{"id":"https://openalex.org/W3044523355","doi":null,"title":"The Effect of Peripheral Pain on Spinal Circuits Following Spinal Cord Injury","display_name":"The Effect of Peripheral Pain on Spinal Circuits Following Spinal Cord Injury","publication_year":2015,"publication_date":"2015-11-11","ids":{"openalex":"https://openalex.org/W3044523355","mag":"3044523355"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/188522","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/188522","pdf_url":"https://hdl.handle.net/1969.1/188522","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1969.1/188522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Joshua Reynolds","orcid":"https://orcid.org/0000-0001-6680-5993","observed_orcids":["https://orcid.org/0000-0001-6680-5993"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joshua Reynolds","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6680-5993","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9879999756813049},{"id":"https://openalex.org/keywords/c-fiber-activation","display_name":"C-fiber activation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/peripheral-pain","display_name":"peripheral pain","score":0.7770000100135803},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/spinal-cord-transection","display_name":"spinal cord transection","score":0.8109999895095825},{"id":"https://openalex.org/keywords/spinal-cord-inflammation","display_name":"myelitis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.6489999890327454},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6060000061988831},{"id":"https://openalex.org/keywords/spinal-cord-circuits","display_name":"spinal cord circuits","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6592575311660767},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6350279450416565},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6219813823699951},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5809019207954407},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42852509021759033},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33374959230422974},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21693983674049377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10213163495063782},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06757247447967529}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/188522","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/188522","pdf_url":"https://hdl.handle.net/1969.1/188522","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3044523355","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/handle/1969.1/188522","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/188522","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/188522","pdf_url":"https://hdl.handle.net/1969.1/188522","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044523355.pdf","grobid_xml":"https://content.openalex.org/works/W3044523355.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2893849361","https://openalex.org/W2967686355","https://openalex.org/W2791006664","https://openalex.org/W2435542596","https://openalex.org/W6989861654","https://openalex.org/W2804484039","https://openalex.org/W2071329829","https://openalex.org/W2982208375","https://openalex.org/W1660050261","https://openalex.org/W2091348520"],"abstract_inverted_index":{"Events":[0],"soon":[1],"after":[2],"spinal":[3,7,24,36,52,108,131,138,162],"cord":[4,8,53,139],"trauma":[5],"alter":[6],"function":[9,37],"and":[10,68,80,156],"drastically":[11],"impact":[12],"functional":[13,70],"outcomes.":[14,71],"Guided":[15],"by":[16,38],"our":[17],"work":[18],"in":[19],"a":[20,40,47,125,130],"transection":[21,132,163],"model":[22,50,127],"of":[23,51,128,145,153,168,183],"learning,":[25],"we":[26,104],"hypothesized":[27],"that":[28,75,160,175],"uncontrollable":[29],"noxious":[30],"input":[31,58],"(C":[32],"fiber":[33,57,84,122,150,170,190],"activation)":[34],"undermines":[35],"engaging":[39],"pro-":[41],"inflammatory":[42,60],"state":[43],"(central":[44],"sensitization).":[45],"In":[46,124],"clinically":[48],"relevant":[49],"injury":[54,185],"(SCI),":[55],"C":[56,83,121,149,169,189],"exacerbates":[59],"processes":[61,98,177],"within":[62],"the":[63,73,92,116,137,141,146,165,181],"lesion,":[64],"increases":[65],"cell":[66,78],"death,":[67],"impairs":[69],"However,":[72],"mechanisms":[74],"underlie":[76],"increased":[77,117],"death":[79],"inflammation":[81,118],"following":[82,192],"activation":[85,191],"have":[86],"not":[87],"been":[88],"fully":[89],"described.":[90],"Specifically,":[91],"extent":[93],"to":[94,115,135],"which":[95],"descending,":[96],"brain-mediated":[97,112,176],"are":[99,178],"required":[100,179],"is":[101],"unknown.":[102],"Here,":[103],"examined":[105],"whether":[106],"local":[107],"circuits,":[109],"or":[110],"descending":[111],"processes,":[113],"contribute":[114],"associated":[119,187],"with":[120,188],"activation.":[123,151],"contusion":[126],"SCI,":[129],"was":[133],"used":[134],"isolate":[136],"from":[140],"brain.":[142],"Electrical":[143],"stimulation":[144],"tail":[147],"provided":[148],"Examination":[152],"hemoglobin,":[154],"IL-18,":[155],"IL-1\u03b2":[157],"concentrations":[158],"revealed":[159],"complete":[161],"reversed":[164],"detrimental":[166],"effects":[167],"input.":[171],"These":[172],"results":[173],"suggest":[174],"for":[180],"development":[182],"secondary":[184],"cascades":[186],"SCI.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-07-29T00:00:00"}
