{"id":"https://openalex.org/W3045993773","doi":"https://doi.org/10.1002/bit.27520","title":"Toward in silico CMC: An industrial collaborative approach to model\u2010based process development","display_name":"Toward in silico CMC: An industrial collaborative approach to model\u2010based process development","publication_year":2020,"publication_date":"2020-07-29","ids":{"openalex":"https://openalex.org/W3045993773","doi":"https://doi.org/10.1002/bit.27520","mag":"3045993773","pmid":"https://pubmed.ncbi.nlm.nih.gov/32725887"},"language":"en","primary_location":{"id":"doi:10.1002/bit.27520","doi":"https://doi.org/10.1002/bit.27520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.27520","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058448395","display_name":"David J. Roush","orcid":"https://orcid.org/0000-0001-8841-7043","observed_orcids":["https://orcid.org/0000-0001-8841-7043"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Roush","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091693367","display_name":"Dilip\u2005N. Asthagiri","orcid":"https://orcid.org/0000-0001-5869-0807","observed_orcids":["https://orcid.org/0000-0001-5869-0807"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dilip Asthagiri","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091554344","display_name":"Deenesh K. Babi","orcid":"https://orcid.org/0000-0001-8117-2944","observed_orcids":["https://orcid.org/0000-0001-8117-2944"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Deenesh K. Babi","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steve Benner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Benner","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030696048","display_name":"Camille Bilodeau","orcid":"https://orcid.org/0000-0002-8358-5280","observed_orcids":["https://orcid.org/0000-0002-8358-5280"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camille Bilodeau","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020701865","display_name":"Giorgio Carta","orcid":"https://orcid.org/0000-0002-8841-8940","observed_orcids":["https://orcid.org/0000-0002-8841-8940"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giorgio Carta","raw_affiliation_strings":["Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069303550","display_name":"Philipp Ernst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Ernst","raw_affiliation_strings":["Bayer AG, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer AG, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084150413","display_name":"Mark Fedesco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Fedesco","raw_affiliation_strings":["Genentech, Inc., San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021108052","display_name":"Sean R. Fitzgibbon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Fitzgibbon","raw_affiliation_strings":["KBI Biopharma, Boulder, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBI Biopharma, Boulder, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023212854","display_name":"Matthew H. Flamm","orcid":"https://orcid.org/0000-0002-2040-5481","observed_orcids":["https://orcid.org/0000-0002-2040-5481"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Flamm","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066567643","display_name":"Jan Griesbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jan Griesbach","raw_affiliation_strings":["F. Hoffman-La Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffman-La Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059099259","display_name":"Tobias Gro\u00dfkopf","orcid":"https://orcid.org/0000-0002-5160-5152","observed_orcids":["https://orcid.org/0000-0002-5160-5152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Grosskopf","raw_affiliation_strings":["Roche Diagnostics GmbH, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113686897","display_name":"Ernst Broberg Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ernst B. Hansen","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041730554","display_name":"Tobias Hahn","orcid":"https://orcid.org/0000-0001-7030-2037","observed_orcids":["https://orcid.org/0000-0001-7030-2037"]},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Hahn","raw_affiliation_strings":["Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen Hunt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Hunt","raw_affiliation_strings":["KBI Biopharma, Boulder, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBI Biopharma, Boulder, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049210761","display_name":"Francis Kobina Insaidoo","orcid":"https://orcid.org/0000-0002-0800-4634","observed_orcids":["https://orcid.org/0000-0002-0800-4634"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Insaidoo","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":"https://orcid.org/0000-0002-0800-4634","affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089483150","display_name":"Abraham M. Lenhoff","orcid":"https://orcid.org/0000-0002-7831-219X","observed_orcids":["https://orcid.org/0000-0002-7831-219X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Lenhoff","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware"],"raw_orcid":"https://orcid.org/0000-0002-7831-219X","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026246272","display_name":"Jasper Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasper