{"id":"https://openalex.org/W304587443","doi":"https://doi.org/10.1023/a:1026699324927","title":"Type II 11\u03b2-Hydroxysteroid Dehydrogenase Expression in Human Colonic Epithelial Cells of Inflammatory Bowel Disease","display_name":"Type II 11\u03b2-Hydroxysteroid Dehydrogenase Expression in Human Colonic Epithelial Cells of Inflammatory Bowel Disease","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W304587443","doi":"https://doi.org/10.1023/a:1026699324927","mag":"304587443","pmid":"https://pubmed.ncbi.nlm.nih.gov/10630506"},"language":"en","primary_location":{"id":"doi:10.1023/a:1026699324927","doi":"https://doi.org/10.1023/a:1026699324927","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1026699324927","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105726819","display_name":"Kenichi Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-Ichi Takahashi","raw_affiliation_strings":["Department of Surgery, Tohoku University School of Medicine, Sendai, Japan","Dept. of Surgery, Tohoku Univ. School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Dept. of Surgery, Tohoku Univ. School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036095821","display_name":"Kouhei Fukushima","orcid":"https://orcid.org/0000-0001-6221-5814","observed_orcids":["https://orcid.org/0000-0001-6221-5814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kouhei Fukushima","raw_affiliation_strings":["MEN - Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MEN - Biomedical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015575554","display_name":"Hironobu Sasano","orcid":"https://orcid.org/0000-0002-6600-8641","observed_orcids":["https://orcid.org/0000-0002-6600-8641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hironobu Sasano","raw_affiliation_strings":["MED - Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MED - Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049330404","display_name":"Iwao Sasaki","orcid":"https://orcid.org/0009-0008-3507-9122","observed_orcids":["https://orcid.org/0009-0008-3507-9122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iwao Sasaki","raw_affiliation_strings":["MED - Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MED - Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110061493","display_name":"Seiki Matsuno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seiki Matsuno","raw_affiliation_strings":["Baker Heart Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Heart Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051067965","display_name":"Zygmunt S. Krozowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zygmunt S. Krozowski","raw_affiliation_strings":["Baker Heart Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Heart Research Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100827233","display_name":"Hiroshi Nagura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Nagura","raw_affiliation_strings":["Baker Heart Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Heart Research Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.2432,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.55966105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"44","issue":"12","first_page":"2516","last_page":"2522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cortisol-metabolism","display_name":"cortisol metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sodium-absorption","display_name":"sodium uptake","score":0.9760000109672546},{"id":"https://openalex.org/keywords/water-uptake-human-physiology","display_name":"water uptake (human physiology)","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8447208404541016},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.7836479544639587},{"id":"https://openalex.org/C2909339193","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Transplant surgery","level":3,"score":0.7671490907669067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5871880650520325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5226951837539673},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5015568733215332},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.46215230226516724},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41599711775779724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34725236892700195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703709006309509},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16491299867630005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11477214097976685}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006913","descriptor_name":"Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D043209","descriptor_name":"11-beta-Hydroxysteroid Dehydrogenase Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1026699324927","doi":"https://doi.org/10.1023/a:1026699324927","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1026699324927","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},{"id":"pmid:10630506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10630506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases and sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1505729347","https://openalex.org/W1507955147","https://openalex.org/W1606491845","https://openalex.org/W1652722348","https://openalex.org/W1874013760","https://openalex.org/W1876102834","https://openalex.org/W1966962224","https://openalex.org/W1974957349","https://openalex.org/W1980378896","https://openalex.org/W1985766240","https://openalex.org/W2017521095","https://openalex.org/W2023678029","https://openalex.org/W2030238751","https://openalex.org/W2031752348","https://openalex.org/W2061562327","https://openalex.org/W2066338366","https://openalex.org/W2072441466","https://openalex.org/W2077198680","https://openalex.org/W2090921019","https://openalex.org/W2092602709","https://openalex.org/W2120383449","https://openalex.org/W2132785209","https://openalex.org/W2142304129","https://openalex.org/W2148114970","https://openalex.org/W2218442061","https://openalex.org/W2270139309","https://openalex.org/W2342314812","https://openalex.org/W2415566058"],"related_works":["https://openalex.org/W2157450482","https://openalex.org/W2158854302","https://openalex.org/W2275963207","https://openalex.org/W2755029006","https://openalex.org/W4378649062","https://openalex.org/W2116242225","https://openalex.org/W2412043992","https://openalex.org/W2738113096","https://openalex.org/W1992469933","https://openalex.org/W2391886522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}