{"id":"https://openalex.org/W3045965460","doi":"https://doi.org/10.1038/s41598-020-69682-9","title":"Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent","display_name":"Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent","publication_year":2020,"publication_date":"2020-07-29","ids":{"openalex":"https://openalex.org/W3045965460","doi":"https://doi.org/10.1038/s41598-020-69682-9","mag":"3045965460","pmid":"https://pubmed.ncbi.nlm.nih.gov/32728172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7391724"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-69682-9","doi":"https://doi.org/10.1038/s41598-020-69682-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69682-9","pdf_url":"https://www.nature.com/articles/s41598-020-69682-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-69682-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109996340","display_name":"Joseph A. Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Reddy","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066599316","display_name":"Melissa Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Nelson","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001039273","display_name":"Christina Dircksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Dircksen","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043457997","display_name":"Marilynn Vetzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilynn Vetzel","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104362171","display_name":"Theresa P. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Johnson","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009939463","display_name":"Vicky A. Cross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicky Cross","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002632070","display_name":"Elaine M. Westrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Westrick","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021018768","display_name":"Longwu Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LongWu Qi","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054013200","display_name":"Spencer J. Hahn","orcid":"https://orcid.org/0000-0003-4402-6459","observed_orcids":["https://orcid.org/0000-0003-4402-6459"]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spencer Hahn","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028583674","display_name":"Hari Krishna R. Santhapuram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hari Krishna Santhapuram","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019071481","display_name":"Garth L. Parham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garth Parham","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Wang","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007106196","display_name":"Jeremy F. Vaughn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy F. Vaughn","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080241729","display_name":"Albert Felten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Felten","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089720680","display_name":"Michael R. Pugh","orcid":"https://orcid.org/0000-0003-0530-6044","observed_orcids":["https://orcid.org/0000-0003-0530-6044"]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Pugh","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033898148","display_name":"June Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Lu","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141038750","display_name":"Patrick J. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Klein","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109371739","display_name":"Iontcho R. Vlahov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iontcho R. Vlahov","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085542989","display_name":"Christopher P. Leamon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher P. Leamon","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA. Christopher.Leamon@novartis.com","Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA. Christopher.Leamon@novartis.com","institution_ids":["https://openalex.org/I906832008"]},{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN, 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085542989"],"corresponding_institution_ids":["https://openalex.org/I906832008"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.4657,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.48242729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"12772","last_page":"12772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.23080000281333923,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.23080000281333923,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.2240000069141388,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-conjugates","display_name":"drug conjugates","score":0.6060000061988831},{"id":"https://openalex.org/keywords/dna-cross-linking-agents","display_name":"DNA cross-linking agents","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dna-alkylation","display_name":"DNA alkylation","score":0.843999981880188},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7448519468307495},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.6961796283721924},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.546663224697113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4934054911136627},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4892148971557617},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.48160240054130554},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.47414085268974304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47214582562446594},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.458175390958786},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.44871240854263306},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4334101974964142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42670392990112305},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4127150774002075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36633357405662537},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2868063449859619},