{"id":"https://openalex.org/W3045761084","doi":"https://doi.org/10.1017/cts.2020.346","title":"4168 Understanding ECM-Based Drug Resistivity in Breast Cancer","display_name":"4168 Understanding ECM-Based Drug Resistivity in Breast Cancer","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3045761084","doi":"https://doi.org/10.1017/cts.2020.346","mag":"3045761084"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2020.346","doi":"https://doi.org/10.1017/cts.2020.346","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.346","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8B340668D9E6A8A4C4096B88A60436E/S2059866120003465a.pdf/div-class-title-4168-understanding-ecm-based-drug-resistivity-in-breast-cancer-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8B340668D9E6A8A4C4096B88A60436E/S2059866120003465a.pdf/div-class-title-4168-understanding-ecm-based-drug-resistivity-in-breast-cancer-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049067553","display_name":"Sarah Libring","orcid":"https://orcid.org/0000-0001-8336-5862","observed_orcids":["https://orcid.org/0000-0001-8336-5862"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Libring","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062544631","display_name":"Aparna B. Shinde","orcid":"https://orcid.org/0000-0002-0822-1313","observed_orcids":["https://orcid.org/0000-0002-0822-1313"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Shinde","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111193860","display_name":"Miad Boodaghidizaji","orcid":"https://orcid.org/0000-0001-8231-0309","observed_orcids":["https://orcid.org/0000-0001-8231-0309"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miad Boodaghidizaji","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015441600","display_name":"Alexandra Plummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Plummer","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048295740","display_name":"Arezoo M. Ardekani","orcid":"https://orcid.org/0000-0003-3301-3193","observed_orcids":["https://orcid.org/0000-0003-3301-3193"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arezoo Ardekani","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090843213","display_name":"Michael K. Wendt","orcid":"https://orcid.org/0000-0002-3665-7413","observed_orcids":["https://orcid.org/0000-0002-3665-7413"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wendt","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054791772","display_name":"Luis Solorio","orcid":"https://orcid.org/0000-0003-0135-8728","observed_orcids":["https://orcid.org/0000-0003-0135-8728"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Solorio","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09370507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"s1","first_page":"113","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tissue-transglutaminase","display_name":"tissue transglutaminase","score":0.949999988079071},{"id":"https://openalex.org/keywords/tgm2","display_name":"TGM2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/fibronectin-matrix","display_name":"fibronectin matrix","score":0.8069999814033508},{"id":"https://openalex.org/keywords/3d-spheroids","display_name":"multicellular spheroids","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neratinib","display_name":"neratinib","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-growth-rate","display_name":"cell growth rate","score":0.597000002861023},{"id":"https://openalex.org/keywords/epithelial-phenotype","display_name":"epithelial phenotype","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6065312027931213},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5047744512557983},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4859684705734253},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4738781154155731},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46891412138938904},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.45788586139678955},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45250403881073},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4521888792514801},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4192691743373871},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4149208664894104},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41410335898399353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3727368414402008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3715968430042267},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3483768701553345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3156816065311432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2798490524291992},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27622950077056885},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2388344407081604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10057488083839417},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1017/cts.2020.346","doi":"https://doi.org/10.1017/cts.2020.346","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.346","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8B340668D9E6A8A4C4096B88A60436E/S2059866120003465a.pdf/div-class-title-4168-understanding-ecm-based-drug-resistivity-in-breast-cancer-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8823421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8823421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/32987","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/32987","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/1303647e-68a4-4b1d-891a-02b65291ffe8/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:12a6ab720eec4734b25cbd2c803c16f2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/12a6ab720eec4734b25cbd2c803c16f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 