{"id":"https://openalex.org/W3045101952","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1350.1350","title":"Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models","display_name":"Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W3045101952","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1350.1350","mag":"3045101952"},"language":"en","primary_location":{"id":"mag:3045101952","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1350.1350","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/1350/116164/Inhibition-of-Oxphos-with-Iacs-010759-Depletes-AML","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058898565","display_name":"Natalia Baran","orcid":"https://orcid.org/0000-0003-0618-4798","observed_orcids":["https://orcid.org/0000-0003-0618-4798"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Baran","raw_affiliation_strings":["Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-0618-4798","affiliations":[{"raw_affiliation_string":"Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100824657","display_name":"Lina Han","orcid":"https://orcid.org/0009-0009-2713-5478","observed_orcids":["https://orcid.org/0009-0009-2713-5478","https://orcid.org/0009-0008-1140-5093"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Han","raw_affiliation_strings":["Department of Leukemia, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0009-0008-1140-5093","affiliations":[{"raw_affiliation_string":"Department of Leukemia, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071278282","display_name":"Shannon Sweeney","orcid":"https://orcid.org/0000-0001-7080-8716","observed_orcids":["https://orcid.org/0000-0001-7080-8716"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Sweeney","raw_affiliation_strings":["Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX"],"raw_orcid":"https://orcid.org/0000-0001-7080-8716","affiliations":[{"raw_affiliation_string":"Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091298013","display_name":"Alessia Lodi","orcid":"https://orcid.org/0000-0002-2104-5713","observed_orcids":["https://orcid.org/0000-0002-2104-5713"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessia Lodi","raw_affiliation_strings":["Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX"],"raw_orcid":"https://orcid.org/0000-0002-2104-5713","affiliations":[{"raw_affiliation_string":"Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015976557","display_name":"Shelley M. Herbrich","orcid":"https://orcid.org/0000-0002-3825-6752","observed_orcids":["https://orcid.org/0000-0002-3825-6752"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley M. Herbrich","raw_affiliation_strings":["Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-3825-6752","affiliations":[{"raw_affiliation_string":"Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071658726","display_name":"Antonio Cavazos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Cavazos","raw_affiliation_strings":["Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044899339","display_name":"Helen Ma","orcid":"https://orcid.org/0000-0002-0416-5115","observed_orcids":["https://orcid.org/0000-0002-0416-5115","https://orcid.org/0000-0002-9408-2654"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Ma","raw_affiliation_strings":["Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-0416-5115","affiliations":[{"raw_affiliation_string":"Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071445059","display_name":"Ningping Feng","orcid":"https://orcid.org/0000-0003-1917-9648","observed_orcids":["https://orcid.org/0000-0003-1917-9648"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ningping Feng","raw_affiliation_strings":["Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-1917-9648","affiliations":[{"raw_affiliation_string":"Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090608091","display_name":"Hsiang-Chun Chen","orcid":"https://orcid.org/0000-0003-2687-0787","observed_orcids":["https://orcid.org/0000-0003-2687-0787"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiang-Chun Chen","raw_affiliation_strings":["Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-2687-0787","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088315079","display_name":"Marcin M. Kami\u0144ski","orcid":"https://orcid.org/0000-0002-9026-0185","observed_orcids":["https://orcid.org/0000-0002-9026-0185"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcin