{"id":"https://openalex.org/W304587982","doi":null,"title":"Evaluation of an interferon-gamma release assay, T-SPOT.TB, in a population with a low prevalence of tuberculosis.","display_name":"Evaluation of an interferon-gamma release assay, T-SPOT.TB, in a population with a low prevalence of tuberculosis.","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W304587982","mag":"304587982","pmid":"https://pubmed.ncbi.nlm.nih.gov/19861016"},"language":"en","primary_location":{"id":"pmid:19861016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19861016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085329392","display_name":"Diane R. Bienek","orcid":"https://orcid.org/0000-0002-8230-8134","observed_orcids":["https://orcid.org/0000-0002-8230-8134"]},"institutions":[{"id":"https://openalex.org/I3130687028","display_name":"United States Department of the Navy","ror":"https://ror.org/03ar0mv07","country_code":"US","type":"government","lineage":["https://openalex.org/I1330347796","https://openalex.org/I3130687028"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Bienek","raw_affiliation_strings":["Naval Institute for Dental and Biomedical Research, Great Lakes, Illinois, USA. diane.bienek@med.navy.mil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naval Institute for Dental and Biomedical Research, Great Lakes, Illinois, USA. diane.bienek@med.navy.mil","institution_ids":["https://openalex.org/I3130687028"]}]},{"author_position":"last","author":{"id":null,"display_name":"C K Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0626,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85106855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"11","first_page":"1416","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12578","display_name":"Diagnosis and treatment of tuberculosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-spot-tb","display_name":"T-SPOT.TB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.996999979019165},{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/diagnostic-test-agreement","display_name":"diagnostic test agreement","score":0.6420000195503235},{"id":"https://openalex.org/keywords/specificity","display_name":"specificity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/false-negative-results","display_name":"false-negative results","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520365595817566},{"id":"https://openalex.org/C2776247216","wikidata":"https://www.wikidata.org/wiki/Q29505","display_name":"Tuberculin","level":3,"score":0.8329794406890869},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8059514164924622},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5747407078742981},{"id":"https://openalex.org/C2780277586","wikidata":"https://www.wikidata.org/wiki/Q6046438","display_name":"Interferon gamma release assay","level":5,"score":0.5113725066184998},{"id":"https://openalex.org/C2780639635","wikidata":"https://www.wikidata.org/wiki/Q4888238","display_name":"Tuberculosis diagnosis","level":4,"score":0.480146586894989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44491660594940186},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40551358461380005},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.38026148080825806},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.18590980768203735},{"id":"https://openalex.org/C2779806340","wikidata":"https://www.wikidata.org/wiki/Q4254929","display_name":"Latent tuberculosis","level":4,"score":0.17169025540351868},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1474728286266327}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005188","descriptor_name":"False Negative Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007087","descriptor_name":"Illinois","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014374","descriptor_name":"Tuberculin Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19861016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19861016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Comparative Study"},{"id":"mag:304587982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19861016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W100521665","https://openalex.org/W2725528400","https://openalex.org/W2371384067","https://openalex.org/W1699905778","https://openalex.org/W4301460628","https://openalex.org/W2414801456","https://openalex.org/W2120549260","https://openalex.org/W2166120132","https://openalex.org/W2604792803","https://openalex.org/W2901861164"],"abstract_inverted_index":{"SETTING:":[0],"Great":[1],"Lakes,":[2],"Illinois,":[3],"USA.":[4],"OBJECTIVE:":[5],"To":[6],"compare":[7],"the":[8,110,127,137,141,144,163,177,182],"performance":[9],"of":[10,28,42,47,54,78,106,112,129,136],"an":[11,151],"interferon-gamma":[12],"release":[13],"assay":[14],"(T-SPOT.TB)":[15],"and":[16,35,63,70,143,168],"tuberculin":[17],"skin":[18],"test":[19,147,180],"(TST)":[20],"in":[21,80,109,155,175],"a":[22,25,48,101,113,130],"population":[23,183],"with":[24,45],"low":[26,86,158],"prevalence":[27],"tuberculosis":[29],"(TB)":[30],"that":[31],"was":[32,72,91],"predominantly":[33],"US-born":[34],"not":[36],"bacille":[37],"Calmette-Gu\u00e9rin-vaccinated.":[38],"DESIGN:":[39],"A":[40],"total":[41],"414":[43],"subjects":[44],"absence":[46,111],"previous":[49],"positive":[50,102,114],"TST":[51,62,71,132],"were":[52],"enrolled,":[53],"whom":[55],"326":[56,96],"yielded":[57],"analyzable":[58],"results":[59],"for":[60,88,160,181],"both":[61],"T-SPOT.TB.":[64],"RESULTS:":[65],"Overall":[66],"agreement":[67,139],"between":[68,140],"T-SPOT.TB":[69,79,103],"98.2%":[73],"(95%CI":[74,93],"96.0-99.3).":[75],"The":[76],"specificity":[77],"individuals":[81],"judged":[82],"to":[83,122],"be":[84],"at":[85,118,157],"risk":[87,124,159],"TB":[89],"infection":[90],"98.9%":[92],"96.9-99.8).":[94],"Of":[95,116],"subjects,":[97],"8":[98],"(2.5%)":[99],"had":[100],"result,":[104],"six":[105],"which":[107],"occurred":[108],"TST.":[115],"these,":[117],"least":[119],"three":[120],"appeared":[121],"have":[123,165,173],"factors,":[125],"suggesting":[126],"possibility":[128],"false-negative":[131],"result.":[133],"CONCLUSION:":[134],"Because":[135],"excellent":[138],"TSPOT.TB":[142],"TST,":[145],"either":[146],"can":[148],"serve":[149],"as":[150],"effective":[152],"diagnostic":[153],"tool":[154],"populations":[156],"TB.":[161],"As":[162],"tests":[164],"specific":[166],"advantages":[167],"disadvantages,":[169],"health":[170],"care":[171],"providers":[172],"leeway":[174],"choosing":[176],"most":[178],"appropriate":[179],"they":[184],"are":[185],"treating.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
