{"id":"https://openalex.org/W3045897262","doi":"https://doi.org/10.1007/s00401-020-02196-w","title":"The physiological roles of tau and A\u03b2: implications for Alzheimer\u2019s disease pathology and therapeutics","display_name":"The physiological roles of tau and A\u03b2: implications for Alzheimer\u2019s disease pathology and therapeutics","publication_year":2020,"publication_date":"2020-07-29","ids":{"openalex":"https://openalex.org/W3045897262","doi":"https://doi.org/10.1007/s00401-020-02196-w","mag":"3045897262","pmid":"https://pubmed.ncbi.nlm.nih.gov/32728795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7498448"},"language":"en","primary_location":{"id":"doi:10.1007/s00401-020-02196-w","doi":"https://doi.org/10.1007/s00401-020-02196-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-020-02196-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-020-02196-w.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3045897262"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00401-020-02196-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084864660","display_name":"Sarah A. Kent","orcid":"https://orcid.org/0000-0002-8545-3724","observed_orcids":["https://orcid.org/0000-0002-8545-3724"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah A. Kent","raw_affiliation_strings":["Translational Neuroscience PhD Programme, Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK"],"raw_orcid":"https://orcid.org/0000-0002-8545-3724","affiliations":[{"raw_affiliation_string":"Translational Neuroscience PhD Programme, Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088747780","display_name":"Tara L. Spires\u2010Jones","orcid":"https://orcid.org/0000-0003-2530-0598","observed_orcids":["https://orcid.org/0000-0003-2530-0598"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tara L. Spires-Jones","raw_affiliation_strings":["Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK"],"raw_orcid":"https://orcid.org/0000-0003-2530-0598","affiliations":[{"raw_affiliation_string":"Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007415039","display_name":"Claire S. Durrant","orcid":"https://orcid.org/0000-0001-7552-7358","observed_orcids":["https://orcid.org/0000-0001-7552-7358"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claire S. Durrant","raw_affiliation_strings":["Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK. claire.durrant@ed.ac.uk","Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK"],"raw_orcid":"https://orcid.org/0000-0001-7552-7358","affiliations":[{"raw_affiliation_string":"Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK. claire.durrant@ed.ac.uk","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Discovery Brain Sciences and the UK Dementia Research Institute, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007415039"],"corresponding_institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":6.3306,"has_fulltext":true,"cited_by_count":482,"citation_normalized_percentile":{"value":0.98593926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"140","issue":"4","first_page":"417","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.996999979019165},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.6779999732971191},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.7820000052452087},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.8700000047683716},{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":0.796999990940094},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9190000295639038},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7870000004768372},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumour-suppressor","display_name":"tumour suppressor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/conserved-protein","display_name":"conserved protein","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7343189716339111},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7212518453598022},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5101428627967834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5027329921722412},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.43166327476501465},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.41572630405426025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2840735912322998},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22752046585083008},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15256842970848083}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00401-020-02196-w","doi":"https://doi.org/10.1007/s00401-020-02196-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-020-02196-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-020-02196-w.