M. Kami\u0144ski","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":"https://orcid.org/0000-0002-9026-0185","affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070840786","display_name":"Kenneth Dunner","orcid":"https://orcid.org/0000-0001-7731-0013","observed_orcids":["https://orcid.org/0000-0001-7731-0013"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Dunner","raw_affiliation_strings":["Department of Cancer Biology, University of Texas MDAnderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-7731-0013","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, University of Texas MDAnderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055404021","display_name":"Guilin Tang","orcid":"https://orcid.org/0000-0002-9482-4806","observed_orcids":["https://orcid.org/0000-0002-9482-4806"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guilin Tang","raw_affiliation_strings":["Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-9482-4806","affiliations":[{"raw_affiliation_string":"Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029855695","display_name":"Gheath Alatrash","orcid":"https://orcid.org/0000-0002-7648-4377","observed_orcids":["https://orcid.org/0000-0002-7648-4377"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gheath Alatrash","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-7648-4377","affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060688708","display_name":"Jennifer R. Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R. Molina","raw_affiliation_strings":["Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053376451","display_name":"M\u00f3nica L. Guzm\u00e1n","orcid":"https://orcid.org/0000-0002-9262-8246","observed_orcids":["https://orcid.org/0000-0002-9262-8246"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M\u00f3nica L. Guzm\u00e1n","raw_affiliation_strings":["Weill Cornell Medical College Division of Hematology/Oncology, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-9262-8246","affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College Division of Hematology/Oncology, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006858509","display_name":"Jing Ning","orcid":"https://orcid.org/0000-0002-5289-331X","observed_orcids":["https://orcid.org/0000-0002-5289-331X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Ning","raw_affiliation_strings":["Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018582351","display_name":"Stefano Tiziani","orcid":"https://orcid.org/0000-0002-7230-0307","observed_orcids":["https://orcid.org/0000-0002-7230-0307","https://orcid.org/0000-0003-1892-2495"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Tiziani","raw_affiliation_strings":["Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX"],"raw_orcid":"https://orcid.org/0000-0002-7230-0307","affiliations":[{"raw_affiliation_string":"Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048521277","display_name":"Joseph R. Marszalek","orcid":"https://orcid.org/0000-0003-2320-3209","observed_orcids":["https://orcid.org/0000-0003-2320-3209"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Marszalek","raw_affiliation_strings":["Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-2320-3209","affiliations":[{"raw_affiliation_string":"Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022647201","display_name":"Marina Y Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Konopleva","raw_affiliation_strings":["Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-9347-2212","affiliations":[{"raw_affiliation_string":"Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.3534907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"130","issue":null,"first_page":"1350","last_page":"1350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/leukemia-initiating-cells","display_name":"leukemia-initiating cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/iacs-010759","display_name":"IACS-010759","score":0.902999997138977},{"id":"https://openalex.org/keywords/oxidative-phosphorylation-inhibition","display_name":"oxidative phosphorylation