{"id":"https://openalex.org/W3044571635","doi":"https://doi.org/10.1073/pnas.2006816117","title":"Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA","display_name":"Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA","publication_year":2020,"publication_date":"2020-07-20","ids":{"openalex":"https://openalex.org/W3044571635","doi":"https://doi.org/10.1073/pnas.2006816117","mag":"3044571635","pmid":"https://pubmed.ncbi.nlm.nih.gov/32690683"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2006816117","doi":"https://doi.org/10.1073/pnas.2006816117","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2006816117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7414172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039430113","display_name":"Francesco Roberto Simonetti","orcid":"https://orcid.org/0000-0002-4165-660X","observed_orcids":["https://orcid.org/0000-0002-4165-660X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesco R. Simonetti","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"],"raw_orcid":"https://orcid.org/0000-0002-4165-660X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer A. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. White","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080171583","display_name":"Camille Tumiotto","orcid":"https://orcid.org/0000-0001-8547-8107","observed_orcids":["https://orcid.org/0000-0001-8547-8107"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camille Tumiotto","raw_affiliation_strings":["Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260;"],"raw_orcid":"https://orcid.org/0000-0001-8547-8107","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260;","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058795870","display_name":"Kristen D. Ritter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristen D. Ritter","raw_affiliation_strings":["AccelevirDx, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AccelevirDx, Baltimore, MD 21205;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064170493","display_name":"Mian Cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mian Cai","raw_affiliation_strings":["AccelevirDx, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AccelevirDx, Baltimore, MD 21205;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045529124","display_name":"Rajesh Tim Gandhi","orcid":"https://orcid.org/0000-0002-9701-6062","observed_orcids":["https://orcid.org/0000-0002-9701-6062","https://orcid.org/0009-0005-4560-9375"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh T. Gandhi","raw_affiliation_strings":["Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063704053","display_name":"Steven G. Deeks","orcid":"https://orcid.org/0000-0001-6371-747X","observed_orcids":["https://orcid.org/0000-0001-6371-747X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G. Deeks","raw_affiliation_strings":["Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA 94118;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA 94118;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060742318","display_name":"Bonnie J. Howell","orcid":"https://orcid.org/0000-0002-5915-9943","observed_orcids":["https://orcid.org/0000-0002-5915-9943"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie J. Howell","raw_affiliation_strings":["Merck &amp; Co., Kenilworth, NJ 07033;"],"raw_orcid":"https://orcid.org/0000-0002-5915-9943","affiliations":[{"raw_affiliation_string":"Merck &amp; Co., Kenilworth, NJ 07033;","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069209710","display_name":"Luis J. Montaner","orcid":"https://orcid.org/0000-0001-5799-6759","observed_orcids":["https://orcid.org/0000-0001-5799-6759"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis J. Montaner","raw_affiliation_strings":["The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":"https://orcid.org/0000-0001-5799-6759","affiliations":[{"raw_affiliation_string":"The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018624004","display_name":"Joel N. Blankson","orcid":"https://orcid.org/0000-0002-9683-8021","observed_orcids":["https://orcid.org/0000-0002-9683-8021"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel N. Blankson","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026746261","display_name":"Albine Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albine Martin","raw_affiliation_strings":["AccelevirDx, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AccelevirDx, Baltimore, MD 21205;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076028154","display_name":"Gregory M. Laird","orcid":"https://orcid.org/0000-0003-2873-4295","observed_orcids":["https://orcid.org/0000-0003-2873-4295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory M. Laird","raw_affiliation_strings":["AccelevirDx, Baltimore, MD 21205;"],"raw_orcid":"https://orcid.org/0000-0003-2873-4295","affiliations":[{"raw_affiliation_string":"AccelevirDx, Baltimore, MD 21205;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079324608","display_name":"Robert F. Siliciano","orcid":"https://orcid.org/0000-0002-1764-1993","observed_orcids":["https://orcid.org/0000-0002-1764-1993"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert F. Siliciano","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","HHMI, Baltimore, MD 21205"],"raw_orcid":"https://orcid.org/0000-0002-1764-1993","affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"HHMI, Baltimore, MD 21205","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038307269","display_name":"John W. Mellors","orcid":"https://orcid.org/0000-0002-3737-9742","observed_orcids":["https://orcid.org/0000-0002-3737-9742"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Mellors","raw_affiliation_strings":["Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260;","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014454124","display_name":"Janet D'Angelo Siliciano","orcid":"https://orcid.org/0000-0001-6712-3775","observed_orcids":["https://orcid.org/0000-0001-6712-3775"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet D. Siliciano","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5079324608"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":7.1375,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.98260171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"117","issue":"31","first_page":"18692","last_page":"18700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.753000020980835},{"id":"https://openalex.org/keywords/defective-proviruses","display_name":"defective proviruses","score":0.8109999895095825},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.8330000042915344},{"id":"https://openalex.org/keywords/viral-rebound","display_name":"viral rebound","score":0.7149999737739563},{"id":"https://openalex.org/keywords/viral-outgrowth-assay","display_name":"viral outgrowth assay","score":0.6790000200271606},{"id":"https://openalex.org/keywords/sequence-variation","display_name":"sequence