{"id":"https://openalex.org/W3045813324","doi":"https://doi.org/10.1017/cts.2020.302","title":"4311 Inflammatory biomarkers of cognitive dysfunction in pediatric obesity: associations between Executive Function, C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor alpha","display_name":"4311 Inflammatory biomarkers of cognitive dysfunction in pediatric obesity: associations between Executive Function, C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor alpha","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3045813324","doi":"https://doi.org/10.1017/cts.2020.302","mag":"3045813324"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2020.302","doi":"https://doi.org/10.1017/cts.2020.302","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.302","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6F8E774202972D1C673F2BD5443359CC/S2059866120003027a.pdf/div-class-title-4311-inflammatory-biomarkers-of-cognitive-dysfunction-in-pediatric-obesity-associations-between-executive-function-c-reactive-protein-interleukin-6-and-tumor-necrosis-factor-alpha-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6F8E774202972D1C673F2BD5443359CC/S2059866120003027a.pdf/div-class-title-4311-inflammatory-biomarkers-of-cognitive-dysfunction-in-pediatric-obesity-associations-between-executive-function-c-reactive-protein-interleukin-6-and-tumor-necrosis-factor-alpha-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110679250","display_name":"Kathryn Prendergast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Prendergast","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Caroline Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Keller","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077291151","display_name":"Shima A. Dowla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shima Dowla","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057070513","display_name":"Marissa A. Gowey","orcid":"https://orcid.org/0000-0002-4986-3021","observed_orcids":["https://orcid.org/0000-0002-4986-3021"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Gowey","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1142546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"s1","first_page":"97","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.9599999785423279},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9660000205039978},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"cognitive flexibility","score":0.8320000171661377},{"id":"https://openalex.org/keywords/inhibitory-control","display_name":"inhibitory control","score":1.0},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-disease-risk","display_name":"chronic disease risk","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7087504863739014},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6303627490997314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5346181988716125},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5206400752067566},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4986724853515625},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4307115077972412},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.41988325119018555},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3724321126937866},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3374834656715393},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.13369673490524292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07858157157897949},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/cts.2020.302","doi":"https://doi.org/10.1017/cts.2020.302","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.302","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6F8E774202972D1C673F2BD5443359CC/S2059866120003027a.pdf/div-class-title-4311-inflammatory-biomarkers-of-cognitive-dysfunction-in-pediatric-obesity-associations-between-executive-function-c-reactive-protein-interleukin-6-and-tumor-necrosis-factor-alpha-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8823345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8823345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e7c86c0425044795ad7ff190603f55d8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e7c86c0425044795ad7ff190603f55d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 4, Pp 97-97 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2020.302","doi":"https://doi.org/10.1017/cts.2020.302","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.302","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6F8E774202972D1C673F2BD5443359CC/S2059866120003027a.pdf/div-class-title-4311-inflammatory-biomarkers-of-cognitive-dysfunction-in-pediatric-obesity-associations-between-executive-function-c-reactive-protein-interleukin-6-and-tumor-necrosis-factor-alpha-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045813324.pdf","grobid_xml":"https://content.openalex.org/works/W3045813324.