{"id":"https://openalex.org/W3045265280","doi":"https://doi.org/10.1016/j.theriogenology.2020.06.021","title":"miRNA-21\u20133p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway","display_name":"miRNA-21\u20133p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway","publication_year":2020,"publication_date":"2020-07-21","ids":{"openalex":"https://openalex.org/W3045265280","doi":"https://doi.org/10.1016/j.theriogenology.2020.06.021","mag":"3045265280","pmid":"https://pubmed.ncbi.nlm.nih.gov/32818880"},"language":"en","primary_location":{"id":"doi:10.1016/j.theriogenology.2020.06.021","doi":"https://doi.org/10.1016/j.theriogenology.2020.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2020.06.021","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.theriogenology.2020.06.021","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010153439","display_name":"Lizhu Ma","orcid":"https://orcid.org/0000-0002-8572-3843","observed_orcids":["https://orcid.org/0000-0002-8572-3843"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lizhu Ma","raw_affiliation_strings":["Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027183173","display_name":"Xiaorong Tang","orcid":"https://orcid.org/0000-0001-8764-9483","observed_orcids":["https://orcid.org/0000-0001-8764-9483"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorong Tang","raw_affiliation_strings":["Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112110677","display_name":"Shun Guo","orcid":"https://orcid.org/0000-0003-3377-542X","observed_orcids":["https://orcid.org/0000-0003-3377-542X"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Guo","raw_affiliation_strings":["Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016385766","display_name":"Mingyue Liang","orcid":"https://orcid.org/0009-0009-0864-3960","observed_orcids":["https://orcid.org/0009-0009-0864-3960"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyue Liang","raw_affiliation_strings":["Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392778","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0001-6834-4705","observed_orcids":["https://orcid.org/0000-0001-6834-4705"]},"institutions":[{"id":"https://openalex.org/I4210106557","display_name":"Xinjiang Academy of Agricultural and Reclamation Science","ror":"https://ror.org/01psdst63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106557"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["College of Animal Science and Technology, State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, 832000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, 832000, China","institution_ids":["https://openalex.org/I4210106557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030672669","display_name":"Zhongliang Jiang","orcid":"https://orcid.org/0000-0001-7822-4520","observed_orcids":["https://orcid.org/0000-0001-7822-4520"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongliang Jiang","raw_affiliation_strings":["Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China. Electronic address: jiangzhongliang@nwafu.edu.cn","Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China. Electronic address: jiangzhongliang@nwafu.edu.cn","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Key Laboratory of Animal Genetic, Breeding and Reproduction in Shaanxi Province, College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030672669"],"corresponding_institution_ids":["https://openalex.org/I89652312"],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":null,"fwci":6.8744,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.97063178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"157","issue":null,"first_page":"226","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.24220000207424164,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-21-3p","display_name":"miR-21-3p","score":0.996999979019165},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.968999981880188},{"id":"https://openalex.org/keywords/follicular-atresia","display_name":"follicular atresia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9305428266525269},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8480491638183594},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7126147747039795},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6348307728767395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6024414896965027},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5529865026473999},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5416287779808044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37628644704818726},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3306676745414734},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31219571828842163},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2541346251964569},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23571571707725525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13940519094467163}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005496","descriptor_name":"Follicular Atresia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.theriogenology.2020.06.021","doi":"https://doi.org/10.1016/j.theriogenology.2020.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2020.06.021","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Theriogenology","raw_type":"journal-article"},{"id":"pmid:32818880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32818880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:2280362","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2280362","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.theriogenology.2020.06.021","doi":"https://doi.org/10.1016/j.theriogenology.2020.06.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2020.06.021","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336350","display_name":"Key Research and Development Projects of Shaanxi Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1709510321","https://openalex.org/W1822594881","https://openalex.org/W1969943708","https://openalex.org/W1974231851","https://openalex.org/W1985725772","https://openalex.org/W1985851879","https://openalex.org/W1994450509","https://openalex.org/W1998055848","https://openalex.org/W1999514481","https://openalex.org/W2000250544","https://openalex.org/W2012458212","https://openalex.org/W2014442719","https://openalex.org/W2021958215","https://openalex.org/W2022333470","https://openalex.org/W2025098484","https://openalex.org/W2025334893","https://openalex.org/W2026446685","https://openalex.org/W2026481212","https://openalex.org/W2048131740","https://openalex.org/W2065899119","https://openalex.org/W2068153705","https://openalex.org/W2072926599","https://openalex.org/W2073990533","https://openalex.org/W2081207546","https://openalex.org/W2096078288","https://openalex.org/W2106465830","https://openalex.org/W2121629705","https://openalex.org/W2122892477","https://openalex.org/W2125768461","https://openalex.org/W2134975640","https://openalex.org/W2135758370","https://openalex.org/W2135810600","https://openalex.org/W2135901758","https://openalex.org/W2148145541","https://openalex.org/W2148321928","https://openalex.org/W2153000015","https://openalex.org/W2158350301","https://openalex.org/W2160530836","https://openalex.org/W2164778558","https://openalex.org/W2178316435","https://openalex.org/W2279085311","https://openalex.org/W2403537081","https://openalex.org/W2463111790","https://openalex.org/W2474919240","https://openalex.org/W2587414698","https://openalex.org/W2624245495","https://openalex.org/W2749693449","https://openalex.org/W2752326209","https://openalex.org/W2758286496","https://openalex.org/W2758797028","https://openalex.org/W2761399066","https://openalex.org/W2765667244","https://openalex.org/W2792601526","https://openalex.org/W2793498776","https://openalex.org/W2793966428","https://openalex.org/W2866751656","https://openalex.org/W2892581569","https://openalex.org/W2912567453","https://openalex.org/W2968590403","https://openalex.org/W2976529879","https://openalex.org/W2983871642","https://openalex.org/W6679952797","https://openalex.org/W6856930615"],"related_works":["https://openalex.org/W2976529879","https://openalex.org/W3095173321","https://openalex.org/W2148145541","https://openalex.org/W4401671337","https://openalex.org/W4400112846","https://openalex.org/W4403001857","https://openalex.org/W2000250544","https://openalex.org/W4386171628","https://openalex.org/W4387847159","https://openalex.org/W4206380528"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-29T00:00:00"}
