{"id":"https://openalex.org/W3045779889","doi":"https://doi.org/10.1039/d0lc00602e","title":"Modeling iontophoretic drug delivery in a microfluidic device","display_name":"Modeling iontophoretic drug delivery in a microfluidic device","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3045779889","doi":"https://doi.org/10.1039/d0lc00602e","mag":"3045779889","pmid":"https://pubmed.ncbi.nlm.nih.gov/32869052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8272289"},"language":"en","primary_location":{"id":"doi:10.1039/d0lc00602e","doi":"https://doi.org/10.1039/d0lc00602e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0lc00602e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2020/lc/d0lc00602e","source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2020/lc/d0lc00602e","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071008633","display_name":"Maryam Moarefian","orcid":"https://orcid.org/0000-0002-1875-0614","observed_orcids":["https://orcid.org/0000-0002-1875-0614"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Moarefian","raw_affiliation_strings":["Blacksburg","Department of Mechanical Engineering","USA","Virginia Polytechnic Institute and State University","Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blacksburg","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Virginia Polytechnic Institute and State University","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027511386","display_name":"Rafael V. Davalos","orcid":"https://orcid.org/0000-0003-1503-9509","observed_orcids":["https://orcid.org/0000-0003-1503-9509"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael V. Davalos","raw_affiliation_strings":["Blacksburg","Department of Biomedical Engineering and Mechanics","USA","Virginia Polytechnic Institute and State University","Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA"],"raw_orcid":"https://orcid.org/0000-0003-1503-9509","affiliations":[{"raw_affiliation_string":"Blacksburg","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Virginia Polytechnic Institute and State University","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044512850","display_name":"Danesh K. Tafti","orcid":"https://orcid.org/0000-0002-9511-3301","observed_orcids":["https://orcid.org/0000-0002-9511-3301"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danesh K. Tafti","raw_affiliation_strings":["Blacksburg","Department of Mechanical Engineering","USA","Virginia Polytechnic Institute and State University","Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blacksburg","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Virginia Polytechnic Institute and State University","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086736683","display_name":"Luke E. K. Achenie","orcid":"https://orcid.org/0000-0001-9850-5346","observed_orcids":["https://orcid.org/0000-0001-9850-5346"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke E. Achenie","raw_affiliation_strings":["Blacksburg","Department of Chemical Engineering","USA","Virginia Polytechnic Institute and State University","Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blacksburg","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Virginia Polytechnic Institute and State University","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042617889","display_name":"Caroline N. Jones","orcid":"https://orcid.org/0000-0001-6003-9335","observed_orcids":["https://orcid.org/0000-0001-6003-9335"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caroline N. Jones","raw_affiliation_strings":["Blacksburg","Department of Bioengineering","Department of Biological Sciences","USA","Virginia Polytechnic Institute and State University","Department of Bioengineering, The University of Texas, Dallas, TX, USA","Department of Biological Sciences, Virginia Polytechnic Institute and State University, Life Sciences 1 Bldg., Rm. 221, 970 Washington Street SW, Blacksburg, VA 24061, USA"],"raw_orcid":"https://orcid.org/0000-0001-6003-9335","affiliations":[{"raw_affiliation_string":"Blacksburg","institution_ids":[]},{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Virginia Polytechnic Institute and State University","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Bioengineering, The University of Texas, Dallas, TX, USA","institution_ids":["https://openalex.org/I162577319"]},{"raw_affiliation_string":"Department of Biological Sciences, Virginia Polytechnic Institute and State University, Life Sciences 1 Bldg., Rm. 221, 970 Washington Street