{"id":"https://openalex.org/W3045075706","doi":"https://doi.org/10.1016/j.jhep.2020.07.028","title":"Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis","display_name":"Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3045075706","doi":"https://doi.org/10.1016/j.jhep.2020.07.028","mag":"3045075706","pmid":"https://pubmed.ncbi.nlm.nih.gov/32717289"},"language":"en","primary_location":{"id":"doi:10.1016/j.jhep.2020.07.028","doi":"https://doi.org/10.1016/j.jhep.2020.07.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2020.07.028","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827820304815/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.journal-of-hepatology.eu/article/S0168827820304815/pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032179758","display_name":"Kristoffer Kj\u00e6rgaard","orcid":"https://orcid.org/0000-0002-6440-2784","observed_orcids":["https://orcid.org/0000-0002-6440-2784"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristoffer Kj\u00e6rgaard","raw_affiliation_strings":["Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008802527","display_name":"Kim Frisch","orcid":"https://orcid.org/0000-0001-9691-2853","observed_orcids":["https://orcid.org/0000-0001-9691-2853"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kim Frisch","raw_affiliation_strings":["Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081857387","display_name":"Michael S\u00f8rensen","orcid":"https://orcid.org/0000-0002-8750-4329","observed_orcids":["https://orcid.org/0000-0002-8750-4329"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael S\u00f8rensen","raw_affiliation_strings":["Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047632381","display_name":"Ole Lajord Munk","orcid":"https://orcid.org/0000-0002-7232-5088","observed_orcids":["https://orcid.org/0000-0002-7232-5088"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole Lajord Munk","raw_affiliation_strings":["Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7232-5088","affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108655297","display_name":"Alan Frederick Hofmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Frederick Hofmann","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007118594","display_name":"Jacob Horsager","orcid":"https://orcid.org/0000-0001-6098-0045","observed_orcids":["https://orcid.org/0000-0001-6098-0045"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob Horsager","raw_affiliation_strings":["Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017741239","display_name":"Anna C. Schacht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anna Christina Schacht","raw_affiliation_strings":["Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103257441","display_name":"Mary Erickson","orcid":"https://orcid.org/0000-0002-6514-6073","observed_orcids":["https://orcid.org/0000-0002-6514-6073"]},"institutions":[{"id":"https://openalex.org/I55878746","display_name":"Intercept Pharmaceuticals (United States)","ror":"https://ror.org/01sx6jc36","country_code":"US","type":"company","lineage":["https://openalex.org/I55878746"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Erickson","raw_affiliation_strings":["Intercept Pharmaceuticals, Inc., San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6514-6073","affiliations":[{"raw_affiliation_string":"Intercept Pharmaceuticals, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I55878746"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55878746","display_name":"Intercept Pharmaceuticals (United States)","ror":"https://ror.org/01sx6jc36","country_code":"US","type":"company","lineage":["https://openalex.org/I55878746"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Shapiro","raw_affiliation_strings":["Intercept Pharmaceuticals, Inc., San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intercept Pharmaceuticals, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I55878746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067335445","display_name":"Susanne Keiding","orcid":"https://orcid.org/0000-0002-7555-9971","observed_orcids":["https://orcid.org/0000-0002-7555-9971"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Susanne Keiding","raw_affiliation_strings":["Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark. Electronic address: susakeid@clin.au.dk","Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7555-9971","affiliations":[{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark. Electronic address: