{"id":"https://openalex.org/W3045557449","doi":"https://doi.org/10.1159/000508901","title":"Real-World Efficacy and Safety of Lenvatinib in Korean Patients with Advanced Hepatocellular Carcinoma: A Multicenter Retrospective Analysis","display_name":"Real-World Efficacy and Safety of Lenvatinib in Korean Patients with Advanced Hepatocellular Carcinoma: A Multicenter Retrospective Analysis","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3045557449","doi":"https://doi.org/10.1159/000508901","mag":"3045557449","pmid":"https://pubmed.ncbi.nlm.nih.gov/33083284","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7548882"},"language":"en","primary_location":{"id":"doi:10.1159/000508901","doi":"https://doi.org/10.1159/000508901","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000508901","pdf_url":null,"source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1159/000508901","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005245624","display_name":"Jaekyung Cheon","orcid":"https://orcid.org/0000-0001-8439-1739","observed_orcids":["https://orcid.org/0000-0001-8439-1739"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaekyung Cheon","raw_affiliation_strings":["Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-8439-1739","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066759908","display_name":"Hong Jae Chon","orcid":"https://orcid.org/0000-0002-6979-5812","observed_orcids":["https://orcid.org/0000-0002-6979-5812"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong\u00a0Jae Chon","raw_affiliation_strings":["Departments of Medical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046707493","display_name":"Yeong Hak Bang","orcid":"https://orcid.org/0000-0001-6544-6431","observed_orcids":["https://orcid.org/0000-0001-6544-6431"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeonghak Bang","raw_affiliation_strings":["Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039396082","display_name":"Neung Hwa Park","orcid":"https://orcid.org/0000-0002-5648-9189","observed_orcids":["https://orcid.org/0000-0002-5648-9189"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Neung\u00a0Hwa Park","raw_affiliation_strings":["Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001822288","display_name":"Jung Woo Shin","orcid":"https://orcid.org/0000-0001-7001-0341","observed_orcids":["https://orcid.org/0000-0001-7001-0341"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung\u00a0Woo Shin","raw_affiliation_strings":["Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089499718","display_name":"Kang Mo Kim","orcid":"https://orcid.org/0000-0002-3180-3178","observed_orcids":["https://orcid.org/0000-0002-3180-3178"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kang\u00a0Mo Kim","raw_affiliation_strings":["Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3180-3178","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018105181","display_name":"Han Chu Lee","orcid":"https://orcid.org/0000-0002-7631-4124","observed_orcids":["https://orcid.org/0000-0002-7631-4124"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han\u00a0Chu Lee","raw_affiliation_strings":["Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-7631-4124","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101989947","display_name":"Joo\u2010Ho Lee","orcid":"https://orcid.org/0000-0001-8499-664X","observed_orcids":["https://orcid.org/0000-0001-8499-664X"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jooho Lee","raw_affiliation_strings":["Departments of Gastroenterology and Hepatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gastroenterology and Hepatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090754319","display_name":"Changhoon Yoo","orcid":"https://orcid.org/0000-0002-1451-8455","observed_orcids":["https://orcid.org/0000-0002-1451-8455","https://orcid.org/0000-0003-3786-4403"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Changhoon Yoo","raw_affiliation_strings":["Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1451-8455","affiliations":[{"raw_affiliation_string":"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050625196","display_name":"Baek\u2010Yeol Ryoo","orcid":"https://orcid.org/0000-0002-9052-833X","observed_orcids":["https://orcid.org/0000-0002-9052-833X"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Baek-Yeol Ryoo","raw_affiliation_strings":["Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":5.3877,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.97437406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"5","first_page":"613","last_page":"624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.996999979019165},{"id":"https://openalex.org/keywords/advanced-hepatocellular-carcinoma","display_name":"advanced hepatocellular carcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/real-world-efficacy","display_name":"real-world efficacy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.652999997138977},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.7570000290870667},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8820000290870667},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.574999988079071},{"id":"https://openalex.org/keywords/korean-patients","display_name":"Korean patients","score":0.7900000214576721},{"id":"https://openalex.org/keywords/reflect-trial","display_name":"REFLECT trial","score":0.671999990940094},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6240000128746033},{"id":"https://openalex.org/keywords/clinical-experience","display_name":"clinical