{"id":"https://openalex.org/W3045771122","doi":"https://doi.org/10.1002/adtp.202000092","title":"From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood\u2013Brain Barrier","display_name":"From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood\u2013Brain Barrier","publication_year":2020,"publication_date":"2020-07-26","ids":{"openalex":"https://openalex.org/W3045771122","doi":"https://doi.org/10.1002/adtp.202000092","mag":"3045771122","pmid":"https://pubmed.ncbi.nlm.nih.gov/33542947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7116687"},"language":"en","primary_location":{"id":"doi:10.1002/adtp.202000092","doi":"https://doi.org/10.1002/adtp.202000092","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adtp.202000092","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adtp.202000092","source":{"id":"https://openalex.org/S4210200121","display_name":"Advanced Therapeutics","issn_l":"2366-3987","issn":["2366-3987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adtp.202000092","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103219658","display_name":"Natascha Hartl","orcid":"https://orcid.org/0009-0002-5862-0141","observed_orcids":["https://orcid.org/0009-0002-5862-0141"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natascha Hartl","raw_affiliation_strings":["Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020054829","display_name":"Friederike Adams","orcid":"https://orcid.org/0000-0002-4362-0387","observed_orcids":["https://orcid.org/0000-0002-4362-0387"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friederike Adams","raw_affiliation_strings":["Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025193205","display_name":"Olivia M. Merkel","orcid":"https://orcid.org/0000-0002-4151-3916","observed_orcids":["https://orcid.org/0000-0002-4151-3916"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Olivia M. Merkel","raw_affiliation_strings":["Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany"],"raw_orcid":"https://orcid.org/0000-0002-4151-3916","affiliations":[{"raw_affiliation_string":"Pharmaceutical Technology and Biopharmaceutics, Department Pharmacy, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, 81377 Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025193205"],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":7.2803,"has_fulltext":true,"cited_by_count":157,"citation_normalized_percentile":{"value":0.98303591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"4","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9760000109672546},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.9800000190734863},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.593999981880188},{"id":"https://openalex.org/keywords/covalent-functionalization","display_name":"covalent functionalization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/adsorption","display_name":"adsorption","score":0.5920000076293945},{"id":"https://openalex.org/keywords/tween-80","display_name":"Tween 80","score":0.9190000295639038},{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/brain-uptake","display_name":"brain uptake","score":0.5350000262260437},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7760000228881836},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.819183886051178},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6792646646499634},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.6083879470825195},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6007189154624939},{"id":"https://openalex.org/C134728086","wikidata":"https://www.wikidata.org/wiki/Q966900","display_name":"Drug delivery to the brain","level":4,"score":0.5845122933387756},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.578458845615387},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.47660961747169495},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45267438888549805},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42965930700302124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4259431064128876},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3811255395412445},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3598670959472656},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33040493726730347},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.242381751537323},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19532084465026855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10685640573501587},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08068355917930603},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06970265507698059},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06556841731071472},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1002/adtp.202000092","doi":"https://doi.org/10.1002/adtp.202000092","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adtp.202000092","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adtp.202000092","source":{"id":"https://openalex.org/S4210200121","display_name":"Advanced