{"id":"https://openalex.org/W3045275291","doi":"https://doi.org/10.3390/cancers12082047","title":"The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF\u03b2 Signaling","display_name":"The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF\u03b2 Signaling","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3045275291","doi":"https://doi.org/10.3390/cancers12082047","mag":"3045275291","pmid":"https://pubmed.ncbi.nlm.nih.gov/32722292"},"language":"en","primary_location":{"id":"doi:10.3390/cancers12082047","doi":"https://doi.org/10.3390/cancers12082047","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12082047","pdf_url":"https://www.mdpi.com/2072-6694/12/8/2047/pdf?version=1596199360","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/12/8/2047/pdf?version=1596199360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079241590","display_name":"Athanasios Pseftogas","orcid":"https://orcid.org/0000-0002-6165-8119","observed_orcids":["https://orcid.org/0000-0002-6165-8119"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Athanasios Pseftogas","raw_affiliation_strings":["Division of Experimental Oncology, IRCCS Istituto Scientfico San Raffaele, 20132, Milan, Italy","School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-6165-8119","affiliations":[{"raw_affiliation_string":"Division of Experimental Oncology, IRCCS Istituto Scientfico San Raffaele, 20132, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090489004","display_name":"Konstantinos Xanthopoulos","orcid":"https://orcid.org/0000-0001-8759-8962","observed_orcids":["https://orcid.org/0000-0001-8759-8962"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Xanthopoulos","raw_affiliation_strings":["School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0001-8759-8962","affiliations":[{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078774167","display_name":"Theofilos Poutahidis","orcid":"https://orcid.org/0000-0002-2951-1811","observed_orcids":["https://orcid.org/0000-0002-2951-1811"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theofilos Poutahidis","raw_affiliation_strings":["School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020943711","display_name":"Chrysanthi Ainali","orcid":"https://orcid.org/0000-0002-0106-9689","observed_orcids":["https://orcid.org/0000-0002-0106-9689"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chrysanthi Ainali","raw_affiliation_strings":["St John\u2019s Institute of Dermatology, School of Basic and Medical Biosciences, King\u2019s College London, London SE1 9RT, UK","St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St John\u2019s Institute of Dermatology, School of Basic and Medical Biosciences, King\u2019s College London, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London SE1 9RT, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073210502","display_name":"Dimitra Dafou","orcid":"https://orcid.org/0000-0003-4170-0612","observed_orcids":["https://orcid.org/0000-0003-4170-0612"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitra Dafou","raw_affiliation_strings":["School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040554468","display_name":"Emmanuel Panteris","orcid":"https://orcid.org/0000-0002-2360-6078","observed_orcids":["https://orcid.org/0000-0002-2360-6078"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanuel Panteris","raw_affiliation_strings":["School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-2360-6078","affiliations":[{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071773421","display_name":"Joseph G. Kern","orcid":"https://orcid.org/0000-0003-2291-6020","observed_orcids":["https://orcid.org/0000-0003-2291-6020"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph G. Kern","raw_affiliation_strings":["Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091215942","display_name":"Xaralabos Varelas","orcid":"https://orcid.org/0000-0002-2882-4541","observed_orcids":["https://orcid.org/0000-0002-2882-4541"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xaralabos Varelas","raw_affiliation_strings":["Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":"https://orcid.org/0000-0002-2882-4541","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045414798","display_name":"Alexandros Hardas","orcid":"https://orcid.org/0000-0001-9906-7552","observed_orcids":["https://orcid.org/0000-0001-9906-7552"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]},{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GB","GR"],"is_corresponding":false,"raw_author_name":"Alexander Hardas","raw_affiliation_strings":["Department of Pathobiology & Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology & Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048386720","display_name":"Christos Gonidas","orcid":"https://orcid.org/0009-0002-7380-5961","observed_orcids":["https://orcid.org/0009-0002-7380-5961"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Gonidas","raw_affiliation_strings":["School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085057179","display_name":"Anastasia Tsingotjidou","orcid":"https://orcid.org/0000-0002-6610-5847","observed_orcids":["https://orcid.org/0000-0002-6610-5847"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Tsingotjidou","raw_affiliation_strings":["School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026381168","display_name":"Eudoxia Hatzivassiliou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eudoxia