Lin","raw_affiliation_strings":["Genentech, Inc., San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110689816","display_name":"Henrik S. Marke","orcid":"https://orcid.org/0000-0002-4277-689X","observed_orcids":["https://orcid.org/0000-0002-4277-689X"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Marke","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruno Marques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159405","display_name":"Century Therapeutics (United States)","ror":"https://ror.org/05mjtbx41","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159405"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno Marques","raw_affiliation_strings":["Century Therapeutics, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Century Therapeutics, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I4210159405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063878432","display_name":"Emmanouil Papadakis","orcid":"https://orcid.org/0000-0002-1216-2600","observed_orcids":["https://orcid.org/0000-0002-1216-2600"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Emmanouil Papadakis","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062101164","display_name":"Fabrice Schlegel","orcid":"https://orcid.org/0000-0002-3350-5182","observed_orcids":["https://orcid.org/0000-0002-3350-5182"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabrice Schlegel","raw_affiliation_strings":["Amgen, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065441631","display_name":"Arne Staby","orcid":"https://orcid.org/0000-0003-0551-8936","observed_orcids":["https://orcid.org/0000-0003-0551-8936"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Arne Staby","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018949074","display_name":"Marcel Stenvang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marcel Stenvang","raw_affiliation_strings":["Novo Nordisk A/S, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091482483","display_name":"Larry Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Sun","raw_affiliation_strings":["Amgen, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029310606","display_name":"Peter M. Tessier","orcid":"https://orcid.org/0000-0002-3220-007X","observed_orcids":["https://orcid.org/0000-0002-3220-007X","https://orcid.org/0009-0002-2386-8040"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Tessier","raw_affiliation_strings":["Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Todd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Todd","raw_affiliation_strings":["KBI Biopharma, Boulder, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBI Biopharma, Boulder, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070703265","display_name":"Eric von Lieres","orcid":"https://orcid.org/0000-0002-0309-8408","observed_orcids":["https://orcid.org/0000-0002-0309-8408"]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eric von Lieres","raw_affiliation_strings":["Institute of Bio- and Geosciences 1, Research Centre Julich, Julich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bio- and Geosciences 1, Research Centre Julich, Julich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026528524","display_name":"John P. Welsh","orcid":"https://orcid.org/0000-0002-2422-037X","observed_orcids":["https://orcid.org/0000-0002-2422-037X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Welsh","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":"https://orcid.org/0000-0002-2422-037X","affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030188668","display_name":"Richard C. Willson","orcid":"https://orcid.org/0000-0002-0900-6148","observed_orcids":["https://orcid.org/0000-0002-0900-6148"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Willson","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-0900-6148","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367477","display_name":"Gang Wang","orcid":"https://orcid.org/0009-0000-8262-2951","observed_orcids":["https://orcid.org/0009-0000-8262-2951"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gang Wang","raw_affiliation_strings":["Boehringer Ingelheim, Ingelheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim, Ingelheim, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015646087","display_name":"Thomas Wucherpfennig","orcid":"https://orcid.org/0009-0002-0776-1542","observed_orcids":["https://orcid.org/0009-0002-0776-1542"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Wucherpfennig","raw_affiliation_strings":["Boehringer Ingelheim, Ingelheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim, Ingelheim, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040890843","display_name":"Oleksandr Zavalov","orcid":"https://orcid.org/0000-0001-7029-8349","observed_orcids":["https://orcid.org/0000-0001-7029-8349"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleksandr Zavalov","raw_affiliation_strings":["Merck & Co., Inc. Kenilworth New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc. Kenilworth New Jersey","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5058448395"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8581,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86465834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"117","issue":"12","first_page":"3986","last_page":"4000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.06970000267028809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioprocess-modeling","display_name":"bioprocess