{"id":"https://openalex.org/W3045685459","doi":"https://doi.org/10.1186/s13059-020-02102-3","title":"Splicing-accessible coding 3\u2032UTRs control protein stability and interaction networks","display_name":"Splicing-accessible coding 3\u2032UTRs control protein stability and interaction networks","publication_year":2020,"publication_date":"2020-07-29","ids":{"openalex":"https://openalex.org/W3045685459","doi":"https://doi.org/10.1186/s13059-020-02102-3","mag":"3045685459","pmid":"https://pubmed.ncbi.nlm.nih.gov/32727563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7392665"},"language":"en","primary_location":{"id":"doi:10.1186/s13059-020-02102-3","doi":"https://doi.org/10.1186/s13059-020-02102-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02102-3","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02102-3","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02102-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081687050","display_name":"Marco Preu\u00dfner","orcid":"https://orcid.org/0000-0001-5155-0844","observed_orcids":["https://orcid.org/0000-0001-5155-0844"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Preussner","raw_affiliation_strings":["Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015935509","display_name":"Qingsong Gao","orcid":"https://orcid.org/0000-0002-9930-8499","observed_orcids":["https://orcid.org/0000-0002-9930-8499"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qingsong Gao","raw_affiliation_strings":["Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine, Laboratory for Systems Biology and Functional Genomics, Robert-R\u00f6ssle-Str. 10, 13125, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine, Laboratory for Systems Biology and Functional Genomics, Robert-R\u00f6ssle-Str. 10, 13125, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109163694","display_name":"Eliot Morrison","orcid":"https://orcid.org/0000-0001-5456-3368","observed_orcids":["https://orcid.org/0000-0001-5456-3368"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eliot Morrison","raw_affiliation_strings":["Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of Protein Biochemistry, Thielallee 63, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of Protein Biochemistry, Thielallee 63, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001798853","display_name":"Olga Herdt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olga Herdt","raw_affiliation_strings":["Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013845611","display_name":"Florian Finkernagel","orcid":"https://orcid.org/0000-0002-1141-7499","observed_orcids":["https://orcid.org/0000-0002-1141-7499"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Finkernagel","raw_affiliation_strings":["Center for Tumor Biology and Immunology (ZTI), Philipps-University Marburg, Hans-Meerwein-Stra\u00dfe 3, 35043, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tumor Biology and Immunology (ZTI), Philipps-University Marburg, Hans-Meerwein-Stra\u00dfe 3, 35043, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089930328","display_name":"Michael Sch\u00fcmann","orcid":"https://orcid.org/0000-0001-6391-9979","observed_orcids":["https://orcid.org/0000-0001-6391-9979"]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schumann","raw_affiliation_strings":["Leibniz-Institut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Strasse 10, 13125, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Strasse 10, 13125, Berlin, Germany","institution_ids":["https://openalex.org/I4210099563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053558676","display_name":"Eberhard Krause","orcid":"https://orcid.org/0000-0001-5019-522X","observed_orcids":["https://orcid.org/0000-0001-5019-522X"]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eberhard Krause","raw_affiliation_strings":["Leibniz-Institut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Strasse 10, 13125, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Strasse 10, 13125, Berlin, Germany","institution_ids":["https://openalex.org/I4210099563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054910477","display_name":"Christian Freund","orcid":"https://orcid.org/0000-0001-7416-8226","observed_orcids":["https://orcid.org/0000-0001-7416-8226"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Freund","raw_affiliation_strings":["Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of Protein Biochemistry, Thielallee 63, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of Protein Biochemistry, Thielallee 63, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344574","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0003-3263-1627","observed_orcids":["https://orcid.org/0000-0003-3263-1627"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China. chenw@sustech.edu.cn","Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China. chenw@sustech.edu.cn","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060003119","display_name":"Florian