Hatzivassiliou","raw_affiliation_strings":["School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017391924","display_name":"George Mosialos","orcid":"https://orcid.org/0000-0002-5342-4873","observed_orcids":["https://orcid.org/0000-0002-5342-4873"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"George Mosialos","raw_affiliation_strings":["School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-5342-4873","affiliations":[{"raw_affiliation_string":"School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017391924"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2324},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2324},"fwci":0.9339,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6992699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"2047","last_page":"2047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyld","display_name":"CYLD","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.921999990940094},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/yap-taz-signaling","display_name":"YAP/TAZ signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mammary-hyperplasia","display_name":"mammary gland hyperplasia","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7523009181022644},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.6791903376579285},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6337190866470337},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6042114496231079},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6033185124397278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5576770901679993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4882543385028839},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4346862733364105},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.41674473881721497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10398021340370178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers12082047","doi":"https://doi.org/10.3390/cancers12082047","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12082047","pdf_url":"https://www.mdpi.com/2072-6694/12/8/2047/pdf?version=1596199360","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:32722292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32722292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.rvc.ac.uk:12888","doi":null,"is_oa":true,"landing_page_url":"https://researchonline.rvc.ac.uk/id/eprint/12888/1/12888_The%20Tumor%20Suppressor%20CYLD%20Inhibits%20Mammary%20Epithelial%20to%20Mesenchymal%20Transition%20by%20the%20Coordinated%20Inhibition%20of%20YAP_TAZ%20and%20TGF%CE%B2%20Signaling_GOLD%20VoR.pdf","pdf_url":"https://researchonline.rvc.ac.uk/id/eprint/12888/1/12888_The%20Tumor%20Suppressor%20CYLD%20Inhibits%20Mammary%20Epithelial%20to%20Mesenchymal%20Transition%20by%20the%20Coordinated%20Inhibition%20of%20YAP_TAZ%20and%20TGF%CE%B2%20Signaling_GOLD%20VoR.pdf","source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7466024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7466024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:95949c3c92b7495fa5ff91cc172a07a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95949c3c92b7495fa5ff91cc172a07a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 12, Iss 2047, p 2047 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers12082047","doi":"https://doi.org/10.3390/cancers12082047","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers12082047","pdf_url":"https://www.mdpi.com/2072-6694/12/8/2047/pdf?version=1596199360","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1304397655","display_name":null,"funder_award_id":"G ZL 088-1/2015-2016","funder_id":"https://openalex.org/F4320323220","funder_display_name":"Alexander S. Onassis Public Benefit Foundation"},{"id":"https://openalex.org/G204514639","display_name":"\u0394\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03b3\u03ba\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03bf\u03cd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 CYLD \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03c2 \u03bc\u03b5\u03c3\u03b5\u03b3\u03c7\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae","funder_award_id":"HFRI-FM17-1731","funder_id":"https://openalex.org/F4320327859","funder_display_name":"Hellenic Foundation for Research and Innovation"},{"id":"https://openalex.org/G470278824","display_name":null,"funder_award_id":"R01HL124392","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7872419441","display_name":null,"funder_award_id":"ARISTEIA-1921-EMBRACE","funder_id":"https://openalex.org/F4320323846","funder_display_name":"Ministry of National Education and Religious Affairs"},{"id":"https://openalex.org/G787380038","display_name":"Determining the roles of the Hippo pathway kinases LATS1 and LATS2 in mammary gland homeostasis and disease","funder_award_id":"F31CA232683","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320323220","display_name":"Alexander S. Onassis Public Benefit Foundation","ror":"https://ror.org/017nq0d63"},{"id":"https://openalex.org/F4320323846","display_name":"Ministry of National Education and Religious Affairs","ror":"https://ror.org/04zvb9t44"},{"id":"https://openalex.org/F4320327859","display_name":"Hellenic Foundation for Research and Innovation","ror":"https://ror.org/05v75r592"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045275291.pdf","grobid_xml":"https://content.openalex.org/works/W3045275291.