4, Pp 113-114 (2020)","raw_type":"article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/32987","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/32987","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1017/cts.2020.346","doi":"https://doi.org/10.1017/cts.2020.346","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2020.346","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D8B340668D9E6A8A4C4096B88A60436E/S2059866120003465a.pdf/div-class-title-4168-understanding-ecm-based-drug-resistivity-in-breast-cancer-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045761084.pdf","grobid_xml":"https://content.openalex.org/works/W3045761084.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098253011","https://openalex.org/W2009798744","https://openalex.org/W3139902671","https://openalex.org/W3196460773","https://openalex.org/W2781664750","https://openalex.org/W1971733949","https://openalex.org/W3083314695","https://openalex.org/W2954451226","https://openalex.org/W2003658695","https://openalex.org/W2029657029"],"abstract_inverted_index":{"OBJECTIVES/GOALS:":[0],"Cell-cell":[1],"(CC)":[2,48],"and":[3,31,49,89,109,126,190,251,264,323,335],"cell-matrix":[4],"interactions":[5,33,334],"(CM)":[6],"are":[7,17,244],"known":[8],"to":[9,27,111,129,161,169,293,309,343],"affect":[10,213],"drug":[11,35,97,127,164,191,292,348],"sensitivity":[12,128,165],"of":[13,145,183,193,232,242,282,290,296,320,332,347],"cancer":[14,59],"cells,":[15],"but":[16,210],"not":[18,212],"effectively":[19,170],"recapitulated":[20],"using":[21,120,252],"2D":[22,42,200],"platforms.":[23],"This":[24],"research":[25],"aims":[26],"determine":[28],"how":[29],"cell":[30,60,136],"matrix":[32,80,222],"confer":[34],"resistivity":[36,192,209,349],"in":[37,85,95,106,199,316],"3":[38,147],"distinct":[39,148],"culturing":[40],"models:":[41],"(no":[43],"CM/limited":[44],"CC),":[45],"3D":[46,50],"spheroids":[47,274],"fibronectin":[51,196],"(both).":[52],"METHODS/STUDY":[53],"POPULATION:":[54],"We":[55,177,268],"examined":[56],"four":[57],"breast":[58],"types.":[61],"The":[62],"cells":[63,108,194],"were":[64,118,234],"derived":[65],"from":[66,350],"a":[67,79,92,100,153,220,247,351],"nonmetastatic":[68],"primary":[69],"tumor":[70],"(HMLE-E2)":[71],"or":[72],"overt":[73],"bone-metastasis":[74],"(BM).":[75],"Transglutaminase":[76],"2":[77],"(TGM2),":[78],"crosslinking":[81],"protein,":[82],"is":[83],"overexpressed":[84],"metastatic":[86],"bone":[87],"tumors":[88],"may":[90],"play":[91],"key":[93],"role":[94],"matrix-conferred":[96],"resistivity.":[98,174],"In":[99,216],"gain-of-function":[101],"model,":[102],"TGM2":[103,184,202,233,243,266,273],"was":[104,133,204],"upregulated":[105],"HMLE-E2":[107],"compared":[110],"shTGM2":[112],"knockdown":[113],"BM":[114],"cells.":[115,298],"Growth":[116],"rates":[117],"analyzed":[119,134],"metabolic":[121],"activity":[122],"over":[123],"8":[124],"days,":[125],"Neratinib":[130,208],"(0-1000":[131],"nM)":[132],"via":[135],"titer.":[137],"To":[138],"account":[139],"for":[140,156],"the":[141,146,163,187,271,280,287,291,294,297,306,321,324,330],"different":[142],"transport":[143,260,318],"properties":[144,319],"culture":[149],"environments,":[150],"we":[151,256,338],"developed":[152],"mathematical":[154,254,341],"model":[155,255],"each":[157],"condition,":[158],"allowing":[159],"us":[160],"normalize":[162],"results":[166],"across":[167],"models":[168,218,342],"compare":[171],"true":[172],"biological":[173],"RESULTS/ANTICIPATED":[175],"RESULTS:":[176],"observed":[178],"that":[179,224,270,305],"increased":[180],"cellular":[181,307],"levels":[182,231,241],"significantly":[185],"increase":[186],"growth":[188,214],"rate":[189,281],"on":[195,227],"matrices.":[197],"Interestingly,":[198],"cultures,":[201],"expression":[203],"correlated":[205,235,245],"with":[206,236,246],"higher":[207],"did":[211],"rates.":[215,239],"spheroid":[217],"without":[219],"significant":[221,259],"component,":[223],"rely":[225],"solely":[226],"cell-cell":[228],"junctions,":[229],"high":[230,263],"lower":[237],"survival":[238],"Lower":[240],"more":[248],"epithelial":[249],"phenotype,":[250],"our":[253],"have":[257,275],"identified":[258],"differences":[261],"between":[262],"low":[265,272],"spheroids.":[267],"theorize":[269],"denser":[276],"packing,":[277],"which":[278],"lowers":[279],"diffusion":[283],"and,":[284],"thus":[285],"reduces":[286],"effective":[288],"concentration":[289],"majority":[295],"DISCUSSION/SIGNIFICANCE":[299],"OF":[300],"IMPACT:":[301],"Our":[302],"studies":[303],"indicate":[304],"response":[308],"drugs":[310],"can":[311,339],"be":[312],"altered":[313],"by":[314],"changes":[315],"both":[317],"tissue":[322],"CM":[325,336],"interactions.":[326],"By":[327],"systematically":[328],"investigating":[329],"effects":[331],"CC":[333],"interactions,":[337],"use":[340],"delineate":[344],"physical":[345],"means":[346],"biologically":[352],"driven":[353],"resistance.":[354]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-08-03T00:00:00"}
