{"id":"https://openalex.org/W3045756993","doi":"https://doi.org/10.1080/13813455.2020.1797106","title":"Role of advanced glycation end products and insulin resistance in diabetic nephropathy","display_name":"Role of advanced glycation end products and insulin resistance in diabetic nephropathy","publication_year":2020,"publication_date":"2020-07-30","ids":{"openalex":"https://openalex.org/W3045756993","doi":"https://doi.org/10.1080/13813455.2020.1797106","mag":"3045756993","pmid":"https://pubmed.ncbi.nlm.nih.gov/32730131"},"language":"en","primary_location":{"id":"doi:10.1080/13813455.2020.1797106","doi":"https://doi.org/10.1080/13813455.2020.1797106","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2020.1797106","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3045756993"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055766159","display_name":"Kirti Parwani","orcid":"https://orcid.org/0000-0001-7784-5755","observed_orcids":["https://orcid.org/0000-0001-7784-5755"]},"institutions":[{"id":"https://openalex.org/I33459947","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24","country_code":"IN","type":"education","lineage":["https://openalex.org/I33459947"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kirti Parwani","raw_affiliation_strings":["Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, Gujarat 388421, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, Gujarat 388421, India","institution_ids":["https://openalex.org/I33459947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024566912","display_name":"Palash Mandal","orcid":"https://orcid.org/0000-0001-6612-3773","observed_orcids":["https://orcid.org/0000-0001-6612-3773"]},"institutions":[{"id":"https://openalex.org/I33459947","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24","country_code":"IN","type":"education","lineage":["https://openalex.org/I33459947"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Palash Mandal","raw_affiliation_strings":["Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, Gujarat 388421, India"],"raw_orcid":"https://orcid.org/0000-0001-6612-3773","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, Gujarat 388421, India","institution_ids":["https://openalex.org/I33459947"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024566912"],"corresponding_institution_ids":["https://openalex.org/I33459947"],"apc_list":null,"apc_paid":null,"fwci":0.8819,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.64732143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"129","issue":"1","first_page":"95","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8790000081062317},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":1.0},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9639999866485596},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9120000004768372},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8980000019073486},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9419999718666077},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9800000190734863},{"id":"https://openalex.org/keywords/podocyte-apoptosis","display_name":"podocyte apoptosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glomerular-hypertrophy","display_name":"glomerular hypertrophy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.781000018119812},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.9062215685844421},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.6744792461395264},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.645648717880249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6424232721328735},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6361085176467896},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.5773545503616333},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.5657163262367249},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.5215190052986145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49666982889175415},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47980955243110657},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.45946383476257324},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40356940031051636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.305401086807251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2852126955986023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2613024115562439},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15942242741584778},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/13813455.2020.1797106","doi":"https://doi.org/10.1080/13813455.2020.1797106","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2020.1797106","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:32730131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32730131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physiology and biochemistry","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326160","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W119790974","https://openalex.org/W938542164","https://openalex.org/W1087960405","https://openalex.org/W1509582521","https://openalex.org/W1511701404","https://openalex.org/W1517570296","https://openalex.org/W1518714662","https://openalex.org/W1582822824","https://openalex.org/W1598235393","https://openalex.org/W1956892253","https://openalex.org/W1964586920","https://openalex.org/W1966846908","https://openalex.org/W1968071120","https://openalex.org/W1968446955","https://openalex.org/W1969488647","https://openalex.org/W1969517023","https://openalex.org/W1970415033","https://openalex.org/W1971886163","https://openalex.org/W1972842521","https://openalex.org/W1973924126","https://openalex.org/W1975646168","https://openalex.org/W1978657102","https://openalex.org/W1979388970","https://openalex.org/W1979480713","https://openalex.org/W1980392624","https://openalex.org/W1981133477","https://openalex.org/W1981550821","https://openalex.org/W1981606978","https://openalex.org/W1982063217","https://openalex.org/W1984403764","https://openalex.org/W1985417086","https://openalex.org/W1986014108","https://openalex.org/W1989254729","https://openalex.org/W1991427290","https://openalex.org/W1991999080","https://openalex.org/W1992256012","https://openalex.org/W1993423729","https://openalex.org/W1994887713","https://openalex.org/W1998614