{"id":"https://openalex.org/W3044596668","doi":"https://doi.org/10.1158/1538-7755.disp19-c029","title":"Abstract C029: Consumption of dietary AGEs during puberty and increased breast cancer risk: A link between lifestyle and cancer disparity","display_name":"Abstract C029: Consumption of dietary AGEs during puberty and increased breast cancer risk: A link between lifestyle and cancer disparity","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3044596668","doi":"https://doi.org/10.1158/1538-7755.disp19-c029","mag":"3044596668"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7755.disp19-c029","doi":"https://doi.org/10.1158/1538-7755.disp19-c029","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7755.disp19-c029","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025112806","display_name":"Callan C. Frye","orcid":"https://orcid.org/0000-0003-0750-7261","observed_orcids":["https://orcid.org/0000-0003-0750-7261"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callan C Frye","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019584943","display_name":"Bradley A. Krisanits","orcid":"https://orcid.org/0000-0001-8259-118X","observed_orcids":["https://orcid.org/0000-0001-8259-118X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley A Krisanits","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047433344","display_name":"Reid Schuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reid Schuster","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224663","display_name":"Jaime F. Randise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Randise","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029824637","display_name":"Lourdes M. Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lourdes M Nogueira","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019011382","display_name":"Kristi L. Helke","orcid":"https://orcid.org/0000-0001-9746-0764","observed_orcids":["https://orcid.org/0000-0001-9746-0764"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi Helke","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047082878","display_name":"Amanda C. LaRue","orcid":"https://orcid.org/0000-0003-4572-1496","observed_orcids":["https://orcid.org/0000-0003-4572-1496"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda C LaRue","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030420068","display_name":"David P. Turner","orcid":"https://orcid.org/0000-0003-3667-8844","observed_orcids":["https://orcid.org/0000-0003-3667-8844"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P Turner","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086296004","display_name":"Victoria J. Findlay","orcid":"https://orcid.org/0000-0002-9994-6319","observed_orcids":["https://orcid.org/0000-0002-9994-6319"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria J Findlay","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"6_Supplement_2","first_page":"C029","last_page":"C029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.972000002861023},{"id":"https://openalex.org/keywords/dietary-ages","display_name":"dietary AGEs","score":0.8130000233650208},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.878000020980835},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9929999709129333},{"id":"https://openalex.org/keywords/breast-cancer-disparities","display_name":"breast cancer disparities","score":0.8289999961853027},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mammary-stroma","display_name":"mammary stroma","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/terminal-end-buds","display_name":"terminal end buds","score":0.6389999985694885},{"id":"https://openalex.org/keywords/ductal-branching","display_name":"ductal branching","score":0.871999979019165},{"id":"https://openalex.org/keywords/pre-neoplastic-lesions","display_name":"pre-neoplastic lesions","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5230000019073486},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.8149999976158142},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6019999980926514},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6610581874847412},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.6381891965866089},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5458909869194031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5346027612686157},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5343282222747803},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.5249007940292358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5133077502250671},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48525238037109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4503740072250366},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3628137707710266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3402712941169739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7755.disp19-c029","doi":"https://doi.org/10.1158/1538-7755.disp19-c029","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7755.disp19-c029","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3048670182","https://openalex.org/W2885969448","https://openalex.org/W4387408495","https://openalex.org/W2593589987","https://openalex.org/W4411288875","https://openalex.org/W4404140587","https://openalex.org/W3033578713","https://openalex.org/W3007123976","https://openalex.org/W4301205256","https://openalex.org/W3011048477"],"abstract_inverted_index":{"Abstract":[0],"Introduction.":[1],"The":[2],"focus":[3],"of":[4,52,151,178,206,326,331,341,387,411,470,490,498],"this":[5,32],"study":[6],"is":[7],"on":[8,15,180,247,495],