experience","score":0.30799999833106995},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.3779999911785126},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.9864159822463989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9004077315330505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7347596883773804},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.650719404220581},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4401792585849762},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4396665394306183},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.43664854764938354},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.3767765164375305},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34795480966567993}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1159/000508901","doi":"https://doi.org/10.1159/000508901","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000508901","pdf_url":null,"source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},{"id":"pmid:33083284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33083284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7548882","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7548882/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fd821f935fe4487089e6703fe5b24405","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fd821f935fe4487089e6703fe5b24405","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liver Cancer, Pp 1-12 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000508901","doi":"https://doi.org/10.1159/000508901","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000508901","pdf_url":null,"source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1971837077","https://openalex.org/W1994193851","https://openalex.org/W2019607817","https://openalex.org/W2046000826","https://openalex.org/W2110643890","https://openalex.org/W2119242310","https://openalex.org/W2120967735","https://openalex.org/W2141444851","https://openalex.org/W2147172608","https://openalex.org/W2277004004","https://openalex.org/W2339815406","https://openalex.org/W2502891277","https://openalex.org/W2528882804","https://openalex.org/W2616059838","https://openalex.org/W2787358630","https://openalex.org/W2796067155","https://openalex.org/W2800499107","https://openalex.org/W2883204623","https://openalex.org/W2888056309","https://openalex.org/W2905923080","https://openalex.org/W2912124024","https://openalex.org/W2915809836","https://openalex.org/W2921046410","https://openalex.org/W2945004896","https://openalex.org/W2953756046","https://openalex.org/W2961374124","https://openalex.org/W2985556259","https://openalex.org/W2999660492","https://openalex.org/W3000401463","https://openalex.org/W3016320614","https://openalex.org/W3017096042","https://openalex.org/W3021228866","https://openalex.org/W3172620927","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W4200535080","https://openalex.org/W3110464552","https://openalex.org/W3021228866","https://openalex.org/W3171160888","https://openalex.org/W3004732627","https://openalex.org/W2949278321","https://openalex.org/W3195352346","https://openalex.org/W4387377857","https://openalex.org/W3123141270","https://openalex.org/W3121032265"],"abstract_inverted_index":{"Introduction/Objective:":[0],"Lenvatinib":[1,73],"demonstrated":[2],"efficacy":[3],"and":[4,29,67,84,108,117,168,197,204,221,228,253,275],"safety":[5],"in":[6,13,23,46,150,277],"patients":[7,24,57,88,111,121,179],"with":[8,58,62,91,181],"advanced":[9,59],"hepatocellular":[10],"carcinoma":[11],"(HCC)":[12],"the":[14,21,77,100,132,136,140,146,212],"randomized":[15],"phase":[16],"III":[17],"REFLECT":[18,133],"trial.":[19,134],"Considering":[20],"discrepancies":[22],"between":[25,64],"clinical":[26],"trial":[27],"data":[28],"daily":[30],"practice,":[31],"an":[32],"account":[33],"of":[34,55,102,104],"practical":[35],"experience":[36],"is":[37],"needed.":[38],"Methods:":[39],"We":[40],"conducted":[41],"a":[42],"multicenter":[43],"retrospective":[44],"analysis":[45],"which":[47],"3":[48],"tertiary":[49],"referral":[50],"centers":[51],"participated.":[52],"A":[53,116,138],"total":[54],"92":[56],"HCC":[60,280],"treated":[61,90,180],"lenvatinib":[63,183,191,268],"September":[65],"2018":[66],"January":[68],"2020":[69],"were":[70,112,199,223,241],"analyzed.":[71],"Results:":[72],"was":[74,154,160,172,269],"used":[75],"as":[76,114],"first-line":[78,182],"therapy":[79,94],"for":[80,85,178],"67":[81],"(72.8%)":[82],"patients,":[83],"25":[86],"(27.2%)":[87],"previously":[89],"other":[92],"systemic":[93],"including":[95],"immune":[96],"checkpoint":[97],"inhibitors.":[98],"At":[99],"time":[101],"initiation":[103],"lenvatinib,":[105],"74":[106],"(80.4%)":[107],"18":[109],"(19.6%)":[110],"classified":[113],"Child-Pugh":[115,137,213],"B,":[118],"respectively.":[119,210,234],"Thirty-five":[120],"(38.0%)":[122],"had":[123],"extensive":[124],"disease":[125],"that":[126],"would":[127],"have":[128],"excluded":[129],"them":[130],"from":[131],"In":[135,211,264],"group,":[139],"response":[141],"rate":[142],"graded":[143],"according":[144],"to":[145,271],"Response":[147],"Evaluation":[148],"Criteria":[149],"Solid":[151],"Tumors":[152],"v1.1":[153],"21.1%,":[155],"median":[156,195,219],"progression-free":[157],"survival":[158,170],"(PFS)":[159],"4.6":[161],"(95%":[162,174,201,206,225,230],"confidence":[163],"interval":[164],"[CI]":[165],"3.1\u20136.1)":[166],"months,":[167,209,233],"overall":[169],"(OS)":[171],"10.7":[173],"CI":[175,202,207,226,231],"4.8\u201316.5)":[176],"months":[177],"(n":[184,192,216,243,249,255],"=":[185,193,217,244,250,256],"57).":[186],"With":[187],"second-":[188],"or":[189],"later-line":[190],"17),":[194],"PFS":[196,220],"OS":[198,222],"4.1":[200],"3.1\u20135.1)":[203],"6.4":[205],"5.1\u20137.7)":[208],"B":[214],"group":[215],"18),":[218],"2.6":[224],"0.6\u20134.6)":[227],"5.3":[229],"2.0\u20138.5)":[232],"The":[235],"most":[236],"common":[237],"grade":[238],"3\u20134":[239],"toxicities":[240],"hyperbilirubinemia":[242],"8;":[245],"8.7%),":[246],"AST":[247],"elevation":[248],"6;":[251],"6.5%),":[252],"diarrhea":[254],"5;":[257],"5.4%)":[258],"across":[259],"all":[260],"study":[261],"patients.":[262],"Conclusions:":[263],"this":[265],"real-world":[266],"study,":[267],"found":[270],"be":[272],"well":[273],"tolerated":[274],"effective":[276],"more":[278],"heterogeneous":[279],"patient":[281],"populations.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-03T00:00:00"}