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296031507","https://openalex.org/W2963340008","https://openalex.org/W2936369686","https://openalex.org/W7124715857","https://openalex.org/W4413115781","https://openalex.org/W4408218927","https://openalex.org/W1979336020","https://openalex.org/W2388332501","https://openalex.org/W4409161533","https://openalex.org/W3166729663"],"abstract_inverted_index":{"OBJECTIVES/GOALS:":[0],"Executive":[1],"function":[2],"(EF)":[3],"deficits":[4,29,81,343],"lead":[5],"to":[6,19,36,89,97,111,137,199,234,278],"poorer":[7],"adherence":[8],"and":[9,23,48,61,73,128,142,147,167,181,190,197,217,246,249,261,270,291,313,337,370,385],"weight":[10,164,191],"loss":[11],"in":[12,30,82,92,100,104,339,346,358,379],"obesity":[13,17,33,93,380,395],"treatment.":[14,396],"Conversely,":[15],"untreated":[16],"leads":[18],"both":[20],"EF":[21,28,80,103,116,141,203,238,271,342],"impairments":[22],"risk":[24,44,68],"of":[25,41,79,115,331,350,376],"chronic":[26,42,71,129],"disease.":[27],"children":[31,152,351],"with":[32,39,102,156,285,304,316,341,352,388],"have":[34,95],"begun":[35],"be":[37,90,98],"associated":[38,315],"biomarkers":[40,114,375],"disease":[43,72,130],"such":[45,53],"as":[46,54,120,354,364],"glucose":[47],"cortisol.":[49],"Elevated":[50],"pro-inflammatory":[51],"biomarkers,":[52],"C-Reactive":[55],"Protein":[56],"(CRP),":[57],"Interleukin":[58],"6":[59],"(IL-6),":[60],"Tumor":[62],"Necrosis":[63],"Factor":[64],"a":[65,162,172,300,347],"(TNFa),":[66],"indicate":[67],"for":[69,171,177,392],"obesity-associated":[70],"may":[74,118,372],"represent":[75,373],"another":[76],"candidate":[77,374],"biomarker":[78],"pediatric":[83,105,163,178,394],"obesity.":[84,106,179],"These":[85],"inflammatory":[86,268],"markers":[87,269],"tend":[88],"elevated":[91],"but":[94],"yet":[96],"examined":[99],"association":[101,303,340],"This":[107],"represents":[108],"an":[109],"opportunity":[110],"identify":[112],"potential":[113,389],"which":[117],"serve":[119],"novel":[121],"treatment":[122],"targets":[123],"that":[124,381],"could":[125],"improve":[126],"outcomes":[127],"prevention.":[131],"Thus,":[132],"the":[133,207,359],"present":[134],"study":[135],"aims":[136],"explore":[138,235],"associations":[139,236,284,323],"between":[140,237,267],"blood":[143],"serum":[144],"CRP,":[145,247],"IL-6,":[146,248,338],"TNFa.":[148,250,368],"METHODS/STUDY":[149],"POPULATION:":[150],"Treatment-seeking":[151],"aged":[153],"8-12":[154],"years":[155],"BMI>95th":[157],"percentile":[158],"were":[159,184,192,224,232,257,272,324,344,362],"recruited":[160],"from":[161],"management":[165],"clinic":[166],"attended":[168],"baseline":[169],"assessments":[170],"family-based":[173],"behavioral":[174],"intervention":[175],"program":[176],"Demographics":[180],"medical":[182],"history":[183],"assessed":[185,205],"via":[186,206,335,367],"parent":[187],"questionnaire.":[188],"Height":[189],"measured":[193,334,366],"by":[194,226],"research":[195,228],"staff":[196],"converted":[198],"zBMI.":[200],"Child":[201],"performance-based":[202],"was":[204,311],"NIH":[208],"Toolbox":[209,240],"Cognitive":[210,241,286],"Battery":[211],"iPad":[212],"application.":[213],"Blood":[214],"draws,":[215],"assays,":[216],"Dual-energy":[218],"X-ray":[219],"Absorptiometry":[220],"(DXA;":[221],"measuring":[222],"adiposity)":[223],"conducted":[225,233],"trained":[227],"personnel.":[229],"Pearson\u2019s":[230],"correlations":[231],"(NIH":[239],"Battery,":[242],"fully":[243],"corrected":[244],"T-scores)":[245],"RESULTS/ANTICIPATED":[251],"RESULTS:":[252],"Children":[253],"(n":[254],"=":[255,276,289,295,308,320],"12)":[256],"primarily":[258],"female":[259],"(76.5%)":[260],"African":[262],"American":[263],"(64.7%).":[264],"Correlation":[265],"coefficients":[266],"highly":[273],"variable":[274],"(r":[275,288,294,307,319],"\u22120.39":[277],"0.52).":[279],"CRP":[280,336,369],"showed":[281],"small,":[282,301],"negative":[283,302],"Flexibility":[287],"\u22120.39)":[290],"Inhibitory":[292,305],"Control":[293,306],"\u22120.34).":[296],"IL-6":[297,371],"also":[298],"demonstrated":[299],"\u22120.37).":[309],"TNFa":[310],"positively":[312],"moderately":[314],"working":[317],"memory":[318],"0.53).":[321],"Remaining":[322],"weak":[325],"(\u22120.3