{"id":"https://openalex.org/W3045044516","doi":"https://doi.org/10.1634/theoncologist.2020-0679","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study","display_name":"A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study","publication_year":2020,"publication_date":"2020-07-23","ids":{"openalex":"https://openalex.org/W3045044516","doi":"https://doi.org/10.1634/theoncologist.2020-0679","mag":"3045044516","pmid":"https://pubmed.ncbi.nlm.nih.gov/32701199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7648334"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.2020-0679","doi":"https://doi.org/10.1634/theoncologist.2020-0679","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0679","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1634/theoncologist.2020-0679","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077414729","display_name":"Richard F. Riedel","orcid":"https://orcid.org/0000-0001-5412-8710","observed_orcids":["https://orcid.org/0000-0001-5412-8710"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard F. Riedel","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074015095","display_name":"Karla V. Ballman","orcid":"https://orcid.org/0000-0002-4492-0357","observed_orcids":["https://orcid.org/0000-0002-4492-0357"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karla V. Ballman","raw_affiliation_strings":["Weill Cornell Medicine, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yao Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Lu","raw_affiliation_strings":["Weill Cornell Medicine, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056823515","display_name":"Steven Attia","orcid":"https://orcid.org/0000-0003-1745-4773","observed_orcids":["https://orcid.org/0000-0003-1745-4773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Attia","raw_affiliation_strings":["Mayo Clinic, Jacksonville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, Florida, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086593114","display_name":"Elizabeth T. Loggers","orcid":"https://orcid.org/0000-0003-3432-0443","observed_orcids":["https://orcid.org/0000-0003-3432-0443"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth T. Loggers","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022982759","display_name":"Kristen Nooshin Ganjoo","orcid":"https://orcid.org/0000-0003-0452-9967","observed_orcids":["https://orcid.org/0000-0003-0452-9967"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen N. Ganjoo","raw_affiliation_strings":["Stanford Cancer Institute, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091362508","display_name":"Michael B. Livingston","orcid":"https://orcid.org/0009-0006-3746-3481","observed_orcids":["https://orcid.org/0009-0006-3746-3481"]},"institutions":[{"id":"https://openalex.org/I4210100342","display_name":"Levine Cancer Institute","ror":"https://ror.org/0174nh398","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289","https://openalex.org/I4210100342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Livingston","raw_affiliation_strings":["Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA","institution_ids":["https://openalex.org/I4210100342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059734562","display_name":"Warren Allen Chow","orcid":"https://orcid.org/0000-0003-0889-5841","observed_orcids":["https://orcid.org/0000-0003-0889-5841"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren Chow","raw_affiliation_strings":["City of Hope Cancer Center, Duarte, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope Cancer Center, Duarte, California, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090813544","display_name":"Jennifer A. Wright","orcid":"https://orcid.org/0009-0003-5298-6369","observed_orcids":["https://orcid.org/0009-0003-5298-6369"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Wright","raw_affiliation_strings":["Eli Lilly and Company, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102727880","display_name":"John Headley Ward","orcid":"https://orcid.org/0000-0002-9108-7900","observed_orcids":["https://orcid.org/0000-0002-9108-7900"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Ward","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036766883","display_name":"Daniel A. Rushing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Rushing","raw_affiliation_strings":["Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003417999","display_name":"Scott H. Okuno","orcid":"https://orcid.org/0000-0002-1297-6946","observed_orcids":["https://orcid.org/0000-0002-1297-6946"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott H. Okuno","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029966550","display_name":"Damon R. Reed","orcid":"https://orcid.org/0000-0002-8238-2465","observed_orcids":["https://orcid.org/0000-0002-8238-2465"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damon R. Reed","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069135591","display_name":"David A. Liebner","orcid":"https://orcid.org/0000-0002-7657-4137","observed_orcids":["https://orcid.org/0000-0002-7657-4137"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Liebner","raw_affiliation_strings":["The Ohio State University, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087055974","display_name":"Vicki