Therapeutics","issn_l":"2366-3987","issn":["2366-3987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Therapeutics","raw_type":"journal-article"},{"id":"pmid:33542947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33542947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6762738","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7116687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7116687","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7116687","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Ther (Weinh)","raw_type":"Text"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:89773","doi":null,"is_oa":true,"landing_page_url":"https://epub.ub.uni-muenchen.de/89773/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Therapeutics","raw_type":"doc-type:article"}],"best_oa_location":{"id":"doi:10.1002/adtp.202000092","doi":"https://doi.org/10.1002/adtp.202000092","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adtp.202000092","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adtp.202000092","source":{"id":"https://openalex.org/S4210200121","display_name":"Advanced Therapeutics","issn_l":"2366-3987","issn":["2366-3987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4754718867","display_name":null,"funder_award_id":"ERC\u20102014\u2010StG \u2010 637830","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G5434504169","display_name":null,"funder_award_id":"2014_A299","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"}],"funders":[{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045771122.pdf","grobid_xml":"https://content.openalex.org/works/W3045771122.grobid-xml"},"referenced_works_count":155,"referenced_works":["https://openalex.org/W47211728","https://openalex.org/W66478222","https://openalex.org/W67874367","https://openalex.org/W109547465","https://openalex.org/W128151115","https://openalex.org/W1482904772","https://openalex.org/W1510378561","https://openalex.org/W1526328115","https://openalex.org/W1528488968","https://openalex.org/W1553061387","https://openalex.org/W1592180778","https://openalex.org/W1880202171","https://openalex.org/W1896390281","https://openalex.org/W1902114397","https://openalex.org/W1920171370","https://openalex.org/W1964000580","https://openalex.org/W1964718511","https://openalex.org/W1965522214","https://openalex.org/W1966720603","https://openalex.org/W1967367130","https://openalex.org/W1968821998","https://openalex.org/W1971287132","https://openalex.org/W1975399536","https://openalex.org/W1975495109","https://openalex.org/W1978075794","https://openalex.org/W1978948741","https://openalex.org/W1979265285","https://openalex.org/W1983533408","https://openalex.org/W1988141190","https://openalex.org/W1988384513","https://openalex.org/W1988660569","https://openalex.org/W1990950895","https://openalex.org/W1991549205","https://openalex.org/W1993431117","https://openalex.org/W1993914665","https://openalex.org/W1996170794","https://openalex.org/W1996719014","https://openalex.org/W1997822484","https://openalex.org/W1998302888","https://openalex.org/W1999476309","https://openalex.org/W2001967956","https://openalex.org/W2004565731","https://openalex.org/W2005542583","https://openalex.org/W2007003442","https://openalex.org/W2007099602","https://openalex.org/W2007589760","https://openalex.org/W2007859813","https://openalex.org/W2008264823","https://openalex.org/W2010444608","https://openalex.org/W2012111901","https://openalex.org/W2014485492","https://openalex.org/W2015582643","https://openalex.org/W2015859925","https://openalex.org/W2017952116","https://openalex.org/W2018121350","https://openalex.org/W2018361874","https://openalex.org/W2018659527","https://openalex.org/W2020855804","https://openalex.org/W2021246059","https://openalex.org/W2021946861","https://openalex.org/W2023406407","https://openalex.org/W2024200101","https://openalex.org/W2025595011","https://openalex.org/W2027504445","https://openalex.org/W2027561558","https://openalex.org/W2028175614","https://openalex.org/W2028441136","https://openalex.org/W2028441784","https://openalex.org/W2028672439","https://openalex.org/W2030282028","https://openalex.org/W2032381925","https://openalex.org/W2034968148","https://openalex.org/W2038037909","https://openalex.org/W2038054558","https://openalex.org/W2040099927","https://openalex.org/W2042141282","https://openalex.org/W2046480913","https://openalex.org/W2046895286","https://openalex.org/W2047090226","https://openalex.org/W2047414721","https://openalex.org/W2049554846","https://openalex.org/W2053202725","https://openalex.org/W2053378823","https://openalex.org/W2053608702","https://openalex.org/W2054637029","https://openalex.org/W2056272101","https://openalex.org/W2058243804","https://openalex.org/W2059813073","https://openalex.org/W2060061127","https://openalex.org/W2061264254","https://openalex.org/W2068492781","