"early":[9,398],"lifestyle":[10,113,430,483],"factors":[11,116],"and":[12,20,29,110,153,164,187,215,226,238,292,303,315,338,370,375,419,431,440,475,484,505],"their":[13,253],"effect":[14],"mammary":[16,44,66,182,224,241,261],"development":[17,45,67,262],"during":[18,42,260,290,417,473],"puberty":[19,291,418,474],"how":[21],"they":[22,92],"relate":[23],"to":[24,48,70,73,123,148,175,251,267,276,280,335],"increased":[25,124,141,149,312,420,476],"breast":[26,75,265,269,294,361,421,437,477],"cancer":[27,54,76,270,422,438,441,478,485],"risk":[28,51,423,439],"disparities.":[30,442],"At":[31],"time":[33],"we":[34,88],"do":[35],"not":[36],"understand":[37],"what":[38],"biological":[39],"changes":[40,366],"occur":[41],"pubertal":[43,65],"which":[46,157,344,401],"leads":[47],"a":[49,111,171,329,388,396],"greater":[50,408],"developing":[53],"in":[55,78,128,135,160,367,377,380,502],"later":[56,79],"life.":[57,80],"Identifying":[58],"the":[59,85,136,143,194,248,264,282,339,384,412,491,496,506],"molecular":[60],"mechanisms":[61],"that":[62,87,120,274],"cause":[63],"aberrant":[64,317],"may":[68,424],"lead":[69],"defined":[71],"strategies":[72,428],"reduce":[74],"burden":[77],"As":[81],"our":[82,129],"bodies":[83],"use":[84,170],"sugars":[86],"consume":[89],"for":[90,104,212,218,299,429],"energy":[91],"generate":[93],"waste":[94],"chemicals":[95],"known":[96],"as":[97],"advanced":[98],"glycation":[99],"end":[100,319],"products":[101],"or":[102,202],"AGEs":[103,286,391,472],"short.":[105],"Significantly,":[106],"low":[107],"income,":[108],"obesity":[109],"sedentary":[112],"are":[114,158,192,210],"established":[115],"driving":[117],"health":[118],"disparity":[119,486],"also":[121],"contribute":[122],"AGE":[125,133,162,179,300,307,324,349,364,415],"accumulation":[126],"levels":[127],"bodies.":[130],"In":[131,359],"particular,":[132],"content":[134],"Western":[137],"Diet":[138],"has":[139],"consistently":[140],"over":[142],"last":[144],"50":[145],"years":[146],"due":[147,275],"consumption":[150,308],"sugar-laden":[152],"cheap":[154],"processed/manufactured":[155],"foods":[156],"high":[159],"reactive":[161,389],"metabolites":[163],"can":[165,402],"promote":[166,293],"obesity.":[167],"Methods.":[168],"We":[169,272],"dietary":[172,285,471],"mouse":[173,240],"model":[174],"assess":[176,252],"impact":[177],"normal":[181],"development.":[183],"Wild":[184],"type":[185],"FVB/n":[186],"RAGE":[188,327],"null":[189],"(RAGE-/-)":[190],"mice":[191],"fed":[193],"respective":[195],"diets":[196],"from":[197,223,393],"weaning":[198],"until":[199],"7":[200],"(pubertal)":[201],"12":[203],"(adult)":[204],"weeks":[205],"age.":[207],"Mammary":[208],"glands":[209,225],"extracted":[211],"whole":[213],"mounting":[214],"paraffin":[216],"embedded":[217],"histology.":[219],"Fibroblasts":[220],"were":[221,233,373],"isolated":[222,236,249],"cultured":[227],"ex":[228],"vivo.":[229],"Transwell":[230],"migration":[231],"assays":[232],"performed":[234,246],"with":[235],"fibroblasts":[237,250],"HC11":[239],"epithelial":[242],"cells.":[243],"qPCR":[244],"was":[245],"activation":[254,325,386],"status.":[255],"Results.":[256],"Early":[257],"life":[258,399],"exposures":[259],"influence":[263,281,403],"microenvironment":[266],"increase":[268,379],"risk.":[271],"show":[273],"an":[277],"innate":[278],"ability":[279],"cellular":[283],"matrix,":[284],"disrupt":[287],"developmental":[288],"programs":[289],"tumor":[295,362,404],"growth.":[296,382],"Through":[297,383],"receptor":[298],"(RAGE)":[301],"dependent":[302],"independent":[304],"mechanisms,":[305],"chronic":[306],"delayed":[309],"ductal":[310,313],"extension,":[311],"branching":[314],"caused":[316],"terminal":[318],"bud":[320],"(TEB)":[321],"morphology.":[322],"Dietary":[323],"mediated":[328,350,365],"program":[330],"activated":[332],"stroma":[333],"leading":[334],"hyperplastic":[336],"growth":[337],"formation":[340],"pre-neoplastic":[342],"lesions":[343],"persisted":[345],"into":[346],"adulthood.":[347],"Importantly,":[348],"effects":[351],"remained":[352],"even":[353],"after":[354,357],"diet":[355,394],"intervention":[356,433],"puberty.":[358],"dietary-AGE":[360],"models,":[363],"tissue":[368],"architecture":[369],"cell":[371],"function":[372],"recapitulated":[374],"resulted":[376],"3-fold":[378],"neoplastic":[381],"perpetual":[385],"stroma,":[390],"derived":[392],"represent":[395],"common":[397],"exposure":[400],"behavior.":[405],"Conclusions.":[406],"A":[407,449,480],"mechanistic":[409],"understanding":[410],"link":[413,481],"between":[414,482],"intake":[416],"define":[425],"novel":[426],"potential":[427],"pharmacological":[432],"aimed":[434],"at":[435],"reducing":[436],"Citation":[443],"Format:":[444],"Callan":[445],"C":[446,461],"Frye,":[447],"Bradley":[448],"Krisanits,":[450],"Reid":[451],"Schuster,":[452],"Jaime":[453],"Randise,":[454],"Lourdes":[455],"M":[456],"Nogueira,":[457],"Kristi":[458],"Helke,":[459],"Amanda":[460],"LaRue,":[462],"David":[463],"P":[464],"Turner,":[465],"Victoria":[466],"J":[467],"Findlay.":[468],"Consumption":[469],"risk:":[479],"[abstract].":[487],"In:":[488],"Proceedings":[489],"Twelfth":[492],"AACR":[493],"Conference":[494],"Science":[497],"Cancer":[499,518],"Health":[500],"Disparities":[501],"Racial/Ethnic":[503],"Minorities":[504],"Medically":[507],"Underserved;":[508],"2019":[509],"Sep":[510],"20-23;":[511],"San":[512],"Francisco,":[513],"CA.":[514],"Philadelphia":[515],"(PA):":[516],"AACR;":[517],"Epidemiol":[519],"Biomarkers":[520],"Prev":[521],"2020;29(6":[522],"Suppl_2):Abstract":[523],"nr":[524],"C029.":[525]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2020-07-29T00:00:00"}