Leigh Keedy","orcid":"https://orcid.org/0000-0002-7213-7562","observed_orcids":["https://orcid.org/0000-0002-7213-7562"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicki L. Keedy","raw_affiliation_strings":["Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071801742","display_name":"Leo Mascarenhas","orcid":"https://orcid.org/0000-0001-7790-0777","observed_orcids":["https://orcid.org/0000-0001-7790-0777"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo Mascarenhas","raw_affiliation_strings":["Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082683623","display_name":"Lara Emily Davis","orcid":"https://orcid.org/0000-0002-6480-1611","observed_orcids":["https://orcid.org/0000-0002-6480-1611"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara E. Davis","raw_affiliation_strings":["Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042631007","display_name":"Christopher W. Ryan","orcid":"https://orcid.org/0000-0002-4259-1123","observed_orcids":["https://orcid.org/0000-0002-4259-1123","https://orcid.org/0000-0003-1757-8311"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Ryan","raw_affiliation_strings":["Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042484310","display_name":"Denise K. Reinke","orcid":"https://orcid.org/0000-0002-8662-7060","observed_orcids":["https://orcid.org/0000-0002-8662-7060","https://orcid.org/0000-0002-0171-5951"]},"institutions":[{"id":"https://openalex.org/I4210141491","display_name":"Sarcoma Alliance for Research through Collaboration","ror":"https://ror.org/04fnb9f41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210141491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise K. Reinke","raw_affiliation_strings":["Sarcoma Alliance for Research through Collaboration (SARC), Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Alliance for Research through Collaboration (SARC), Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210141491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068677359","display_name":"Robert G. Maki","orcid":"https://orcid.org/0000-0002-9853-2528","observed_orcids":["https://orcid.org/0000-0002-9853-2528"]},"institutions":[{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Maki","raw_affiliation_strings":["Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":26,"corresponding_author_ids":["https://openalex.org/A5077414729"],"corresponding_institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":1.5465,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85331543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"11","first_page":"e1655","last_page":"e1662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liposarcoma","display_name":"liposarcoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/metastatic-soft-tissue-sarcoma","display_name":"metastatic soft tissue sarcoma","score":0.7279999852180481},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7310000061988831},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8999999761581421},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dedifferentiated-liposarcoma","display_name":"dedifferentiated liposarcoma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/myxoid-liposarcoma","display_name":"myxoid liposarcoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pleomorphic-liposarcoma","display_name":"pleomorphic liposarcoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.9446835517883301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8299046158790588},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7112691402435303},{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.6367617249488831},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6157771944999695},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5851620435714722},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5519555807113647},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5385165810585022},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.5102112293243408},{"id":"https://openalex.org/C2779568860","wikidata":"https://www.wikidata.org/wiki/Q1827425","display_name":"Liposarcoma","level":3,"score":0.4619489312171936},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4376826882362366},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.408980131149292},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.36023032665252686},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3459368646144867},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.32546570897102356},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.30266720056533813},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.18019118905067444},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15185341238975525},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.15008562803268433},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.12247657775878906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11903464794158936},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.08261141180992126},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008080","descriptor_name":"Liposarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1634/theoncologist.2020-0679","doi":"https://doi.org/10.1634/theoncologist.2020-0679","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0679","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7648334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7648334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologist","raw_type":"Text"},{"id":"pmid:32701199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32701199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt73z1b9ww","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/73z1b9ww","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist, vol 