modeling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/industry-collaboration","display_name":"industry partnerships","score":0.8059999942779541},{"id":"https://openalex.org/keywords/biophysical-modeling","display_name":"biophysical model","score":0.7179999947547913},{"id":"https://openalex.org/keywords/clinical-drug-development","display_name":"clinical development","score":0.7850000262260437},{"id":"https://openalex.org/keywords/commercial-production","display_name":"commercial production","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.7814552187919617},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5649870038032532},{"id":"https://openalex.org/C76956256","wikidata":"https://www.wikidata.org/wiki/Q27610560","display_name":"Process modeling","level":3,"score":0.5024383068084717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4819064438343048},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.48168525099754333},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.46337974071502686},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.45315811038017273},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.41829031705856323},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4102945029735565},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.38859128952026367},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.3230457007884979},{"id":"https://openalex.org/C174998907","wikidata":"https://www.wikidata.org/wiki/Q357662","display_name":"Work in process","level":2,"score":0.24859508872032166},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.1292726695537567},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.07757344841957092},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bit.27520","doi":"https://doi.org/10.1002/bit.27520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.27520","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:32725887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32725887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1514933132","https://openalex.org/W1592512006","https://openalex.org/W1606664220","https://openalex.org/W2082568784","https://openalex.org/W2086623749","https://openalex.org/W2130870013","https://openalex.org/W2229493445","https://openalex.org/W2334916814","https://openalex.org/W2338950774","https://openalex.org/W2389280509","https://openalex.org/W2578859733","https://openalex.org/W2581342061","https://openalex.org/W2585408730","https://openalex.org/W2585413710","https://openalex.org/W2585609993","https://openalex.org/W2596757965","https://openalex.org/W2614928532","https://openalex.org/W2738574530","https://openalex.org/W2758192228","https://openalex.org/W2762472815","https://openalex.org/W2902697606","https://openalex.org/W2913499731","https://openalex.org/W2965872925","https://openalex.org/W2968060382","https://openalex.org/W3014443303","https://openalex.org/W4234798793","https://openalex.org/W6986606641"],"related_works":["https://openalex.org/W7204097245","https://openalex.org/W4399500800","https://openalex.org/W4221033952","https://openalex.org/W2965872925","https://openalex.org/W7166653244","https://openalex.org/W2241512721","https://openalex.org/W6908778464","https://openalex.org/W3158833935","https://openalex.org/W2093170330","https://openalex.org/W2541034714"],"abstract_inverted_index":{"The":[0,148],"Third":[1],"Modeling":[2,27],"Workshop":[3,20,79],"focusing":[4],"on":[5],"bioprocess":[6,155],"modeling":[7,92,156],"was":[8,80],"held":[9],"in":[10,13,24,91,116,122],"Kenilworth,":[11],"NJ":[12],"May":[14],"2019.":[15],"A":[16],"summary":[17],"of":[18,32,59,71,77,85,96,142,154],"these":[19,117],"proceedings":[21],"is":[22,28,40],"captured":[23],"this":[25],"manuscript.":[26,124],"an":[29,159],"active":[30],"area":[31],"research":[33],"within":[34],"the":[35,46,56,78,102,123,168],"biotechnology":[36],"community,":[37],"and":[38,49,63,69,88,105,111,119,134,145],"there":[39],"a":[41,74,151],"critical":[42],"need":[43],"to":[44,54,132],"assess":[45],"current":[47,86],"state":[48,162],"opportunities":[50],"for":[51,139],"continued":[52],"investment":[53],"realize":[55],"full":[57],"potential":[58],"models,":[60],"including":[61],"resource":[62],"time":[64],"savings.":[65],"Beyond":[66],"individual":[67],"presentations":[68],"topics":[70],"novel":[72],"interest,":[73],"substantial":[75],"portion":[76],"devoted":[81],"toward":[82],"group":[83],"discussions":[84,118],"states":[87],"future":[89,161],"directions":[90],"fields.":[93],"All":[94],"scales":[95],"modeling,":[97,113],"from":[98,129],"biophysical":[99],"models":[100],"at":[101],"molecular":[103],"level":[104],"up":[106],"through":[107],"large":[108],"scale":[109],"facility":[110],"plant":[112],"were":[114],"considered":[115,138],"are":[120,136],"summarized":[121],"Model":[125],"life":[126],"cycle":[127],"management":[128],"model":[130],"development":[131,144],"implementation":[133],"sustainment":[135],"also":[137],"different":[140],"stages":[141],"clinical":[143],"commercial":[146],"production.":[147],"manuscript":[149],"provides":[150],"comprehensive":[152],"overview":[153],"while":[157],"suggesting":[158],"ideal":[160],"with":[163],"standardized":[164],"approaches":[165],"aligned":[166],"across":[167],"industry.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-03T00:00:00"}