{"id":"https://openalex.org/W3045673299","doi":"https://doi.org/10.1002/pro.3921","title":"Tumorigenic p53 mutants undergo common structural disruptions including conversion to \u03b1\u2010sheet structure","display_name":"Tumorigenic p53 mutants undergo common structural disruptions including conversion to \u03b1\u2010sheet structure","publication_year":2020,"publication_date":"2020-07-27","ids":{"openalex":"https://openalex.org/W3045673299","doi":"https://doi.org/10.1002/pro.3921","mag":"3045673299","pmid":"https://pubmed.ncbi.nlm.nih.gov/32715544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7454552"},"language":"en","primary_location":{"id":"doi:10.1002/pro.3921","doi":"https://doi.org/10.1002/pro.3921","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3921","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3921","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071600061","display_name":"Dennis Bromley","orcid":"https://orcid.org/0009-0007-0303-8062","observed_orcids":["https://orcid.org/0009-0007-0303-8062"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Bromley","raw_affiliation_strings":["Division of Biomedical and Health Informatics, Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical and Health Informatics, Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021239442","display_name":"Valerie Daggett","orcid":"https://orcid.org/0000-0002-5116-6102","observed_orcids":["https://orcid.org/0000-0002-5116-6102"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valerie Daggett","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, Washington, USA","Division of Biomedical and Health Informatics, Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA"],"raw_orcid":"https://orcid.org/0000-0002-5116-6102","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Biomedical and Health Informatics, Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021239442"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.2854,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.42322158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"29","issue":"9","first_page":"1983","last_page":"1999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.7950000166893005},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.48500001430511475},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7959743738174438},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5419434309005737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47163674235343933},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.4579469561576843},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.44211965799331665},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.41014519333839417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083822965621948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.400770902633667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2736424207687378},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.24298208951950073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2220367193222046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16136732697486877}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/pro.3921","doi":"https://doi.org/10.1002/pro.3921","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3921","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3921","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmid:32715544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32715544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7454552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7454552/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1651244","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1651244","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/pro.3921","doi":"https://doi.org/10.1002/pro.3921","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3921","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3921","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G122673668","display_name":null,"funder_award_id":"DE\u2013AC02\u201305CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G1286236842","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1337544421","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G1369429258","display_name":null,"funder_award_id":"GMS 50789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1677143136","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G1687207835","display_name":"MOLECULAR DYNAMICS SIMULATIONS OF PROTEIN UNFOLDING","funder_award_id":"R29GM050789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G223002938","display_name":null,"funder_award_id":"DE-AC02 \u2212 05CH11231","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G3083819904","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G382641700","display_name":null,"funder_award_id":"DE-AC02\u201305CH11231","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G419881185","display_name":null,"funder_award_id":"DEAC02\u201305CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G42916606","display_name":null,"funder_award_id":"DE AC02 05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4501827968","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4628798189","display_name":"Molecular Dynamics Simulations of Protein Unfolding","funder_award_id":"R01GM050789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5076365615","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G5877009442","display_name":"Community metabolism and greenhouse gas fluxes in industrial salt ponds pre- and post-restoration","funder_award_id":"50789","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6467562540","display_name":null,"funder_award_id":"GMS 50789","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6652958823","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7787287669","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G9000889631","display_name":"University of Washington Biomedical Informatics and Data Science Research Training Program","funder_award_id":"T15LM007442","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320317220","display_name":"National Energy Research Scientific Computing Center","ror":"https://ror.org/05v3mvq14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045673299.pdf","grobid_xml":"https://content.openalex.org/works/W3045673299.