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},{"id":"pmid:32728795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32728795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neuropathologica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7498448","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7498448/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathol","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/60cc638f-78ae-4bc1-8b46-7364d1bcafc4","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/60cc638f-78ae-4bc1-8b46-7364d1bcafc4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kent, S, Spires-Jones, T & Durrant, C 2020, 'The physiological roles of tau and A\u03b2: implications for Alzheimer\u2019s disease pathology and therapeutics', Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02196-w","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00401-020-02196-w","doi":"https://doi.org/10.1007/s00401-020-02196-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00401-020-02196-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00401-020-02196-w.pdf","source":{"id":"https://openalex.org/S198620474","display_name":"Acta Neuropathologica","issn_l":"0001-6322","issn":["0001-6322","1432-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1830711314","display_name":"Translational Neuroscience - training the next generation of basic neuroscientists to embrace clinical research.","funder_award_id":"108890/B/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6479783853","display_name":null,"funder_award_id":"681181","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045897262.pdf","grobid_xml":"https://content.openalex.org/works/W3045897262.grobid-xml"},"referenced_works_count":304,"referenced_works":["https://openalex.org/W162134209","https://openalex.org/W1498240529","https://openalex.org/W1509178893","https://openalex.org/W1535978977","https://openalex.org/W1541837233","https://openalex.org/W1542215809","https://openalex.org/W1576762681","https://openalex.org/W1604272660","https://openalex.org/W1625738754","https://openalex.org/W1663825042","https://openalex.org/W1675105744","https://openalex.org/W1788877136","https://openalex.org/W1834356056","https://openalex.org/W1848819616","https://openalex.org/W1888485834","https://openalex.org/W1893543180","https://openalex.org/W1903262881","https://openalex.org/W1928655587","https://openalex.org/W1964049915","https://openalex.org/W1965107086","https://openalex.org/W1965381538","https://openalex.org/W1967410657","https://openalex.org/W1968641736","https://openalex.org/W1968937229","https://openalex.org/W1972132912","https://openalex.org/W1972355725","https://openalex.org/W1972673102","https://openalex.org/W1973026127","https://openalex.org/W1973417023","https://openalex.org/W1974179395","https://openalex.org/W1974596754","https://openalex.org/W1975040221","https://openalex.org/W1975110703","https://openalex.org/W1975321314","https://openalex.org/W1975775468","https://openalex.org/W1977688919","https://openalex.org/W1981662243","https://openalex.org/W1984924722","https://openalex.org/W1988622751","https://openalex.org/W1988829843","https://openalex.org/W1989130535","https://openalex.org/W1989349429","https://openalex.org/W1989453114","https://openalex.org/W1989839696","https://openalex.org/W1990439587","https://openalex.org/W1990752558","https://openalex.org/W1992423329","https://openalex.org/W1993158184","https://openalex.org/W1994336523","https://openalex.org/W1997955194","https://openalex.org/W2000303735","https://openalex.org/W2006761942","https://openalex.org/W2007426180","https://openalex.org/W2010199350","https://openalex.org/W2012034410","https://openalex.org/W2012139588","https://openalex.org/W2014739744","https://openalex.org/W2017151574","https://openalex.org/W2017500142","https://openalex.org/W2017917068","https://openalex.org/W2018006224","https://openalex.org/W2018348569","https://openalex.org/W2022532556","https://openalex.org/W2025391244","https://openalex.org/W2025516399","https://openalex.org/W2027397361","https://openalex.org/W2029562178","https://openalex.org/W2030249003","https://openalex.org/W2030317956","https://openalex.org/W2030602441","https://openalex.org/W2033154907","https://openalex.org/W2033641488","https://openalex.org/W2034286717","https://openalex.org/W2035466313","https://openalex.org/W2035506508","https://openalex.org/W2038012168","https://openalex.org/W2038085294","https://openalex.org/W2038114139","https://openalex.org/W2039314393","https://openalex.org/W2039384491","https://openalex.org/W2039956388","https://openalex.org/W2040739550","https://openalex.org/W2042171021","https://openalex.org/W2042783882","https://openalex.org/W2045671840","https://openalex.org/W2046847750","https://openalex.org/W2048231959","https://openalex.org/W2048997999","https://openalex.org/W2051054786","https://openalex.org/W2052742260","https://openalex.org/W2053030721","https://openalex.org/W2053043919","https://openalex.org/W2056046302","https://openalex.org/W2056079743","https://openalex.org/W2057068434","https://openalex.org/W2057230171","https://openalex.org/W2058407317","https://openalex.org/W2059010387","https://openalex.org/W2060458492","https://openalex.org/W2060831684","https://openalex.org/W2063038783","https://openalex.org/W2064244929","https://openalex.org/W2064770