variation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6807016134262085},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5615336894989014},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5149598717689514},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.4968734085559845},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49018150568008423},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.48509109020233154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.428339421749115},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.4183606207370758},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30812638998031616},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.25664710998535156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.219760924577713},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.17119812965393066},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2006816117","doi":"https://doi.org/10.1073/pnas.2006816117","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2006816117","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:32690683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32690683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6719580","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7414172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7414172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7414172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7414172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7414172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1162399445","display_name":null,"funder_award_id":"UM1 AI26621","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G1386795942","display_name":null,"funder_award_id":"UM1 AI069481","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1826974679","display_name":null,"funder_award_id":"R44 AI124996","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2705185627","display_name":"BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy","funder_award_id":"UM1AI126620","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3936548522","display_name":null,"funder_award_id":"UM1 AI26620","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G4553935269","display_name":null,"funder_award_id":"UM1-AI-068636","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4602781468","display_name":"Combined Immunologic Approaches to Cure HIV-1","funder_award_id":"UM1AI126603","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6050242356","display_name":"Centralized Resource to Accurately Quantify Latent and Expressed HIV Reservoirs","funder_award_id":"U24AI143502","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6619532180","display_name":"Host and viral genomic determinants of HIV latent reservoir size and characteristics in individuals with substance use disorders","funder_award_id":"R61DA047022","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G857487509","display_name":null,"funder_award_id":"UM1-AI068634","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8770058065","display_name":"Development of a quantitative assay for intact HIV DNA measures in tissue","funder_award_id":"R43AI142866","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000863735","display_name":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","funder_award_id":"5um1ai068636-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000874350","display_name":"The Johns Hopkins Center for AIDS Research (JHU CFAR)","funder_award_id":"P30AI094189","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000884504","display_name":"AIDS Clinical Trial Group Laboratory Center","funder_award_id":"UM1AI106701","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000886520","display_name":"Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG)","funder_award_id":"5um1ai068634-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G96469372","display_name":null,"funder_award_id":"R01 AI140789","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G97119092","display_name":null,"funder_award_id":"P30 AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337544","display_name":"Office of Extramural Research, National Institutes of Health","ror":"https://ror.org/05aq6yn88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1497870368","https://openalex.org/W1964849737","https://openalex.org/W1990993204","https://openalex.org/W2001375348","https://openalex.org/W2011208161","https://openalex.org/W2052680578","https://openalex.org/W2060829964","https://openalex.org/W2063628696","https://openalex.org/W2064416623","https://openalex.org/W2080166804","https://openalex.org/W2090646713","https://openalex.org/W2101516953","https://openalex.org/W2114538357","https://openalex.org/W2115580899","https://openalex.org/W2117633297","https://openalex.org/W2139250164","https://openalex.org/W2144549163","https://openalex.org/W2272185077","https://openalex.org/W2480104137","https://openalex.org/W2512878063","https://openalex.org/W2549615728","https://openalex.org/W2598871150","https://openalex.org/W2602545542","https://openalex.org/W2605860823","https://openalex.org/W2625382334","https://openalex.org/W2625399959","https://openalex.org/W2749571720","https://openalex.org/W2752406059","https://openalex.org/W2766409016","https://openalex.org/W2793229524","https://openalex.org/W2794108759","https://openalex.org/W2911228036","https://openalex.org/W2958952516","https://openalex.org/W2991511456","https://openalex.org/W2998280724","https://openalex.org/W3003221987","https://openalex.org/W3005267901","https://openalex.org/W3005734087","https://openalex.org/W3009799602","https://openalex.org/W3011123312","https://openalex.org/W3036355166"],"related_works":["https://openalex.org/W2370565492","https://openalex.org/W2016766059","https://openalex.org/W2029741357","https://openalex.org/W2144907742","https://openalex.org/W1748700469","https://openalex.org/W2009366069","https://openalex.org/W2620872782","https://openalex.org/W2086431635","https://openalex.org/W4253376477","https://openalex.org/W1764550320"],"abstract_inverted_index":{"Significance":[0],"Despite":[1],"clinically":[2],"effective":[3],"antiretroviral":[4],"therapy":[5],"(ART),":[6],"replication-competent":[7],"HIV-1":[8,41,65],"persists":[9],"as":[10,56],"latent":[11,33],"proviral":[12,52],"DNA":[13,53],"capable":[14],"of":[15,76,115],"rekindling":[16],"viral":[17,101],"replication":[18],"when":[19],"ART":[20],"is":[21],"stopped.":[22],"To":[23],"cure":[24],"the":[25,50],"infection,":[26],"therapies":[27],"are":[28,42,91],"being":[29],"developed":[30,49],"to":[31,44],"eliminate":[32],"HIV-1.":[34],"Accurate":[35],"assays":[36],"for":[37,63],"intact":[38,51,64,83],"or":[39],"rebound-competent":[40],"important":[43],"this":[45],"effort.":[46],"We":[47,80,104],"previously":[48,98],"assay":[54,62],"(IPDA)":[55],"a":[57,73],"more":[58],"accurate":[59],"and":[60],"scalable":[61],"proviruses.":[66],"Here":[67],"we":[68],"present":[69,92],"IPDA":[70,108],"analysis":[71],"in":[72,113],"diverse":[74],"cohort":[75],"400":[77],"ART-treated":[78],"individuals.":[79],"confirm":[81],"that":[82,107],"proviruses,":[84,90],"although":[85],"vastly":[86],"outnumbered":[87],"by":[88,100],"defective":[89],"at":[93],"significantly":[94],"higher":[95],"frequencies":[96],"than":[97],"detected":[99],"outgrowth":[102],"assays.":[103],"also":[105],"show":[106],"amplicon":[109],"signal":[110],"issues,":[111],"observed":[112],"6.3%":[114],"samples,":[116],"result":[117],"from":[118],"sequence":[119],"polymorphisms.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
