{"id":"https://openalex.org/W3045405384","doi":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","title":"Effectiveness of angiotensin receptor inhibitors and non-lysine in functional mitral regurgitation","display_name":"Effectiveness of angiotensin receptor inhibitors and non-lysine in functional mitral regurgitation","publication_year":2020,"publication_date":"2020-07-15","ids":{"openalex":"https://openalex.org/W3045405384","doi":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","mag":"3045405384"},"language":"en","primary_location":{"id":"doi:10.30629/0023-2149-2020-98-2-106-114","doi":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","is_oa":true,"landing_page_url":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","pdf_url":"https://www.clinmedjournal.com/jour/article/download/19/19","source":{"id":"https://openalex.org/S2752393482","display_name":"Clinical Medicine (Russian Journal)","issn_l":"0023-2149","issn":["0023-2149","2412-1339"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320238","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310320238"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine (Russian Journal)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.clinmedjournal.com/jour/article/download/19/19","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078974836","display_name":"\u0420\u044f\u0437\u0430\u043d\u043e\u0432 \u0410\u043b\u0435\u043a\u0441\u0435\u0439 \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-2823-7774","observed_orcids":["https://orcid.org/0000-0003-2823-7774","https://orcid.org/0000-0001-9574-6021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. S. Ryazanov","raw_affiliation_strings":["Clinical and Diagnostic Center No. 4 \u043ef the Moscow Department of health"],"raw_orcid":"https://orcid.org/0000-0003-2823-7774","affiliations":[{"raw_affiliation_string":"Clinical and Diagnostic Center No. 4 \u043ef the Moscow Department of health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062563956","display_name":"Konstantin I. Kapitonov","orcid":"https://orcid.org/0000-0002-2750-0852","observed_orcids":["https://orcid.org/0000-0002-2750-0852"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K. I. Kapitonov","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University of Ministry \u043ef Health \u043ef Russia (Sechenov University)"],"raw_orcid":"https://orcid.org/0000-0002-2750-0852","affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University of Ministry \u043ef Health \u043ef Russia (Sechenov University)","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020615043","display_name":"\u041c\u0430\u043a\u0430\u0440\u043e\u0432\u0441\u043a\u0430\u044f \u041c\u0430\u0440\u0438\u044f \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-2313-2159","observed_orcids":["https://orcid.org/0000-0002-2313-2159"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. V. Makarovskaya","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University of Ministry \u043ef Health \u043ef Russia (Sechenov University)"],"raw_orcid":"https://orcid.org/0000-0002-2313-2159","affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University of Ministry \u043ef Health \u043ef Russia (Sechenov University)","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073116147","display_name":"Alexey A. Kudryavtsev","orcid":"https://orcid.org/0000-0001-8294-5136","observed_orcids":["https://orcid.org/0000-0001-8294-5136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Kudryavtsev","raw_affiliation_strings":["Clinical and Diagnostic Center No. 4 \u043ef the Moscow Department of health"],"raw_orcid":"https://orcid.org/0000-0001-8294-5136","affiliations":[{"raw_affiliation_string":"Clinical and Diagnostic Center No. 4 \u043ef the Moscow Department of health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"2","first_page":"106","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9340000152587891},{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":1.0},{"id":"https://openalex.org/keywords/secondary-mitral-regurgitation","display_name":"functional mitral regurgitation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8140000104904175},{"id":"https://openalex.org/keywords/neprilysin-inhibition","display_name":"neprilysin inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.7689999938011169},{"id":"https://openalex.org/keywords/left-ventricular-volume","display_name":"left ventricular volume","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mitral-valve-closure","display_name":"mitral valve closure","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.9403061866760254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8935412764549255},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7282067537307739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7133738994598389},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7053101062774658},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.6301982998847961},{"id":"https://openalex.org/C2909944400","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Functional mitral