{"id":"https://openalex.org/W3045471086","doi":null,"title":"How to interprete subclinical thyroid dysfunction in the prevention and management of heart failure events? Individual participant data analysis from six prospective cohorts","display_name":"How to interprete subclinical thyroid dysfunction in the prevention and management of heart failure events? Individual participant data analysis from six prospective cohorts","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W3045471086","mag":"3045471086"},"language":"en","primary_location":{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3015817","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/117149","pdf_url":"http://hdl.handle.net/1887/117149","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, 33, 332 - 332","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1887/117149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086449617","display_name":"Bari\u015f Gencer","orcid":"https://orcid.org/0000-0002-8954-9694","observed_orcids":["https://orcid.org/0000-0002-8954-9694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bari\u015f Gencer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8954-9694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063842125","display_name":"Tinh\u2010Hai Collet","orcid":"https://orcid.org/0000-0002-3243-1222","observed_orcids":["https://orcid.org/0000-0002-3243-1222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tinh\u2010Hai Collet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3243-1222","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482910","display_name":"Vanessa S. Virgini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanessa Virgini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027941695","display_name":"Diana Bauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Bauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013373829","display_name":"Jacobijn Gussekloo","orcid":"https://orcid.org/0000-0001-7186-8278","observed_orcids":["https://orcid.org/0000-0001-7186-8278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacobijn Gussekloo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7186-8278","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056927598","display_name":"Anne Rentoumis Cappola","orcid":"https://orcid.org/0000-0002-0883-9754","observed_orcids":["https://orcid.org/0000-0002-0883-9754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Rentoumis Cappola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0883-9754","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056089291","display_name":"Massimo Iacoviello","orcid":"https://orcid.org/0000-0001-9613-5062","observed_orcids":["https://orcid.org/0000-0001-9613-5062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Iacoviello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9613-5062","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040307802","display_name":"Kay\u2010Tee Khaw","orcid":"https://orcid.org/0000-0002-8802-2903","observed_orcids":["https://orcid.org/0000-0002-8802-2903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.\u2010T. Khaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036223262","display_name":"R.D.J. Westendorp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.D.J. Westendorp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028632973","display_name":"Nicolas Rodondi","orcid":"https://orcid.org/0000-0001-9083-6896","observed_orcids":["https://orcid.org/0000-0001-9083-6896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Rodondi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9083-6896","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47239493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":null,"first_page":"332","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-thyroid-dysfunction","display_name":"subclinical thyroid dysfunction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7260000109672546},{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/subclinical-hyperthyroidism","display_name":"subclinical hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/tsh-levels","display_name":"TSH levels","score":0.8199999928474426},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/heart-failure-mortality","display_name":"heart failure mortality","score":0.9419999718666077},{"id":"https://openalex.org/keywords/thyroid-function-tests","display_name":"thyroid function tests","score":0.656000018119812},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9812948107719421},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.8515030145645142},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5814794898033142},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.570003867149353},{"id":"https://openalex.org/C2994032529","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid dysfunction","level":3,"score":0.43469002842903137},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3959146738052368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3437303900718689},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3362199664115906},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3216385245323181}],"mesh":[],"locations_count":7,"locations":[{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3015817","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/117149","pdf_url":"http://hdl.handle.net/1887/117149","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, 