{"id":"https://openalex.org/W3045396391","doi":"https://doi.org/10.1093/chromsci/bmaa031","title":"Stability-Indicating RP-HPLC and CE Methods for Simultaneous Determination of Bisoprolol and Perindopril in Pharmaceutical Formulation: A Comparative Study","display_name":"Stability-Indicating RP-HPLC and CE Methods for Simultaneous Determination of Bisoprolol and Perindopril in Pharmaceutical Formulation: A Comparative Study","publication_year":2020,"publication_date":"2020-06-05","ids":{"openalex":"https://openalex.org/W3045396391","doi":"https://doi.org/10.1093/chromsci/bmaa031","mag":"3045396391","pmid":"https://pubmed.ncbi.nlm.nih.gov/32705119"},"language":"en","primary_location":{"id":"doi:10.1093/chromsci/bmaa031","doi":"https://doi.org/10.1093/chromsci/bmaa031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chromsci/bmaa031","pdf_url":null,"source":{"id":"https://openalex.org/S144192255","display_name":"Journal of Chromatographic Science","issn_l":"0021-9665","issn":["0021-9665","1945-239X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatographic Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091775498","display_name":"Said A. Hassan","orcid":"https://orcid.org/0000-0002-4766-0255","observed_orcids":["https://orcid.org/0000-0002-4766-0255"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Said A Hassan","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078292721","display_name":"Nancy W. Nashat","orcid":"https://orcid.org/0000-0001-6859-6371","observed_orcids":["https://orcid.org/0000-0001-6859-6371"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Nancy W Nashat","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-6859-6371","affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058361723","display_name":"Mohamed R. Elghobashy","orcid":"https://orcid.org/0000-0003-0383-2091","observed_orcids":["https://orcid.org/0000-0003-0383-2091"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed R Elghobashy","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102749369","display_name":"Samah Sayed Abbas","orcid":"https://orcid.org/0000-0002-9089-9114","observed_orcids":["https://orcid.org/0000-0002-9089-9114","https://orcid.org/0000-0003-4801-1705"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samah S Abbas","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012477222","display_name":"Azza A. Moustafa","orcid":"https://orcid.org/0000-0001-8609-9440","observed_orcids":["https://orcid.org/0000-0001-8609-9440"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Azza A Moustafa","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078292721"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":4822,"currency":"USD","value_usd":4822},"apc_paid":null,"fwci":1.4239,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76752523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58","issue":"8","first_page":"747","last_page":"758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisoprolol","display_name":"bisoprolol","score":1.0},{"id":"https://openalex.org/keywords/perindopril","display_name":"perindopril","score":1.0},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.8949999809265137},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pharmaceutical-impurities","display_name":"drug impurities","score":0.734000027179718},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.6899999976158142},{"id":"https://openalex.org/keywords/capillary-electrophoresis","display_name":"capillary electrophoresis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/reversed-phase-hplc","display_name":"reversed-phase HPLC","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2779670145","wikidata":"https://www.wikidata.org/wiki/Q412515","display_name":"Bisoprolol","level":3,"score":0.9351789355278015},{"id":"https://openalex.org/C2779200603","wikidata":"https://www.wikidata.org/wiki/Q277785","display_name":"Perindopril","level":3,"score":0.9105651378631592},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8660030961036682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8495306372642517},{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.7781463861465454},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6668680906295776},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.5625911951065063},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.5192704200744629},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.4923323392868042},{"id":"https://openalex.org/C45188465","wikidata":"https://www.wikidata.org/wiki/Q645497","display_name":"Reversed-phase