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1234382164","https://openalex.org/W1482000562","https://openalex.org/W1611419331","https://openalex.org/W1872124954","https://openalex.org/W1919304720","https://openalex.org/W1965481841","https://openalex.org/W1973260880","https://openalex.org/W1973562447","https://openalex.org/W1976472776","https://openalex.org/W1984457233","https://openalex.org/W1985339653","https://openalex.org/W1997146393","https://openalex.org/W2006519535","https://openalex.org/W2014691022","https://openalex.org/W2016899606","https://openalex.org/W2025721764","https://openalex.org/W2028330103","https://openalex.org/W2029454644","https://openalex.org/W2031211461","https://openalex.org/W2041576667","https://openalex.org/W2051147623","https://openalex.org/W2054883000","https://openalex.org/W2060803227","https://openalex.org/W2068010171","https://openalex.org/W2074396589","https://openalex.org/W2081434237","https://openalex.org/W2083415193","https://openalex.org/W2105666596","https://openalex.org/W2107277218","https://openalex.org/W2107554012","https://openalex.org/W2123106337","https://openalex.org/W2127215376","https://openalex.org/W2129945166","https://openalex.org/W2130410032","https://openalex.org/W2138929006","https://openalex.org/W2146204355","https://openalex.org/W2151260549","https://openalex.org/W2154853638","https://openalex.org/W2156107660","https://openalex.org/W2159437901","https://openalex.org/W2159753708","https://openalex.org/W2179971431","https://openalex.org/W2188225473","https://openalex.org/W2288337573","https://openalex.org/W2300447747","https://openalex.org/W2338076448","https://openalex.org/W2374374054","https://openalex.org/W2396250854","https://openalex.org/W2504829444","https://openalex.org/W2516150954","https://openalex.org/W2551296814","https://openalex.org/W2560689174","https://openalex.org/W2576208023","https://openalex.org/W2606001457","https://openalex.org/W2611221628","https://openalex.org/W2772425736","https://openalex.org/W2783337717","https://openalex.org/W2806257681","https://openalex.org/W2883461704","https://openalex.org/W2891780076","https://openalex.org/W2894407493","https://openalex.org/W2894875281","https://openalex.org/W2899655237","https://openalex.org/W2901068426","https://openalex.org/W2903298719","https://openalex.org/W2903729144","https://openalex.org/W2906067435","https://openalex.org/W2921134123","https://openalex.org/W2990223547","https://openalex.org/W2991757371","https://openalex.org/W6640105233","https://openalex.org/W6754459784","https://openalex.org/W6759742757"],"related_works":["https://openalex.org/W3118667519","https://openalex.org/W4392681959","https://openalex.org/W4253170077","https://openalex.org/W4389790735","https://openalex.org/W1670324689","https://openalex.org/W3030570121","https://openalex.org/W2077418945","https://openalex.org/W2776389664","https://openalex.org/W4387931142","https://openalex.org/W2218503759"],"abstract_inverted_index":{"Downregulation":[0],"of":[1,28,47,58,82,87,107,119,131,149,158,191],"the":[2,26,55,59,79,85,104,120,155,161],"cylindromatosis":[3],"(CYLD)":[4],"tumor":[5],"suppressor":[6],"has":[7],"been":[8],"associated":[9,114],"with":[10,66,100,115,135],"breast":[11,127,198],"cancer":[12,128],"development":[13],"and":[14,34,70,84,160,175,186],"progression.":[15],"Here,":[16],"we":[17],"report":[18],"a":[19,146,150,180,188],"critical":[20,147],"role":[21],"for":[22],"CYLD":[23,37,76,132,144,193],"in":[24,32,35,94,125,164,168,195],"maintaining":[25],"phenotype":[27],"mammary":[29,48,110,165],"epithelial":[30,43,49,166],"cells":[31,50],"vitro":[33],"vivo.":[36],"downregulation":[38,130],"or":[39],"inactivation":[40,77],"induced":[41],"an":[42],"to":[44,170],"mesenchymal":[45],"transition":[46],"that":[51,153,184],"was":[52],"dependent":[53],"on":[54],"concomitant":[56],"activation":[57,157],"transcription":[60,122],"factors":[61],"Yes-associated":[62],"protein":[63],"(YAP)/transcriptional":[64],"coactivator":[65],"PDZ-binding":[67],"motif":[68],"(TAZ)":[69],"transforming":[71],"growth":[72],"factor":[73],"beta":[74],"(TGF\uf062)signaling.":[75],"enhanced":[78,116,136],"nuclear":[80,117],"localization":[81],"YAP/TAZ":[83,121,159],"phosphorylation":[86],"Small":[88],"Mothers":[89],"Against":[90],"Decapentaplegic":[91],"(SMAD)2/3":[92],"proteins":[93],"confluent":[95],"cell":[96],"culture":[97],"conditions.":[98],"Consistent":[99],"these":[101],"findings":[102],"were":[103,113],"hyperplastic":[105],"alterations":[106],"CYLD-deficient":[108],"mouse":[109],"epithelia,":[111],"which":[112],"expression":[118,133,194],"factors.":[123],"Furthermore,":[124],"human":[126,197],"samples,":[129],"correlates":[134],"YAP/TAZ-regulated":[137],"target":[138],"gene":[139],"expression.":[140],"Our":[141],"results":[142],"identify":[143],"as":[145],"regulator":[148],"signaling":[151],"node":[152],"prevents":[154],"coordinated":[156],"TGF\uf062":[162],"pathway":[163],"cells,":[167],"order":[169],"maintain":[171],"their":[172],"phenotypic":[173],"identity":[174],"homeostasis.":[176],"Consequently,":[177],"they":[178],"provide":[179],"novel":[181],"conceptual":[182],"framework":[183],"supports":[185],"explains":[187],"causal":[189],"implication":[190],"deficient":[192],"aggressive":[196],"cancers.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}