Heyd","orcid":"https://orcid.org/0000-0001-9377-9882","observed_orcids":["https://orcid.org/0000-0001-9377-9882"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Heyd","raw_affiliation_strings":["Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany. florian.heyd@fu-berlin.de","Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9377-9882","affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany. florian.heyd@fu-berlin.de","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Laboratory of RNA Biochemistry, Takustrasse 6, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060003119","https://openalex.org/A5100344574"],"corresponding_institution_ids":["https://openalex.org/I3045169105","https://openalex.org/I75951250"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.2149,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.77251226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"186","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pxxp-motif","display_name":"PXXP motif","score":0.8240000009536743},{"id":"https://openalex.org/keywords/proline-rich-proteins","display_name":"proline-rich proteins","score":0.7139999866485596},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.796999990940094},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.875},{"id":"https://openalex.org/keywords/interactome-rewiring","display_name":"interactome rewiring","score":0.8799999952316284},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nonsense-mediated-mrna-decay","display_name":"nonsense-mediated mRNA decay","score":0.8410000205039978},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8218997716903687},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7121528387069702},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.7024792432785034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6441914439201355},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5891594886779785},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5696293711662292},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5661506652832031},{"id":"https://openalex.org/C12464233","wikidata":"https://www.wikidata.org/wiki/Q937624","display_name":"Five prime untranslated region","level":5,"score":0.46875476837158203},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.4606904983520508},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4543347954750061},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.4528364837169647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44767674803733826},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.437914103269577},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4101618230342865},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.391154944896698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3376834988594055},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.30589592456817627},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1551588475704193}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054707","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13059-020-02102-3","doi":"https://doi.org/10.1186/s13059-020-02102-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02102-3","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02102-3","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmid:32727563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32727563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7392665","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7392665/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmh:oai:edoc.mdc-berlin.de:19161","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/19161/7/19161suppl.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:2201d5578c144f41bc65e2e846538ab0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2201d5578c144f41bc65e2e846538ab0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, Vol 21, Iss 1, Pp 1-24 (2020)","raw_type":"article"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/30418","doi":null,"is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/30418","pdf_url":null,"source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"doi:10.17169/refubium-30159","doi":"https://doi.org/10.17169/refubium-30159","is_oa":true,"landing_page_url":"https://doi.org/10.17169/refubium-30159","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13059-020-02102-3","doi":"https://doi.org/10.1186/s13059-020-02102-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02102-3","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02102-3","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2146881008","display_name":null,"funder_award_id":"TRR186","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2158383703","display_name":null,"funder_award_id":"HE 5398/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3533295474","display_name":null,"funder_award_id":"HE5398/4-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3608627912","display_name":"TRR 186: Molekulare Schalter zur r\u00e4umlichen und kinetischen Regulation der zellul\u00e4ren Signaltransmission","funder_award_id":"278001972","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4555656945","display_name":"Berlin-Institut f\u00fcr Medizinische Systembiologie","funder_award_id":"0315362C","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G5865915336","display_name":null,"funder_award_id":"BIMSB 0315362A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7252417842","display_name":null,"funder_award_id":"HE5398/4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320328454","display_name":"Peter und Traudl Engelhorn Stiftung","ror":"https://ror.org/03vcxxt90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045685459.pdf","grobid_xml":"https://content.openalex.org/works/W3045685459.