SW, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042617889"],"corresponding_institution_ids":["https://openalex.org/I162577319","https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":1.3637,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.75010611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"18","first_page":"3310","last_page":"3321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.875,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.875,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iontophoresis","display_name":"iontophoresis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7770000100135803},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7749999761581421},{"id":"https://openalex.org/keywords/electrophoresis","display_name":"electrophoresis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-diffusion","display_name":"drug diffusion","score":0.7570000290870667},{"id":"https://openalex.org/keywords/finite-element-analysis","display_name":"finite element analysis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.5450000166893005},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.796999990940094},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C183529106","wikidata":"https://www.wikidata.org/wiki/Q1528394","display_name":"Iontophoresis","level":2,"score":0.9118762016296387},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7808880805969238},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6375706195831299},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5168919563293457},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46236398816108704},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3946385383605957},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31574898958206177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2532972991466522},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23810061812400818},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1039/d0lc00602e","doi":"https://doi.org/10.1039/d0lc00602e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0lc00602e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2020/lc/d0lc00602e","source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},{"id":"pmid:32869052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32869052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a chip","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7340776","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8272289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8272289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8272289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lab Chip","raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/101040","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/101040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.1039/d0lc00602e","doi":"https://doi.org/10.1039/d0lc00602e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0lc00602e","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2020/lc/d0lc00602e","source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3205746995","display_name":null,"funder_award_id":"R35 GM133610","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5595489588","display_name":"Virginia Tech-Initiative for Maximizing Student Development (VT-IMSD)","funder_award_id":"R25GM072767","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045779889.pdf","grobid_xml":"https://content.openalex.org/works/W3045779889.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1490324405","https://openalex.org/W1521859708","https://openalex.org/W1602400330","https://openalex.org/W1953478528","https://openalex.org/W1972187956","https://openalex.org/W1984685797","https://openalex.org/W1992492638","https://openalex.org/W1993805713","https://openalex.org/W2004123015","https://openalex.org/W2004616899","https://openalex.org/W2006664445","https://openalex.org/W2008311131","https://openalex.org/W2015332296","https://openalex.org/W2026584798","https://openalex.org/W2027147390","https://openalex.org/W2029288974","https://openalex.org/W2036861430","https://openalex.org/W2037818888","https://openalex.org/W2039855642","https://openalex.org/W2043792293","https://openalex.org/W2046872475","https://openalex.org/W2047592628","https://openalex.org/W2048320403","https://openalex.org/W2054337002","https://openalex.org/W2055976971","https://openalex.org/W2085901248","https://openalex.org/W2087772617","https://openalex.org/W2100481885","https://openalex.org/W2112791462","https://openalex.org/W2116996913","https://openalex.org/W2126963077","https://openalex.org/W2132804365","https://openalex.org/W