{"id":"https://openalex.org/W3045545314","doi":"https://doi.org/10.1073/pnas.2004372117","title":"Kinetically distinct processing pathways diversify the CD8 + T cell response to a single viral epitope","display_name":"Kinetically distinct processing pathways diversify the CD8 + T cell response to a single viral epitope","publication_year":2020,"publication_date":"2020-07-27","ids":{"openalex":"https://openalex.org/W3045545314","doi":"https://doi.org/10.1073/pnas.2004372117","mag":"3045545314","pmid":"https://pubmed.ncbi.nlm.nih.gov/32719124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7430976"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2004372117","doi":"https://doi.org/10.1073/pnas.2004372117","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2004372117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7430976","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025145135","display_name":"Gabriela L. Cosma","orcid":"https://orcid.org/0000-0003-4612-348X","observed_orcids":["https://orcid.org/0000-0003-4612-348X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela L. Cosma","raw_affiliation_strings":["Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;","Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;"],"raw_orcid":"https://orcid.org/0000-0003-4612-348X","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015442970","display_name":"Jenna L Lobby","orcid":"https://orcid.org/0000-0002-1395-2583","observed_orcids":["https://orcid.org/0000-0002-1395-2583"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna L. Lobby","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;"],"raw_orcid":"https://orcid.org/0000-0002-1395-2583","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070756331","display_name":"Elizabeth J. Fay","orcid":"https://orcid.org/0000-0003-1712-757X","observed_orcids":["https://orcid.org/0000-0003-1712-757X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Fay","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046312271","display_name":"Nicholas Anthony Siciliano","orcid":"https://orcid.org/0009-0002-2971-0009","observed_orcids":["https://orcid.org/0009-0002-2971-0009"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Siciliano","raw_affiliation_strings":["Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009461787","display_name":"Ryan Andrew Langlois","orcid":"https://orcid.org/0000-0002-0515-571X","observed_orcids":["https://orcid.org/0000-0002-0515-571X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Langlois","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455;"],"raw_orcid":"https://orcid.org/0000-0002-0515-571X","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055438317","display_name":"Laurence Crane Eisenlohr","orcid":"https://orcid.org/0000-0002-8475-7910","observed_orcids":["https://orcid.org/0000-0002-8475-7910"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laurence C. Eisenlohr","raw_affiliation_strings":["Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;","Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;","Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-8475-7910","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055438317"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I149251103","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.6016,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62351936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"117","issue":"32","first_page":"19399","last_page":"19407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.807750940322876},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.7105064988136292},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.678575336933136},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6317467093467712},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.5805938243865967},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5786174535751343},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5159231424331665},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.512122392654419},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5049403309822083},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.48240411281585693},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4775344133377075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4739244878292084},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4334460198879242},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42762404680252075},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34847211837768555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34502553939819336},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26396816968917847},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2515983283519745},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.24560046195983887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21994176506996155},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11696341633796692},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2004372117","doi":"https://doi.org/10.1073/pnas.2004372117","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2004372117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6739623","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7430976","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7430976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7430976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:32719124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32719124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6739623","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7430976","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5142191982","display_name":null,"funder_award_id":"RO1 