susakeid@clin.au.dk","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067335445"],"corresponding_institution_ids":["https://openalex.org/I2802335433"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":7.9121,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.98702502,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"74","issue":"1","first_page":"58","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obeticholic-acid","display_name":"obeticholic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bile-acid-transport","display_name":"bile acid transport","score":0.6600000262260437},{"id":"https://openalex.org/keywords/conjugated-bile-acids","display_name":"bile acid conjugates","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.8730658888816833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6508667469024658},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.642986536026001},{"id":"https://openalex.org/C94033540","wikidata":"https://www.wikidata.org/wiki/Q5746981","display_name":"Bone canaliculus","level":2,"score":0.5450459122657776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5416995882987976},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49369367957115173},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4433370530605316},{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.42915040254592896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42092663049697876},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.41814249753952026},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1607503890991211},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.12373542785644531},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099150","descriptor_name":"Receptor, Farnesoid X-Activated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jhep.2020.07.028","doi":"https://doi.org/10.1016/j.jhep.2020.07.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2020.07.028","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827820304815/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:32717289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32717289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/f96d797c-dbc8-4770-8658-243bece3aad2","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/f96d797c-dbc8-4770-8658-243bece3aad2","pdf_url":"https://pure.au.dk/ws/files/274433018/1_s2.0_S0168827820304815_main.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kj\u00e6rgaard, K, Frisch, K, S\u00f8rensen, M, Munk, O L, Hofmann, A F, Horsager, J, Schacht, A C, Erickson, M, Shapiro, D A & Keiding, S 2021, 'Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis', Journal of Hepatology, vol. 74, no. 1, pp. 58-65. https://doi.org/10.1016/j.jhep.2020.07.028, https://doi.org/10.1016/j.jhep.2020.07.028","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.jhep.2020.07.028","doi":"https://doi.org/10.1016/j.jhep.2020.07.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2020.07.028","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827820304815/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309928","display_name":"Aarhus Universitet","ror":"https://ror.org/01aj84f44"},{"id":"https://openalex.org/F4320309929","display_name":"Aarhus Universitetshospital","ror":"https://ror.org/040r8fr65"},{"id":"https://openalex.org/F4320310672","display_name":"Institut for Klinisk Medicin, Aarhus Universitet","ror":"https://ror.org/01aj84f44"},{"id":"https://openalex.org/F4320318040","display_name":"Intercept Pharmaceuticals","ror":"https://ror.org/01sx6jc36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3045075706.pdf","grobid_xml":"https://content.openalex.org/works/W3045075706.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W53137987","https://openalex.org/W184794586","https://openalex.org/W1548320525","https://openalex.org/W1677336966","https://openalex.org/W1903778324","https://openalex.org/W1968322810","https://openalex.org/W1969152071","https://openalex.org/W1987523828","https://openalex.org/W1994968614","https://openalex.org/W1996583648","https://openalex.org/W2023394529","https://openalex.org/W2032058959","https://openalex.org/W2049515100","https://openalex.org/W2049822964","https://openalex.org/W2052390133","https://openalex.org/W2053581007","https://openalex.org/W2074274895","https://openalex.org/W2078165560","https://openalex.org/W2089526803","https://openalex.org/W2090573979","https://openalex.org/W2095160124","https://openalex.org/W2100345391","https://openalex.org/W2122678100","https://openalex.org/W2165869744","https://openalex.org/W2278937442","https://openalex.org/W2286499419","https://openalex.org/W2294353976","https://openalex.org/W2341058973","https://openalex.org/W2518389324","https://openalex.org/W2535490199","https://openalex.org/W2565993