regurgitation","level":4,"score":0.4957979619503021},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4530676007270813},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.44900235533714294},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.4271990656852722},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42369064688682556},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4157341718673706},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4149557948112488},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.1650051772594452}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30629/0023-2149-2020-98-2-106-114","doi":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","is_oa":true,"landing_page_url":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","pdf_url":"https://www.clinmedjournal.com/jour/article/download/19/19","source":{"id":"https://openalex.org/S2752393482","display_name":"Clinical Medicine (Russian Journal)","issn_l":"0023-2149","issn":["0023-2149","2412-1339"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320238","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310320238"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine (Russian Journal)","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30629/0023-2149-2020-98-2-106-114","doi":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","is_oa":true,"landing_page_url":"https://doi.org/10.30629/0023-2149-2020-98-2-106-114","pdf_url":"https://www.clinmedjournal.com/jour/article/download/19/19","source":{"id":"https://openalex.org/S2752393482","display_name":"Clinical Medicine (Russian Journal)","issn_l":"0023-2149","issn":["0023-2149","2412-1339"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320238","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310320238"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine (Russian Journal)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045405384.pdf","grobid_xml":"https://content.openalex.org/works/W3045405384.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1994696840","https://openalex.org/W2001417292","https://openalex.org/W2054436867","https://openalex.org/W2078395346","https://openalex.org/W2102751471","https://openalex.org/W2109088822","https://openalex.org/W2113698123","https://openalex.org/W2119340816","https://openalex.org/W2120749120","https://openalex.org/W2127821952","https://openalex.org/W2135521686","https://openalex.org/W2143094666","https://openalex.org/W2151173136","https://openalex.org/W2155091700","https://openalex.org/W2160995044","https://openalex.org/W2299395117","https://openalex.org/W2310782429","https://openalex.org/W2322644991","https://openalex.org/W2396319370","https://openalex.org/W2789252278","https://openalex.org/W2886220148","https://openalex.org/W4238907867"],"related_works":["https://openalex.org/W3116962238","https://openalex.org/W2920977137","https://openalex.org/W4362710119","https://openalex.org/W4313986280","https://openalex.org/W2905337999","https://openalex.org/W7160704032","https://openalex.org/W7131124118","https://openalex.org/W4411541258","https://openalex.org/W4384470633","https://openalex.org/W4408848514"],"abstract_inverted_index":{"Objective:":[0],"sacubitrile/valsartan":[1,34,132,168],"is":[2],"superior":[3],"to":[4,16,39,57,171],"valsartan":[5,36,137,173],"in":[6,37,68,84,118,130,135,150,166,195,228,231],"modifying":[7],"functional":[8,54,244,271],"mitral":[9,113,203],"regurgitation":[10,74,124,161],"(MR)":[11],"for":[12,43,261],"the":[13,17,21,69,73,77,85,89,94,97,102,106,112,119,123,131,136,151,167,172,191,196,202,209,212,215,229,235],"better":[14],"thanks":[15],"double":[18],"inhibition":[19],"of":[20,72,87,93,101,108,111,122,198,201,211,214,265],"renin-angiotensin":[22],"and":[23,27,105,205,256,270],"neprilysin":[24,257],"system.":[25],"Material":[26],"methods.":[28],"This":[29],"double-blind":[30],"study":[31],"randomly":[32],"assigned":[33],"or":[35],"addition":[38],"standard":[40],"drug":[41,263],"therapy":[42],"heart":[44,50,268],"failure":[45,51,269],"among":[46],"90":[47,157],"patients":[48,158,241,266],"with":[49,52,208,242,267],"chronic":[53],"MR":[55,248],"(secondary":[56],"left":[58,95,103],"ventricular":[59],"(LV)":[60],"dysfunction).":[61],"The":[62,116,160],"primary":[63],"endpoint":[64],"was":[65,126],"a":[66],"change":[67,230],"effective":[70,120],"area":[71,107,121,197],"hole":[75,125],"during":[76],"12-month":[78],"follow-up.":[79],"Secondary":[80],"endpoints":[81],"included":[82,156],"changes":[83,194],"volume":[86,92,100,162,219],"regurgitation,":[88],"final":[90,98,216],"systolic":[91],"ventricle,":[96,104],"diastolic":[99,218],"incomplete":[109,199],"closure":[110,200],"valves.":[114],"Results.":[115],"decrease":[117],"significantly":[127,164],"more":[128,249],"pronounced":[129],"group":[133,138,169,174],"than":[134,250],"(\u20130.048":[139],"\u00b1":[140,144],"0.095":[141],"vs":[142],"\u20130.012":[143],"0.105":[145],"cm2;":[146],"p":[147,182],"=":[148,183,221],"0.032)":[149],"treatment":[152,237,264],"efficacy":[153],"analysis,":[154],"which":[155],"(100%).":[159],"also":[163],"decreased":[165],"compared":[170],"(mean":[175],"difference":[176],"\u20137.3":[177],"ml;":[178],"95%":[179],"CI":[180],"12.6\u20131.9;":[181],"0.009).":[184],"There":[185,223],"were":[186,224],"no":[187,225],"significant":[188,226],"differences":[189,227],"between":[190,234],"groups":[192],"regarding":[193],"valves":[204],"LV":[206,217],"volumes,":[207],"exception":[210],"index":[213],"(\u0440":[220],"0.044).":[222],"blood":[232],"pressure":[233],"two":[236],"groups.":[238],"Conclusion.":[239],"Among":[240],"secondary":[243],"MR,":[245],"sakubitril/valsartan":[246],"reduced":[247],"valsartan.":[251],"Thus,":[252],"angiotensin":[253],"receptor":[254],"inhibitors":[255],"can":[258],"be":[259],"considered":[260],"optimal":[262],"MR.":[272]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-07-29T00:00:00"}