{"id":"https://openalex.org/W3045895699","doi":"https://doi.org/10.4049/jimmunol.192.supp.201.13","title":"Targeting natural killer cell reactivity by employing antibody to NKp46: implications for type 1 diabetes (THER6P.857)","display_name":"Targeting natural killer cell reactivity by employing antibody to NKp46: implications for type 1 diabetes (THER6P.857)","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W3045895699","doi":"https://doi.org/10.4049/jimmunol.192.supp.201.13","mag":"3045895699"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.192.supp.201.13","doi":"https://doi.org/10.4049/jimmunol.192.supp.201.13","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.201.13","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058198790","display_name":"Rami Yossef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rami Yossef","raw_affiliation_strings":["Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024720121","display_name":"Uzi Hadad","orcid":"https://orcid.org/0000-0002-7643-1275","observed_orcids":["https://orcid.org/0000-0002-7643-1275"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Uzi Hadad","raw_affiliation_strings":["Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038051461","display_name":"Stipan Jonji\u0107","orcid":"https://orcid.org/0000-0001-5003-3108","observed_orcids":["https://orcid.org/0000-0001-5003-3108"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Stipan Jonji\u0107","raw_affiliation_strings":["Faculty of Medicine, University of Rijeka , Rijeka,","3Faculty of Medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Rijeka , Rijeka,","institution_ids":["https://openalex.org/I154347574"]},{"raw_affiliation_string":"3Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035583924","display_name":"Ofer Mandelboim","orcid":"https://orcid.org/0000-0002-9354-1855","observed_orcids":["https://orcid.org/0000-0002-9354-1855"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ofer Mandelboim","raw_affiliation_strings":["The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School , Jerusalem,","2The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School , Jerusalem,","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]},{"raw_affiliation_string":"2The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037912517","display_name":"Angel Porgador","orcid":"https://orcid.org/0000-0003-1540-4449","observed_orcids":["https://orcid.org/0000-0003-1540-4449"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Angel Porgador","raw_affiliation_strings":["Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, Virology and Genetics, Ben-Gurion University , Beer-Sheva,","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"1Microbiology, Immunology, Virology and Genetics, Ben-Gurion University, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":"Supplement_1","first_page":"201.13","last_page":"201.13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkp46","display_name":"NKp46","score":0.9789999723434448},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nk-cell-activation-receptors","display_name":"NK cell activation receptors","score":0.5649999976158142},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.9440000057220459},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5646072626113892},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5627782344818115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4804486930370331},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46173250675201416},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44437944889068604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4338945746421814},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4287784993648529},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07076224684715271},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.065562903881073}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.192.supp.201.13","doi":"https://doi.org/10.4049/jimmunol.192.supp.201.13","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.201.13","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972325998","https://openalex.org/W2110954768","https://openalex.org/W4250819366","https://openalex.org/W2904834602","https://openalex.org/W4377100983","https://openalex.org/W2087337997","https://openalex.org/W2341427475","https://openalex.org/W2135214901","https://openalex.org/W2004825621","https://openalex.org/W2769299881"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"killer":[2],"(NK)":[3],"cells":[4,12,18,21],"belong":[5],"to":[6,15,59,128,148,192],"the":[7,23,35,48,62,66,85,100,120,130,188,199],"innate":[8],"lymphoid":[9],"cells.":[10],"NK":[11,53,138,159],"are":[13],"able":[14,127,147],"eliminate":[16],"transformed":[17],"and":[19,40,55,71,76,175,206],"virus-infected":[20],"without":[22],"need":[24],"of":[25,47,52,65,87,99,133,184,201],"prior":[26],"antigen":[27],"stimulation.":[28],"Their":[29],"cytotoxic":[30,150],"activity":[31,151],"is":[32,44,57,82],"regulated":[33],"through":[34],"delicate":[36],"balance":[37],"between":[38],"activating":[39,50],"inhibitory":[41],"signals.":[42],"NKp46":[43,81,101,134,202],"a":[45],"member":[46],"primary":[49,136,164],"receptors":[51],"cells;":[54],"it":[56],"reported":[58,79],"interact":[60],"with":[61],"hemagglutinin":[63],"(HA)":[64],"influenza":[67],"virus,":[68],"heparan":[69],"sulfate":[70],"vimentin.":[72],"Moreover,":[73],"our":[74,163],"group":[75,190],"others":[77],"have":[78],"that":[80,97],"involved":[83],"in":[84,170,187,203],"development":[86,105,169,205],"type":[88],"1":[89],"diabetes":[90],"(T1D)":[91],"autoimmune":[92],"disease.":[93],"Subsequently,":[94],"we":[95,115,166],"hypothesized":[96],"blocking":[98],"could":[102],"prevent":[103],"T1D":[104,168,204],"or":[106],"prolong":[107],"its":[108],"honeymoon":[109],"period.":[110],"To":[111,161],"address":[112],"this":[113],"goal":[114],"characterized":[116],"monoclonal":[117],"antibodies":[118],"for":[119,210],"murine":[121,137],"NKp46.":[122],"One":[123],"mAb,":[124],"F15,":[125],"was":[126],"down-regulate":[129,149],"surface":[131],"expression":[132],"on":[135],"cell":[139],"following":[140],"antibody":[141],"injection.":[142],"Additionally,":[143],"F15":[144],"treatments":[145],"were":[146],"mediated":[152],"by":[153,157],"NKp46,":[154],"but":[155],"not":[156],"other":[158],"receptors.":[160],"test":[162],"assumption,":[165],"examined":[167],"two":[171],"models,":[172],"NOD":[173],"mice":[174,186],"low-dose":[176],"streptozotocin.":[177],"The":[178],"results":[179],"showed":[180],"significantly":[181],"lower":[182],"incidence":[183],"diabetic":[185],"F15-treated":[189],"comparing":[191],"control":[193],"groups.":[194],"This":[195],"study":[196],"directly":[197],"demonstrates":[198],"involvement":[200],"suggests":[207],"possible":[208],"treatment":[209],"early":[211],"insulitis":[212]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2020-08-03T00:00:00"}