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2394590973854065},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23840263485908508},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2298314869403839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18217787146568298},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007624","descriptor_name":"KB Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-020-69682-9","doi":"https://doi.org/10.1038/s41598-020-69682-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69682-9","pdf_url":"https://www.nature.com/articles/s41598-020-69682-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7391724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7391724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32728172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32728172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:62cffd133d60412fb62fcc23f334889b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/62cffd133d60412fb62fcc23f334889b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)","raw_type":"article"},{"id":"pmh:oai:oak.novartis.com:41901","doi":null,"is_oa":true,"landing_page_url":"https://www.nature.com/articles/s41598-020-69682-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400709","display_name":"The Novartis Repository (Novartis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1283582996","host_organization_name":"Novartis (Switzerland)","host_organization_lineage":["https://openalex.org/I1283582996"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-69682-9","doi":"https://doi.org/10.1038/s41598-020-69682-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-69682-9","pdf_url":"https://www.nature.com/articles/s41598-020-69682-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045965460.pdf","grobid_xml":"https://content.openalex.org/works/W3045965460.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1507264290","https://openalex.org/W1973108158","https://openalex.org/W1991632485","https://openalex.org/W2008807793","https://openalex.org/W2011974163","https://openalex.org/W2027110022","https://openalex.org/W2046036094","https://openalex.org/W2052004281","https://openalex.org/W2074033060","https://openalex.org/W2077908737","https://openalex.org/W2080419990","https://openalex.org/W2094288422","https://openalex.org/W2127373755","https://openalex.org/W2133374918","https://openalex.org/W2134039025","https://openalex.org/W2140853963","https://openalex.org/W2148111285","https://openalex.org/W2158998685","https://openalex.org/W2167486320","https://openalex.org/W2293327002","https://openalex.org/W2313984291","https://openalex.org/W2397198015","https://openalex.org/W2409077865","https://openalex.org/W2524928664","https://openalex.org/W2560431464","https://openalex.org/W2603010884","https://openalex.org/W2748365505","https://openalex.org/W2772445058","https://openalex.org/W2774586064","https://openalex.org/W2806683929","https://openalex.org/W2887577080","https://openalex.org/W2904320090","https://openalex.org/W3002681906","https://openalex.org/W3005471253","https://openalex.org/W3009586897"],"related_works":["https://openalex.org/W2740051881","https://openalex.org/W2495706357","https://openalex.org/W1506446568","https://openalex.org/W2090540963","https://openalex.org/W2127168225","https://openalex.org/W2734620733","https://openalex.org/W2565793739","https://openalex.org/W2806683929","https://openalex.org/W2052004281","https://openalex.org/W2059965787"],"abstract_inverted_index":{"Folate":[0],"receptor":[1],"(FR)-targeted":[2],"small":[3],"molecule":[4],"drug":[5,207],"conjugates":[6],"(SMDCs)":[7],"have":[8],"shown":[9],"promising":[10],"results":[11],"in":[12,65,92,197],"early":[13],"stage":[14],"clinical":[15],"trials":[16],"with":[17,33,63,75,98,188],"microtubule":[18,77],"destabilizing":[19],"agents,":[20],"such":[21],"as":[22,206],"vintafolide":[23],"and":[24,140,159],"EC1456.":[25],"In":[26],"our":[27],"effort":[28],"to":[29,59,90,124,173],"develop":[30],"FR-targeted":[31],"SMDCs":[32,73],"varying":[34],"mechanisms":[35],"of":[36,44,81,94,129,154,177],"action,":[37],"we":[38],"synthesized":[39],"EC2629,":[40,187],"a":[41,45,51,106,109],"folate":[42,72],"conjugate":[43],"DNA":[46,191],"crosslinking":[47],"agent":[48,56],"based":[49],"on":[50],"novel":[52],"DNA-alkylating":[53],"moiety.":[54],"This":[55],"was":[57,115],"found":[58],"be":[60,195],"extremely":[61],"potent":[62],"an":[64],"vitro":[66],"IC50":[67],"~":[68],"100\u00d7":[69],"lower":[70],"than":[71],"constructed":[74],"various":[76],"inhibitors.":[78],"EC2629":[79,166],"treatment":[80],"nude":[82],"mice":[83],"bearing":[84],"FR-positive":[85,137,148,199],"KB":[86],"human":[87],"xenografts":[88],"led":[89],"cures":[91],"100%":[93],"the":[95],"test":[96],"animals":[97],"very":[99],"low":[100],"dose":[101],"levels":[102],"(300":[103],"nmol/kg)":[104],"following":[105],"convenient":[107],"once":[108],"week":[110],"schedule.":[111],"The":[112],"observed":[113,135],"activity":[114,171],"not":[116],"accompanied":[117],"by":[118],"any":[119],"noticeable":[120],"weight":[121],"loss":[122],"(up":[123],"20":[125],"weeks":[126],"post":[127],"end":[128],"dosing).":[130],"Complete":[131],"responses":[132],"were":[133],"also":[134],"against":[136,147],"paclitaxel":[138],"(KB-PR)":[139],"cisplatin":[141],"(KB-CR)":[142],"resistant":[143],"models.":[144],"When":[145],"evaluated":[146],"patient":[149],"derived":[150],"xenograft":[151],"(PDX)":[152],"models":[153],"ovarian":[155],"(ST070),":[156],"endometrial":[157],"(ST040)":[158],"triple":[160],"negative":[161],"breast":[162],"cancers":[163],"(ST502,":[164],"ST738),":[165],"showed":[167],"significantly":[168],"greater":[169],"anti-tumor":[170],"compared":[172],"their":[174],"corresponding":[175],"standard":[176],"care":[178],"treatments.":[179],"Taken":[180],"together,":[181],"these":[182],"studies":[183],"thus":[184],"demonstrated":[185],"that":[186,203],"its":[189],"distinct":[190],"reacting":[192],"mechanism,":[193],"may":[194],"useful":[196],"treating":[198],"tumors,":[200],"including":[201],"those":[202],"are":[204],"classified":[205],"resistant.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-08-03T00:00:00"}