{"id":"https://openalex.org/W3045559812","doi":"https://doi.org/10.1161/str.51.suppl_1.176","title":"Abstract 176: Platelet Cyclophilin D Mediates Neutrophil Recruitment and Ischemic Stroke Outcomes in Mice","display_name":"Abstract 176: Platelet Cyclophilin D Mediates Neutrophil Recruitment and Ischemic Stroke Outcomes in Mice","publication_year":2020,"publication_date":"2020-02-01","ids":{"openalex":"https://openalex.org/W3045559812","doi":"https://doi.org/10.1161/str.51.suppl_1.176","mag":"3045559812"},"language":"en","primary_location":{"id":"doi:10.1161/str.51.suppl_1.176","doi":"https://doi.org/10.1161/str.51.suppl_1.176","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.51.suppl_1.176","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037659762","display_name":"Frederik Denorme","orcid":"https://orcid.org/0000-0003-1442-3568","observed_orcids":["https://orcid.org/0000-0003-1442-3568"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederik Denorme","raw_affiliation_strings":["Molecular Medicine, Univ of Utah, Salt Lake City, UT","Frederik Denorme"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine, Univ of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Frederik Denorme","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044779122","display_name":"Bhanukanth Manne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhanukanth Manne","raw_affiliation_strings":["Molecular Medicine, Univ of Utah, Salt Lake Cty, UT","Bhanukanth Manne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine, Univ of Utah, Salt Lake Cty, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Bhanukanth Manne","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040599553","display_name":"Yasuhiro Kosaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kosaka","raw_affiliation_strings":["Univ of Utah, Salt Lake Cty, UT","Yasuhiro Kosaka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Utah, Salt Lake Cty, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Yasuhiro Kosaka","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004516666","display_name":"Jennifer Juhl Majersik","orcid":"https://orcid.org/0000-0003-3191-262X","observed_orcids":["https://orcid.org/0000-0003-3191-262X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Majersik","raw_affiliation_strings":["Neurology, Univ of Utah, Salt Lake Cty, UT","Jennifer Majersik"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Univ of Utah, Salt Lake Cty, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Jennifer Majersik","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018999774","display_name":"Benjamin T. Kile","orcid":"https://orcid.org/0000-0002-8836-8947","observed_orcids":["https://orcid.org/0000-0002-8836-8947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Kile","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Melbourne, Australia","Benjamin Kile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Melbourne, Australia","institution_ids":[]},{"raw_affiliation_string":"Benjamin Kile","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007461026","display_name":"Matthew Thomas Rondina","orcid":"https://orcid.org/0000-0003-3455-3730","observed_orcids":["https://orcid.org/0000-0003-3455-3730"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Rondina","raw_affiliation_strings":["Internal Medicine, Univ of Utah, Salt Lake Cty, UT","Matthew Rondina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Univ of Utah, Salt Lake Cty, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Matthew Rondina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091378889","display_name":"Robert A. Campbell","orcid":"https://orcid.org/0000-0003-0027-694X","observed_orcids":["https://orcid.org/0000-0003-0027-694X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Campbell","raw_affiliation_strings":["Univ of Utah, Salt Lake Cty, UT","Robert Campbell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Utah, Salt Lake Cty, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Robert Campbell","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.09269999712705612,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophilin-d","display_name":"cyclophilin D","score":0.9430000185966492},{"id":"https://openalex.org/keywords/platelet-neutrophil-aggregates","display_name":"platelet-neutrophil aggregates","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7549999952316284},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.4869999885559082},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tmem16f","display_name":"TMEM16F","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelet-targeted-therapy","display_name":"platelet-targeted therapy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/human-platelets","display_name":"human