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1542927170","https://openalex.org/W1596947964","https://openalex.org/W1964727443","https://openalex.org/W1968569455","https://openalex.org/W1969412365","https://openalex.org/W1977709885","https://openalex.org/W1988528648","https://openalex.org/W1989421606","https://openalex.org/W1989632697","https://openalex.org/W1997065647","https://openalex.org/W2000227815","https://openalex.org/W2004581292","https://openalex.org/W2011920499","https://openalex.org/W2013321787","https://openalex.org/W2014776147","https://openalex.org/W2034691490","https://openalex.org/W2045128688","https://openalex.org/W2058555336","https://openalex.org/W2059126678","https://openalex.org/W2063354556","https://openalex.org/W2073324553","https://openalex.org/W2077116876","https://openalex.org/W2078381702","https://openalex.org/W2097338146","https://openalex.org/W2102115661","https://openalex.org/W2103273849","https://openalex.org/W2106013076","https://openalex.org/W2113525941","https://openalex.org/W2124989632","https://openalex.org/W2128551987","https://openalex.org/W2137613081","https://openalex.org/W2144818107","https://openalex.org/W2145070407","https://openalex.org/W2150900888","https://openalex.org/W2151462466","https://openalex.org/W2154350719","https://openalex.org/W2155804510","https://openalex.org/W2157936723","https://openalex.org/W2159457776","https://openalex.org/W2172098255","https://openalex.org/W2234931430","https://openalex.org/W2258573009","https://openalex.org/W2418956892","https://openalex.org/W2762868004","https://openalex.org/W2790599046","https://openalex.org/W2798058472","https://openalex.org/W2804265440","https://openalex.org/W2901758876","https://openalex.org/W2986545595","https://openalex.org/W3010073072"],"related_works":["https://openalex.org/W6920698325","https://openalex.org/W2089240490","https://openalex.org/W2890344905","https://openalex.org/W2178279848","https://openalex.org/W2043983768","https://openalex.org/W2751247278","https://openalex.org/W3022110501","https://openalex.org/W2054574453","https://openalex.org/W2921713516","https://openalex.org/W3209811834"],"abstract_inverted_index":{"BACKGROUND:":[0],"3'-Untranslated":[1],"regions":[2],"(3'UTRs)":[3],"play":[4],"crucial":[5],"roles":[6],"in":[7,21,49,109],"mRNA":[8,14],"metabolism,":[9],"such":[10],"as":[11,98],"by":[12,127],"controlling":[13],"stability,":[15,86],"translation":[16,134],"efficiency,":[17],"and":[18,55,70,83,161,164],"localization.":[19],"Intriguingly,":[20],"some":[22],"genes":[23],"the":[24,155,169],"3'UTR":[25],"is":[26,125],"longer":[27],"than":[28,51],"their":[29],"coding":[30],"regions,":[31],"pointing":[32],"to":[33,72,133],"additional,":[34],"unknown":[35],"functions.":[36],"Here,":[37],"we":[38],"describe":[39,147],"a":[40,99,128,136,148],"protein-coding":[41,57],"function":[42],"of":[43,53,67,91,105,118,135,171],"3'UTRs":[44],"upon":[45],"frameshift-inducing":[46,119],"alternative":[47,120],"splicing":[48,121],"more":[50],"10%":[52],"human":[54],"mouse":[56],"genes.":[58],"RESULTS:":[59],"3'UTR-encoded":[60],"amino":[61],"acid":[62],"sequences":[63],"show":[64],"an":[65,76],"enrichment":[66],"PxxP":[68],"motifs":[69],"lead":[71],"interactome":[73],"rewiring.":[74],"Furthermore,":[75],"elevated":[77],"proline":[78],"content":[79],"increases":[80],"protein":[81,85,92,159,175],"disorder":[82],"reduces":[84],"thus":[87],"allowing":[88],"splicing-controlled":[89],"regulation":[90],"half-life.":[93],"This":[94],"could":[95],"also":[96],"act":[97],"surveillance":[100],"mechanism":[101,152],"for":[102,168],"erroneous":[103],"skipping":[104],"penultimate":[106],"exons":[107],"resulting":[108],"transcripts":[110],"that":[111,153],"escape":[112],"nonsense":[113],"mediated":[114],"decay.":[115],"The":[116],"impact":[117],"on":[122],"disease":[123],"development":[124],"emphasized":[126],"retinitis":[129],"pigmentosa-causing":[130],"mutation":[131],"leading":[132],"3'UTR-encoded,":[137],"proline-rich,":[138],"destabilized":[139],"frameshift-protein":[140],"with":[141],"altered":[142],"protein-protein":[143,162],"interactions.":[144],"CONCLUSIONS:":[145],"We":[146],"widespread,":[149],"evolutionarily":[150],"conserved":[151],"enriches":[154],"mammalian":[156],"proteome,":[157],"controls":[158],"expression":[160],"interactions,":[163],"has":[165],"important":[166],"implications":[167],"discovery":[170],"novel,":[172],"potentially":[173],"disease-relevant":[174],"variants.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-03T00:00:00"}