792","https://openalex.org/W2066011396","https://openalex.org/W2067763791","https://openalex.org/W2067902437","https://openalex.org/W2068934700","https://openalex.org/W2069123600","https://openalex.org/W2069554147","https://openalex.org/W2072360118","https://openalex.org/W2075949692","https://openalex.org/W2076303434","https://openalex.org/W2076333797","https://openalex.org/W2077279038","https://openalex.org/W2077905824","https://openalex.org/W2078485743","https://openalex.org/W2078917784","https://openalex.org/W2079363741","https://openalex.org/W2079402113","https://openalex.org/W2081881251","https://openalex.org/W2082429191","https://openalex.org/W2085325049","https://openalex.org/W2087140195","https://openalex.org/W2087485873","https://openalex.org/W2089795127","https://openalex.org/W2091505182","https://openalex.org/W2091770852","https://openalex.org/W2092176884","https://openalex.org/W2093303625","https://openalex.org/W2094929105","https://openalex.org/W2096027030","https://openalex.org/W2096117341","https://openalex.org/W2096361230","https://openalex.org/W2098881376","https://openalex.org/W2099183368","https://openalex.org/W2099390250","https://openalex.org/W2100510279","https://openalex.org/W2101240671","https://openalex.org/W2103381318","https://openalex.org/W2105213882","https://openalex.org/W2105631420","https://openalex.org/W2106041409","https://openalex.org/W2107877547","https://openalex.org/W2108076222","https://openalex.org/W2108629610","https://openalex.org/W2114444638","https://openalex.org/W2114832016","https://openalex.org/W2115017507","https://openalex.org/W2116381020","https://openalex.org/W2117526022","https://openalex.org/W2119089570","https://openalex.org/W2120809101","https://openalex.org/W2121469208","https://openalex.org/W2122620510","https://openalex.org/W2122843800","https://openalex.org/W2124296777","https://openalex.org/W2124794865","https://openalex.org/W2125072799","https://openalex.org/W2125784083","https://openalex.org/W2128122026","https://openalex.org/W2129733921","https://openalex.org/W2130144581","https://openalex.org/W2132154794","https://openalex.org/W2133019124","https://openalex.org/W2134157741","https://openalex.org/W2134518776","https://openalex.org/W2135348375","https://openalex.org/W2135661040","https://openalex.org/W2136903466","https://openalex.org/W2137903075","https://openalex.org/W2138206059","https://openalex.org/W2138485921","https://openalex.org/W2138860063","https://openalex.org/W2139396488","https://openalex.org/W2142980305","https://openalex.org/W2143535578","https://openalex.org/W2147008830","https://openalex.org/W2150106491","https://openalex.org/W2150472993","https://openalex.org/W2150635872","https://openalex.org/W2150999725","https://openalex.org/W2153084709","https://openalex.org/W2153284686","https://openalex.org/W2153669928","https://openalex.org/W2155048015","https://openalex.org/W2155636825","https://openalex.org/W2156326104","https://openalex.org/W2157124870","https://openalex.org/W2157665412","https://openalex.org/W2158314129","https://openalex.org/W2158592797","https://openalex.org/W2162948131","https://openalex.org/W2163772343","https://openalex.org/W2164239948","https://openalex.org/W2232424546","https://openalex.org/W2299800011","https://openalex.org/W2304354332","https://openalex.org/W2314634699","https://openalex.org/W2319314169","https://openalex.org/W2327550735","https://openalex.org/W2402047081","https://openalex.org/W2407359553","https://openalex.org/W2419578831","https://openalex.org/W2428473372","https://openalex.org/W2465435205","https://openalex.org/W2495536687","https://openalex.org/W2507989145","https://openalex.org/W2509488704","https://openalex.org/W2514975062","https://openalex.org/W2525826975","https://openalex.org/W2529572398","https://openalex.org/W2531898330","https://openalex.org/W2555210589","https://openalex.org/W2564253771","https://openalex.org/W2564604933","https://openalex.org/W2568763740","https://openalex.org/W2585424956","https://openalex.org/W2599367511","https://openalex.org/W2603451911","https://openalex.org/W2605036205","https://openalex.org/W2606756014","https://openalex.org/W2607259606","https://openalex.org/W2613492737","https://openalex.org/W2695553179","https://openalex.org/W2730417813","https://openalex.org/W2736307756","https://openalex.org/W2751298713","https://openalex.org/W2751803963","https://openalex.org/W2756095359","https://openalex.org/W2770013809","https://openalex.org/W2770659015","https://openalex.org/W2772494502","https://openalex.org/W2772497853","https://openalex.org/W2773340666","https://openalex.org/W2783348747","https://openalex.org/W2783557169","https://openalex.org/W2783808220","https://openalex.org/W2786608785","https://openalex.org/W2788377962","https://openalex.org/W2793412161","https://openalex.org/W2793954600","https://openalex.org/W2795693194","https://openalex.org/W2800292154","https://openalex.org/W2800314394","https://openalex.org/W2802048471","https://openalex.org/W2802918776","https://openalex.org