381","https://openalex.org/W2593535068","https://openalex.org/W2605729742","https://openalex.org/W2613600150","https://openalex.org/W2673358573","https://openalex.org/W2735817229","https://openalex.org/W2761773602","https://openalex.org/W2775129631","https://openalex.org/W2791796281","https://openalex.org/W2951907718","https://openalex.org/W2959572757","https://openalex.org/W2968737992","https://openalex.org/W2977774421","https://openalex.org/W7155173416"],"related_works":["https://openalex.org/W2510200355","https://openalex.org/W2527742702","https://openalex.org/W4293229976","https://openalex.org/W2947175560","https://openalex.org/W2177411457","https://openalex.org/W2547953369","https://openalex.org/W2761773602","https://openalex.org/W2433753961","https://openalex.org/W2921019268","https://openalex.org/W2921445754"],"abstract_inverted_index":{"Background":[0],"&":[1],"Aims":[2],"Obeticholic":[3],"acid":[4,13,22,51,142,280,336],"(OCA)":[5,337],"is":[6,315],"an":[7,230],"agonist":[8],"of":[9,33,67,108,119,135,160,178,188,198,210,221,238,244,261,276,342,367],"the":[10,64,80,109,136,139,184,205,234,273,277,300,322,332,365,377,386],"nuclear":[11],"bile":[12,21,35,121,129,141,279,288,308,324,343,368,382],"receptor":[14],"farnesoid":[15],"X":[16],"receptor,":[17],"which":[18,321],"regulates":[19],"hepatic":[20,31,153,172,274],"metabolism.":[23],"We":[24,329],"tested":[25,330],"whether":[26,331],"OCA":[27,170,271,298,363,374],"treatment":[28,48,88,111,333],"would":[29,338],"influence":[30],"transport":[32,118,275,366],"conjugated":[34,120,140,278,287],"acids":[36,122,344,369,383],"in":[37,71,94,229,233,320,348,385],"patients":[38,56,81,263,350],"with":[39,49,57,59,90,168,264,269,334,346,351],"primary":[40,352],"biliary":[41,126,216,293,313,353],"cholangitis":[42,314],"(PBC)":[43],"who":[44],"responded":[45],"inadequately":[46],"to":[47,84,255,305,372],"ursodeoxycholic":[50],"(UDCA).":[52],"Methods":[53],"Eight":[54],"UDCA-treated":[55,262],"PBC":[58,265],"alkaline":[60],"phosphatase":[61],"\u22651.5":[62],"times":[63],"upper":[65],"limit":[66],"normal":[68],"range":[69],"participated":[70],"a":[72,99,176,196,219,242,296,316],"double-blind,":[73],"placebo-controlled":[74],"study.":[75],"While":[76],"continuing":[77],"on":[78],"UDCA,":[79],"were":[82],"randomised":[83],"two":[85,110],"3-month":[86],"crossover":[87],"periods":[89],"placebo":[91,347],"and":[92,128,163,204,284],"OCA,":[93],"random":[95],"order,":[96],"separated":[97],"by":[98,131,175,195,218,241,388],"1-month":[100],"washout":[101],"period":[102],"without":[103],"study":[104,260],"treatment.":[105],"After":[106],"each":[107],"periods,":[112],"we":[113],"determined":[114],"rate":[115,206],"constants":[116],"for":[117,208],"between":[123],"blood,":[124],"hepatocytes,":[125],"canaliculi,":[127],"ducts":[130,325],"positron":[132],"emission":[133],"tomography":[134],"liver":[137,318,340,387],"using":[138,158],"tracer":[143,281],"[":[144],"N":[145],"-methyl-":[146],"11":[147,150,189,211,239,253,282],"C]cholylsarcosine":[148],"(":[149,180,200,223,246],"C-CSar).":[151],"The":[152],"blood":[154,173,192,371],"perfusion":[155,174],"was":[156],"measured":[157],"infusion":[159],"indocyanine":[161],"green":[162],"Fick's":[164],"principle.":[165],"Results":[166],"Compared":[167],"placebo,":[169,270],"increased":[171,272,364],"median":[177,197,220,243,252],"11%":[179,199],"p":[181,201,224,247],"=":[182,202,225,248],"0.045),":[183],"unidirectional":[185],"uptake":[186],"clearance":[187],"C-CSar":[190,212,240],"from":[191,213,250,290,370],"into":[193,215,292],"hepatocytes":[194,214,291,302],"0.01),":[203,249],"constant":[207],"secretion":[209],"canaliculi":[217],"73%":[222],"0.03).":[226],"This":[227,259],"resulted":[228],"OCA-induced":[231],"decrease":[232],"hepatocyte":[235],"residence":[236],"time":[237,301,378],"30%":[245],"group":[251],"min":[254],"8":[256,349],"min.":[257],"Conclusions":[258],"showed":[266,361],"that,":[267],"compared":[268,345],"C-CSar,":[283],"thus":[285],"endogenous":[286],"acids,":[289],"canaliculi.":[294],"As":[295],"result,":[297],"reduced":[299,376],"are":[303,326],"exposed":[304],"potentially":[306,380],"cytotoxic":[307],"acids.":[309],"Lay":[310],"summary":[311],"Primary":[312],"chronic":[317],"disease":[319],"small":[323],"progressively":[327],"destroyed.":[328],"obeticholic":[335],"improve":[339],"excretion":[341],"cholangitis.":[354],"A":[355],"special":[356],"scanning":[357],"technique":[358],"(PET":[359],"scan)":[360],"that":[362,379],"bile.":[373],"thereby":[375],"toxic":[381],"reside":[384],"approximately":[389],"one-third.":[390]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}