platelets","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8879114389419556},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8050724267959595},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7338932752609253},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6714127063751221},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5907146334648132},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46989843249320984},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4632142186164856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45106038451194763},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.44786280393600464},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.434089720249176},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4255075454711914},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.423663854598999},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.51.suppl_1.176","doi":"https://doi.org/10.1161/str.51.suppl_1.176","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.51.suppl_1.176","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2986928689","https://openalex.org/W2994321509","https://openalex.org/W3173263316","https://openalex.org/W2751949016","https://openalex.org/W2610442541","https://openalex.org/W4311484836","https://openalex.org/W2156076525","https://openalex.org/W3082062306","https://openalex.org/W4285370687","https://openalex.org/W1998886022"],"abstract_inverted_index":{"Rationale:":[0],"Besides":[1],"their":[2],"role":[3,32],"in":[4,36,62,107,152,160,176,180,212,222,252,256],"thrombosis,":[5],"platelets":[6,63,109,235,270],"also":[7,99],"mediate":[8],"inflammation":[9],"through":[10],"platelet-neutrophil":[11],"aggregates":[12],"(PNA).":[13],"Recently,":[14],"cyclophilin":[15],"D":[16],"(CypD)-mediated":[17],"platelet":[18,34,50,116,133,283,290],"necrosis":[19,284],"emerged":[20],"as":[21],"a":[22,74,171,294],"potential":[23,295],"mediator":[24],"of":[25,33,49,115,199],"detrimental":[26],"PNA":[27,196],"during":[28,163,230],"thrombosis.":[29],"However,":[30],"the":[31,47,102,164,181],"CypD":[35,51,60,103,117,134,291],"ischemic":[37,53,111,138,210,231,238,279,303],"stroke":[38,82,93,139,211,239],"has":[39],"never":[40],"been":[41],"examined.":[42],"Objective:":[43],"Here,":[44],"we":[45,189],"investigate":[46],"contribution":[48],"following":[52,209,278],"stroke.":[54,112,232,280,304],"Methods:":[55],"We":[56,98],"generated":[57],"mice":[58,70,129,154,185],"lacking":[59],"specifically":[61],"(KO).":[64],"Both":[65],"wild-type":[66],"(WT)":[67],"and":[68,89,92,122,194,206,242,262],"KO":[69,153,184,223],"were":[71,96],"subjected":[72],"to":[73,127,158,274,298],"1h":[75],"transient":[76],"middle":[77],"cerebral":[78,195],"artery":[79],"occlusion":[80],"(tMCAO)":[81],"model.":[83],"Twenty-four":[84,167],"hours":[85,168],"after":[86,110,130,169,302],"occlusion,":[87],"neurological":[88,120,207],"motor":[90,123],"function,":[91],"infarct":[94,140,204],"size":[95,205],"determined.":[97],"examined":[100],"if":[101],"pathway":[104],"was":[105,155,178,220],"altered":[106],"human":[108],"Results:":[113],"Loss":[114],"significantly":[118,136,191,201],"improved":[119],"(p<0.001)":[121],"(p<0.005)":[124],"functions":[125],"compared":[126],"WT":[128,213],"tMCAO.":[131],"Furthermore,":[132],"deficient":[135],"reduced":[137,203],"volume":[141],"(39.1\u00b115.7mm":[142],"3":[143,146],"vs.":[144],"78.6\u00b127.7mm":[145],",":[147],"n=15;":[148],"p<0.0001).":[149],"Smaller":[150],"infarcts":[151],"not":[156,286],"due":[157],"difference":[159],"blood":[161],"flow":[162],"ischemia":[165],"stage.":[166],"stroke,":[170],"greater":[172],"than":[173],"2-fold":[174],"reduction":[175],"neutrophils":[177,200,273],"observed":[179,190,221],"brains":[182],"from":[183,237],"(p<0.0001).":[186],"In":[187],"addition,":[188],"fewer":[192],"circulating":[193],"(p<0.01).":[197],"Depletion":[198],"(p<0.05)":[202],"damage":[208,301],"mice,":[214,224],"however,":[215],"no":[216],"additional":[217],"protective":[218],"effect":[219],"suggesting":[225],"necrotic":[226,269],"PNAs":[227],"are":[228],"critical":[229],"RNA-sequencing":[233],"on":[234],"isolated":[236],"patients":[240],"(n=8)":[241],"healthy":[243],"aged,":[244],"gender":[245],"matched":[246],"controls":[247],"(n=7)":[248],"revealed":[249],"significant":[250],"increases":[251],"several":[253],"targets":[254],"involved":[255],"CypD-mediated":[257],"necrosis,":[258],"including":[259],"MCUR1,":[260],"TMEM16F":[261],"calpain2":[263],"(p<0.005).":[264],"Conclusion:":[265],"Our":[266],"results":[267],"demonstrate":[268],"interact":[271],"with":[272],"exacerbate":[275],"brain":[276,300],"injury":[277],"As":[281],"inhibiting":[282],"does":[285],"compromise":[287],"hemostasis,":[288],"targeting":[289],"may":[292],"be":[293],"therapeutic":[296],"strategy":[297],"limit":[299]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2020-08-03T00:00:00"}