25, iss 11","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt73z1b9ww","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/73z1b9ww","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Oncologist, vol 25, iss 11","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1634/theoncologist.2020-0679","doi":"https://doi.org/10.1634/theoncologist.2020-0679","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0679","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1955072209","https://openalex.org/W1968209756","https://openalex.org/W2101776780","https://openalex.org/W2107230638","https://openalex.org/W2116922255","https://openalex.org/W2129931005","https://openalex.org/W2139511378","https://openalex.org/W2259955047","https://openalex.org/W2343607850","https://openalex.org/W2537836937","https://openalex.org/W2592120231","https://openalex.org/W2618284892","https://openalex.org/W2743017226","https://openalex.org/W2747718763","https://openalex.org/W2762797139","https://openalex.org/W2808043936","https://openalex.org/W2891103201","https://openalex.org/W2941090871","https://openalex.org/W2967300456","https://openalex.org/W2971112156","https://openalex.org/W4292712479"],"related_works":["https://openalex.org/W2891705564","https://openalex.org/W2808647193","https://openalex.org/W2972636614","https://openalex.org/W2537836937","https://openalex.org/W3000252093","https://openalex.org/W2520323945","https://openalex.org/W7162490637","https://openalex.org/W2941090871","https://openalex.org/W2069926948","https://openalex.org/W2747718763"],"abstract_inverted_index":{"LESSONS":[0],"LEARNED:":[1],"The":[2,133],"results":[3],"from":[4],"the":[5,18,237],"liposarcoma":[6,91,100,122,149],"cohort":[7],"of":[8,21,29,85,241],"SARC024":[9],"confirm":[10],"previously":[11],"published":[12],"data":[13],"and":[14,68,214],"do":[15],"not":[16,246],"support":[17],"routine":[19],"use":[20],"regorafenib":[22,86,106,170,213],"in":[23,41,89,251],"this":[24],"patient":[25,39],"population.":[26],"Continued":[27],"exploration":[28],"novel":[30],"therapies,":[31],"including":[32],"combination":[33],"approaches,":[34],"is":[35,49],"warranted":[36],"for":[37,66,127,169,177,212,220],"a":[38,50,55,80],"population":[40],"whom":[42],"limited":[43],"treatment":[44],"options":[45],"exist.":[46],"BACKGROUND:":[47],"Regorafenib":[48,244],"multitargeted":[51],"kinase":[52,56],"inhibitor":[53],"with":[54,95,120,148],"profile":[57,240],"overlapping,":[58],"but":[59],"distinct":[60],"from,":[61],"pazopanib,":[62],"an":[63],"agent":[64],"approved":[65],"recurrent":[67],"metastatic":[69],"non-gastrointestinal":[70],"stromal":[71],"tumor":[72],"(GIST),":[73],"non-adipocytic":[74],"soft":[75],"tissue":[76],"sarcoma.":[77],"We":[78],"conducted":[79],"randomized,":[81],"phase":[82],"II":[83],"study":[84],"versus":[87,171],"placebo":[88,110,128],"refractory":[90],"patients.":[92],"METHODS:":[93],"Patients":[94,119],"advanced":[96],"or":[97,109],"metastatic,":[98],"treatment-refractory":[99,252],"were":[101,124,157,193,234,259],"randomized":[102],"1:1":[103],"to":[104,141,236,248],"receive":[105],"160":[107],"mg":[108],"once":[111],"daily":[112],"(3":[113],"weeks":[114],"on,":[115],"1":[116],"week":[117],"off).":[118],"well-differentiated":[121],"only":[123],"excluded.":[125],"Crossover":[126],"was":[129,136,161,199,206],"allowed":[130],"upon":[131],"progression.":[132],"primary":[134],"endpoint":[135],"progression-free":[137],"survival":[138,205],"(PFS),":[139],"according":[140],"RECIST":[142],"version":[143],"1.1.":[144],"RESULTS:":[145],"Forty-eight":[146],"subjects":[147],"(34":[150],"dedifferentiated,":[151],"12":[152],"myxoid/round":[153],"cell,":[154],"2":[155],"pleomorphic)":[156],"enrolled.":[158],"Median":[159,203],"PFS":[160,250],"1.87":[162],"(95%":[163,173,184,208,216,225],"confidence":[164],"interval":[165],"[CI],":[166],"0.92-3.67)":[167],"months":[168,176,211,219],"2.07":[172],"CI,":[174,185,209,217,226],"1.64-3.44)":[175],"placebo;":[178],"stratified":[179,222],"hazard":[180],"ratio":[181],"[HR],":[182],"0.85":[183],"0.46,":[186],"1.58),":[187],"p":[188,228],"=":[189,229],".62.":[190],"No":[191,254],"responses":[192],"seen":[194],"on":[195,201],"regorafenib.":[196,242],"One":[197],"PR":[198],"observed":[200],"placebo.":[202],"overall":[204],"6.46":[207],"4.16-23.48)":[210],"4.89":[215],"3.02-9.77)":[218],"placebo,":[221],"HR,":[223],"0.66":[224],"0.31-1.40),":[227],".28).":[230],"Treatment-related":[231],"adverse":[232],"events":[233],"similar":[235],"known":[238],"safety":[239,257],"CONCLUSION:":[243],"did":[245],"appear":[247],"improve":[249],"liposarcoma.":[253],"new":[255],"significant":[256],"signals":[258],"observed.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-07-29T00:00:00"}