2139647458","https://openalex.org/W2146190709","https://openalex.org/W2167076800","https://openalex.org/W2170907793","https://openalex.org/W2190597631","https://openalex.org/W2407836966","https://openalex.org/W2519675171","https://openalex.org/W2553067677","https://openalex.org/W2555875250","https://openalex.org/W2771951717","https://openalex.org/W2789581209","https://openalex.org/W2793842733","https://openalex.org/W2794619678","https://openalex.org/W2795325405","https://openalex.org/W2807617529","https://openalex.org/W2808097870","https://openalex.org/W2898336474","https://openalex.org/W2899320780","https://openalex.org/W2905103367","https://openalex.org/W2910404825","https://openalex.org/W2911904767","https://openalex.org/W2924968160","https://openalex.org/W2928663587","https://openalex.org/W2935840824","https://openalex.org/W2972401625","https://openalex.org/W3005620080","https://openalex.org/W3021397781","https://openalex.org/W4242180006","https://openalex.org/W4251663120"],"related_works":["https://openalex.org/W7221794792","https://openalex.org/W2618081993","https://openalex.org/W2975633326","https://openalex.org/W2951109394","https://openalex.org/W2100481885","https://openalex.org/W2058597106","https://openalex.org/W2405850547","https://openalex.org/W2053158068","https://openalex.org/W7045108536","https://openalex.org/W1967120264"],"abstract_inverted_index":{"Iontophoresis":[0],"employs":[1],"low-intensity":[2,42],"electrical":[3,228],"voltage":[4],"and":[5,69,77,104,124,212,224,234,242,255],"continuous":[6],"constant":[7],"current":[8,229],"to":[9,38,49,54,63,91,183,203,276,290],"direct":[10],"a":[11,15,25,96,176,199,218,225,285],"charged":[12,97,127,136],"drug":[13,18,52,67,98,115,128,139,154,208,232,257],"into":[14,271],"tissue.":[16],"Iontophoretic":[17],"delivery":[19,53,68,233,258,267],"has":[20,198],"recently":[21],"been":[22],"used":[23,195],"as":[24],"novel":[26],"method":[27],"for":[28,209,265],"cancer":[29,109],"treatment":[30],"in":[31,45,85,105,130,141,156,187],"vivo.":[32],"There":[33],"is":[34],"an":[35,59,84,100,134],"urgent":[36],"need":[37],"precisely":[39,64],"model":[40,92,161,259,291],"the":[41,93,114,117,131,142,157,167,172,184,188,205,277,292],"electric":[43,222],"fields":[44],"cell":[46,236],"culture":[47],"systems":[48],"optimize":[50],"iontophoretic":[51],"tumors.":[55,273],"Here,":[56],"we":[57,82],"present":[58],"iontophoresis-on-chip":[60],"(IOC)":[61],"platform":[62,169,254,279],"quantify":[65],"carboplatin":[66],"its":[70],"corresponding":[71],"anti-cancer":[72],"efficacy":[73],"under":[74],"various":[75],"voltages":[76],"currents.":[78],"In":[79],"this":[80],"study,":[81],"use":[83],"vitro":[86],"heparin-based":[87,158],"hydrogel":[88,118],"microfluidic":[89,189],"device":[90],"movement":[94],"of":[95,113,126,133,152,175,260,268,287],"across":[99],"extracellular":[101,144],"matrix":[102,145],"(ECM)":[103],"MDA-MB-231":[106],"triple-negative":[107],"breast":[108],"(TNBC)":[110],"cells.":[111],"Transport":[112],"through":[116],"was":[119,146,194],"modeled":[120],"based":[121],"on":[122],"diffusion":[123],"electrophoresis":[125],"molecules":[129],"direction":[132],"oppositely":[135],"electrode.":[137],"The":[138,160,252],"concentration":[140,174,186],"tumor":[143,235],"computed":[147],"using":[148,166],"finite":[149],"element":[150],"modeling":[151],"transient":[153],"transport":[155],"hydrogel.":[159],"predictions":[162],"were":[163],"then":[164],"validated":[165],"IOC":[168,253,278],"by":[170,238,283],"comparing":[171],"predicted":[173],"fluorescent":[177],"cationic":[178],"dye":[179],"(Alexa":[180],"Fluor":[181,192],"594\u00ae)":[182],"actual":[185],"device.":[190],"Alexa":[191],"594\u00ae":[193],"because":[196],"it":[197],"molecular":[200],"weight":[201],"close":[202],"paclitaxel,":[204],"gold":[206],"standard":[207],"treating":[210],"TNBC,":[211],"carboplatin.":[213],"Our":[214],"results":[215],"demonstrated":[216],"that":[217],"50":[219],"mV":[220],"DC":[221],"field":[223],"3":[226],"mA":[227],"significantly":[230],"increased":[231],"death":[237],"48.12%":[239],"\u00b1":[240,244],"14.33":[241],"39.13%":[243],"12.86,":[245],"respectively":[246],"(n":[247],"=":[248],"3,":[249],"p-value":[250],"<0.05).":[251],"mathematical":[256],"iontophoresis":[261],"are":[262],"promising":[263],"tools":[264],"precise":[266],"chemotherapeutic":[269],"drugs":[270],"solid":[272],"Further":[274],"improvements":[275],"can":[280],"be":[281],"made":[282],"adding":[284],"layer":[286],"epidermal":[288],"cells":[289],"skin.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-08-03T00:00:00"}