inhibition","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.8230000138282776},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8569999933242798},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6359098553657532},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6137943863868713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5786535143852234},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.536967396736145},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48066771030426025},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4772341549396515},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.47472915053367615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4132690131664276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3649764955043793},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.29958122968673706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28833574056625366},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15136513113975525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1496618092060089},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07417666912078857}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3045101952","doi":"https://doi.org/10.1182/blood.v130.suppl_1.1350.1350","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/130/Supplement%201/1350/116164/Inhibition-of-Oxphos-with-Iacs-010759-Depletes-AML","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335884861","https://openalex.org/W2911558096","https://openalex.org/W1990136541","https://openalex.org/W2580606084","https://openalex.org/W2263076831","https://openalex.org/W3083488659","https://openalex.org/W2980080190","https://openalex.org/W2908501597","https://openalex.org/W2560499115","https://openalex.org/W2593132976","https://openalex.org/W2557078898","https://openalex.org/W2979382316","https://openalex.org/W2594729779","https://openalex.org/W2573451211","https://openalex.org/W2200192717","https://openalex.org/W2562450777","https://openalex.org/W2590833518","https://openalex.org/W2592143385","https://openalex.org/W2910835415","https://openalex.org/W2612339675"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[3],"Metabolic":[4],"reprogramming":[5],"of":[6,14,28,33,54,88,98,167,176,187,204,236,243,251,257,266,274,286,340,371,400,408,415,421,436,445,452,464,472,486,517,524,532,538,547,563,572,580,611,618,622,658,707],"energy-generating":[7],"pathways":[8],"is":[9,162],"a":[10,21,112,154,163,255,491,554,600,607],"core":[11],"oncogenic":[12],"property":[13],"leukemias":[15],"and":[16,59,63,74,207,214,279,294,321,331,419,428,454,459,475,505,519,536,620,640],"other":[17],"cancers":[18],"that":[19,170,594,605,631],"provides":[20,148],"potential":[22,155,313],"therapeutic":[23,158,603],"vulnerability.":[24],"In":[26,185,226,467,490],"light":[27],"recent":[29],"studies":[30,399],"demonstrating":[31],"reliance":[32],"Leukemia":[34],"Initiating":[35],"Cells":[36],"(LIC)":[37],"on":[38,56,82,328,348,488],"OxPhos":[39,152,168,465,596],"(Skrtic":[40,143],"et":[41,92,181,510],"al.,":[42,46,93,182,511],"2011;":[43],"Lagadinou":[44],"at":[45,144,201,284,374],"2013),":[47],"we":[48,110],"aimed":[49],"to":[50,102,333,366,389,498,644,709],"determine":[51],"the":[52,188,310,422,432,581,628],"effects":[53,198],"OxPhosi":[55,231,334,390,550,585],"AML":[57,70,122,189,212,216,258,363,386,401,441,496,565,612,634,661],"bulk":[58,293],"LICs":[60,613],"in":[61,64,115,118,199,211,254,335,361,384,480,553,584,651,660],"vitro":[62,200],"vivo":[65],"using":[66],"patient-derived":[67],"xenograft":[68],"(PDX)":[69],"models.":[71],"Methods":[73],"Results:":[75],"Our":[76,591],"gene":[77,85],"set":[78],"enrichment":[79,97],"analysis":[80,265,435,516],"conducted":[81],"publicly":[83],"available":[84],"expression":[86,407],"profiles":[87],"LIC-enriched":[89],"populations":[90],"(Ng":[91],"2016)":[94],"confirmed":[95,552],"significant":[96,113],"OxPhos-related":[99],"genes":[100],"relative":[101,530],"no":[103],"LIC.":[104],"Using":[105],"transmission":[106],"electron":[107],"microscopy":[108],"(TEM),":[109],"found":[111],"increase":[114,531],"mitochondria":[116,319],"numbers":[117,562],"8":[119],"primary":[120,440,569],"CD34+":[121,131,215,224,245,252,300],"samples":[123,190,259,352,378,403],"compared":[124],"with":[125,139,219,228,343,355,368,379,391,449,484,560,597],"3":[126],"healthy":[127],"bone":[128],"marrow":[129],"(hBM)":[130],"sample":[132],"(19\u00b18":[133],"vs":[134],"8\u00b11,p=0.01,":[135],"Fig.":[136],"1A),":[137],"consistent":[138,483],"previously":[140],"reported":[141],"data":[142],"al.,2011).":[145],"This":[146,307],"finding":[147],"rationale":[149],"for":[150,157,292,299,627],"assessing":[151],"as":[153,260],"target":[156],"intervention.":[159],"IACS-010759":[161,193,248,367,501,576,598,659],"novel":[164,601],"potent":[165],"inhibitor":[166],"(OxPhosi)":[169],"blocks":[171],"cellular":[172],"respiration":[173],"through":[174],"inhibition":[175,617],"mitochondrial":[177,311