{"id":"https://openalex.org/W3045228630","doi":"https://doi.org/10.1371/journal.pone.0236363","title":"Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats","display_name":"Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3045228630","doi":"https://doi.org/10.1371/journal.pone.0236363","mag":"3045228630","pmid":"https://pubmed.ncbi.nlm.nih.gov/32706815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7380603"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0236363","doi":"https://doi.org/10.1371/journal.pone.0236363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0236363","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236363&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236363&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089779113","display_name":"Mayako Yamazaki","orcid":"https://orcid.org/0000-0002-1654-1851","observed_orcids":["https://orcid.org/0000-0002-1654-1851"]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mayako Yamazaki","raw_affiliation_strings":["Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1654-1851","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015017255","display_name":"Sokichi Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sokichi Honda","raw_affiliation_strings":["Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082869378","display_name":"Keisuke Tamaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keisuke Tamaki","raw_affiliation_strings":["Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058972665","display_name":"Megumi Irie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Megumi Irie","raw_affiliation_strings":["Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112167267","display_name":"Takuma Mihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takuma Mihara","raw_affiliation_strings":["Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I142395110"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015017255","https://openalex.org/A5058972665","https://openalex.org/A5082869378","https://openalex.org/A5089779113","https://openalex.org/A5112167267"],"corresponding_institution_ids":["https://openalex.org/I142395110"],"apc_list":{"value":1695,"currency":"USD","value_usd":1695},"apc_paid":{"value":1695,"currency":"USD","value_usd":1695},"fwci":0.7125,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.62199857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"15","issue":"7","first_page":"e0236363","last_page":"e0236363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02630000002682209,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gaba-a-receptor-antagonists","display_name":"GABA-A receptor antagonists","score":0.7829999923706055},{"id":"https://openalex.org/keywords/auditory-steady-state-response","display_name":"auditory steady-state response","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":0.8209999799728394},{"id":"https://openalex.org/keywords/event-related-spectral-perturbation","display_name":"event-related spectral perturbation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuronal-synchronization","display_name":"neuronal synchronization","score":0.8529999852180481},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6729999780654907},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.9850543141365051},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.8918612003326416},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6027094125747681},{"id":"https://openalex.org/C2777010014","wikidata":"https://www.wikidata.org/wiki/Q852376","display_name":"Convulsion","level":3,"score":0.5616863369941711},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5351449251174927},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5255162715911865},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.5238430500030518},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4951561987400055},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.42991408705711365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4009305238723755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36982080340385437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33346274495124817},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2941686511039734},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.2325902283191681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22987136244773865}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003292","descriptor_name":"Convulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003292","descriptor_name":"Convulsants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0236363","doi":"https://doi.org/10.1371/journal.pone.0236363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0236363","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236363&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:32706815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32706815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7380603","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7380603/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e6093c24cf8049f390753691001475b2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6093c24cf8049f390753691001475b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 15, Iss 7, p e0236363 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0236363","doi":"https://doi.org/10.1371/journal.pone.0236363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0236363","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236363&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8313999772071838,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045228630.pdf","grobid_xml":"https://content.openalex.org/works/W3045228630.