https://openalex.org/W2068597696","https://openalex.org/W2072205289","https://openalex.org/W2072273122","https://openalex.org/W2073558493","https://openalex.org/W2075347200","https://openalex.org/W2075904111","https://openalex.org/W2076341348","https://openalex.org/W2077128382","https://openalex.org/W2078004577","https://openalex.org/W2080952168","https://openalex.org/W2088093158","https://openalex.org/W2090699004","https://openalex.org/W2090866080","https://openalex.org/W2091282668","https://openalex.org/W2091647200","https://openalex.org/W2092530725","https://openalex.org/W2094264010","https://openalex.org/W2098643414","https://openalex.org/W2101099825","https://openalex.org/W2101312385","https://openalex.org/W2105680795","https://openalex.org/W2107427650","https://openalex.org/W2107883807","https://openalex.org/W2111001050","https://openalex.org/W2112001901","https://openalex.org/W2112007587","https://openalex.org/W2121101037","https://openalex.org/W2125787509","https://openalex.org/W2136578375","https://openalex.org/W2136593164","https://openalex.org/W2140181820","https://openalex.org/W2140718540","https://openalex.org/W2140897179","https://openalex.org/W2144117958","https://openalex.org/W2148133227","https://openalex.org/W2150111232","https://openalex.org/W2152001041","https://openalex.org/W2152471217","https://openalex.org/W2159821105","https://openalex.org/W2163136989","https://openalex.org/W2163695841","https://openalex.org/W2167235509","https://openalex.org/W2170341619","https://openalex.org/W2226465672","https://openalex.org/W2280316322","https://openalex.org/W2305086776","https://openalex.org/W2328819375","https://openalex.org/W2329297051","https://openalex.org/W2336700193","https://openalex.org/W2410747147","https://openalex.org/W2414909242","https://openalex.org/W2549003643","https://openalex.org/W2561694948","https://openalex.org/W2587799316","https://openalex.org/W2597180564","https://openalex.org/W2599633442","https://openalex.org/W2601589334","https://openalex.org/W2618101247","https://openalex.org/W2770798870","https://openalex.org/W2896927014","https://openalex.org/W2900540317","https://openalex.org/W2939514183","https://openalex.org/W2949773701","https://openalex.org/W4399243863"],"related_works":["https://openalex.org/W3048225131","https://openalex.org/W2387569177","https://openalex.org/W2139835982","https://openalex.org/W2018121350","https://openalex.org/W2170341619","https://openalex.org/W2090866080","https://openalex.org/W2107883807","https://openalex.org/W3082302402","https://openalex.org/W2444197879","https://openalex.org/W2611011205"],"abstract_inverted_index":{"The":[0],"blood-brain":[1],"barrier":[2],"(BBB)":[3],"is":[4,35,92],"composed":[5],"of":[6,86,108,129,154],"brain":[7,87,123,137],"endothelial":[8,88,138],"cells,":[9],"pericytes,":[10],"and":[11,180],"astrocytes,":[12],"which":[13,147],"build":[14],"a":[15,155],"tight":[16],"cellular":[17],"barrier.":[18,162],"Therapeutic":[19],"(macro)molecules":[20],"are":[21,45,97,145,166],"not":[22],"able":[23,46],"to":[24,47,110,120,159,168],"transit":[25],"through":[26],"the":[27,58,127,152],"BBB":[28,59,134],"in":[29,132],"their":[30,117],"free":[31],"form.":[32],"This":[33,90],"limitation":[34],"bypassed":[36],"by":[37,83],"apolipoprotein":[38],"E":[39],"(ApoE)-functionalized":[40],"polymeric":[41,79],"nanoparticles":[42],"(NPs)":[43],"that":[44,112],"transport":[48],"drugs":[49],"(e.g.":[50],"dalargin,":[51],"loperamide,":[52],"doxorubicin,":[53],"nerve":[54],"growth":[55],"factor)":[56],"across":[57],"via":[60],"low":[61],"density":[62],"lipoprotein":[63],"(LDL)":[64],"receptor":[65],"mediated":[66],"transcytosis.":[67],"Coating":[68],"with":[69,100,142],"polysorbate":[70],"80":[71],"or":[72,140,177],"poloxamer":[73],"188":[74],"facilitates":[75],"ApoE":[76,101,109],"adsorption":[77],"onto":[78],"NPs":[80,96,111],"enabling":[81],"recognition":[82],"LDL":[84],"receptors":[85],"cells.":[89],"effect":[91],"even":[93],"enhanced":[94],"when":[95],"directly":[98],"coated":[99],"without":[102],"surfactant":[103],"anchor.":[104],"Similarly,":[105],"covalent":[106],"coupling":[107],"bear":[113],"reactive":[114],"groups":[115],"on":[116],"surface":[118],"leads":[119],"significantly":[121],"improved":[122],"uptake":[124],"while":[125],"avoiding":[126],"use":[128],"surfactants.":[130],"Several":[131],"vitro":[133],"models":[135,165],"using":[136],"cells":[139,144],"co-cultures":[141],"astrocytes/pericytes/glioma":[143],"described":[146],"provide":[148],"first":[149],"insights":[150],"regarding":[151],"ability":[153],"drug":[156],"delivery":[157],"system":[158],"cross":[160],"this":[161],"In":[163],"vivo":[164],"employed":[167],"simulate":[169],"central":[170],"nervous":[171],"system-relevant":[172],"diseases":[173],"such":[174],"as":[175],"Alzheimer's":[176],"Parkinson's":[178],"disease":[179],"cerebral":[181],"cancer.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-08-03T00:00:00"}