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1594163597","https://openalex.org/W1650797637","https://openalex.org/W1736696355","https://openalex.org/W1967058595","https://openalex.org/W1970329518","https://openalex.org/W1971689309","https://openalex.org/W1975892289","https://openalex.org/W1978782811","https://openalex.org/W1984493861","https://openalex.org/W1986076152","https://openalex.org/W1987517037","https://openalex.org/W1996095116","https://openalex.org/W2000408345","https://openalex.org/W2000948278","https://openalex.org/W2001625355","https://openalex.org/W2005918656","https://openalex.org/W2008708467","https://openalex.org/W2010777656","https://openalex.org/W2020098545","https://openalex.org/W2024957762","https://openalex.org/W2027392184","https://openalex.org/W2029582401","https://openalex.org/W2029667189","https://openalex.org/W2030502598","https://openalex.org/W2030608968","https://openalex.org/W2033093495","https://openalex.org/W2037936747","https://openalex.org/W2038798987","https://openalex.org/W2044010514","https://openalex.org/W2046345348","https://openalex.org/W2047596219","https://openalex.org/W2051606057","https://openalex.org/W2062202414","https://openalex.org/W2063057151","https://openalex.org/W2070504654","https://openalex.org/W2071545816","https://openalex.org/W2072052957","https://openalex.org/W2079792983","https://openalex.org/W2081288740","https://openalex.org/W2082103873","https://openalex.org/W2083382121","https://openalex.org/W2084938591","https://openalex.org/W2086531624","https://openalex.org/W2086702072","https://openalex.org/W2089289562","https://openalex.org/W2089298522","https://openalex.org/W2090617952","https://openalex.org/W2090780313","https://openalex.org/W2092902276","https://openalex.org/W2093797483","https://openalex.org/W2094607113","https://openalex.org/W2096276671","https://openalex.org/W2097253105","https://openalex.org/W2101298197","https://openalex.org/W2101817300","https://openalex.org/W2102898692","https://openalex.org/W2103473238","https://openalex.org/W2105376260","https://openalex.org/W2108768863","https://openalex.org/W2109998141","https://openalex.org/W2110947069","https://openalex.org/W2114422004","https://openalex.org/W2117178889","https://openalex.org/W2123575677","https://openalex.org/W2123637853","https://openalex.org/W2124585949","https://openalex.org/W2128080369","https://openalex.org/W2128678940","https://openalex.org/W2130479394","https://openalex.org/W2132188221","https://openalex.org/W2132629607","https://openalex.org/W2136860964","https://openalex.org/W2136937497","https://openalex.org/W2138023380","https://openalex.org/W2140797187","https://openalex.org/W2142765738","https://openalex.org/W2146223593","https://openalex.org/W2148077714","https://openalex.org/W2152023928","https://openalex.org/W2155333098","https://openalex.org/W2160817213","https://openalex.org/W2165699943","https://openalex.org/W2171380824","https://openalex.org/W2215016686","https://openalex.org/W2309048437","https://openalex.org/W2312641146","https://openalex.org/W2341209396","https://openalex.org/W2504378293","https://openalex.org/W2513031068","https://openalex.org/W2690412492","https://openalex.org/W2774176177","https://openalex.org/W2774243923","https://openalex.org/W2806111497","https://openalex.org/W2854673270","https://openalex.org/W2898722785","https://openalex.org/W2908593759","https://openalex.org/W2908811118","https://openalex.org/W2937031418","https://openalex.org/W2981129681","https://openalex.org/W3005243146","https://openalex.org/W4235939487","https://openalex.org/W6671112572"],"related_works":["https://openalex.org/W7096544307","https://openalex.org/W2099459640","https://openalex.org/W658915987","https://openalex.org/W2033093495","https://openalex.org/W2766823761","https://openalex.org/W3013763244","https://openalex.org/W2204928208","https://openalex.org/W7160438268","https://openalex.org/W2036736126","https://openalex.org/W2090291378"],"abstract_inverted_index":{"The":[0],"p53":[1,55,69,145],"protein":[2],"is":[3,18],"a":[4,61,97,106,135],"commonly":[5],"studied":[6],"cancer":[7,93,153],"target":[8],"because":[9],"of":[10,23,27,37,52,101,108,123,152],"its":[11,140],"role":[12,136],"in":[13,41,81,120,137,142],"tumor":[14],"suppression.":[15],"Unfortunately,":[16],"it":[17,87],"susceptible":[19],"to":[20,33,72,91,111,133],"mutation-associated":[21],"loss":[22],"function;":[24],"approximately":[25],"50%":[26],"cancers":[28],"are":[29,39],"associated":[30],"with":[31,148],"mutations":[32],"p53,":[34],"the":[35,42,82,124,143,149],"majority":[36],"which":[38],"located":[40],"central":[43],"DNA-binding":[44],"domain.":[45],"Here,":[46],"we":[47],"report":[48],"molecular":[49],"dynamics":[50],"simulations":[51,146],"wild-type":[53],"(WT)":[54],"and":[56,130,139],"20":[57],"different":[58],"mutants,":[59],"including":[60],"stabilized":[62],"pseudo-WT":[63],"mutant.":[64,113],"Our":[65],"findings":[66],"indicate":[67],"that":[68,86],"mutants":[70],"tend":[71],"exacerbate":[73],"latent":[74],"structural-disruption":[75,102],"tendencies,":[76],"or":[77],"vulnerabilities,":[78],"already":[79],"present":[80],"WT":[83],"protein,":[84],"suggesting":[85],"may":[88],"be":[89],"possible":[90],"develop":[92],"therapies":[94],"by":[95],"targeting":[96],"relatively":[98],"small":[99],"set":[100],"motifs":[103],"rather":[104],"than":[105],"multitude":[107],"effects":[109],"specific":[110],"each":[112],"In":[114],"addition,":[115],"\u03b1-sheet":[116],"secondary":[117],"structure":[118],"formed":[119],"almost":[121],"all":[122],"proteins.":[125],"\u03b1-Sheet":[126],"has":[127],"been":[128],"hypothesized":[129],"recently":[131],"demonstrated":[132],"play":[134],"amyloidogenesis,":[138],"presence":[141],"reported":[144],"coincides":[147],"recent":[150],"re-consideration":[151],"as":[154],"an":[155],"amyloid":[156],"disease.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-03T00:00:00"}