chromatography","level":3,"score":0.3399162292480469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/chromsci/bmaa031","doi":"https://doi.org/10.1093/chromsci/bmaa031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chromsci/bmaa031","pdf_url":null,"source":{"id":"https://openalex.org/S144192255","display_name":"Journal of Chromatographic Science","issn_l":"0021-9665","issn":["0021-9665","1945-239X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatographic Science","raw_type":"journal-article"},{"id":"pmid:32705119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32705119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatographic science","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W13604522","https://openalex.org/W639767525","https://openalex.org/W647101430","https://openalex.org/W951010298","https://openalex.org/W965163634","https://openalex.org/W1972540349","https://openalex.org/W1983311529","https://openalex.org/W1988531659","https://openalex.org/W1992814088","https://openalex.org/W2031876598","https://openalex.org/W2033768472","https://openalex.org/W2042885652","https://openalex.org/W2045035334","https://openalex.org/W2046131182","https://openalex.org/W2055503119","https://openalex.org/W2059650274","https://openalex.org/W2061369270","https://openalex.org/W2078110876","https://openalex.org/W2098037894","https://openalex.org/W2098528610","https://openalex.org/W2119813631","https://openalex.org/W2152715447","https://openalex.org/W2181772198","https://openalex.org/W2315035451","https://openalex.org/W2331776179","https://openalex.org/W2476592727","https://openalex.org/W2572233533","https://openalex.org/W2587566178","https://openalex.org/W2594986899","https://openalex.org/W2752034641","https://openalex.org/W2794127837","https://openalex.org/W2883173767","https://openalex.org/W2894142707","https://openalex.org/W4254944834","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2572169789","https://openalex.org/W4414424062","https://openalex.org/W6949420222","https://openalex.org/W4296571137","https://openalex.org/W7128298702","https://openalex.org/W149416456","https://openalex.org/W4415277053","https://openalex.org/W4362456557","https://openalex.org/W2319261284","https://openalex.org/W7100020132"],"abstract_inverted_index":{"Two":[0],"fast,":[1],"accurate":[2],"and":[3,9,18,57,84,95,101,127,169],"selective":[4],"stability-indicating":[5],"methods":[6,108],"were":[7,53,61,109,161],"developed":[8],"validated":[10,110],"for":[11,82,99],"the":[12,39,49,71,89,113,130,134,152,157,165],"simultaneous":[13],"determination":[14,132,166],"of":[15,20,48,91,133,167],"bisoprolol,":[16],"perindopril":[17,85,144,170],"three":[19,148],"their":[21,172],"possible":[22],"degradation":[23,51,136],"products.":[24,137],"The":[25,46,80,106,119],"first":[26],"proposed":[27,107],"method":[28,121],"was":[29,41,86,140],"a":[30,42,67,75],"gradient":[31],"reversed":[32],"phase-high-performance":[33],"liquid":[34],"chromatography":[35],"(HPLC)":[36],"method,":[37],"whereas":[38],"second":[40],"capillary":[43,102],"electrophoresis":[44,103],"method.":[45],"structures":[47],"obtained":[50,135],"products":[52],"elucidated":[54],"using":[55],"infrared":[56],"mass":[58],"spectrometry.":[59],"They":[60,160],"also":[62],"confirmed":[63],"to":[64,77,112,123,142,147],"be":[65,124],"either":[66],"drug":[68],"impurity":[69,145],"in":[70,88,129,164,171],"British":[72,158],"Pharmacopoeia":[73],"or":[74],"precursor":[76],"such":[78],"impurity.":[79],"linearity":[81],"bisoprolol":[83,168],"achieved":[87],"range":[90],"1-20":[92],"\u03bcg":[93,97],"mL-1":[94,98],"5-30":[96],"HPLC":[100,120],"methods,":[104],"respectively.":[105],"according":[111],"International":[114],"Conference":[115],"on":[116],"Harmonisation":[117],"guidelines.":[118],"proved":[122],"more":[125],"sensitive":[126],"succeeded":[128],"quantitative":[131],"Also,":[138],"it":[139],"able":[141],"quantify":[143],"up":[146],"times":[149],"lower":[150],"than":[151],"desired":[153],"limit":[154],"set":[155],"by":[156],"Pharmacopoeia.":[159],"successfully":[162],"employed":[163],"combined":[173],"pharmaceutical":[174],"formulation.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-29T00:00:00"}