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1534553826","https://openalex.org/W1840994181","https://openalex.org/W1960644352","https://openalex.org/W1967810931","https://openalex.org/W1968700646","https://openalex.org/W1973541245","https://openalex.org/W1974123318","https://openalex.org/W1977998932","https://openalex.org/W1979219206","https://openalex.org/W1980573935","https://openalex.org/W1987393817","https://openalex.org/W2001555806","https://openalex.org/W2005839666","https://openalex.org/W2007380470","https://openalex.org/W2010004647","https://openalex.org/W2010250068","https://openalex.org/W2013280216","https://openalex.org/W2026172642","https://openalex.org/W2028861046","https://openalex.org/W2028884770","https://openalex.org/W2029037348","https://openalex.org/W2037549116","https://openalex.org/W2038010521","https://openalex.org/W2039746020","https://openalex.org/W2042311142","https://openalex.org/W2043350008","https://openalex.org/W2047347093","https://openalex.org/W2057558890","https://openalex.org/W2060160257","https://openalex.org/W2081063176","https://openalex.org/W2082020973","https://openalex.org/W2089912569","https://openalex.org/W2095060637","https://openalex.org/W2099427806","https://openalex.org/W2103592460","https://openalex.org/W2103946141","https://openalex.org/W2108696245","https://openalex.org/W2109848582","https://openalex.org/W2117024164","https://openalex.org/W2124289190","https://openalex.org/W2128470552","https://openalex.org/W2138797652","https://openalex.org/W2143017628","https://openalex.org/W2145677204","https://openalex.org/W2149244679","https://openalex.org/W2149561999","https://openalex.org/W2156026059","https://openalex.org/W2158137297","https://openalex.org/W2162462925","https://openalex.org/W2166269667","https://openalex.org/W2170696995","https://openalex.org/W2171321840","https://openalex.org/W2171907536","https://openalex.org/W2320983896","https://openalex.org/W2564374281","https://openalex.org/W2580207551","https://openalex.org/W2593470778","https://openalex.org/W2739175229","https://openalex.org/W2951828943","https://openalex.org/W2973978594"],"related_works":["https://openalex.org/W2010250068","https://openalex.org/W4395661274","https://openalex.org/W203174961","https://openalex.org/W2043350008","https://openalex.org/W2039680151","https://openalex.org/W2048704435","https://openalex.org/W2104489756","https://openalex.org/W1974145046","https://openalex.org/W7133517857","https://openalex.org/W1968519746"],"abstract_inverted_index":{"Auditory":[0],"steady-state":[1],"responses":[2],"(ASSRs)":[3],"are":[4,21,59,88],"states":[5],"in":[6,34,47,62,68,74,104,181,189,195],"which":[7],"the":[8,12,28,35,94,158,165,182,204,211],"electrical":[9],"activity":[10,46],"of":[11,31,96,160,172,206,213],"brain":[13,183],"reacts":[14],"steadily":[15],"to":[16,23,43,86,210],"repeated":[17],"auditory":[18],"stimuli.":[19],"They":[20],"known":[22],"be":[24],"useful":[25],"for":[26,40],"testing":[27],"functional":[29],"integrity":[30],"neural":[32,69],"circuits":[33],"cortex,":[36],"as":[37,39,175],"well":[38],"their":[41],"capacity":[42],"generate":[44],"synchronous":[45],"both":[48],"human":[49],"and":[50,83,110,115,135,140,147,151],"animal":[51],"models.":[52],"Furthermore,":[53,157],"abnormal":[54],"gamma":[55,155],"oscillations":[56],"on":[57,102],"ASSR":[58,87,103,118],"typically":[60],"observed":[61,194],"patients":[63],"with":[64,121,164,191,197],"schizophrenia":[65],"(SZ).":[66],"Changes":[67],"synchrony":[70],"may":[71],"reflect":[72],"aberrations":[73],"cortical":[75],"gamma-aminobutyric":[76],"acid":[77],"(GABA)":[78],"neurotransmission.":[79],"However,":[80],"GABA's":[81],"impact":[82],"effects":[84],"related":[85],"still":[89],"unclear.":[90],"Here,":[91],"we":[92],"examined":[93],"effect":[95],"a":[97],"GABAa":[98,207],"receptor":[99,208],"antagonist,":[100],"(+)-bicuculline,":[101],"free-moving":[105],"rats.":[106],"(+)-Bicuculline":[107],"(1,":[108],"2":[109,134],"4":[111,136,148],"mg/kg,":[112],"sc)":[113],"markedly":[114],"dose-dependently":[116,152],"reduced":[117,128],"signals,":[119],"consistent":[120,163],"current":[122],"hypotheses.":[123],"In":[124],"particular,":[125],"(+)-bicuculline":[126,173,192],"significantly":[127,150],"event-related":[129],"spectral":[130],"perturbations":[131],"(ERSPs)":[132],"at":[133],"mg/kg":[137],"between":[138],"10":[139],"30":[141],"minutes":[142],"post-dose.":[143],"Further,":[144],"bicuculline":[145],"(2":[146],"mg/kg)":[149],"increased":[153],"baseline":[154],"power.":[156],"occurrence":[159],"convulsions":[161],"was":[162],"drug's":[166],"pharmacokinetics.":[167],"For":[168],"example,":[169],"high":[170],"doses":[171],"such":[174],"those":[176],"greater":[177],"than":[178],"880":[179],"ng/g":[180],"induced":[184],"convulsion.":[185],"Additionally,":[186],"time-dependent":[187],"changes":[188],"ERSP":[190],"were":[193],"accordance":[196],"drug":[198],"concentration.":[199],"This":[200],"study":[201],"partially":[202],"unraveled":[203],"contribution":[205],"signals":[209],"generation":[212],"ASSR.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-07-29T00:00:00"}