AI10056103","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8479729262","display_name":"Mechanisms and consequences of epithelial cell survival from influenza virus infection.","funder_award_id":"R01AI132962","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000889659","display_name":"Immunology Training Program","funder_award_id":"T32AI007313","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W148249900","https://openalex.org/W236267061","https://openalex.org/W1482666345","https://openalex.org/W1488666711","https://openalex.org/W1511501520","https://openalex.org/W1514133345","https://openalex.org/W1514695246","https://openalex.org/W1514863737","https://openalex.org/W1517755581","https://openalex.org/W1527289043","https://openalex.org/W1542030293","https://openalex.org/W1628290415","https://openalex.org/W1925735392","https://openalex.org/W1932862612","https://openalex.org/W1965085113","https://openalex.org/W1967219468","https://openalex.org/W1973635674","https://openalex.org/W1981318444","https://openalex.org/W1987668067","https://openalex.org/W1989125189","https://openalex.org/W1990806106","https://openalex.org/W2006629564","https://openalex.org/W2012057388","https://openalex.org/W2012137725","https://openalex.org/W2012265138","https://openalex.org/W2014430462","https://openalex.org/W2021676181","https://openalex.org/W2023563008","https://openalex.org/W2029220273","https://openalex.org/W2034764834","https://openalex.org/W2038620796","https://openalex.org/W2039027426","https://openalex.org/W2046760991","https://openalex.org/W2062813693","https://openalex.org/W2065596124","https://openalex.org/W2086069231","https://openalex.org/W2089822384","https://openalex.org/W2093539004","https://openalex.org/W2095353797","https://openalex.org/W2104011738","https://openalex.org/W2110202168","https://openalex.org/W2116445116","https://openalex.org/W2116650389","https://openalex.org/W2117111409","https://openalex.org/W2121076324","https://openalex.org/W2129574945","https://openalex.org/W2146239407","https://openalex.org/W2149851166","https://openalex.org/W2150286046","https://openalex.org/W2152542101","https://openalex.org/W2155548828","https://openalex.org/W2158997720","https://openalex.org/W2159046366","https://openalex.org/W2165341516","https://openalex.org/W2179438021","https://openalex.org/W2262506123","https://openalex.org/W2289054941","https://openalex.org/W2310062606","https://openalex.org/W2580169875","https://openalex.org/W2611366899","https://openalex.org/W2743010030","https://openalex.org/W2753357806","https://openalex.org/W2777469091","https://openalex.org/W2794708707","https://openalex.org/W2795300196","https://openalex.org/W2886379694","https://openalex.org/W2886867089","https://openalex.org/W2919425005","https://openalex.org/W2937493411","https://openalex.org/W2981904272","https://openalex.org/W4313333876","https://openalex.org/W4313422268"],"related_works":["https://openalex.org/W7023843817","https://openalex.org/W1781159025","https://openalex.org/W2115543775","https://openalex.org/W2107426217","https://openalex.org/W7096625986","https://openalex.org/W2003529032","https://openalex.org/W2098039852","https://openalex.org/W7100915616","https://openalex.org/W2059907123","https://openalex.org/W2013110475"],"abstract_inverted_index":{"Significance":[0],"CD8":[1,92,111],"+":[2,93,112],"T":[3,94,113],"cells":[4],"eliminate":[5],"infections":[6],"and":[7,54,57,71,89,97],"cancers":[8],"through":[9],"recognition":[10],"of":[11,106],"antigen-derived":[12],"peptides":[13],"displayed":[14],"at":[15],"the":[16,39,46,67,83],"cell":[17,84,95],"surface":[18,85],"in":[19],"combination":[20],"with":[21,86],"MHC":[22],"class":[23],"I":[24],"molecules.":[25],"We":[26],"show":[27],"that":[28,42,63],"a":[29,49],"single":[30],"glycoprotein-derived":[31],"epitope":[32],"is":[33,43,64,80],"generated":[34],"from":[35,77],"two":[36],"sources:":[37],"1)":[38],"conventional":[40],"cohort":[41],"delivered":[44,81],"to":[45,66,82,109],"endoplasmic":[47],"reticulum,":[48],"fraction":[50,62],"failing":[51],"quality":[52],"control":[53],"undergoing":[55],"ERAD,":[56],"2)":[58],"an":[59],"exceedingly":[60],"minor":[61],"mislocalized":[65,78],"cytosol":[68],"during":[69],"translation":[70],"immediately":[72],"degraded.":[73],"Notably,":[74],"peptide":[75],"derived":[76],"antigen":[79],"faster":[87],"kinetics":[88],"drives":[90],"greater":[91],"expansion":[96],"functionality.":[98],"These":[99],"findings":[100],"provide":[101],"key":[102],"insights":[103],"for":[104],"development":[105],"vaccines":[107],"intended":[108],"elicit":[110],"cell-mediated":[114],"protection.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-03T00:00:00"}