],"complex":[178],"I":[179],"(Molina":[180,509],"AACR2016).":[183],"80%":[186],"studied":[191],"(n=50),":[192],"exposure":[194],"induced":[195],"profound":[196,272],"growth-inhibitory":[197],"an":[202,652],"EC50":[203,239],"3.1nM":[205],"(0.1-11.7nM)":[206],"5.0":[208],"nM":[209,288,296],"(0.9-12.8nM)":[210],"blasts":[213],"LIC":[217,237,437,525,548],"respectively,":[218],"minimal":[220],"toxicity":[221],"against":[222],"hBM":[223,244,481],"cells.":[225,246],"line":[227],"viability":[229,372,393],"data,":[230],"reduced":[232],"colony":[233],"forming":[234],"ability":[235],"(n=5,":[238],"13-30nM)":[240],"but":[241],"not":[242],"Further,":[247,431],"induces":[249],"differentiation":[250],"cells":[253,521,535,566],"subset":[256],"determined":[261],"by":[262,304,324,541,549],"flow":[263,317],"cytometric":[264],"colonies":[267],"collected":[268],"after":[269],"treatment.":[270],"Next,":[271],"reduction":[273,394],"both,":[275],"oxygen-dependent":[276],"ATP":[277],"production":[278],"spare":[280],"respiratory":[281,638],"capacity":[282,639],"(SRC),":[283],"IC50s":[285],"20.5":[287],"(range,":[289,297],"1.3*10-5":[290],"-528)":[291],"51.4":[295],"1.3-528)":[298],"cells,":[301,482],"was":[302,478,551],"shown":[303,323,626],"Seahorse":[305],"assay.":[306],"translated":[308],"into":[309],"membrane":[312],"loss":[314],"(TMRE,":[315],"JC1":[316],"cytometry),":[318],"swelling":[320],"degeneration":[322],"TEM.":[325],"Based":[327],"genomic":[329],"characteristics":[330],"responses":[332],"vitro,":[336],"two":[337],"distinct":[338],"groups":[339],"patients":[341],"(pts)":[342],"unique":[344,608],"metabolic":[345,609],"pattern":[346],"based":[347],"SRC":[349,357,381],"were":[350,364,387],"identified:":[351],"from":[353,438,494,568],"pts":[354,402,442],"low":[356,636],"(36.3\u00b117.4":[358],"pmol/min)":[359],"enriched":[360,383],"IDH1/2-mutated":[362],"sensitive":[365,643],"median":[369],"60%":[370],"drop":[373],"123":[375],"nM,":[376],"while":[377],"high":[380],"(86.7\u00b120),":[382],"TP53-mutated":[385],"resistant":[388],"30%":[392],"(p=0.03).":[395],"The":[397,545],"proteome":[398],"revealed":[404],"dose-dependent":[405],"increased":[406,450,460],"energy":[409,615],"stress":[410],"response":[411],"protein":[412],"pAMPK,":[413],"upregulation":[414],"glycolysis":[416],"marker":[417],"PFKFB":[418],"decrease":[420,471,523],"fatty":[423],"acids":[424,447],"oxidation":[425],"markers":[426],"CPT1":[427],"ACC1.":[429],"intracellular":[433],"metabolome":[434],"4":[439],"showed":[443,578],"modulation":[444],"amino":[446],"(AA)":[448],"level":[451,462,474],"glutamine":[453],"aspartate,":[455],"decreased":[456],"TCA":[457,476],"intermediates":[458,477],"lactate":[461],"indicative":[463],"perturbation.":[466],"contrast,":[468],"only":[469],"moderate":[470],"AA":[473],"observed":[479],"lack":[485],"cytotoxicity":[487],"hBM.":[489],"PDX":[492],"model":[493],"MLL-rearranged":[495],"refractory":[497],"standard":[499],"chemotherapy,":[500],"treatment":[502],"prolonged":[503],"survival":[504,583],"delayed":[506],"disease":[507],"progression":[508],"AACR":[512],"2016).":[513],"Mass":[514],"cytometry":[515],"BM":[518,564],"spleen":[520],"demonstrated":[522],"(CD34+,":[526],"CD38-,":[527],"CD123+,":[528],"CD33+),":[529],"CD11c+":[533],"differentiated":[534],"suppression":[537],"proliferation":[539,619],"measured":[540],"Ki67":[542],"(Fig.":[543,587],"1B).":[544],"depletion":[546],"secondary":[555],"transplantation":[556],"experiment.":[557],"Mice":[558],"injected":[559],"similar":[561],"isolated":[567],"engrafted":[570],"recipients":[571],"vehicle,":[573],"Ara-C":[574],"or":[575],",":[577],"improvement":[579],"overall":[582],"arm":[586],"1C).":[588],"Conclusion:":[590],"study":[592],"demonstrates":[593],"inhibiting":[595],"constitutes":[599],"promising":[602],"approach":[604],"targets":[606],"vulnerability":[610],"via":[614],"depletion,":[616],"induction":[621],"differentiation.":[623],"We":[624],"have":[625,635],"first":[629],"time":[630],"IDH1/2":[632],"mutated":[633],"spared":[637],"are":[641,648],"highly":[642],"IACS-010759.":[645],"These":[646],"findings":[647],"being":[649],"tested":[650],"ongoing":[653],"Phase":[654],"1":[655],"clinical":[656],"trial":[657],"(NCT02882321).":[662],"Download":[672,675,685,688],":":[673,686],"high-res":[676],"image":[677,690],"(279KB)":[678],"full-size":[689],"Disclosures":[702],"No":[704],"relevant":[705],"conflicts":[706],"interest":[708],"declare.":[710]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
