{"id":"https://openalex.org/W3045192608","doi":"https://doi.org/10.1016/s2055-6640(20)31387-x","title":"Levels of SAMHD1 and natural ribonucleotides may alter anti-HIV potency of antiretroviral agents in primary CD4 + CCR5 + placental macrophages","display_name":"Levels of SAMHD1 and natural ribonucleotides may alter anti-HIV potency of antiretroviral agents in primary CD4 + CCR5 + placental macrophages","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W3045192608","doi":"https://doi.org/10.1016/s2055-6640(20)31387-x","mag":"3045192608"},"language":"en","primary_location":{"id":"doi:10.1016/s2055-6640(20)31387-x","doi":"https://doi.org/10.1016/s2055-6640(20)31387-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31387-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S205566402031387X/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S205566402031387X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013698403","display_name":"Christina Gavegnano","orcid":"https://orcid.org/0000-0002-0770-5535","observed_orcids":["https://orcid.org/0000-0002-0770-5535"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Gavegnano","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","Veterans Affairs Medical Center, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072991309","display_name":"Erica L. Johnson","orcid":"https://orcid.org/0000-0003-3230-8715","observed_orcids":["https://orcid.org/0000-0003-3230-8715"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.L. Johnson","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088309742","display_name":"Sijia Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Tao","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008698527","display_name":"\u00c1ngel Onzari Luna Santos","orcid":"https://orcid.org/0000-0001-6751-504X","observed_orcids":["https://orcid.org/0000-0001-6751-504X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Santos","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087052821","display_name":"Raymond F. Schinazi","orcid":"https://orcid.org/0000-0002-6688-3614","observed_orcids":["https://orcid.org/0000-0002-6688-3614"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.F. Schinazi","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","Veterans Affairs Medical Center, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039700578","display_name":"Rana Chakraborty","orcid":"https://orcid.org/0000-0002-6585-0087","observed_orcids":["https://orcid.org/0000-0002-6585-0087"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Chakraborty","raw_affiliation_strings":["Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36631574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.4652999937534332,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-tropism","display_name":"HIV-1 tropism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ccr5-antagonist","display_name":"CCR5 antagonist","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ultra-deep-sequencing","display_name":"ultra-deep sequencing","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/placental-macrophages","display_name":"placental macrophages","score":0.8389999866485596},{"id":"https://openalex.org/keywords/samhd1","display_name":"SAMHD1","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2776315342","wikidata":"https://www.wikidata.org/wiki/Q21105865","display_name":"SAMHD1","level":5,"score":0.7103006839752197},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6272769570350647},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5535081028938293},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.476149320602417},{"id":"https://openalex.org/C3018457394","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral drug","level":5,"score":0.46595579385757446},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4313596189022064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33293473720550537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30060404539108276},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.23980996012687683},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11730900406837463},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.11595997214317322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11103400588035583},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.09136179089546204},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.054388612508773804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0447370707988739}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s2055-6640(20)31387-x","doi":"https://doi.org/10.1016/s2055-6640(20)31387-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31387-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S205566402031387X/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fcb074b7fa464ff9b9d83840f170f09b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fcb074b7fa464ff9b9d83840f170f09b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virus Eradication, Vol 1, Iss , Pp 32- (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s2055-6640(20)31387-x","doi":"https://doi.org/10.1016/s2055-6640(20)31387-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2055-6640(20)31387-x","pdf_url":"https://www.sciencedirect.com/science/article/pii/S205566402031387X/pdf","source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045192608.pdf","grobid_xml":"https://content.openalex.org/works/W3045192608.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045101570","https://openalex.org/W2330266770","https://openalex.org/W2119951120","https://openalex.org/W2793105514","https://openalex.org/W2105474701","https://openalex.org/W2059487888","https://openalex.org/W3045354155","https://openalex.org/W2067391188","https://openalex.org/W2128618062","https://openalex.org/W2125205795"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2020-07-29T00:00:00"}