{"id":"https://openalex.org/W3045938012","doi":"https://doi.org/10.1101/2020.07.28.225631","title":"Understanding the Human Brain using Brain Organoids and a Structure-Function Theory","display_name":"Understanding the Human Brain using Brain Organoids and a Structure-Function Theory","publication_year":2020,"publication_date":"2020-07-28","ids":{"openalex":"https://openalex.org/W3045938012","doi":"https://doi.org/10.1101/2020.07.28.225631","mag":"3045938012"},"language":"en","primary_location":{"id":"doi:10.1101/2020.07.28.225631","doi":"https://doi.org/10.1101/2020.07.28.225631","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.28.225631","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.07.28.225631.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.07.28.225631.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073467232","display_name":"Gabriel A. Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriel A. Silva","raw_affiliation_strings":["Department of Bioengineering and Department of Neurosciences University of California San Diego, La Jolla CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Department of Neurosciences University of California San Diego, La Jolla CA 92037","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048323500","display_name":"Alysson Renato Muotri","orcid":"https://orcid.org/0000-0003-0867-2875","observed_orcids":["https://orcid.org/0000-0003-0867-2875"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alysson R. Muotri","raw_affiliation_strings":["Department of Pediatrics and Department of Cellular and Molecular Medicine, University of California San Diego"],"raw_orcid":"https://orcid.org/0000-0003-0867-2875","affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Department of Cellular and Molecular Medicine, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":null,"display_name":"Christopher White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290206253","display_name":"Microsoft (United States)","ror":"https://ror.org/00d0nc645","country_code":"US","type":"company","lineage":["https://openalex.org/I1290206253"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher White","raw_affiliation_strings":["Microsoft Research Redmond , Washington 98052","Microsoft Research#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microsoft Research Redmond , Washington 98052","institution_ids":["https://openalex.org/I1290206253"]},{"raw_affiliation_string":"Microsoft Research#TAB#","institution_ids":["https://openalex.org/I1290206253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073467232"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10320","display_name":"Neural Networks and Applications","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13062","display_name":"Cognitive Computing and Networks","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.8870000243186951},{"id":"https://openalex.org/keywords/constraint-based-modeling","display_name":"constraint-based modeling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.640611469745636},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6017265915870667},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5366745591163635},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.5301398038864136},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4695347547531128},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4657462537288666},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41933512687683105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34832295775413513},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26775431632995605},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09316226840019226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.07.28.225631","doi":"https://doi.org/10.1101/2020.07.28.225631","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.28.225631","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.07.28.225631.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.07.28.225631","doi":"https://doi.org/10.1101/2020.07.28.225631","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.28.225631","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.07.28.225631.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045938012.pdf","grobid_xml":"https://content.openalex.org/works/W3045938012.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W316919195","https://openalex.org/W1512746852","https://openalex.org/W1964287957","https://openalex.org/W1983787958","https://openalex.org/W2005926822","https://openalex.org/W2042060110","https://openalex.org/W2046572522","https://openalex.org/W2051785391","https://openalex.org/W2060697891","https://openalex.org/W2061155652","https://openalex.org/W2078529082","https://openalex.org/W2104073505","https://openalex.org/W2106233502","https://openalex.org/W2135171759","https://openalex.org/W2147270524","https://openalex.org/W2253932600","https://openalex.org/W2259578665","https://openalex.org/W2295635668","https://openalex.org/W2605700843","https://openalex.org/W2612743911","https://openalex.org/W2617749727","https://openalex.org/W2798813502","https://openalex.org/W2837184251","https://openalex.org/W2897058286","https://openalex.org/W2898251109","https://openalex.org/W2964390777","https://openalex.org/W2970454553","https://openalex.org/W2971462245","https://openalex.org/W2998412226","https://openalex.org/W3135209450"],"related_works":["https://openalex.org/W4286255038","https://openalex.org/W2891598274","https://openalex.org/W4385778928","https://openalex.org/W4379881354","https://openalex.org/W4388364274","https://openalex.org/W3083895765","https://openalex.org/W3095518540","https://openalex.org/W3141878431","https://openalex.org/W7212246396","https://openalex.org/W7216357747"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"basic":[2],"neurobiology-clinical":[3],"trial":[4],"paradigm":[5],"motivates":[6],"our":[7],"use":[8,161],"of":[9,15,41,47,55,66,128,147,162],"constrained":[10],"mathematical":[11,48,68],"models":[12,49,69,127,146],"and":[13,24,44,60,103,116,143,150,152,160],"analysis":[14],"personalized":[16],"human-derived":[17,71],"brain":[18,34,58,72,93,129],"organoids":[19,73,130],"toward":[20],"predicting":[21],"clinical":[22,117],"outcomes":[23],"safely":[25],"developing":[26],"new":[27,79],"therapeutics.":[28],"Physical":[29],"constraints":[30,124,139],"imposed":[31],"on":[32],"the":[33,37,45,57,82,92,155],"can":[35,164],"guide":[36],"analyses":[38],"an":[39,75],"interpretation":[40],"experimental":[42,100],"data":[43],"construction":[46],"that":[50,94,121,157],"attempt":[51],"to":[52,88,107,126,166],"make":[53,154],"sense":[54],"how":[56,61],"works":[59],"cognitive":[62,114],"functions":[63],"emerge.":[64],"Development":[65],"these":[67,138],"for":[70,77,169],"offer":[74,131],"opportunity":[76],"testing":[78,89],"hypotheses":[80],"about":[81,91],"human":[83],"brain.":[84],"When":[85],"it":[86],"comes":[87],"ideas":[90],"require":[95],"a":[96,132],"careful":[97],"balance":[98],"between":[99],"accessibility,":[101],"manipulation,":[102],"complexity,":[104],"in":[105,141],"order":[106],"connect":[108],"neurobiological":[109],"details":[110],"with":[111],"higher":[112],"level":[113],"properties":[115],"considerations,":[118],"we":[119,136,153],"argue":[120],"fundamental":[122],"structure-function":[123],"applied":[125],"path":[133],"forward.":[134],"Moreover,":[135],"show":[137],"appear":[140],"canonical":[142],"novel":[144],"math":[145],"neural":[148],"activity":[149],"learning,":[151],"case":[156],"constraint-based":[158],"modeling":[159],"representations":[163],"bridge":[165],"machine":[167],"learning":[168],"powerful":[170],"mutual":[171],"benefit.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-08-03T00:00:00"}