/W2803318546","https://openalex.org/W2804293160","https://openalex.org/W2806036204","https://openalex.org/W2806462749","https://openalex.org/W2807347144","https://openalex.org/W2810622900","https://openalex.org/W2811255209","https://openalex.org/W2845880205","https://openalex.org/W2886162341","https://openalex.org/W2887875778","https://openalex.org/W2891038139","https://openalex.org/W2896921600","https://openalex.org/W2897655055","https://openalex.org/W2901207656","https://openalex.org/W2901880202","https://openalex.org/W2905076673","https://openalex.org/W2909479706","https://openalex.org/W2910046798","https://openalex.org/W2912894829","https://openalex.org/W2914926567","https://openalex.org/W2917312928","https://openalex.org/W2920830526","https://openalex.org/W2921691737","https://openalex.org/W2945288323","https://openalex.org/W2948989680","https://openalex.org/W2954918480","https://openalex.org/W2956696709","https://openalex.org/W2963219749","https://openalex.org/W2967572416","https://openalex.org/W2971448217","https://openalex.org/W2971541306","https://openalex.org/W2972429320","https://openalex.org/W2972919080","https://openalex.org/W2973642727","https://openalex.org/W2974638894","https://openalex.org/W2976163884","https://openalex.org/W2978211780","https://openalex.org/W2982235746","https://openalex.org/W2989839125","https://openalex.org/W2989847323","https://openalex.org/W2991061401","https://openalex.org/W2995323110","https://openalex.org/W2997706401","https://openalex.org/W2998093355","https://openalex.org/W2999513790","https://openalex.org/W3004475010","https://openalex.org/W3005361370","https://openalex.org/W3007853567","https://openalex.org/W3009159814","https://openalex.org/W3010134088","https://openalex.org/W3011438444","https://openalex.org/W3011713276","https://openalex.org/W3025327790","https://openalex.org/W3025418474","https://openalex.org/W3034909353","https://openalex.org/W3042806206","https://openalex.org/W4211139529","https://openalex.org/W4365787461"],"related_works":["https://openalex.org/W3047818817","https://openalex.org/W4390176391","https://openalex.org/W7115595543","https://openalex.org/W2908092937","https://openalex.org/W4386337201","https://openalex.org/W3031468935","https://openalex.org/W2071916510","https://openalex.org/W2238232606","https://openalex.org/W3197490415","https://openalex.org/W2781579290"],"abstract_inverted_index":{"Tau":[0,62],"and":[1,39,100,104,111,117,131,137,149,179,184,194],"amyloid":[2],"beta":[3],"(A\u03b2)":[4],"are":[5],"the":[6,21,124,164,177,190],"prime":[7],"suspects":[8],"for":[9,166,189],"driving":[10],"pathology":[11],"in":[12,80,123],"Alzheimer's":[13],"disease":[14],"(AD)":[15],"and,":[16],"as":[17,133,161,163],"such,":[18],"have":[19,33,41],"become":[20],"focus":[22],"of":[23,73,83,147,175,182,192],"therapeutic":[24,167],"development.":[25,168],"Recent":[26],"research,":[27],"however,":[28],"shows":[29],"that":[30,171],"these":[31,155],"proteins":[32],"been":[34,64],"highly":[35],"conserved":[36],"throughout":[37],"evolution":[38],"may":[40,47,157],"crucial,":[42],"physiological":[43,145,178],"roles.":[44],"Such":[45],"functions":[46,156],"be":[48,54,67,187],"lost":[49],"during":[50],"AD":[51],"progression":[52],"or":[53,59],"unintentionally":[55],"disrupted":[56],"by":[57],"tau-":[58],"A\u03b2-targeting":[60],"therapies.":[61],"has":[63],"revealed":[65],"to":[66,76,114,154,159],"more":[68],"than":[69],"a":[70,78,81,172],"simple":[71],"stabiliser":[72],"microtubules,":[74],"reported":[75],"play":[77],"role":[79],"range":[82],"biological":[84],"processes":[85],"including":[86],"myelination,":[87],"glucose":[88],"metabolism,":[89],"axonal":[90],"transport,":[91],"microtubule":[92],"dynamics,":[93],"iron":[94],"homeostasis,":[95],"neurogenesis,":[96,120],"motor":[97],"function,":[98],"learning":[99,116],"memory,":[101,118],"neuronal":[102],"excitability,":[103],"DNA":[105],"protection.":[106],"A\u03b2":[107,185],"is":[108,112],"similarly":[109],"multifunctional,":[110],"proposed":[113],"regulate":[115],"angiogenesis,":[119],"repair":[121],"leaks":[122],"blood-brain":[125],"barrier,":[126],"promote":[127],"recovery":[128],"from":[129],"injury,":[130],"act":[132],"an":[134],"antimicrobial":[135],"peptide":[136],"tumour":[138],"suppressor.":[139],"This":[140],"review":[141],"will":[142,186],"discuss":[143],"potential":[144],"roles":[146,181],"tau":[148,183],"A\u03b2,":[150],"highlighting":[151],"how":[152],"changes":[153],"contribute":[158],"pathology,":[160],"well":[162],"implications":[165],"We":[169],"propose":[170],"balanced":[173],"consideration":[174],"both":[176],"pathological":[180],"essential":[188],"design":[191],"safe":[193],"effective":[195],"therapeutics.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":67},{"year":2025,"cited_by_count":92},{"year":2024,"cited_by_count":102},{"year":2023,"cited_by_count":77},{"year":2022,"cited_by_count":77},{"year":2021,"cited_by_count":57},{"year":2020,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2020-08-03T00:00:00"}