33, 332 - 332","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940754011002711","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/117149","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/117149/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, Vol. 33, p. 332-332","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3015817","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/117149","pdf_url":"https://hdl.handle.net/1887/117149","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:iris.unil.ch:iris/254461","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/254461","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference output"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/117149","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/117149","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"33","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:serval.unil.ch:BIB_E136B69AEC94","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_E136B69AEC94","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Congress of the European-Society-of-Cardiology (ESC), vol. 33, pp. 332","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:3045471086","doi":null,"is_oa":false,"landing_page_url":"https://www.narcis.nl/publication/RecordID/oai%3Ascholarlypublications.universiteitleiden.nl%3Aitem_3015817","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal","raw_type":null}],"best_oa_location":{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3015817","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/117149","pdf_url":"http://hdl.handle.net/1887/117149","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal, 33, 332 - 332","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045471086.pdf","grobid_xml":"https://content.openalex.org/works/W3045471086.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000333200","https://openalex.org/W179414209","https://openalex.org/W2947558834","https://openalex.org/W4285335496","https://openalex.org/W2008420499","https://openalex.org/W2302515435","https://openalex.org/W2110776403","https://openalex.org/W2038464170","https://openalex.org/W2117664343","https://openalex.org/W4405286697"],"abstract_inverted_index":{"Background:":[0],"Guidelines":[1],"of":[2,7,23,47,63,74,149,228,263],"the":[3,32,83,259],"Diagnosis":[4],"and":[5,38,60,86,101,138,145,157,197,206,236,245,261],"Management":[6],"Heart":[8],"Failure":[9],"(HF)":[10],"recommend":[11],"investigating":[12],"exacerbating":[13],"conditions,":[14],"such":[15],"as":[16,91,97,104,118],"thyroid":[17,36,57],"dysfunction,":[18],"but":[19],"without":[20],"specifying":[21],"impact":[22],"different":[24],"TSH":[25,92,98,105,159,176,183,190,203,211,238,242,247,256],"levels.":[26,113],"Limited":[27],"prospective":[28,54,80],"data":[29,50,67],"exist":[30],"regarding":[31],"association":[33],"between":[34],"subclinical":[35,95,102,135,140],"dysfunction":[37],"HF":[39,64,114,120,127,150,229],"events.":[40,65,128],"Methods:":[41],"We":[42],"performed":[43],"a":[44],"pooled":[45],"analysis":[46],"individual":[48],"participant":[49],"using":[51],"all":[52],"available":[53],"cohorts":[55,81],"with":[56,71,109,154,233],"function":[58],"tests":[59],"subsequent":[61],"follow-up":[62,75],"Individual":[66],"on":[68],"25,390":[69,131],"participants":[70],"216,247":[72],"person-years":[73],"were":[76,116,152,231],"supplied":[77],"from":[78],"6":[79],"in":[82,258],"United":[84],"States":[85],"Europe.":[87],"Euthyroidism":[88],"was":[89,168,198],"defined":[90,117],"0.45-4.49":[93],"mIU/L,":[94,107,178,185],"hypothyroidism":[96,136],"4.5-19.9":[99],"mIU/L":[100,205,213,244],"hyperthyroidism":[103,141],"<0.45":[106],"both":[108,155,234],"normal":[110],"free":[111],"thyroxine":[112],"events":[115,151,230],"acute":[119],"events,":[121],"hospitalization":[122],"or":[123],"death":[124],"related":[125],"to":[126,254],"Results:":[129],"Among":[130],"participants,":[132],"2068":[133],"had":[134],"(8.1%)":[137],"648":[139],"(2.6%).":[142],"In":[143],"age-":[144],"gender-adjusted":[146],"analyses,":[147],"risks":[148],"increased":[153,232],"higher":[156,235],"lower":[158,237],"levels":[160,257],"(P":[161,193,214],"for":[162,175,182,189,194,202,210,215,222,241,246],"quadratic":[163],"pattern<0.01):":[164],"hazard":[165],"ratio":[166],"(HR)":[167],"1.01":[169],"(95%":[170],"confidence":[171],"interval":[172],"[CI]":[173],"0.81-1.26)":[174],"4.5-6.9":[177],"1.65":[179],"(CI":[180,187,200,208],"0.84-3.23)":[181],"7.0-9.9":[184],"1.86":[186],"1.27-2.72)":[188],"10.0-19.9":[191],"mIUL/L":[192],"trend":[195],"<0.01),":[196],"1.31":[199],"0.88-1.95)":[201],"0.10-0.44":[204],"1.94":[207],"1.01-3.72)":[209],"<0.10":[212,248],"trend=0.047).":[216],"Risks":[217,227],"remained":[218],"similar":[219],"after":[220],"adjustment":[221],"cardiovascular":[223],"risk":[224],"factors.":[225],"Conclusion:":[226],"levels,":[239],"particularly":[240],"\u226510":[243],"mIU/L.":[249],"Our":[250],"findings":[251],"might":[252],"help":[253],"interpret":[255],"prevention":[260],"investigation":[262],"HF.":[264]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-07-29T00:00:00"}