770","https://openalex.org/W1999451304","https://openalex.org/W2000054651","https://openalex.org/W2000478369","https://openalex.org/W2004482266","https://openalex.org/W2004771015","https://openalex.org/W2005152294","https://openalex.org/W2007659337","https://openalex.org/W2008428741","https://openalex.org/W2009003391","https://openalex.org/W2010036181","https://openalex.org/W2012792172","https://openalex.org/W2020267609","https://openalex.org/W2025347981","https://openalex.org/W2027142963","https://openalex.org/W2029686598","https://openalex.org/W2030120780","https://openalex.org/W2032055976","https://openalex.org/W2034124474","https://openalex.org/W2037141143","https://openalex.org/W2041655090","https://openalex.org/W2042667331","https://openalex.org/W2043918491","https://openalex.org/W2044321635","https://openalex.org/W2044437167","https://openalex.org/W2046401692","https://openalex.org/W2049117288","https://openalex.org/W2052034057","https://openalex.org/W2055801973","https://openalex.org/W2055827648","https://openalex.org/W2058398821","https://openalex.org/W2060449981","https://openalex.org/W2061906058","https://openalex.org/W2068793587","https://openalex.org/W2069509032","https://openalex.org/W2069589041","https://openalex.org/W2069811052","https://openalex.org/W2071675524","https://openalex.org/W2076480821","https://openalex.org/W2077088113","https://openalex.org/W2079643102","https://openalex.org/W2084203388","https://openalex.org/W2085333075","https://openalex.org/W2085341182","https://openalex.org/W2086327676","https://openalex.org/W2089878313","https://openalex.org/W2090839709","https://openalex.org/W2091668959","https://openalex.org/W2091819703","https://openalex.org/W2092970668","https://openalex.org/W2094939617","https://openalex.org/W2095847921","https://openalex.org/W2096341618","https://openalex.org/W2096532656","https://openalex.org/W2096602740","https://openalex.org/W2096987196","https://openalex.org/W2097547726","https://openalex.org/W2101997680","https://openalex.org/W2103814475","https://openalex.org/W2105476490","https://openalex.org/W2109579153","https://openalex.org/W2113417828","https://openalex.org/W2115293825","https://openalex.org/W2119536830","https://openalex.org/W2120293565","https://openalex.org/W2121527030","https://openalex.org/W2121596834","https://openalex.org/W2124098523","https://openalex.org/W2126728583","https://openalex.org/W2128730397","https://openalex.org/W2129228748","https://openalex.org/W2131812809","https://openalex.org/W2134659783","https://openalex.org/W2138561622","https://openalex.org/W2140491925","https://openalex.org/W2143201143","https://openalex.org/W2143385565","https://openalex.org/W2143497024","https://openalex.org/W2150894134","https://openalex.org/W2153661281","https://openalex.org/W2153966472","https://openalex.org/W2154904208","https://openalex.org/W2156390796","https://openalex.org/W2156719803","https://openalex.org/W2169083105","https://openalex.org/W2173537782","https://openalex.org/W2234490952","https://openalex.org/W2262208894","https://openalex.org/W2303878865","https://openalex.org/W2335364913","https://openalex.org/W2337454357","https://openalex.org/W2343961997","https://openalex.org/W2396172434","https://openalex.org/W2405307702","https://openalex.org/W2405624971","https://openalex.org/W2410759580","https://openalex.org/W2416390589","https://openalex.org/W2473083890","https://openalex.org/W2511514816","https://openalex.org/W2550737605","https://openalex.org/W2593083600","https://openalex.org/W2600283285","https://openalex.org/W2613211673","https://openalex.org/W2615726842","https://openalex.org/W2619610986","https://openalex.org/W2652575518","https://openalex.org/W2769264260","https://openalex.org/W2869351274","https://openalex.org/W2912023033","https://openalex.org/W2942972633","https://openalex.org/W2995365972","https://openalex.org/W3014147211","https://openalex.org/W4234561867","https://openalex.org/W4241041106","https://openalex.org/W4243328821","https://openalex.org/W4253337782","https://openalex.org/W4254523290"],"related_works":["https://openalex.org/W4394698659","https://openalex.org/W4206288942","https://openalex.org/W2553975694","https://openalex.org/W2043700489","https://openalex.org/W2038912720","https://openalex.org/W2550737605","https://openalex.org/W2361597252","https://openalex.org/W2053600859","https://openalex.org/W4405211828","https://openalex.org/W4308772909"],"abstract_inverted_index":{"Metabolic":[0],"syndrome":[1],"(MetS),":[2],"i.e.":[3],"a":[4],"cluster":[5],"of":[6,28,40,52,58,79,93,99,109,129],"physiological":[7,139],"and":[8,26,61,107,127,138,144],"biochemical":[9,137],"abnormalities":[10],"can":[11,32],"lead":[12],"to":[13,50,67,116,124],"diabetic":[14],"nephropathy":[15],"(DN).":[16],"Insulin":[17],"resistance,":[18],"impaired":[19],"fasting":[20],"glucose":[21],"are":[22,47,114],"the":[23,68,125],"main":[24],"signs":[25],"symptoms":[27],"MetS.":[29],"Excess":[30],"sugar":[31],"induce":[33,117],"various":[34],"substantial":[35],"structural":[36],"changes":[37],"like":[38,82],"formation":[39],"advanced":[41,71],"glycation":[42,72],"end":[43,73],"products":[44,74],"(AGEs).":[45],"AGEs":[46,64,143],"formed":[48],"due":[49],"reaction":[51],"reducing":[53],"sugars":[54],"with":[55,91],"amino":[56],"groups":[57],"proteins,":[59],"lipids":[60],"nucleic":[62],"acids.":[63],"when":[65],"bound":[66],"receptor":[69],"for":[70],"(RAGE)":[75],"activate":[76],"increased":[77],"production":[78],"pro-inflammatory":[80],"markers":[81],"interleukin-6":[83],"(IL-6),":[84],"tumour":[85],"necrosis":[86],"factor":[87],"alpha":[88],"(TNF-\u03b1)":[89],"along":[90],"induction":[92],"endoplasmic":[94],"reticulum":[95],"(ER)":[96],"stress.":[97],"Accumulation":[98],"AGEs,":[100],"enhanced":[101],"reactive":[102],"oxygen":[103],"species":[104],"(ROS)":[105],"generation":[106],"activation":[108],"protein":[110],"kinase":[111],"C":[112],"(PKC),":[113],"considered":[115],"glomerular":[118],"hypertrophy,":[119],"podocyte":[120],"apoptosis,":[121],"therefore":[122],"contributing":[123],"development":[126],"progression":[128],"DN.":[130,145],"In":[131],"this":[132],"review,":[133],"we":[134],"decipher":[135],"different":[136],"factors":[140],"that":[141],"link":[142]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-08-03T00:00:00"}
