25],"sealing":[27,255],"TJs":[29],"was":[30,51,55,81,240],"investigated":[31],"and":[32,42,61,96,117,140,173,200,202,221,225,251],"also":[33,82],"expression":[35,57,88,164,195,248],"level":[36],"claudins":[38,59,197,250],"in":[39,43,63,86,89,104,111,118,138,151,205,244],"mouse":[40],"cervix":[41,65,91,110,137],"epithelial":[44,257],"Madin\u2011Darby":[45],"Canine":[46],"Kidney":[47],"(MDCK)":[48],"cells.":[49],"It":[50],"found":[52],"that":[53,232],"there":[54,80],"reduced":[56,194],"\u20111":[60],"\u201110":[62],"7\u2011month\u2011old":[67,141],"transgenic":[68],"K14E7":[69,94,119,152],"mice":[70,113,120,143,153],"treated":[71,114,121,144,154],"with":[72,75,115,122,145,155],"17\u03b2\u2011estradiol":[73],"(E2),":[74],"invasive":[76],"cancer.":[77],"addition,":[79],"a":[83,193,218],"transient":[84],"increase":[85,204],"claudin\u20111":[87],"2\u2011month\u2011old":[93],"mice,":[95],"claudin\u201110":[97],"accumulated":[98],"at":[99],"border":[101],"cells":[103,161,172,214],"upper":[106],"layer":[107],"FvB":[112,142],"E2,":[116,146],"or":[123,156],"without":[124,157],"E2.":[125,158],"These":[126,229],"changes":[127,243],"were":[128],"accompanied":[129,191,241],"an":[131,184,203],"augmented":[132],"paracellular":[133],"permeability":[134],"2\u2011":[139],"which":[147],"became":[148],"more":[149],"pronounced":[150],"MDCK":[160,213],"stable":[163],"increased":[167],"space":[169],"between":[170],"adjacent":[171],"architecture":[176],"monolayers,":[179],"induced":[180,235],"development":[182],"acute":[185],"peak":[186],"transepithelial":[188],"electrical":[189],"resistance":[190],"\u20111,":[198],"\u20112":[199],"\u201110,":[201],"claudin\u20114.":[206],"Moreover,":[207],"enhances":[209],"ability":[211],"to":[215],"migrate":[216],"through":[217],"3D":[219],"matrix":[220],"induces":[222],"cell":[223,233],"stiffening":[224],"stress":[226],"fiber":[227],"formation.":[228],"observations":[230],"revealed":[231],"transformation":[234],"HPV16":[237],"pattern":[246],"degree":[253],"TJs.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-08-03T00:00:00"}
